CN104012568A - A pesticide composition comprising dinetofuran and cyflumetofen - Google Patents
A pesticide composition comprising dinetofuran and cyflumetofen Download PDFInfo
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- CN104012568A CN104012568A CN201410240960.5A CN201410240960A CN104012568A CN 104012568 A CN104012568 A CN 104012568A CN 201410240960 A CN201410240960 A CN 201410240960A CN 104012568 A CN104012568 A CN 104012568A
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- mti
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Abstract
The invention discloses a pesticide composition comprising dinetofuran and cyflumetofen. Effective components of the pesticide composition comprise the dinetofuran and the cyflumetofen. The weight ratio of the dinetofuran to the cyflumetofen is 20:1-1:20, preferably 10:1-1:5. The pesticide composition has obvious synergistic effects and can be used for control of various pests in agriculture, especially suitable for control of red spiders, tea lesser leafhoppers, aleyrodid, aphid and scale insects. The pesticide composition reduces the pesticide using amount, reduces the residue amount of pesticides on crops, relives pollution to the environment and delays generation of pest resistance to pesticides.
Description
Technical field
The present invention relates to composition pesticide and application thereof, specifically a kind of to take MTI-446 and cyflumetofen be the multiple binary complex of active ingredient, is mainly used in the control of the upper insect of agricultural.
Background technology
MTI-446 (dinotefuran) belongs to third generation nicotinic insecticide, and Main Function, in insect neurotransmission system, is brought into play insecticidal action thereby insect is benumbed.This medicament insecticidal spectrum is wide, can be used for the control of insect such as Homoptera, Lepidoptera, coleoptera on the crops such as paddy rice, fruit tree, vegetables.
Cyflumetofen (Cyflumetofen) belongs to novel acyl group acetonitrile class miticide, and the mechanism of action is to suppress mitochondria electrical conductivity.Be mainly used on the crops such as fruit tree, vegetables, tea tree and flowers and prevent and treat mite pest, the diseases such as the insects such as diamond-back moth, prodenia litura, striped rice borer, rice fulgorid, black peach aphid and rice blast, powdery mildew, downy mildew are also had to good preventive and therapeutic effect simultaneously.
The pesticide resistance problem of pest is a global problem, is the emphasis problem that agricultural science and technology worker pays close attention to always.Impact along with on factors such as the increase of the continuity year in year out of Chemical Control of Harmful Insects, agricultural chemicals usage amount and non-science use agricultural chemicals, causes pest resistance day by day serious, and the pest species that produces resistance is on the increase.Meanwhile, due to high-intensity use agricultural chemicals, caused that Practice for Pesticide Residue in Agricultural Products exceeds standard, the series of problems such as contaminated environment and the increase of peasant's drug cost, be unfavorable for agriculture sustainable development.
Therefore, development is efficient, low toxicity, low-residual, the different mechanism of action, has again the complex preparation of synergistic function simultaneously, not only contribute to delay the generation of pest resistance to insecticide, but also can extend the service life of pesticide species, reduce using dosage, cost-saving, reduce the pollution to environment.
The inventor conducts in-depth research the compounded formula screening of MTI-446 and cyflumetofen, find that MTI-446 and cyflumetofen carry out composite, within the scope of certain compound proportion, there is obvious synergistic function, in actual use simultaneously, to the insect in agricultural, especially two spotted spider mite, tea lesser leafhopper, aleyrodid, aphid and scale insect have outstanding control efficiency, after further study, have completed the present invention.
Summary of the invention
The object of the present invention is to provide a kind of composition pesticide that contains MTI-446 and cyflumetofen, this complex composition has obvious synergistic function, can be used for preventing and treating the various pests in agricultural, be especially suitable for the control of two spotted spider mite, tea lesser leafhopper, aleyrodid, aphid and scale insect.
