CN104035796A - EWOD (electrowetting on dielectric) chip liquid drop driving method and EWOD chip liquid drop driving system - Google Patents
EWOD (electrowetting on dielectric) chip liquid drop driving method and EWOD chip liquid drop driving system Download PDFInfo
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Abstract
The invention provides an EWOD (electrowetting on dielectric) chip liquid drop driving method and an EWOD chip liquid drop driving system. A first capacitor and a second capacitor are relevant to relative positions of liquid drops and driving electrodes, but are irrelevant to driving voltage signal frequency and compositions of the liquid drops, so that the calculated amount in an operation process is required to be reduced greatly. Moreover, by using the EWOD chip liquid drop driving method, whether movement of the liquid drops fails or not can be quickly detected, after the movement of the liquid drops fails, the current stay positions of the liquid drops can be known, namely, when the liquid drops stay on a first driving electrode, a second driving electrode is electrified, so that the liquid drops can overcome obstacles and reach target positions, and follow-up operation of technicians is facilitated.
Description
Technical field
The present invention relates to biochemical analysis field, relate in particular to a kind of EWOD chip liquid drop driving method and system.
Background technology
Recent two decades microflow control technique is along with the fast development of micro production technique has also obtained very large breakthrough, utilize the digital microfluidic technology of the moistening mechanism of dielectric (Elector Wetting on Dielectric, be called for short EWOD) to become the new focus of microflow control technique.Utilizing digital microfluidic technology to control drop, is by controlling, the drive electrode of EWOD chip to be powered up, and drop just can be controlled respectively array drive electrode and be powered up chronologically toward the direction motion that powers up drive electrode, and drop will be driven.
Due to obstacles such as EWOD chip surface defectiveness, dusts, obstacle can hinder the motion of drop, if drop is interrupted in motion process, can not complete the path of having planned.As shown in Figure 1, in array electrode, drop moves to No. 4 drive electrodes from No. 1 drive electrode, and No. 1 drive electrode is that initial position, No. 4 drive electrodes are target location, on No. 3 electrodes by " star
" as obstacle.Due to the driving voltage on drive electrode, that peripheral control circuit just set before drop setting in motion, from No. 2 to No. 5, pair array electrode applies driving voltage successively, drop will correspondingly complete from No. 1 drive electrode and move to drive electrode No. 4, but on liquid drop movement to 3 drive electrode, owing to being subject to dust impact, rest on No. 3 drive electrodes, now can control follow-up motion and bring a series of difficulty.
Therefore need now a kind of method can impelling drop to complete the movement length of setting, thereby reach target location, facilitate technician to carry out subsequent operation.
Summary of the invention
The invention provides a kind of EWOD chip liquid drop driving method, Apparatus and system, can complete the movement length of setting, thereby reach target location, facilitate technician to carry out subsequent operation.
To achieve these goals, the invention provides following technological means:
An EWOD chip liquid drop driving method, comprising:
Detect the electric capacity of the first drive electrode and the second drive electrode, obtain the first electric capacity and the second electric capacity, wherein drop is positioned at the top of the first drive electrode described in EWOD chip, and described the second drive electrode is charged electrode;
Whether the difference that judges described the second electric capacity and described the first electric capacity is less than zero;
When described difference is less than zero, control described the second drive electrode and power up.
Preferably, the electric capacity of detection the first drive electrode and the second drive electrode comprises:
Utilize capacitance detecting instrument by predeterminated frequency, to detect the electric capacity of the first drive electrode and the second drive electrode, described electric capacity electric pilot is connected with described the second drive electrode with described the first drive electrode respectively.
Preferably, described predeterminated frequency comprises: 50HZ.
Preferably, described control the second drive electrode powers up and comprises:
By photoelectric coupling switch, controlling described the second drive electrode shake powers up.
