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CN104174058B - VHP sterilization device and method - Google Patents

VHP sterilization device and method Download PDF

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Publication number
CN104174058B
CN104174058B CN201410449682.4A CN201410449682A CN104174058B CN 104174058 B CN104174058 B CN 104174058B CN 201410449682 A CN201410449682 A CN 201410449682A CN 104174058 B CN104174058 B CN 104174058B
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pipeline
sterilization chamber
air
vhp
sterilizing
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CN104174058A (en
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直国富
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SHANGHAI YANFU PHARMACEUTICAL SYSTEM ENGINEERING Co Ltd
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SHANGHAI YANFU PHARMACEUTICAL SYSTEM ENGINEERING Co Ltd
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Abstract

The invention discloses a VHP sterilization device and method. The sterilization device is arranged between a material area and a sterile area, and comprises an air source, a hydrogen peroxide storage device, a sterilization chamber, a dehumidification pipeline, a sterilization pipeline, a vent line and an air exhaust pipeline, wherein the dehumidification pipeline is connected with the air source and the sterilization chamber; the sterilization pipeline is connected with the air source, the hydrogen peroxide storage device and the sterilization chamber; the vent line is connected with the sterile area and the sterilization chamber; and the air exhaust pipeline is connected with the material area and the sterilization chamber. The sterilization method utilizing the sterilization device comprises three steps of dehumidifying, sterilizing and venting. Compared with the prior art, the scheme disclosed by the invention has the advantages that vapor hydrogen peroxide serves as a sterilizing medium, dehumidification, sterilization and ventilation are performed due to reasonable pipeline arrangement, and the sterilization effect and safety are effectively improved.

Description

A kind of VHP bactericidal units and method
Technical field
The present invention relates to sterilizing installation field, more particularly to a kind of VHP bactericidal units and method.
Background technology
Traditional clean room air sterilization technology is mainly carried out disinfection or is sterilized using ozone or formaldehyde, but with aseptic The development of pharmaceutical production, to production environment and it is safe and environment-friendly require more and more higher, the negative effect that formaldehyde fumigation brings is more next More draw attention, and formaldehyde easily condenses and adsorbs in disinfecting process, produces a large amount of residuals, and people have stayed in for a long time formaldehyde It is very big to human health damage in the environment of residual, and bactericidal effect is undesirable.Therefore, this technology can not meet doctor Medicine production field is for the requirement of sterilizing.
The content of the invention
The present invention provides a kind of VHP bactericidal units and method, to solve prior art in have that bactericidal effect is poor, peace The low problem of full property.
The invention provides a kind of VHP bactericidal units, are arranged between material area and aseptic area, the bactericidal unit includes Source of the gas, hydrogen peroxide bin, sterilization chamber, dehumidifying pipeline, sterilizing pipeline, air pipeline and exhaust pipeline, the dehumidification pipe Road connects source of the gas and sterilization chamber, the sterilizing pipeline connection source of the gas, hydrogen peroxide bin and sterilization chamber, the ventilation duct Road connects aseptic area and sterilization chamber, the exhaust pipeline connection material area and sterilization chamber;
During dehumidifying, the sterilizing pipeline and air pipeline are closed, and the dehumidifying pipeline and exhaust pipeline are opened, in source of the gas Air enters sterilization chamber after being dehumidified via dehumidifying pipeline, and is expelled to material area via the exhaust pipeline;
During sterilizing, the dehumidifying pipeline and air pipeline are closed, and the sterilizing pipeline and exhaust pipeline are opened, in source of the gas Hydrogen peroxide in air and hydrogen peroxide bin is generated after vaporized hydrogen peroxide via sterilizing pipeline, into sterilization chamber, And it is expelled to material area via the exhaust pipeline;
During ventilation, the dehumidifying pipeline and sterilizing pipeline are closed, and the air pipeline and exhaust pipeline are opened, in aseptic area Filtrated air enter sterilization chamber via air pipeline, and be expelled to material area via the exhaust pipeline.
Further, the dehumidifying pipeline includes the first valve and dehumidifier, and the source of the gas passes sequentially through first valve Door and dehumidifier connect sterilization chamber.
