CL2020001843A1 - Genes pesticidas y métodos de uso. (solicitud divisional 201702681) - Google Patents
Genes pesticidas y métodos de uso. (solicitud divisional 201702681)Info
- Publication number
- CL2020001843A1 CL2020001843A1 CL2020001843A CL2020001843A CL2020001843A1 CL 2020001843 A1 CL2020001843 A1 CL 2020001843A1 CL 2020001843 A CL2020001843 A CL 2020001843A CL 2020001843 A CL2020001843 A CL 2020001843A CL 2020001843 A1 CL2020001843 A1 CL 2020001843A1
- Authority
- CL
- Chile
- Prior art keywords
- polypeptides
- methods
- compositions
- pests
- organisms
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000000575 pesticide Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 241000607479 Yersinia pestis Species 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 230000000361 pesticidal effect Effects 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 241000238631 Hexapoda Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
- A01N63/22—Bacillus
- A01N63/23—B. thuringiensis
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
- C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pest Control & Pesticides (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Insects & Arthropods (AREA)
- Physiology (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Se proveen composiciones con actividad pesticida y métodos de uso de las mismas. Las composiciones incluyen polipéptidos aislados y recombinantes que poseen actividad pesticida, moléculas de ácidos nucleicos recombinantes y sintéticos que codifican los polipéptidos, construcciones de ADN y vectores que comprenden las moléculas de ácido nucleico, células huésped que comprenden los vectores, y anticuerpos para los polipéptidos. Las secuencias de nucleótidos que codifican los polipéptidos se pueden utilizar en construcciones de ADN o casetes de expresión para la transformación y expresión en organismos de interés. Las composiciones y métodos provistos son útiles para la producción de organismos con una mejor resistencia o tolerancia a las plagas. También se proporcionan plantas y semillas transgénicas que comprenden una secuencia de nucleótidos que codifica una proteína pesticida de la invención. Tales plantas son resistentes a los insectos y otras plagas. Se proveen métodos para la producción de los diversos polipéptidos descriptos en la presente, y para el uso de esos polipéptidos en el control o eliminación de una plaga. También se incluyen métodos y kits para la detección de polipéptidos de la invención en una muestra.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562151156P | 2015-04-22 | 2015-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2020001843A1 true CL2020001843A1 (es) | 2020-11-06 |
Family
ID=55969457
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002681A CL2017002681A1 (es) | 2015-04-22 | 2017-10-20 | Genes pesticidas y métodos de uso |
| CL2019000897A CL2019000897A1 (es) | 2015-04-22 | 2019-04-03 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2019000898A CL2019000898A1 (es) | 2015-04-22 | 2019-04-03 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2019000899A CL2019000899A1 (es) | 2015-04-22 | 2019-04-03 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2020001838A CL2020001838A1 (es) | 2015-04-22 | 2020-07-10 | Genes pesticidas y métodos de uso. (divisional solicitud 201702681) |
| CL2020001841A CL2020001841A1 (es) | 2015-04-22 | 2020-07-10 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2020001842A CL2020001842A1 (es) | 2015-04-22 | 2020-07-10 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2020001840A CL2020001840A1 (es) | 2015-04-22 | 2020-07-10 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2020001843A CL2020001843A1 (es) | 2015-04-22 | 2020-07-10 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