Preferably, the process that described shake powers up comprises:
Described in described photoelectric coupling switch Closed control, the second drive electrode powered up after the very first time, disconnects the second time;
Said process is repeated after preset times, then photoelectric coupling switch was disconnected after closed the 3rd time.
Preferably, the described very first time comprises 100ms, and described the second time comprises 50ms, and described the 3rd time comprises 800ms, and described preset times comprises 4 times.
Preferably, also comprise:
When described difference is not less than zero, control next drive electrode charged.
Preferably, also comprise:
In advance that photoelectric coupling switch is closed, control described the second drive electrode and power up 500ms.
An EWOD chip liquid drop drive system, comprising:
A plurality of drive electrodes, the capacitance detecting instrument being connected with described a plurality of drive electrodes, the controller being connected with described capacitance detecting instrument, the photoelectrical coupler being connected with described controller, described photoelectrical coupler is connected with described a plurality of drive electrodes, and described a plurality of drive electrodes comprise the first drive electrode, the second drive electrode;
Described capacitance detecting instrument, for detection of the electric capacity of the first drive electrode and the second drive electrode, obtain the first electric capacity and the second electric capacity, wherein drop is positioned at described the first drive electrode, described the second drive electrode is charged electrode, and the first electric capacity and the second electric capacity are sent to controller;
Described controller, for judging whether the difference of described the second electric capacity and described the first electric capacity is less than zero; When described difference is not less than zero, control photoelectrical coupler charged to next drive electrode, when described difference is less than zero, control photoelectrical coupler described the second drive electrode is powered up.
10, system as claimed in claim 9, is characterized in that, described capacitance detecting instrument is connected with described controller by multiplexer.
Known through technique scheme, the first electric capacity and the second electric capacity that in EWOD chip liquid drop driving method provided by the present invention, use, relevant with the relative position of drop and drive electrode, irrelevant with the constituent of drive voltage signal frequency and drop, so greatly reduced the calculated amount of calculating process, and this law can fast detecting to the drop failure of whether moving, after moving unsuccessfully, can learn the stop place of current drop, when drop rests on the first drive electrode, power up to the second drive electrode, so that surmounting obstacles, drop reaches target location, facilitate technician to carry out subsequent operation.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, to the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skills, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
Fig. 1 is the schematic diagram of drop when EWOD chip moves in prior art;
Fig. 2 is the electric capacity schematic diagram of the disclosed EWOD chip of the embodiment of the present invention and drop;
Fig. 3 is that the disclosed drop of the embodiment of the present invention is at the schematic diagram of the first drive electrode to the second drive electrode motion process;
Fig. 4 is the schematic diagram of the disclosed drop of the embodiment of the present invention the first electric capacity and second electric capacity in the first drive electrode to the second drive electrode motion process;
Fig. 5 is the structural representation of the disclosed EWOD chip liquid drop of embodiment of the present invention drive system;
Fig. 6 is the process flow diagram of the disclosed EWOD chip liquid drop of embodiment of the present invention driving method;
Fig. 7 is the experimental result picture after the disclosed employing of embodiment of the present invention EWOD chip liquid drop driving method.
Embodiment
In the present inventor's research and probe, find, can adopt the position of the control system detection drop based on visual feedback, controller reaches the object of location droplet position by detecting drop cross section circle and the relative position of drive electrode, yet the control system based on visual feedback needs the computing machine of a set of high-precision video equipment and stronger computing power to go real-time processing video data, and use cost is higher.
Can also adopt sensor-based feedback control system to know the position of drop, concrete method comprises: utilize sensor to detect the ac signal of EWOD chip, then compare with applied drive voltage signal, to reach the object of FEEDBACK CONTROL, but this technology is larger to the characteristic dependence of drop, and drop on EWOD chip can change through characteristic after biological, chemical reaction, after drop characteristics changes, its electric conductivity also can change, and this will affect the accuracy that sensor detects electric signal.