Further, the sterilizing pipeline includes VHP generators, the second valve, dosing pump, the 3rd valve, the source of the gas The air-in of VHP generators is connected by the second valve, the hydrogen peroxide bin passes sequentially through dosing pump and the 3rd Valve connects the hydrogen peroxide input port of VHP generators, the delivery outlet connection sterilization chamber of the VHP generators.
Further, it is additionally provided with pre-heater between the air-in of the source of the gas and VHP generators.
Further, the air pipeline includes the 4th valve, draft fan and ventilation filter, and the aseptic area is successively Sterilization chamber is connected by the 4th valve, draft fan and ventilation filter.
Further, the exhaust pipeline include the 5th valve, exhaust fan and exhaust-air filter, the sterilization chamber according to It is secondary that material area is connected by the 5th valve, exhaust-air filter and exhaust fan.
Further, the exhaust-air filter includes drainage screen and the manganese dioxide powder being coated on the drainage screen End.
Further, after the sterilization chamber includes that the openable hatch door of two fans, two described fan hatch doors are opened, it is respectively used to Connection material area and sterilization chamber and aseptic area and sterilization chamber, the hatch door includes door body and doorframe, with door body on doorframe Cooperation at arrange it is fluted, jacking mechanism and sealing ring are provided with the groove, the sealing ring is arranged at the notch of groove, institute When stating door body closing, the sealing ring is ejected under jacking mechanism effect on the outside of groove, is combined closely with door body.
Present invention also offers a kind of VHP sterilizing methods, comprise the following steps:
Dehumidifying, opens dehumidifying pipeline and exhaust pipeline, closes sterilizing pipeline and air pipeline, by the air of low dew point via Dehumidifying pipeline sends into sterilization chamber after being dehumidified, and is expelled to material area via the exhaust pipeline, so that in sterilization chamber Humiture and pressure reach preset value;
Sterilizing, opens sterilizing pipeline and exhaust pipeline, dehumidifying pipeline and air pipeline is closed, by air and hydrogen peroxide Jing Generated after vaporized hydrogen peroxide by sterilizing pipeline, send into sterilization chamber, and material area is expelled to via the exhaust pipeline;
Ventilation, opens air pipeline and exhaust pipeline, dehumidifying pipeline and sterilizing pipeline is closed, by the aseptic sky in aseptic area Gas sends into sterilization chamber via air pipeline, and is expelled to material area via the exhaust pipeline, until in the sterilization chamber Concentrations of vapor hydrogen peroxide be less than preset concentration.
Further, the persistent period of the sterilization steps is 60~90 minutes.
The present invention using vaporized hydrogen peroxide as sterile medium, arranged by rational pipeline, dehumidified, sterilize with And ventilation, it is effectively improved sterilization effect and safety.Additionally, employing the exhaust gas purification side of catalysis type in exhaust pipeline Formula, by coating manganese dioxide powder on drainage screen, can cause the vaporized hydrogen peroxide discharged to react, and decompose It is do not have influential water and oxygen on environment, prevents pollution.
Description of the drawings
Fig. 1 is a kind of structural representation of VHP bactericidal units that the embodiment of the present invention one is provided;
Fig. 2 is the cabin door structure schematic diagram of sterilization chamber in the embodiment of the present invention one;
Fig. 3 is a kind of schematic flow sheet of VHP sterilizing methods that the embodiment of the present invention one is provided;
Fig. 4 is a kind of piping arrangement of VHP bactericidal units that the embodiment of the present invention two is provided.
Specific embodiment
The embodiment of the present invention is described in further detail with reference to Figure of description.
Embodiment one
A kind of VHP bactericidal units that the embodiment of the present invention one is provided, are arranged between material area and aseptic area.Aseptic area is Finger needs to carry out the region of sterile working, and personnel and relative article must be kept in the region in aseptic condition, Therefore have to be carried out disinfection by bactericidal unit when article is sent into into aseptic area by material area.When using, operator exist Material area side by need sterilizing article be put in bactericidal unit, after carrying out sterilization treatment, by aseptic area side take out to Use in aseptic area.