Family Applications Before (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002681A CL2017002681A1 (es) | 2015-04-22 | 2017-10-20 | Genes pesticidas y métodos de uso |
| CL2019000897A CL2019000897A1 (es) | 2015-04-22 | 2019-04-03 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2019000898A CL2019000898A1 (es) | 2015-04-22 | 2019-04-03 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2019000899A CL2019000899A1 (es) | 2015-04-22 | 2019-04-03 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2020001838A CL2020001838A1 (es) | 2015-04-22 | 2020-07-10 | Genes pesticidas y métodos de uso. (divisional solicitud 201702681) |
| CL2020001841A CL2020001841A1 (es) | 2015-04-22 | 2020-07-10 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2020001842A CL2020001842A1 (es) | 2015-04-22 | 2020-07-10 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
| CL2020001840A CL2020001840A1 (es) | 2015-04-22 | 2020-07-10 | Genes pesticidas y métodos de uso. (solicitud divisional 201702681) |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US10053707B2 (es) |
| EP (1) | EP3286320A2 (es) |
| KR (1) | KR20170138549A (es) |
| CN (2) | CN114644689A (es) |
| AR (5) | AR104341A1 (es) |
| AU (2) | AU2016252027B9 (es) |
| BR (1) | BR112017022852A2 (es) |
| CA (1) | CA2981088A1 (es) |
| CL (9) | CL2017002681A1 (es) |
| MA (1) | MA41951A (es) |
| MX (2) | MX2017013062A (es) |
| PH (1) | PH12017501887A1 (es) |
| RU (2) | RU2020138227A (es) |
| UA (1) | UA126058C2 (es) |
| WO (1) | WO2016171999A2 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160304898A1 (en) * | 2015-04-17 | 2016-10-20 | AgBiome, Inc. | Pesticidal Genes and Methods of Use |
| CN114644689A (zh) | 2015-04-22 | 2022-06-21 | 农业生物群落股份有限公司 | 杀虫基因和使用方法 |
| ES2889906T3 (es) | 2015-05-21 | 2022-01-14 | Harpoon Therapeutics Inc | Proteínas de unión triespecíficas y usos médicos |
| WO2017034853A1 (en) * | 2015-08-25 | 2017-03-02 | Dow Agrosciences Llc | Irdig17912 insecticidal cry toxins |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| US10100106B2 (en) | 2016-05-20 | 2018-10-16 | Harpoon Therapeutics, Inc. | Single domain serum albumin binding protein |
| IL314953A (en) | 2016-05-20 | 2024-10-01 | Harpoon Therapeutics Inc | CD3 binding proteins with single chain variable segment and their use in cancer therapy |
| BR112019004406A2 (pt) * | 2016-09-06 | 2019-06-25 | Agbiome Inc | genes pesticidas e métodos de uso |
| KR102275008B1 (ko) * | 2016-11-23 | 2021-07-13 | 하푼 테라퓨틱스, 인크. | 전립선 특이 막 항원 결합 단백질 |
| US10844134B2 (en) | 2016-11-23 | 2020-11-24 | Harpoon Therapeutics, Inc. | PSMA targeting trispecific proteins and methods of use |
| WO2018160754A2 (en) | 2017-02-28 | 2018-09-07 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| BR112019021380A2 (pt) | 2017-04-11 | 2020-05-05 | Agbiome Inc | genes pesticidas e métodos de uso |
| EP3621994A4 (en) | 2017-05-12 | 2020-12-30 | Harpoon Therapeutics, Inc. | MESOTHELINE BINDING PROTEINS |
| KR20200026810A (ko) | 2017-05-12 | 2020-03-11 | 하푼 테라퓨틱스, 인크. | Msln 표적화 삼중 특이적 단백질 및 사용 방법 |
| US20190040411A1 (en) * | 2017-08-03 | 2019-02-07 | AgBiome, Inc. | Pesticidal genes and methods of use |
| RS65978B1 (sr) | 2017-10-13 | 2024-10-31 | Harpoon Therapeutics Inc | Trispecifični proteini i postupci primene |
| CA3078799A1 (en) | 2017-10-13 | 2019-04-18 | Harpoon Therapeutics, Inc. | B cell maturation antigen binding proteins |
| MX2021003554A (es) | 2018-09-25 | 2021-05-27 | Harpoon Therapeutics Inc | Proteinas de union a dll3 y metodos de uso. |
| EP4045661A4 (en) * | 2019-10-14 | 2023-11-22 | Syngenta Crop Protection AG | INSECTICIDAL PROTEINS |
| BR112022016550A2 (pt) | 2020-02-21 | 2022-11-16 | Harpoon Therapeutics Inc | Proteínas de ligação a flt3 e métodos de uso |
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