Therefore inventor finds to need a kind of very simple and convenient, do not rely on again the detection method of the characteristic of liquid, thereby learn the position of liquid, and according to the position judgment liquid of liquid whether because obstacle stops.
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is only the present invention's part embodiment, rather than whole embodiment.Embodiment based in the present invention, those of ordinary skills, not making the every other embodiment obtaining under creative work prerequisite, belong to the scope of protection of the invention.
Before introducing specific implementation of the present invention, paper is the principle that realizes of the present invention once, as shown in Figure 2, is the schematic equivalent circuit of EWOD chip and drop, and the drive electrode of take describes as example as one.Under actual conditions, drop is that motion is on the surface of EWOD chip, EWOD chip comprises drive electrode 201, on drive electrode, there is dielectric layer 202 and detest water layer 203, in the present invention in order to narrate conveniently, drop, on position corresponding to EWOD chip surface drive electrode, is sketched as drop is on drive electrode.
Equivalent electrical circuit consists of two parallel Circuits System, the Circuits System on upper strata is null electrode 204 and detests water layer 203, the Circuits System of lower floor is for detesting water layer 203, dielectric layer 202 and drive motor 201, its dielectric layer and detest water layer and form capacitor, and drop surrounding medium forms a capacitor; Because the drop in EWOD chip has certain conductivity, the part that includes drop has just formed electric capacity and the resistance being parallel to each other.The meniscus of drop can change the electric field between drive electrode, but with respect to drive electrode the ratio with polar plate spacing, meniscus is less to the change amount of electric field, can ignore.When only having single drive electrode, its reactance only comprises electric capacity, and the formula of being expressed as is:
C
eq＝aA+(b-a)A
L……(1)
A is that its value of constant being inversely proportional to polar plate spacing is less in formula (1), and b is that its value of constant being inversely proportional to medium thickness is larger; A represents the surface area of drive electrode, A
lrepresent that drop is positioned at the cross section area of a circle on conduction drive electrode.In digital microcurrent-controlled chip, drop is on adjacent electrode, to complete the object that transports drop by an electrode movement, and clearly, the size of drive electrode electric capacity can represent the function of droplet position, because A
lsize depend on the position of drop, therefore, the feedback position that the round heart in drop cross section of take is droplet position, this feedback position can obtain indirectly by detecting the electric capacity of adjacent driven electrode.
As shown in Figure 3, for drop is moved to the schematic diagram of the final position process of the second drive electrode by the initial position of the first drive electrode, wherein the distance of the round heart distance in drop cross section the first drive electrode is x
0, this drop cross section radius of circle is r, and the first drive electrode and the second drive electrode are all the square drive electrode of width L, and the spacing of the first and second drive electrodes is L
gso the electric capacity expression formula of the first drive electrode is:
The electric capacity expression formula of the second drive electrode is so:
The electric capacity of the second drive electrode and first, second drive electrode electric capacity and ratio be drop cross section circle home position x
0function, the ratio of electric capacity is:
Wherein, a is a constant being inversely proportional to polar plate spacing h, and b is a constant being inversely proportional to medium thickness d; Because the thickness d of dielectric layer is much smaller than spacing h between bottom crown on EWOD chip, thus the value of constant b much larger than the value of constant a, so equation can be reduced to equation (5):
In EWOD chip, in order successfully to drive drop, must guarantee that the area of drop cross section circle is a bit larger tham the area of drive electrode,
, spacing L between while drive electrode
g<<L, therefore can obtain
be an available hypothesis condition, under condition for validity, equation can be reduced to again equation (6):
From formula (6), the position x of drop
0irrelevant with the constituent of drop, but relevant with the ratio of the electric capacity of adjacent driven electrode.Therefore, measure the electric capacity that EWOD chip and drop form, just can estimate the real time position of drop.