Another object of the present invention is to the composition pesticide that contains MTI-446 and cyflumetofen, in use can reduce dosage, reduced the residual quantity of agricultural chemicals on crops, delay the generation of pest resistance to insecticide, can also make it to the control efficiency of various insects, than single dose, use and compare obvious raising separately, laborsaving, economical, reduce farmer's burdens.
Technical solution of the present invention: a kind of composition pesticide that contains MTI-446 and cyflumetofen, take MTI-446 and cyflumetofen as active ingredient, the weight ratio of MTI-446 and cyflumetofen is 20:1～1:20, preferably than being 10:1～1:5, MTI-446 and the percentage by weight of cyflumetofen weight summation in composition pesticide are 1%～85%, and all the other are in agricultural chemicals, to allow to use and acceptable auxiliary element.
Described auxiliary element is one or more the combination in solvent, emulsifier, wetting agent, dispersant, stabilizing agent, antifreezing agent, thickener, disintegrant, binding agent, defoamer, bleeding agent, synergist, fire retardant and filler, above material is known substance conventional in pesticidal preparations, according to being prepared into the different formulations of pesticide, change to some extent, but be not particularly limited.
Composition pesticide of the present invention can be prepared into by known method any one formulation of using in applicable agricultural production, and reasonable formulation has suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wetting powder, ultra low volume liquids, microcapsule suspending agent and thermal fog.
The frequency of administration of composition pesticide of the present invention and amount of application have small variations with crops, insect, weather condition variation, can be by using suitable dosage to reach the object of effective control.
Compared with prior art, the invention has the advantages that:
1, MTI-446 and cyflumetofen are composite has a synergistic function, than the independent use of single dose, has obviously improved the control efficiency to insect, has expanded insecticidal spectrum simultaneously, has solved the defect to some insect weak effect when single dose is used separately.
2, two kinds of active ingredients of MTI-446 and cyflumetofen are composite, reduced agricultural chemicals usage amount, reduced use cost, alleviated pollution to environment, delayed pest resistance to insecticide generation, increased service life of agricultural chemicals.
Embodiment
In order to understand better essence of the present invention, below in conjunction with embodiment, content of the present invention is described further, but can not be considered as limitation of the present invention.
(1) formulation embodiment
In following each embodiment, active ingredient adopts the former medicine of 98% MTI-446 and the former medicine of 97% cyflumetofen, and each component percentage composition is weight percentage.
Embodiment 1:25% MTI-446 cyflumetofen suspending agent.
MTI-446 15%, cyflumetofen 10%, Fluhyzon formaldehyde condensation products sodium sulfonate 10%, naphthalene sulfonate 10%, CMC 1.5%, glycerine 2%, silicone oil 0.2%, deionized water supplies 100%.Above-mentioned active ingredient, dispersant, wetting agent, thickener, antifreezing agent, defoamer and deionized water are mixed, sand milling in high speed shear dispersion, sand mill, the high dispersive forming in water-medium, stable suspension system, can make 25% MTI-446 cyflumetofen suspending agent.
Embodiment 2:40% MTI-446 cyflumetofen aqueous emulsion.
MTI-446 25%, cyflumetofen 15%, 1-METHYLPYRROLIDONE 20%, castor oil polyoxyethylene ether 15%, fatty alcohol-polyoxyethylene ether phosphoric acid 5%, sodium sorbate 1%, glycerine 1%, deionized water supplies 100%.Above-mentioned active ingredient, solvent, emulsifier, dispersant and stabilizing agent are mixed to form to oil phase, antifreezing agent dissolves and forms water in water, under clipper effect, slowly oil phase is added in water, and continue to shear approximately 30 minutes, can make 40% MTI-446 cyflumetofen aqueous emulsion.
Embodiment 3:35% MTI-446 cyflumetofen microemulsion.
