CN104013632A - Pasting film for treating oral ulcer and preparation method of pasting film - Google Patents
Pasting film for treating oral ulcer and preparation method of pasting film Download PDFInfo
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- CN104013632A CN104013632A CN201410261996.1A CN201410261996A CN104013632A CN 104013632 A CN104013632 A CN 104013632A CN 201410261996 A CN201410261996 A CN 201410261996A CN 104013632 A CN104013632 A CN 104013632A
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- pad pasting
- oral ulcer
- dexamethasone
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Abstract
The invention relates to the technical field of medical apparatuses and instruments, and particularly relates to a pasting film for treating oral ulcer and a preparation method of the pasting film. By virtue of coaxial electrostatic spinning method, dexamethasone, vitamin C and vitamin B2 are encapsulated into polyoxyethylene nano fiber in proportion. According to the pasting film for treating oral ulcer and a preparation method of the pasting film, the pasting film consists of core-shell structure nano fibers, is guaranteed to have large enough medicine storage amount and release area; moreover, the used polyoxyethylene is relatively moderate in solution rate in an oral cavity, and can continuously keep the ulcer part to have effective medicine concentration.
Description
Technical field
The present invention relates to technical field of medical instruments, especially relate to a kind of pad pasting for the treatment of oral ulcer and preparation method thereof.
Background technology
Oral ulcer is a kind of cause of disease common oral mucosa disease complicated, that easily recur.In daily life, the oral ulcer causing because of bite, scald, abrade, scuffing etc. is comparatively common.Once formation oral ulcer, not only affects patient's diet orthobiosis, sometimes even causes general disease.For oral ulcer, clinical symptomatic treatment of take local application is as main, and clinical application has the dosage forms such as powder, unguentum, membrane and injection, but how because action time in mouth is shorter, all directly affects the treatment.As powders such as Chinese medicine BINGPENG SAN, during use, must be applied to affected part, medicine can run off with saliva very soon; Unguentum is difficult to be coated in affected part; Although conventional membrane can be affixed on ulcer surface, be very easy to come off, and generally within a few minutes, dissolve and disappear, drug osmotic effect is inadequate.
For current conventional dental ulcer treatment paster, the subject matter of existence is: due to the special physiological environment in oral cavity, most plaster time of staying in oral cavity is short, and the feature that is difficult to applicable oral cavity reaches lasting active drug concentration at diseased region.In order to extend plaster at intraoral adhesion time, and make physiological make-up and the environment in its applicable oral cavity, often plaster is prepared into the thin film with certain flexibility that thickness is very little, but this makes diseased region not reach effective drug level the drug loading that affects plaster.Therefore, prepare drug loading large, discharge lasting plaster, be the key for the treatment of oral ulcer.
Summary of the invention
The technical problem to be solved in the present invention is: short in order to overcome in prior art most plaster time of staying in oral cavity, the feature that is difficult to be applicable to oral cavity reaches the problem of lasting active drug concentration at diseased region, a kind of pad pasting for the treatment of oral ulcer and preparation method thereof is provided, pad pasting is fibrous by nuclear shell structure nano, guarantee its enough large drug storage amount and discharge area, and the dissolution velocity of the polyethylene glycol oxide using in oral cavity is more moderate, can make ulcer place continue to remain on effective drug level.
The technical solution adopted for the present invention to solve the technical problems is: a kind of pad pasting for the treatment of oral ulcer, described pad pasting is nano fiber non-woven fabric, described non-woven fabrics is fibrous by nuclear shell structure nano, described nuclear shell structure nano fiber shell is polyethylene glycol oxide shell, and described nuclear shell structure nano fiber stratum nucleare is the mixture of dexamethasone, vitamin C and vitamin B2.
Particularly, the mass ratio of described dexamethasone, vitamin C and vitamin B2 is 1-3:0.5-1:1-5.
As preferably, the mass ratio of described dexamethasone, vitamin C and vitamin B2 is 1:1:1.
A preparation method for the treatment of the pad pasting of oral ulcer, comprises the steps:
Step 1) polyethylene glycol oxide is mixed with to the aqueous solution that mass fraction is 4-10wt%,
Step 2) dexamethasone, vitamin C and vitamin B2 are made in proportion to the aqueous solution that mass fraction is 01.%-1%,
Step 3) coaxial electrostatic spinning: by step 1) and step 2) in preparation solution join respectively in solution feedway, using polyoxyethylene aqueous solution as shell, using the aqueous solution of dexamethasone, vitamin C and vitamin B2 as stratum nucleare, spinning voltage 15～25kV is set, spinning distance 10～18cm between spinning mouth and receiving system, stratum nucleare and shell flow velocity equate, flow speed control is at 0.6～1ml/h, receiving device is the aluminium foil of ground connection, starting drive carries out electrostatic spinning, collects the pad pasting for the treatment of oral ulcer on aluminium foil.
The invention has the beneficial effects as follows: a kind of pad pasting for the treatment of oral ulcer provided by the invention and preparation method thereof, pad pasting is fibrous by nuclear shell structure nano, guarantee its enough large drug storage amount and discharge area, and the dissolution velocity of the polyethylene glycol oxide using in oral cavity is more moderate, can make ulcer place continue to remain on effective drug level.
