Nothing Special   »   [go: up one dir, main page]

CL2022001710A1 - Substituted bicyclic derivatives of piperidine useful as t-cell activators - Google Patents

Substituted bicyclic derivatives of piperidine useful as t-cell activators

Info

Publication number
CL2022001710A1
CL2022001710A1 CL2022001710A CL2022001710A CL2022001710A1 CL 2022001710 A1 CL2022001710 A1 CL 2022001710A1 CL 2022001710 A CL2022001710 A CL 2022001710A CL 2022001710 A CL2022001710 A CL 2022001710A CL 2022001710 A1 CL2022001710 A1 CL 2022001710A1
Authority
CL
Chile
Prior art keywords
substituted bicyclic
compounds
cell activators
bicyclic derivatives
useful
Prior art date
Application number
CL2022001710A
Other languages
Spanish (es)
Inventor
G Gentles Robert
Velaparthi Upender
Ding Min
E Olson Richard
w martin Scott
Roy Saumya
Rao Jalagam Prasada
Sankara Warrier Jayakumar
Chupak Louis
Grunenfelder Denise
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of CL2022001710A1 publication Critical patent/CL2022001710A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen los compuestos de la Fórmula (I): o una sal del mismo, en donde: X es CR6 o N; Y es CR3 o N; R1, R2, R3, R4, R5, R6, R7, y m son como se definen en la presente. También se describen métodos para usar tales compuestos para inhibir la actividad de uno o ambos de diacilglicerol quinasa alfa (DGK alfa) y diacilglicerol quinasa zeta (DGK zeta), y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles en el tratamiento de infecciones virales y trastornos proliferativos, como el cáncer.Compounds of Formula (I) are described: or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, R7, and m are as defined herein. Also described are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK alpha) and diacylglycerol kinase zeta (DGK zeta), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

CL2022001710A 2019-12-23 2022-06-20 Substituted bicyclic derivatives of piperidine useful as t-cell activators CL2022001710A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN201911053552 2019-12-23

Publications (1)

Publication Number Publication Date
CL2022001710A1 true CL2022001710A1 (en) 2023-01-13

Family

ID=74191945

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022001710A CL2022001710A1 (en) 2019-12-23 2022-06-20 Substituted bicyclic derivatives of piperidine useful as t-cell activators

Country Status (16)

Country Link
US (1) US11964973B2 (en)
EP (1) EP4081523A1 (en)
JP (1) JP2023508052A (en)
KR (1) KR20220119455A (en)
CN (1) CN114901660B (en)
AR (1) AR120823A1 (en)
AU (1) AU2020412615A1 (en)
BR (1) BR112022012195A2 (en)
CA (1) CA3163013A1 (en)
CL (1) CL2022001710A1 (en)
CO (1) CO2022008675A2 (en)
IL (1) IL294272A (en)
MX (1) MX2022007842A (en)
PE (1) PE20221487A1 (en)
TW (1) TWI843922B (en)
WO (1) WO2021133750A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20220303A (en) 2019-12-24 2022-09-02 Gilead Sciences Inc Diacylglycerol kinase modulating compounds
EP4359389A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3222439A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3222277A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
AU2022297367A1 (en) 2021-06-23 2023-12-07 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2023122778A1 (en) * 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Pyridazinone derivatives useful as t cell activators
WO2023150186A1 (en) * 2022-02-01 2023-08-10 Arvinas Operations, Inc. Dgk targeting compounds and uses thereof
WO2023165525A1 (en) * 2022-03-01 2023-09-07 Insilico Medicine Ip Limited Diacylglycerol kinase (dgk) alpha inhibitors and uses thereof
CN118871438A (en) 2022-03-01 2024-10-29 英矽智能科技知识产权有限公司 Diacylglycerol kinase (DGK) alpha inhibitors and uses thereof
WO2023184327A1 (en) * 2022-03-31 2023-10-05 InventisBio Co., Ltd. Kinase inhibitors, preparation methods and uses thereof
WO2024137865A1 (en) * 2022-12-22 2024-06-27 Gossamer Bio Services, Inc. Compounds useful as t cell activators
WO2024160277A1 (en) * 2023-02-02 2024-08-08 Beigene, Ltd. Heterocyclic compounds
WO2024165468A1 (en) 2023-02-06 2024-08-15 Bayer Aktiengesellschaft Combination of ccr8 antibodies with dgk inhibitors in the treatment of cancer