MTI-446 15%, cyflumetofen 20%, cyclohexanone 15%, fat alcohol alcohol APEO 15%, xylitol 1.5%, organosilicon 1.5%, double to kill 2%, deionized water supplies 100%.Active ingredient is dissolved completely with solvent, and then add emulsifier, stabilizing agent, bleeding agent, synergist to mix, finally add deionized water, after fully stirring, can make 35% MTI-446 cyflumetofen microemulsion.
Embodiment 4:70% MTI-446 cyflumetofen wetting powder.
MTI-446 45%, cyflumetofen 25%, poly-second carboxylic esters sodium salt 6%, sodium butylnaphthalenesulfonate 7%, kaolin supplies 100%.By above-mentioned, active ingredient, dispersant, wetting agent and filler are mixed, after mechanical disintegration, again through air-flow crushing, mix, can make 70% MTI-446 cyflumetofen wetting powder.
Embodiment 5:25% MTI-446 cyflumetofen water dispersible granules.
MTI-446 10%, cyflumetofen 15%, to hydroxyphenyl lignin sulfonic acid sodium salt 15%, neopelex 5%, ammonium sulfate 3%, polyvinyl alcohol 2%, kaolin supplies 100%.Above-mentioned active ingredient, dispersant, wetting agent, disintegrant, binding agent and filler are mixed, with micro jet, pulverize, through mediating, then add in fluidized bed prilling dryer and carry out granulation, dry, screening, can make 25% MTI-446 cyflumetofen water dispersible granules.
Embodiment 6:10% MTI-446 cyflumetofen ultra low volume liquids.
MTI-446 6%, cyflumetofen 4%, 1-METHYLPYRROLIDONE 10%, DMF 8%, calcium dodecyl benzene sulfonate 2.5%, castor oil polyoxyethylene ether 2%, double to kill 1.5%, cottonseed oil complements to 100%.After above-mentioned active ingredient is dissolved by stirring solvent, then add other auxiliary agent, be fully uniformly mixed, can make 10% MTI-446 cyflumetofen ultra low volume liquids.
Embodiment 7:5% MTI-446 cyflumetofen microcapsule suspending agent.
MTI-446 4%, cyflumetofen 1%, the urea resin prepolymer aqueous solution 20%, cyclohexanone 15%, castor oil polyoxyethylene ether 5%, sodium lignin sulfonate 2%, sodium hydroxide 2%, deionized water complements to 100%.By above-mentioned active ingredient, macromolecule cyst material, solvent, make to be dissolved into even oil phase, under shearing condition, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent, dispersant, surplus is supplied by deionized water, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, can make 5% MTI-446 cyflumetofen microcapsule suspending agent.
Embodiment 8:6% MTI-446 cyflumetofen thermal fog.
MTI-446 4%, cyflumetofen 2%, 1-METHYLPYRROLIDONE 15%, alkylphenol polyoxyethylene 10%, calcium dodecyl benzene sulfonate 5%, azone 2%, ammonium polyphosphate 2%, soybean oil complements to 100%.Above-mentioned active ingredient and solvent are dropped in the reaction vessel of band stirring, after active ingredient is fully dissolved, then add other auxiliary agent, fully stir about is 60 minutes, and it is mixed, and can make 6% MTI-446 cyflumetofen thermal fog.
(2) indoor biological activity determination and field efficacy checking.
1, MTI-446 and the cyflumetofen indoor joint toxicity measuring to tea lesser leafhopper.
For examination worm: select field to gather and the indoor tea lesser leafhopper nymph in 3 age of raising breeding.
Reagent agent: the former medicine of 98% MTI-446 and the former medicine of 97% cyflumetofen.
Test method: adopt infusion process to measure, concrete grammar is as follows.
Choose the fresh tea tree germ tip 3 strains, in for reagent liquid, flood after 30 seconds, take out nature and dry, with wet absorbent cotton, encase root moisturizing, outsourcing preservative film, is placed in teat glass (200mm * 30mm), and every processing repeats for 4 times.The tea lesser leafhopper nymph in 3 age of then slightly anaesthetizing with ether with writing brush access, 20 of every pipes, the mouth of pipe is tightened with white gauze.Be disposed, be placed in observation ward.If containing the processing of the corresponding organic solvent of medicament not in contrast.After processing, 24h investigation examination worm death condition, records total borer population and dead borer population.