As shown in Figure 4, be the equivalent capacity C of the first drive electrode and the second drive electrode
1and C
2capacitance detecting instrument measured value, wherein transverse axis is the time, the longitudinal axis be capacitance as shown in Figure 4, equivalent capacity C
1value initial time time maximum, be approximately 10pF, when liquid drop movement during to final position its value be reduced to 0, and C
2variation and C
1just in time contrary; As equivalent capacity C
1=C
2time liquid drop movement between first, second drive electrode, can the move length of the first drive electrode of drop is described.Therefore, when C being detected
2-C
1can illustrate that drop can complete on the first drive electrode at>=0 o'clock moves, and on the second drive electrode; When C being detected
2-C
1during <0, illustrating that drop could not reach successfully moves on the second drive electrode.Now also need to power up to continue to drive liquid drop movement to the second drive electrode.
As shown in Figure 5, introduce EWOD chip liquid drop drive system provided by the invention below, comprising:
A plurality of drive electrodes 100, the capacitance detecting instrument 200 being connected with described a plurality of drive electrodes, the controller 300 being connected with described capacitance detecting instrument 200, the photoelectrical coupler 400 being connected with described controller, described photoelectrical coupler 400 is connected with described a plurality of drive electrodes 100, and described a plurality of drive electrodes 100 comprise the first drive electrode 101, the second drive electrode 102;
A kind of EWOD chip liquid drop driving method embodiment providing as shown in Figure 6, in the system shown in Fig. 5, carry out following steps:
Step S101: detect the electric capacity of the first drive electrode 101 and the second drive electrode 102, obtain the first capacitor C 1 and the second capacitor C 2, wherein drop is positioned at described the first drive electrode 101, and described the second drive electrode 102 is charged electrode;
At native system, comprise a plurality of drive electrodes 1,2,3 ... N, N is natural number, take the first drive electrode 101 and the second drive electrode 102 describes as example, wherein drop is positioned at the reference position of the first drive electrode 101, for drop is moved to the second drive electrode 102 directions, first on the second drive electrode 102, add driving voltage, be about to photoelectric coupling switch closed, control described the second drive electrode 102 and power up 500ms.
Under normal circumstances, do not consider defect on EWOD chip and the impact of dust, the driving voltage that adds 500ms on the second drive electrode 102, can make drop move to the second drive electrode 102 from the first drive electrode 101, therefore by photoelectrical coupler closed pair the second drive electrode 102, power up 500ms.
In order to know the position of current drop, judge whether drop reaches on the second drive electrode 102, the present invention detects the first drive electrode 101 and the second drive electrode 102 electric capacity by capacitance detecting instrument by predeterminated frequency, thereby obtain the first capacitor C 1 and the second capacitor C 2, and judge according to the difference of the first capacitor C 1 and the second capacitor C 2 whether drop reaches on the second drive electrode 102.
Because the speed that drop moves on the first drive electrode 101 and the second drive electrode 102 is very fast, suppose that the time that drop arrives the second drive electrode 102 by the first drive electrode 101 is under normal circumstances T, therefore as long as guarantee that the frequency of the detection of capacitance detecting instrument is less than 1/T, be capacitance detecting instrument when detecting the first capacitor C 1 and the second capacitor C 2, liquid has moved on the second drive electrode 102 in theory.Preferably, the predeterminated frequency of capacitance detecting instrument is 50HZ.
Step S102: judge whether described the second capacitor C 2 and the difference of described the first capacitor C 1 are less than zero;
The second capacitor C 2 is deducted to the first capacitor C 1 and obtain difference, difference is compared with zero, judge the size of the first capacitor C 1 and the second capacitor C 2, as shown in Figure 4, because drop is in the motion process by the first drive electrode 101 to second drive electrodes 102, the first capacitor C 1 reduces gradually, the second capacitor C 2 increases gradually, in the time of in the middle of moving to two electrodes, the first capacitor C 1 equals the second capacitor C 2, and this time difference value equals zero; When drop is on the first drive electrode 101, the first capacitor C 1 is greater than the second capacitor C 2, so difference is less than zero, when drop is on the second drive electrode 102, the second capacitor C 2 is greater than the first capacitor C 1, so difference is greater than zero.