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324893A (en) 1979-04-18 1982-04-13 American Home Products Corporation 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
UY27304A1 (en) 2001-05-24 2002-12-31 Avanir Pharmaceuticals INHIBITORS OF THE INHIBITOR FACTOR OF MIGRATION OF MACROPHAGES AND METHODS FOR IDENTIFICATION
RU2005102004A (en) 2002-06-27 2005-10-20 Шеринг Акциенгезельшафт (De) SUBSTITUTED QUINOLINS AS CCR5 RECEPTOR ANTAGONISTS
GB0230018D0 (en) 2002-12-23 2003-01-29 Syngenta Ltd Fungicides
TW200418829A (en) 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
TWI289141B (en) 2003-03-11 2007-11-01 Hoffmann La Roche F. Ag. Quinolinone derivatives and uses thereof
JP2006521400A (en) 2003-03-26 2006-09-21 バイエル・フアーマシユーチカルズ・コーポレーシヨン Compounds for the treatment of diabetes and related disorders and their use
GB0316915D0 (en) 2003-07-18 2003-08-20 Glaxo Group Ltd Compounds
WO2005009967A2 (en) 2003-07-22 2005-02-03 Janssen Pharmaceutica, N.V. Quinolinone derivatives as inhibitors of c-fms kinase
WO2005021546A1 (en) 2003-08-22 2005-03-10 Avanir Pharmaceuticals Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases
US7381401B2 (en) * 2004-01-08 2008-06-03 The University Of Chicago T cell anergy is reversed by active Ras and regulated by diacylglycerol kinase
TWI380996B (en) 2004-09-17 2013-01-01 Hoffmann La Roche Anti-ox40l antibodies
DK1866339T3 (en) 2005-03-25 2013-09-02 Gitr Inc GTR-binding molecules and their applications
ME02461B (en) 2005-05-10 2017-02-20 Incyte Holdings Corp Modulators of indoleamine 2,3-dioxygenase and methods of using the same
EP1907424B1 (en) 2005-07-01 2015-07-29 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
ES2540561T3 (en) 2005-12-20 2015-07-10 Incyte Corporation N-hydroxyamidinoheterocycles as indolamine 2,3-dioxygenase modulators
GB0605689D0 (en) 2006-03-21 2006-05-03 Novartis Ag Organic compounds
JP2007308402A (en) 2006-05-17 2007-11-29 Sumitomo Chemical Co Ltd Cinnamoyl compound and its application
JP2007308441A (en) 2006-05-22 2007-11-29 Sumitomo Chemical Co Ltd Heterocycle-containing compound and its application
EP2064207B1 (en) 2006-09-19 2013-11-06 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (en) 2006-09-19 2008-02-08 Incyte Corp COMPOUNDS DERIVED FROM HETEROCICLO N-HIDROXIAMINO; PHARMACEUTICAL COMPOSITION, USEFUL TO TREAT CANCER, VIRAL INFECTIONS AND NEURODEGENERATIVE DISORDERS BETWEEN OTHERS.
JP2010504945A (en) 2006-09-29 2010-02-18 テイボテク・フアーマシユーチカルズ・リミテツド Quinolinone derivatives
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
EP3124046B1 (en) 2007-07-12 2019-12-25 GITR, Inc. Combination therapies employing gitr binding molecules
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
CN101932325B (en) 2007-11-30 2014-05-28 新联基因公司 Ido inhibitors
WO2009156652A1 (en) 2008-05-29 2009-12-30 Saint-Gobain Centre De Recherches Et D'etudes Europeen Cellular structure containing aluminium titanate
AR072999A1 (en) 2008-08-11 2010-10-06 Medarex Inc HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE
US20110281908A1 (en) 2008-10-06 2011-11-17 Emory University Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
KR20200047793A (en) 2008-12-09 2020-05-07 제넨테크, 인크. Anti-pd-l1 antibodies and their use to enhance t-cell function
WO2010088414A2 (en) 2009-01-28 2010-08-05 Emory University Subunit selective nmda receptor potentiators for the treatment of neurological conditions
EP2473531A4 (en) 2009-09-03 2013-05-01 Merck Sharp & Dohme Anti-gitr antibodies
WO2011056652A1 (en) 2009-10-28 2011-05-12 Newlink Genetics Imidazole derivatives as ido inhibitors
PE20121398A1 (en) 2009-12-10 2012-10-26 Hoffmann La Roche BINDING ANTIBODIES PREFERENTIALLY TO THE EXTRACELLULAR DOMAIN 4 OF HUMAN CSF1R