With DPS statistical analysis software, carry out statistical analysis, calculate the LC of each medicament
50, and according to the co-toxicity coefficient (CTC value) of the abundant method calculating of Sun Yun mixture.
Actual measurement toxicity index (ATI)=(standard medicament LC
50/ reagent agent LC
50) * 100.
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture.
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] * 100.
According to the NY/T11547.7-2006 insecticide synergy criteria for classifying: co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.
Table 1, MTI-446 and the cyflumetofen indoor joint toxicity measuring to tea lesser leafhopper.
As can be seen from Table 1, when MTI-446 and cyflumetofen are composite in 20:1～1:20 scope of (by weight), co-toxicity coefficient (CTC) is all greater than 120, tea lesser leafhopper is shown to synergistic function, when especially composite in 10:1～1:5 scope of (by weight), synergistic function is more obvious, and co-toxicity coefficient (CTC) is all greater than 160, and visible MTI-446 and cyflumetofen be composite has reasonability and feasibility.
2, MTI-446 and the cyflumetofen indoor joint toxicity measuring to citrus red mite.
For examination worm: select field to gather and the indoor female one-tenth mite of citrus red mite of raising breeding.
Reagent agent: the former medicine of 98% MTI-446 and the former medicine of 97% cyflumetofen.
Test method adopts leaf butterfly spray-on process, and concrete operation method is as follows:
Choose the Citrus leaf of healthy growth, with card punch, make leaf butterfly, in culture dish, place a wet sponge piece, on it, put filter paper, foliation butterfly on filter paper, every ware is put 2 leaf butterflies, select the female one-tenth mite of citrus red mite healthy, that the length of time is consistent and be inoculated into leaf butterfly above, 20 of every leaf butterfly inoculations.
The culture dish that is connected to leaf butterfly is placed under potter spray tower, under 50PSI pressure, sprays, spray amount is 1ml, after sedimentation 1min, take out culture dish, then the culture dish of processing is put into 25 ℃, in 12H/12H illumination box, cultivate, after 48h, check dead borer population, calculate lethality.4 repetitions are established in every processing, and establish clear water blank and process.
With DPS statistical analysis software, carry out statistical analysis, calculate the LC of each medicament
50, and according to the co-toxicity coefficient (CTC value) of the abundant method calculating of Sun Yun mixture.
Actual measurement toxicity index (ATI)=(standard medicament LC
50/ reagent agent LC
50) * 100.
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture.
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] * 100.
According to the NY/T11547.7-2006 insecticide synergy criteria for classifying: co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.
Table 2, MTI-446 and the cyflumetofen indoor joint toxicity measuring to citrus red mite.
As can be seen from Table 2, when MTI-446 and cyflumetofen are composite in 20:1～1:20 scope of (by weight), co-toxicity coefficient (CTC) is all greater than 120, citrus red mite is shown to synergistic function, when especially composite in 10:1～1:5 scope of (by weight), synergistic function is more obvious, and co-toxicity coefficient (CTC) is all greater than 160, and visible MTI-446 and cyflumetofen be composite has reasonability and feasibility.
3, the composite field control effectiveness test to tea lesser leafhopper of MTI-446 and cyflumetofen.
This embodiment is used for preventing and treating tea lesser leafhopper, adopts spray-on process.Dispenser Qian Mei presses community 5 samplings of diagonal, every tealeaves tree 2～3 strains (depending on insect density) of choosing tea lesser leafhopper ovum and adult, and tea lesser leafhopper quantity in statistics demarcation strain, usings this insect population radix before as dispenser.After medicine, 3d, 7d, 14d investigate respectively residual tea lesser leafhopper borer population alive, record the borer population of living, and calculate control efficiency.Control efficiency computational methods are as follows:
Preventive effect (%)=(1-CK
1* Pt
1/ CK
2* Pt
2) * 100.