Step S103: when described difference is not less than zero, control next drive electrode charged;
When difference equals zero, show that drop is between the first drive electrode 101 and the second drive electrode 102, from EWOD theory, drop can reach on the second drive electrode 102, when difference is greater than zero, shows on liquid drop movement to the second drive electrode 102.
All restrictions if having time owing to powering up on the second drive motor, on the second drive electrode 102, reach after power-up time, just can auto-breaking, when liquid drop movement is to after on the second drive electrode 102, in order to make drop continue motion, power up to the 3rd drive electrode, the mode of powering up is similarly the mode that adopts the closed 500ms of photoelectrical coupler, to impel liquid drop movement to the three drive electrodes.After moving to the 3rd drive electrode, then control 4 wheel driven moving electrode and power up, until liquid drop movement is to target location.
Step S104: when described difference is less than zero, control described the second drive electrode 102 and power up.
When difference is less than zero, show that drop rests on the first drive motor, do not move to the second drive electrode 102 motions, owing to showing that the impact of dust, defect is excessive, affected the motion of drop, the driving voltage of the 500ms adding in advance on the second drive electrode 102 is not enough to drive drop to surmount obstacles, and therefore applies driving voltage, so that drop is crossed the obstacles such as dust or defect again.Concrete, by photoelectric coupling switch, control described the second drive electrode 102 shakes and power up.
Specifically, when applying voltage, in order to make drop more easily depart from chip surface, the mode that adopts shake to power up powers up, and specifically comprises:
Described in described photoelectric coupling switch Closed control, the second drive electrode 102 powered up after the very first time, disconnects the second time; Said process is repeated after preset times, then photoelectric coupling switch was disconnected after closed the 3rd time.
Because drop is obstructed by obstacles such as dust or defects, in order to make drop more easily depart from chip surface, move, the mode that adopts shake to power up powers up, power up a period of time, stop powering up a period of time again, and then power up again and disconnect, continue to carry out after certain number of times, just can make drop depart from the obstacles such as dust or defect, finally the second drive electrode 102 is powered up to the 3rd time, impel drop to continue motion and reach the second drive electrode 102.
Rule of thumb the ON time first of photoelectric coupling switch is 500ms herein, and be 300ms trip time; If the difference of the second capacitor C 2 and the first capacitor C 1 detected, be less than zero, as shown in Figure 5, just illustrate that drop still rests on the first drive electrode 101, then continue to apply driving voltage to the second drive electrode 102, the mode of photoelectric coupling switch is to power up for five times, and each power-up time is 100ms in first four times, be spaced apart 50ms, the 5th time power-up time is 800ms, and by the driving of front 4 vibrating types, thereby drop more can easily overcome the successful leaping over obstacles of resistance.
After the second drive electrode 102 powers up, then be back to step S101, re-execute step S101 and step S102, until the difference of the first capacitor C 1 and the second capacitor C 2 is not less than zero.
Known through technique scheme, the first capacitor C 1 of using in EWOD chip liquid drop driving method provided by the present invention and the second capacitor C 2, relevant with the relative position of drop and drive electrode, irrelevant with the constituent of drive voltage signal frequency and drop, so need to greatly reduce the calculated amount of calculating process, and this law can fast detecting to the drop failure of whether moving, after moving unsuccessfully, can learn the stop place of current drop, when drop rests on the first drive electrode 101, power up to the second drive electrode 102, so that surmounting obstacles, drop reaches target location, facilitate technician to carry out subsequent operation.