The specific embodiment
Below in conjunction with specific embodiment, further the present invention is set forth, should be understood that and quote embodiment only for the present invention is described, and be not used in, limit the scope of the invention.
Embodiment 1
A kind of pad pasting for the treatment of oral ulcer, pad pasting is by the fibrous non-woven fabrics of nuclear shell structure nano, nuclear shell structure nano fiber shell is polyethylene glycol oxide shell, and nuclear shell structure nano fiber stratum nucleare is the mixture of dexamethasone, vitamin C and vitamin B2, and its mass ratio is 1:1:1.
A preparation method for the treatment of the pad pasting of oral ulcer, comprises the steps:
Polyethylene glycol oxide is mixed with to the aqueous solution that mass fraction is 4wt%, by dexamethasone, it is 1% aqueous solution that vitamin C and vitamin B2 make mass fraction according to the above ratio, two kinds of aqueous solutions are joined respectively in solution feedway, using polyoxyethylene aqueous solution as shell, by dexamethasone, the aqueous solution of vitamin C and vitamin B2 is as stratum nucleare, spinning voltage 15kV is set, spinning between spinning mouth and receiving system is apart from 18cm, stratum nucleare and shell flow velocity equate, flow speed control is at 1ml/h, receiving device is the aluminum paper tinsel of ground connection, starting drive carries out electrostatic spinning, on aluminium foil, collect the pad pasting for the treatment of oral ulcer.
Embodiment 2
A kind of pad pasting for the treatment of oral ulcer, pad pasting is by the fibrous non-woven fabrics of nuclear shell structure nano, nuclear shell structure nano fiber shell is polyethylene glycol oxide shell, and nuclear shell structure nano fiber stratum nucleare is the mixture of dexamethasone, vitamin C and vitamin B2, and its mass ratio is 1:0.5:1.
A preparation method for the treatment of the pad pasting of oral ulcer, comprises the steps:
Polyethylene glycol oxide is mixed with to the aqueous solution that mass fraction is 6wt%, by dexamethasone, it is 0.1% aqueous solution that vitamin C and vitamin B2 make mass fraction according to the above ratio, two kinds of aqueous solutions are joined respectively in solution feedway, using polyoxyethylene aqueous solution as shell, by dexamethasone, the aqueous solution of vitamin C and vitamin B2 is as stratum nucleare, spinning voltage 25kV is set, spinning between spinning mouth and receiving system is apart from 15cm, stratum nucleare and shell flow velocity equate, flow speed control is at 0.6ml/h, receiving device is the aluminum paper tinsel of ground connection, starting drive carries out electrostatic spinning, on aluminium foil, collect the pad pasting for the treatment of oral ulcer.
Embodiment 3
A kind of pad pasting for the treatment of oral ulcer, pad pasting is by the fibrous non-woven fabrics of nuclear shell structure nano, nuclear shell structure nano fiber shell is polyethylene glycol oxide shell, and nuclear shell structure nano fiber stratum nucleare is the mixture of dexamethasone, vitamin C and vitamin B2, and its mass ratio is 1:0.5:5.
A preparation method for the treatment of the pad pasting of oral ulcer, comprises the steps:
Polyethylene glycol oxide is mixed with to the aqueous solution that mass fraction is 10wt%, by dexamethasone, it is 0.5% aqueous solution that vitamin C and vitamin B2 make mass fraction according to the above ratio, two kinds of aqueous solutions are joined respectively in solution feedway, using polyoxyethylene aqueous solution as shell, by dexamethasone, the aqueous solution of vitamin C and vitamin B2 is as stratum nucleare, spinning voltage 20kV is set, spinning between spinning mouth and receiving system is apart from 10cm, stratum nucleare and shell flow velocity equate, flow speed control is at 0.8ml/h, receiving device is the aluminum paper tinsel of ground connection, starting drive carries out electrostatic spinning, on aluminium foil, collect the pad pasting for the treatment of oral ulcer.
Embodiment 4
A kind of pad pasting for the treatment of oral ulcer, pad pasting is by the fibrous non-woven fabrics of nuclear shell structure nano, nuclear shell structure nano fiber shell is polyethylene glycol oxide shell, and nuclear shell structure nano fiber stratum nucleare is the mixture of dexamethasone, vitamin C and vitamin B2, and its mass ratio is 3:0.5:5.
A preparation method for the treatment of the pad pasting of oral ulcer, comprises the steps:
Polyethylene glycol oxide is mixed with to the aqueous solution that mass fraction is 7wt%, by dexamethasone, it is 0.8% aqueous solution that vitamin C and vitamin B2 make mass fraction according to the above ratio, two kinds of aqueous solutions are joined respectively in solution feedway, using polyoxyethylene aqueous solution as shell, by dexamethasone, the aqueous solution of vitamin C and vitamin B2 is as stratum nucleare, spinning voltage 18kV is set, spinning between spinning mouth and receiving system is apart from 13cm, stratum nucleare and shell flow velocity equate, flow speed control is at 0.9ml/h, receiving device is the aluminum paper tinsel of ground connection, starting drive carries out electrostatic spinning, on aluminium foil, collect the pad pasting for the treatment of oral ulcer.