The concrete structure of the bactericidal unit is as shown in figure 1, including source of the gas 1, hydrogen peroxide bin 2, sterilization chamber 3, remove Wet pipeline 4, sterilizing pipeline 5, air pipeline 6 and exhaust pipeline 7.Dehumidifying pipeline 4 connection source of the gas 1 and sterilization chamber 3, the sterilizing The connection source of the gas 1 of pipeline 5, hydrogen peroxide bin 2 and sterilization chamber 3, the connection aseptic area A of the air pipeline 6 and sterilization chamber 3, the connection material area B of the exhaust pipeline 7 and sterilization chamber 3.
Above-mentioned several pipelines are provided with corresponding valve, by valve being turned on or off come control piper.In work During work, the bactericidal unit includes following several working conditions:
First, except wet condition
In dehumidifying, the sterilizing pipeline 5 and air pipeline 6 are closed, and the dehumidifying pipeline 4 and exhaust pipeline 7 are opened, gas Air in source 1 enters sterilization chamber 3 after being dehumidified via dehumidifying pipeline 4, is then expelled to thing via the exhaust pipeline 7 Material area B.
2nd, sterilizing state
In sterilizing, the dehumidifying pipeline 4 and air pipeline 6 are closed, and the sterilizing pipeline 5 and exhaust pipeline 7 are opened, gas The hydrogen peroxide in air and hydrogen peroxide bin 2 in source 1 is generated after vaporized hydrogen peroxide via sterilizing pipeline, enters death of monks or nuns Bacterium chamber 3, is then expelled to material area B via the exhaust pipeline 7.
3rd, ventilation state
In ventilation, the dehumidifying pipeline 4 and sterilizing pipeline 5 are closed, and the air pipeline 6 and exhaust pipeline 7 are opened, nothing Filtrated air in bacterium area A enters sterilization chamber 3 via air pipeline 6, is then expelled to material area via the exhaust pipeline 7 B。
Wherein, the dehumidifying pipeline 4 includes the first valve and dehumidifier, the source of the gas pass sequentially through first valve and Dehumidifier connects sterilization chamber.
The sterilizing pipeline 5 includes VHP generators, the second valve, dosing pump, the 3rd valve, and the source of the gas passes through second Valve connects the air-in of VHP generators, and the hydrogen peroxide bin passes sequentially through dosing pump and the connection of the 3rd valve The hydrogen oxide input port of VHP generators, the delivery outlet connection sterilization chamber of the VHP generators.Additionally, the source of the gas with Pre-heater is additionally provided between the air-in of VHP generators, for carrying out pre-add to the air into VHP generators Heat, to improve the production efficiency of vaporized hydrogen peroxide.
The air pipeline 6 includes the 4th valve, draft fan and ventilation filter, and the aseptic area passes sequentially through described 4th valve, draft fan and ventilation filter connection sterilization chamber.
The exhaust pipeline 7 includes the 5th valve, exhaust fan and exhaust-air filter, and the sterilization chamber passes sequentially through institute State the 5th valve, exhaust-air filter and exhaust fan connection material area.Wherein, exhaust-air filter includes drainage screen and is coated in Manganese dioxide powder on the drainage screen, by coating manganese dioxide powder on drainage screen, can cause the vaporization discharged Hydrogen peroxide is reacted, and is decomposed into and do not have influential water and oxygen on environment, prevents pollution.
After the sterilization chamber 3 includes that the openable hatch door 8 of two fans, two described fan hatch doors are opened, it is respectively used to connect thing Material area and sterilization chamber and aseptic area and sterilization chamber so that article can be sent into by material area, and have aseptic area to take out.Cabin The concrete structure of door can adopt structure as shown in Figure 2, including door body 81 and doorframe 82, on doorframe with set at the cooperation of door body Groove 83 is equipped with, in the groove 83 jacking mechanism and sealing ring 85 is provided with, the sealing ring 85 is arranged at the notch of groove 83, When the door body is closed, the sealing ring 85 is ejected under jacking mechanism effect on the outside of groove, is combined closely with door body.