Introduce the specific embodiment of EWOD chip liquid drop driving method of the present invention below:
Employing deionized water is experimental subjects, and the medium of controlling drop is air.In experimentation, with micro syringe, first the deionized water drop of certain volume size is placed on adjacent two drive electrodes of chip bottom crown, single drive electrode is of a size of 1 * 1mm, spacing g=20 μ m between drive electrode, and drive electrode is shaped as square.Then with double faced adhesive tape, totally 300 μ m are thick that top crown and bottom crown are combined to " sandwich " structure shown in pie graph 2 figure, carry out after the EWOD chip liquid drop driving method providing of the present invention, and the 1 μ L liquid drop movement video interception obtaining,
As shown in Figure 7, on chip, between bottom crown, spacing is 300 μ m, and driving voltage is 40V
rMS.In Fig. 7, from (a), to (e), for drop, from No. 1 drive electrode shown in Fig. 1, move on No. 5 drive electrodes; Figure (e) to (i), drop moves to the diagram on drive electrode No. 1 from No. 5 drive electrodes shown in Fig. 1.
In experimentation, drop moves right from No. 2 drive electrodes and moves on No. 5 moving electrodes, then in the time of on moving to again No. 1 drive electrode left, there is not the situation of being lived by " card ", but there is the situation that repeats to power up to drive electrode, there is shake in the part that drop is positioned at drive electrode top, this when just explanation powers up for the first time drop success is not driven, to respective drive electrode, apply driving voltage for the second time after drop just successfully driven.Experimental result shows that the position detecting system based on equivalent capacity can greatly improve the success ratio of liquid drop movement.
As shown in Figure 5, the present invention also provides a kind of EWOD chip liquid drop drive system, comprising:
A plurality of drive electrodes 100, the capacitance detecting instrument 200 being connected with described a plurality of drive electrodes, the controller 300 being connected with described capacitance detecting instrument 200, the photoelectrical coupler 400 being connected with described controller, described photoelectrical coupler 400 is connected with described a plurality of drive electrodes 100, and described a plurality of drive electrodes 100 comprise the first drive electrode 101, the second drive electrode 102;
Described capacitance detecting instrument 200, electric capacity for detection of the first drive electrode 101 and the second drive electrode 102, obtain the first electric capacity and the second electric capacity, wherein drop is positioned at described the first drive electrode 101, described the second drive electrode 102 is charged electrode, and the first electric capacity and the second electric capacity are sent to controller;
Described controller 300, for judging whether the difference of described the second electric capacity and described the first electric capacity is less than zero; When described difference is not less than zero, control photoelectrical coupler charged to next drive electrode, when described difference is less than zero, control photoelectrical coupler described the second drive electrode is powered up.
Preferably, described capacitance detecting instrument 100 is connected with described controller 300 by multiplexer.
At a channel, transmit multiple signals, be just multiplexing technique MultiplexiI1g simultaneously.Adopt multiplexing technique a plurality of signal combination can be got up and transmitted on a physical channel.The present invention selects the single-ended input analog multiplexer of MPC506AU16 passage, and this multiplexer is connected to detect respectively the electric capacity of the drive electrode of EWOD chip with the corresponding pin of controller with the drive electrode of EWOD chip.
Preferably, described controller comprises: single-chip microcomputer, it is flexible that single-chip microcomputer has control mode, the simple advantage of programming mode.
If the function described in the present embodiment method usings that the form of SFU software functional unit realizes and during as production marketing independently or use, can be stored in a computing equipment read/write memory medium.Understanding based on such, the part that the embodiment of the present invention contributes to prior art or the part of this technical scheme can embody with the form of software product, this software product is stored in a storage medium, comprise that some instructions are with so that a computing equipment (can be personal computer, server, mobile computing device or the network equipment etc.) carry out all or part of step of method described in each embodiment of the present invention.And aforesaid storage medium comprises: USB flash disk, portable hard drive, ROM (read-only memory) (ROM, Read-Only Memory), the various media that can be program code stored such as random access memory (RAM, Random Access Memory), magnetic disc or CD.