PT2542256T (en) 2010-03-04 2019-09-05 Macrogenics Inc Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof
CN102918060B (en) 2010-03-05 2016-04-06 霍夫曼-拉罗奇有限公司 Anti-human CSF-1R antibody and uses thereof
RU2617966C2 (en) 2010-03-05 2017-04-28 Ф.Хоффманн-Ля Рош Аг Antibodies to human csf-1r and use thereof
NZ712765A (en) 2010-05-04 2017-01-27 Five Prime Therapeutics Inc Antibodies that bind csf1r
EP2592933B1 (en) 2010-07-16 2017-04-05 Anderson Gaweco Mif inhibitors and their uses
HUE041958T2 (en) 2010-09-09 2019-06-28 Pfizer 4-1bb binding molecules
EP3354640A3 (en) 2011-04-13 2018-10-31 Innovimmune Biotherapeutics, Inc. Mif inhibitors and their uses
NO2694640T3 (en) 2011-04-15 2018-03-17
HUE037651T2 (en) 2011-04-20 2018-09-28 Medimmune Llc Antibodies and other molecules that bind b7-h1 and pd-1
RS61033B1 (en) 2011-11-28 2020-12-31 Merck Patent Gmbh Anti-pd-l1 antibodies and uses thereof
CA2853889A1 (en) 2011-12-15 2013-06-20 F. Hoffmann-La Roche Ag Antibodies against human csf-1r and uses thereof
CA2861122A1 (en) 2012-02-06 2013-08-15 Genentech, Inc. Compositions and methods for using csf1r inhibitors
AR089939A1 (en) 2012-02-09 2014-10-01 Glenmark Pharmaceuticals Sa BICYCLE COMPOUNDS AS INHIBITORS OF mPGES-1
AR090263A1 (en) 2012-03-08 2014-10-29 Hoffmann La Roche COMBINED ANTIBODY THERAPY AGAINST HUMAN CSF-1R AND USES OF THE SAME
RU2670743C9 (en) 2012-05-11 2018-12-19 Файв Прайм Терапьютикс, Инк. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
AR091649A1 (en) 2012-07-02 2015-02-18 Bristol Myers Squibb Co OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
KR20200140400A (en) 2012-08-31 2020-12-15 파이브 프라임 테라퓨틱스, 인크. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
US9937205B2 (en) 2012-09-04 2018-04-10 The Trustees Of The University Of Pennsylvania Inhibition of diacylglycerol kinase to augment adoptive T cell transfer
EA201792214A1 (en) 2015-04-10 2018-01-31 Араксис Фарма Ллк COMPOUNDS OF SUBSTITUTE QUINAZOLINE
ES2883285T3 (en) 2015-12-17 2021-12-07 Merck Patent Gmbh Tlr7 / 8 antagonists and their uses
US10946020B2 (en) 2016-04-06 2021-03-16 University Of Virginia Patent Foundation Compositions and methods for treating cancer
NZ754994A (en) 2016-12-22 2022-12-23 Amgen Inc Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
GB201700814D0 (en) 2017-01-17 2017-03-01 Liverpool School Tropical Medicine Compounds
JOP20190272A1 (en) 2017-05-22 2019-11-21 Amgen Inc Kras g12c inhibitors and methods of using the same
US20200231551A1 (en) 2017-06-26 2020-07-23 University Of Virginia Patent Foundation Compositions and uses thereof
EP3689876A4 (en) 2017-09-28 2021-05-05 Nanjing Transthera Biosciences Co. Ltd. Pde9 inhibitor and use thereof
AU2019291794B2 (en) * 2018-06-27 2022-06-16 Bristol-Myers Squibb Company Substituted naphthyridinone compounds useful as T cell activators
HRP20230627T1 (en) 2018-06-27 2023-09-29 Bristol-Myers Squibb Company Naphthyridinone compounds useful as t cell activators
CN111471059B (en) * 2019-01-23 2022-12-02 药捷安康(南京)科技股份有限公司 PDE9 inhibitors and uses thereof
AR119821A1 (en) 2019-08-28 2022-01-12 Bristol Myers Squibb Co SUBSTITUTED PYRIDOPYRIMIDINOL COMPOUNDS USEFUL AS T-CELL ACTIVATORS
CA3162767A1 (en) 2019-11-28 2021-06-03 Bayer Aktiengesellschaft Substituted aminoquinolones as dgkalpha inhibitors for immune activation
BR112022010112A2 (en) 2019-11-28 2022-09-06 Bayer Ag SUBSTITUTED AMINOQUINOLONES AS DGKALFA INHIBITORS FOR IMMUNOLOGICAL ACTIVATION
EP4065584A1 (en) 2019-11-28 2022-10-05 Bayer Aktiengesellschaft Substituted aminoquinolones as dgkalpha inhibitors for immune activation