In practical application, above-mentioned jacking mechanism can adopt the mechanism of pneumatic type.Because sealing ring 85 is arranged at groove 83 notch so that inside grooves can form a cavity 86, jacking mechanism can be a gas passage 87 and for controlling Make the valve of the gas passage, the cavity 86 in gas passage connection source of the gas and groove, when needing to hold out against, by source of the gas via gas Body passage is to 86 input compressed gas in cavity, so that sealing ring 85 is ejected in the presence of compressed gas, reaches sealing effect Really.
With reference to above-mentioned bactericidal unit, the embodiment of the present invention one additionally provides a kind of VHP sterilizing methods, including as shown in Figure 3 The step of:
Step 301, dehumidifying.
Dehumidifying pipeline and exhaust pipeline are opened, sterilizing pipeline and air pipeline is closed, by the air of low dew point via dehumidifying Pipeline sends into sterilization chamber after being dehumidified, and is expelled to material area via the exhaust pipeline, so that the temperature in sterilization chamber Humidity and pressure reach preset value.In the present embodiment, after the air that dew point is -22 is heated to 30 degrees centigrade and is dehumidified Sterilization chamber is sent into, to reach preferable effect on moisture extraction.
Step 302, sterilizing.
Sterilizing pipeline and exhaust pipeline is opened, dehumidifying pipeline and air pipeline is closed, by air and hydrogen peroxide via going out Tube road is generated after vaporized hydrogen peroxide, sends into sterilization chamber, and is expelled to material area via the exhaust pipeline.
The persistent period of the step is 60~90 minutes, is obtained in that preferable sterilization effect.
Step 303, ventilation.
Air pipeline and exhaust pipeline are opened, dehumidifying pipeline and sterilizing pipeline is closed, by the filtrated air Jing in aseptic area Sterilization chamber is sent into by air pipeline, and material area is expelled to via the exhaust pipeline, until the vapour in the sterilization chamber Change concentration of hydrogen peroxide and be less than preset concentration.In general pharmaceutical industry, the preset concentration for typically setting is as 1PPM.
Embodiment two
A kind of VHP bactericidal units that the embodiment of the present invention two is provided, pipeline arranging structure such as Fig. 4 institutes of the bactericidal unit Show.
Dehumidifying pipeline 4 shares a source of the gas 1 with sterilizing pipeline 5, and by the source of the gas compressed air is provided.Dehumidifying pipeline 4 includes First valve 41 and dehumidifier 42, source of the gas 1 passes sequentially through first valve 41 and the connection sterilization chamber 3 of dehumidifier 42.Sterilizing Pipeline 5 includes VHP generators 55, pre-heater 51, the second valve 52, the valve 54 of dosing pump 53 and the 3rd, and the source of the gas is according to 1 time The air-in of VHP generators 55 is connected by pre-heater 51, the second valve 52, the hydrogen peroxide bin 2 is successively The hydrogen peroxide input port of VHP generators 55, the output of the VHP generators 55 are connected by dosing pump 53 and the 3rd valve 54 Mouth connection sterilization chamber 3.Air pipeline 6 includes the 4th valve 61, draft fan 62 and ventilation filter 63, the aseptic area A Pass sequentially through the 4th valve 61, draft fan 62 and ventilation filter 63 connection sterilization chamber 3.The exhaust pipeline 7 is wrapped The 5th valve 71, exhaust fan 72 and exhaust-air filter 73 are included, the sterilization chamber passes sequentially through the 5th valve 71, air draft Filter 73 and the connection material area B of exhaust fan 72.
Concrete operating principle when being sterilized using the bactericidal unit is as follows:
After the article for needing sterilizing is put into into sterilization chamber, dehumidified first.
In dehumidifying, the first valve 41 and the 5th valve 71 are opened, close the second valve 51, the 3rd valve 54 and the 4th valve Door 61 so that the sterilizing pipeline 5 and air pipeline 6 are closed, the dehumidifying pipeline 4 and exhaust pipeline 7 are opened.By low dew point Air sends into sterilization chamber after being dehumidified via dehumidifying pipeline, and is expelled to material area via the exhaust pipeline, so as to go out The humiture and pressure of bacterium within the chamber reaches preset value.