In this instructions, each embodiment adopts the mode of going forward one by one to describe, and each embodiment stresses is the difference with other embodiment, between each embodiment same or similar part mutually referring to.
Above-mentioned explanation to the disclosed embodiments, makes professional and technical personnel in the field can realize or use the present invention.To the multiple modification of these embodiment, will be apparent for those skilled in the art, General Principle as defined herein can, in the situation that not departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention will can not be restricted to these embodiment shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (10)
1. an EWOD chip liquid drop driving method, is characterized in that, comprising:
Detect the electric capacity of the first drive electrode and the second drive electrode, obtain the first electric capacity and the second electric capacity, wherein drop is positioned at the top of the first drive electrode described in EWOD chip, and described the second drive electrode is charged electrode;
Whether the difference that judges described the second electric capacity and described the first electric capacity is less than zero;
When described difference is less than zero, control described the second drive electrode and power up.
2. the method for claim 1, is characterized in that, the electric capacity that detects the first drive electrode and the second drive electrode comprises:
Utilize capacitance detecting instrument by predeterminated frequency, to detect the electric capacity of the first drive electrode and the second drive electrode, described electric capacity electric pilot is connected with described the second drive electrode with described the first drive electrode respectively.
3. the method for claim 1, is characterized in that, also comprises:
When described difference is not less than zero, control next drive electrode charged.
4. the method for claim 1, is characterized in that, described control the second drive electrode powers up and comprises:
By photoelectric coupling switch, controlling described the second drive electrode shake powers up.
5. method as claimed in claim 4, is characterized in that, the process that described shake powers up comprises:
Described in described photoelectric coupling switch Closed control, the second drive electrode powered up after the very first time, disconnects the second time;
Said process is repeated after preset times, then photoelectric coupling switch was disconnected after closed the 3rd time.
6. method as claimed in claim 5, is characterized in that, the described very first time comprises 100ms, and described the second time comprises 50ms, and described the 3rd time comprises 800ms, and described preset times comprises 4 times.
7. the method for claim 1, is characterized in that, also comprises:
When described difference is not less than zero, control next drive electrode charged.
8. the method for claim 1, is characterized in that, also comprises:
In advance that photoelectric coupling switch is closed, control described the second drive electrode and power up 500ms.
9. an EWOD chip liquid drop drive system, is characterized in that, comprising:
A plurality of drive electrodes, the capacitance detecting instrument being connected with described a plurality of drive electrodes, the controller being connected with described capacitance detecting instrument, the photoelectrical coupler being connected with described controller, described photoelectrical coupler is connected with described a plurality of drive electrodes, and described a plurality of drive electrodes comprise the first drive electrode, the second drive electrode;
Described capacitance detecting instrument, for detection of the electric capacity of the first drive electrode and the second drive electrode, obtain the first electric capacity and the second electric capacity, wherein drop is positioned at described the first drive electrode, described the second drive electrode is charged electrode, and the first electric capacity and the second electric capacity are sent to controller;
Described controller, for judging whether the difference of described the second electric capacity and described the first electric capacity is less than zero; When described difference is not less than zero, control photoelectrical coupler charged to next drive electrode, when described difference is less than zero, control photoelectrical coupler described the second drive electrode is powered up.
10. system as claimed in claim 9, is characterized in that, described capacitance detecting instrument is connected with described controller by multiplexer.
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| CN107617451A (en) * | 2017-09-29 | 2018-01-23 | 京东方科技集团股份有限公司 | The driving method and drive system of a kind of micro-fluidic chip |
| CN107617451B (en) * | 2017-09-29 | 2019-06-04 | 京东方科技集团股份有限公司 | A kind of driving method and drive system of micro-fluidic chip |
| CN107497509A (en) * | 2017-10-11 | 2017-12-22 | 京东方科技集团股份有限公司 | Microfluidic system and its driving method |
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