Also Published As

Publication number Publication date
BR112022012195A2 (en) 2022-09-06
AR120823A1 (en) 2022-03-23
MX2022007842A (en) 2022-07-19
JP2023508052A (en) 2023-02-28
KR20220119455A (en) 2022-08-29
CO2022008675A2 (en) 2022-07-19
US20210188845A1 (en) 2021-06-24
PE20221487A1 (en) 2022-09-26
TWI843922B (en) 2024-06-01
CA3163013A1 (en) 2021-07-01
AU2020412615A1 (en) 2022-08-18
EP4081523A1 (en) 2022-11-02
IL294272A (en) 2022-08-01
WO2021133750A1 (en) 2021-07-01
CN114901660B (en) 2024-10-15
US11964973B2 (en) 2024-04-23
CN114901660A (en) 2022-08-12
TW202136254A (en) 2021-10-01

Similar Documents

Publication Publication Date Title
CL2022001710A1 (en) Substituted bicyclic derivatives of piperidine useful as t-cell activators
CL2020003260A1 (en) Substituted naphthyridinone compounds useful as t cell activators
CO2022002424A2 (en) Substituted Pyridopyrimidinonyl Compounds Useful as T Cell Activators
BR112022012204A2 (en) SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS T-CELL ACTIVATORS
EA202190137A1 (en) NAPHTHYRIDINE COMPOUNDS FOR USE AS T-CELL ACTIVATORS
BR112022012220A2 (en) SUBSTITUTED PIPERAZINE QUINOLINONYL COMPOUNDS USEFUL AS T-CELL ACTIVATORS
BR112022012179A2 (en) SUBSTITUTED QUINAZOLINE COMPOUNDS USEFUL AS T-CELL ACTIVATORS
BR112022012222A2 (en) SUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS T-CELL ACTIVATORS
CO2018002061A2 (en) Heterocyclic compounds useful as modulators of tumor necrosis factor (tnf) alpha
CO2018002060A2 (en) Pharmaceutical compounds
PE20200700A1 (en) MACROCYCLIC COMPOUNDS AND USES OF THEM
PE20180117A1 (en) INDOLAMINE-2,3-DIOXYGENASE INHIBITORS FOR THE TREATMENT OF CANCER
AR111233A1 (en) TYK2 INHIBITORS, USES AND METHODS FOR THE PRODUCTION OF THE SAME
CO2019000932A2 (en) New 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of viral infection.
BR112017010354B8 (en) TRIAZOLOPYRIMIDINE COMPOUNDS, THEIR USE, AND PHARMACEUTICAL COMPOSITION
CU20160111A7 (en) BICYCLIC HETEROCICLYL COMPOUNDS AS IRAK4 INHIBITORS
CL2020001234A1 (en) Sting modulating compounds and methods of preparation and use.
AR075729A1 (en) DERIVATIVES OF BENZOFURANILO, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE TREATMENT OF OBESITY AND / OR DIABETES.
CO2020002961A2 (en) Pyruvate kinase activators for use in the treatment of blood disorders
CL2019000662A1 (en) Dopamine-b-hydroxylase inhibitors.
PE20180355A1 (en) DEACETOXITUBULISIN H AND ANALOGS OF IT
AR070266A1 (en) DERIVATIVES OF N- (2-AMINO-PHENYL) -AMIDA, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER.
UY37774A (en) SUBSTITUTED 5-CYANOINDOL COMPOUNDS AND USES OF THE SAME
PE20141352A1 (en) PHENYL-3-AZA-BICYCLE [3,1,0] HEX-3-IL-METHANONES AND ITS USE AS A MEDICINAL PRODUCT
CO2020010306A2 (en) 7-substituted sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of liver cancer.