After completing dehumidifying, then sterilized.
In sterilizing, the second valve 51, the 3rd valve and the 5th valve 71 are opened, close the first valve 41 and the 4th valve 61 so that the dehumidifying pipeline 4 and air pipeline 6 are closed, the sterilizing pipeline 5 and exhaust pipeline 7 are opened.By air and peroxide Change hydrogen to generate after vaporized hydrogen peroxide via sterilizing pipeline, send into sterilization chamber, and material is expelled to via the exhaust pipeline Area, now article completed sterilizing.
After the completion of sterilizing, then it is aerated.
In ventilation, the 4th valve 61 and the 5th valve 71 are opened, close the first valve 41, the second valve 51 and the 3rd valve Door 54 so that dehumidifying pipeline 4 and sterilizing pipeline 5 are closed, and the air pipeline 6 and exhaust pipeline 7 are opened.By the nothing in aseptic area Bacterium air sends into sterilization chamber via air pipeline, and is expelled to material area via the exhaust pipeline, until the sterilization chamber Indoor concentrations of vapor hydrogen peroxide is less than preset concentration.Now, the air in sterilization chamber has been replaced in aseptic area Air, can open the hatch door of aseptic area side, take out article.
Obviously, those skilled in the art can carry out the essence of various changes and modification without deviating from the present invention to the present invention God and scope.So, if these modifications of the present invention and modification belong to the scope of the claims in the present invention and its equivalent technologies Within, then the present invention is also intended to comprising these changes and modification.

Claims (10)

1. a kind of VHP bactericidal units, are arranged between material area and aseptic area, it is characterised in that the bactericidal unit includes gas Source, hydrogen peroxide bin, sterilization chamber, dehumidifying pipeline, sterilizing pipeline, air pipeline and exhaust pipeline, the dehumidifying pipeline Connection source of the gas and sterilization chamber, the sterilizing pipeline connection source of the gas, hydrogen peroxide bin and sterilization chamber, the air pipeline Connection aseptic area and sterilization chamber, the exhaust pipeline connection material area and sterilization chamber;The sterilization chamber includes that two fans can be opened The hatch door for opening, after two described fan hatch doors are opened, is respectively used to connect material area with sterilization chamber and aseptic area and sterilization chamber Room so that article can be sent into by material area, and taken out by aseptic area;
During dehumidifying, the sterilizing pipeline and air pipeline are closed, and the dehumidifying pipeline and exhaust pipeline are opened, the air in source of the gas Sterilization chamber is entered after being dehumidified via dehumidifying pipeline, and material area is expelled to via the exhaust pipeline;
During sterilizing, the dehumidifying pipeline and air pipeline are closed, and the sterilizing pipeline and exhaust pipeline are opened, the air in source of the gas And the hydrogen peroxide in hydrogen peroxide bin is generated after vaporized hydrogen peroxide via sterilizing pipeline, into sterilization chamber, and Jing Material area is expelled to by the exhaust pipeline;
During ventilation, the dehumidifying pipeline and sterilizing pipeline are closed, and the air pipeline and exhaust pipeline are opened, the nothing in aseptic area Bacterium air enters sterilization chamber via air pipeline, and is expelled to material area via the exhaust pipeline.
2. VHP bactericidal units according to claim 1, it is characterised in that the dehumidifying pipeline includes the first valve and removes Wet device, the source of the gas passes sequentially through first valve and dehumidifier connection sterilization chamber.
3. VHP bactericidal units according to claim 1, it is characterised in that the sterilizing pipeline include VHP generators, the Two valves, dosing pump, the 3rd valve, the source of the gas connects the air-in of VHP generators, the peroxide by the second valve Change the hydrogen peroxide input port that hydrogen reservoir passes sequentially through dosing pump and the 3rd valve connection VHP generators, the VHP generators Delivery outlet connection sterilization chamber.
4. VHP bactericidal units according to claim 3, it is characterised in that the source of the gas is input into the air of VHP generators Pre-heater is additionally provided between mouthful.