Wherein: CK
1represent the front insect population number of check plot medicine; Pt
1represent insect population number after treatment region medicine;
CK
2represent insect population number after the medicine of check plot; Pt
2represent the front insect population number for the treatment of region medicine;
Table 3 is respectively processed the result of the test of chemical control tea lesser leafhopper.
As can be seen from Table 3, when 25% MTI-446 cyflumetofen suspending agent is used 1500-2000 times, after medicine, 3d, 7d, 14d are all better than each single dose to the preventive effect of tea lesser leafhopper and use separately, and after medicine, 14d preventive effect all still reaches more than 85% simultaneously, illustrates that this compound drug has good lasting effect.In pilot survey process, do not find that this compound drug produces poisoning to tea tree.
4, the composite field control effectiveness test to citrus red mite of MTI-446 and cyflumetofen.
This embodiment is used for preventing and treating citrus red mite, investigation insect population radix before dispenser, after medicine, 7d, 14d, 30d investigate respectively residual mite number alive, 2 strains are looked in investigation Shi Mei community, every strain is looked into respectively 5 blades by orientation, 4 of the four corners of the world, each community is looked into 40 blades altogether, records the mite number of living, and calculates control efficiency.Control efficiency computational methods are as follows:
Control efficiency (%)=(1-CK
1* Pt
1/ CK
2* Pt
2) * 100.
Wherein: CK
1represent the front insect population number of check plot medicine; Pt
1represent insect population number after treatment region medicine;
CK
2represent insect population number after the medicine of check plot; Pt
2represent the front insect population number for the treatment of region medicine;
Table 4, respectively process the result of the test of chemical control citrus red mite.
As can be seen from Table 4, when 25% MTI-446 cyflumetofen water dispersible granules is used 1500-2000 times, after medicine, 7d, 14d, 30d are all better than each single dose to the preventive effect of citrus red mite and use separately, and after medicine, 30d preventive effect all still reaches more than 80% simultaneously, illustrates that this compound drug has good lasting effect.In pilot survey process, do not find that this compound drug produces poisoning to oranges and tangerines.
In sum, it is the compound pesticide composition of MTI-446 and cyflumetofen that the present invention adopts two kinds of active components, has synergistic function, compare with existing unitary agent, insecticidal effect obviously improves, and the lasting period is long, to crop safety, be worth applying in agricultural production.
Claims (4)
1. a composition pesticide that contains MTI-446 and cyflumetofen, it is characterized in that: active ingredient is MTI-446 and cyflumetofen, wherein the weight ratio of MTI-446 and cyflumetofen is 20:1～1:20, preferably, than being 10:1～1:5, MTI-446 and the cyflumetofen gross weight percentage composition in composition is 1～85%.
2. a kind of composition pesticide that contains MTI-446 and cyflumetofen according to claim 1, is characterized in that: its formulation is a kind of in suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wetting powder, ultra low volume liquids, microcapsule suspending agent and thermal fog.
3. a kind of composition pesticide that contains MTI-446 and cyflumetofen according to claim 1, is applicable to prevent and treat the insect in agricultural.
4. a kind of composition pesticide that contains MTI-446 and cyflumetofen according to claim 3, described insect is two spotted spider mite, tea lesser leafhopper, aleyrodid, aphid and scale insect.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107439581A (en) * | 2017-08-11 | 2017-12-08 | 江西省科学院微生物研究所 | A kind of MTI-446 thermal fog and its preparation method and application |
-
2014
- 2014-05-30 CN CN201410240960.5A patent/CN104012568A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107439581A (en) * | 2017-08-11 | 2017-12-08 | 江西省科学院微生物研究所 | A kind of MTI-446 thermal fog and its preparation method and application |
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Application publication date: 20140903 |