Embodiment 5
A kind of pad pasting for the treatment of oral ulcer, pad pasting is by the fibrous non-woven fabrics of nuclear shell structure nano, nuclear shell structure nano fiber shell is polyethylene glycol oxide shell, and nuclear shell structure nano fiber stratum nucleare is the mixture of dexamethasone, vitamin C and vitamin B2, and its mass ratio is 3:1:5.
A preparation method for the treatment of the pad pasting of oral ulcer, comprises the steps:
Polyethylene glycol oxide is mixed with to the aqueous solution that mass fraction is 7wt%, by dexamethasone, it is 0.8% aqueous solution that vitamin C and vitamin B2 make mass fraction according to the above ratio, two kinds of aqueous solutions are joined respectively in solution feedway, using polyoxyethylene aqueous solution as shell, by dexamethasone, the aqueous solution of vitamin C and vitamin B2 is as stratum nucleare, spinning voltage 18kV is set, spinning between spinning mouth and receiving system is apart from 13cm, stratum nucleare and shell flow velocity equate, flow speed control is at 0.9ml/h, receiving device is the aluminum paper tinsel of ground connection, starting drive carries out electrostatic spinning, on aluminium foil, collect the pad pasting for the treatment of oral ulcer.
The above-mentioned foundation desirable embodiment of the present invention of take is enlightenment, and by above-mentioned description, relevant staff can, within not departing from the scope of this invention technological thought, carry out various change and modification completely.The technical scope of this invention is not limited to the content in description, must determine its technical scope according to claim scope.
Claims (4)
1. a pad pasting for the treatment of oral ulcer, it is characterized in that: described pad pasting is nano fiber non-woven fabric, described non-woven fabrics is fibrous by nuclear shell structure nano, described nuclear shell structure nano fiber shell is polyethylene glycol oxide shell, and described nuclear shell structure nano fiber stratum nucleare is the mixture of dexamethasone, vitamin C and vitamin B2.
2. a kind of pad pasting for the treatment of oral ulcer as claimed in claim 1, is characterized in that: the mass ratio of described dexamethasone, vitamin C and vitamin B2 is 1-3: 0.5-1: 1-5.
3. a kind of pad pasting for the treatment of oral ulcer as claimed in claim 1, is characterized in that: the mass ratio of described dexamethasone, vitamin C and vitamin B2 is 1: 1: 1.
4. a kind of preparation method for the treatment of the pad pasting of oral ulcer as described in claim 1-3 any one, is characterized in that comprising the steps:
Step 1) polyethylene glycol oxide is mixed with to the aqueous solution that mass fraction is 4-10wt%,
Step 2) dexamethasone, vitamin C and vitamin B2 are made in proportion to the aqueous solution that mass fraction is 01.%-1%,
Step 3) coaxial electrostatic spinning: by step 1) and step 2) in preparation solution join respectively in solution feedway, using polyoxyethylene aqueous solution as shell, using the aqueous solution of dexamethasone, vitamin C and vitamin B2 as stratum nucleare, spinning voltage 15～25kV is set, spinning distance 10～18cm between spinning mouth and receiving system, stratum nucleare and shell flow velocity equate, flow speed control is at 0.6～1ml/h, receiving device is the aluminium foil of ground connection, starting drive carries out electrostatic spinning, collects the pad pasting for the treatment of oral ulcer on aluminium foil.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410261996.1A CN104013632A (en) | 2014-06-13 | 2014-06-13 | Pasting film for treating oral ulcer and preparation method of pasting film |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410261996.1A CN104013632A (en) | 2014-06-13 | 2014-06-13 | Pasting film for treating oral ulcer and preparation method of pasting film |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN110195294A (en) * | 2019-07-05 | 2019-09-03 | 四川大学 | A kind of nano fibrous membrane and preparation method thereof of double load core/shell structures |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083224A (en) * | 2013-02-06 | 2013-05-08 | 东华大学 | Method for preparing dexamethasone slow-release medicine carrier |
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2014
- 2014-06-13 CN CN201410261996.1A patent/CN104013632A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083224A (en) * | 2013-02-06 | 2013-05-08 | 东华大学 | Method for preparing dexamethasone slow-release medicine carrier |
Non-Patent Citations (2)
| Title |
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| 国家食品药品监督管理局执业药师资格认证中心 编写: "《药学综合知识与技能》", 31 March 2008, 中国医药科技出版社 * |
| 陈维明 等: "负载地塞米松的SF/PEO纳米纤维膜的药物缓释行为及抗氧化性能研究", 《2013年全国高分子学术论文报告会论文摘要集——主题H：医用高分子》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN110195294A (en) * | 2019-07-05 | 2019-09-03 | 四川大学 | A kind of nano fibrous membrane and preparation method thereof of double load core/shell structures |
| CN110195294B (en) * | 2019-07-05 | 2021-09-07 | 四川大学 | Nanofiber membrane with double-load core/shell structure and preparation method thereof |
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Application publication date: 20140903 |