5. VHP bactericidal units according to claim 1, it is characterised in that the air pipeline includes the 4th valve, ventilation Blower fan and ventilation filter, the aseptic area passes sequentially through the connection sterilizing of the 4th valve, draft fan and ventilation filter Chamber.
6. VHP bactericidal units according to claim 1, it is characterised in that the exhaust pipeline includes the 5th valve, air draft Blower fan and exhaust-air filter, the sterilization chamber passes sequentially through the 5th valve, exhaust-air filter and exhaust fan junctional complex Material area.
7. VHP bactericidal units according to claim 6, it is characterised in that the exhaust-air filter include drainage screen and The manganese dioxide powder being coated on the drainage screen.
8. VHP bactericidal units according to claim 1, it is characterised in that the sterilization chamber includes the openable cabin of two fans Door, after two described fan hatch doors are opened, is respectively used to connect material area and sterilization chamber and aseptic area and sterilization chamber, described Hatch door includes door body and doorframe, arranges fluted with the cooperation of door body on doorframe, and jacking mechanism and sealing are provided with the groove Circle, the sealing ring is arranged at the notch of groove so that the inside grooves form a cavity, and the jacking mechanism is one Gas passage and the valve for controlling the gas passage are constituted, and the gas passage connects the source of the gas and the cavity, institute When stating door body closing, the source of the gas is input into compressed gas via the gas passage into the cavity, so that the sealing ring Eject on the outside of groove in the presence of compressed gas, combine closely with door body.
9. a kind of VHP sterilizing methods of the VHP bactericidal units using as any one of claim 1-8, it is characterised in that Comprise the following steps:
Dehumidifying, opens dehumidifying pipeline and exhaust pipeline, closes sterilizing pipeline and air pipeline, is -22 degrees Celsius low by dew point Dew point air be heated to 30 degree dehumidified via dehumidifying pipeline after send into sterilization chamber, and be expelled to via the exhaust pipeline Material area, so that the humiture and pressure in sterilization chamber reaches preset value;
Sterilizing, opens sterilizing pipeline and exhaust pipeline, closes dehumidifying pipeline and air pipeline, by air and hydrogen peroxide via going out Tube road is generated after vaporized hydrogen peroxide, sends into sterilization chamber, and is expelled to material area via the exhaust pipeline;
Ventilation, opens air pipeline and exhaust pipeline, dehumidifying pipeline and sterilizing pipeline is closed, by the filtrated air Jing in aseptic area Sterilization chamber is sent into by air pipeline, and material area is expelled to via the exhaust pipeline, until the vapour in the sterilization chamber Change concentration of hydrogen peroxide and be less than preset concentration.
10. VHP sterilizing methods according to claim 9, it is characterised in that the persistent period of the sterilization steps is 60~ 90 minutes.
CN201410449682.4A 2014-09-05 2014-09-05 VHP sterilization device and method Active CN104174058B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3600456T3 (en) * 2017-03-27 2023-10-02 Regeneron Pharma PROCEDURE FOR STERILIZATION
IL259945B2 (en) 2018-06-11 2024-03-01 Dusmit Ltd Technique for denaturing of small organic items in premises
CN110585908A (en) * 2019-09-18 2019-12-20 无锡零界净化设备股份有限公司 Catalytic decomposition filter paper and filter for VHP (very high molecular weight) sterilization device
CN111254053B (en) * 2019-12-31 2023-06-02 浙江泰林医学工程有限公司 Hydrogen peroxide instantaneous sterilization device and sterilization method
CN111426022A (en) * 2020-04-02 2020-07-17 克莱门特捷联制冷设备(上海)有限公司 Disinfection and sterilization device and disinfection and sterilization method for air conditioning unit

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CN202314532U (en) * 2011-11-25 2012-07-11 四川汇宇制药有限公司 Hydrogen peroxide sterilization device
CN202440293U (en) * 2011-11-25 2012-09-19 四川汇宇制药有限公司 Isolator air treatment system

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CN202314532U (en) * 2011-11-25 2012-07-11 四川汇宇制药有限公司 Hydrogen peroxide sterilization device
CN202440293U (en) * 2011-11-25 2012-09-19 四川汇宇制药有限公司 Isolator air treatment system

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