CL2016000882A1 - Composiciones de arni contra el componente c5 del complemento y métodos para su uso (divisional de sol. n°2710-15). - Google Patents
Composiciones de arni contra el componente c5 del complemento y métodos para su uso (divisional de sol. n°2710-15).Info
- Publication number
- CL2016000882A1 CL2016000882A1 CL2016000882A CL2016000882A CL2016000882A1 CL 2016000882 A1 CL2016000882 A1 CL 2016000882A1 CL 2016000882 A CL2016000882 A CL 2016000882A CL 2016000882 A CL2016000882 A CL 2016000882A CL 2016000882 A1 CL2016000882 A1 CL 2016000882A1
- Authority
- CL
- Chile
- Prior art keywords
- complement
- methods
- arni
- compositions
- against component
- Prior art date
Links
- 230000000295 complement effect Effects 0.000 title abstract 2
- 241000320892 Clerodendrum phlomidis Species 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 241000237955 Nassarius Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920002477 rna polymer Polymers 0.000 abstract 1
Classifications
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/31—Chemical structure of the backbone
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- C12N2310/3125—Methylphosphonates
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- C12N2310/321—2'-O-R Modification
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- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Urology & Nephrology (AREA)
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Abstract
ÁCIDO RIBONUCLEICO DE HEBRA DOBLE (ARNhd) PARA INHBIR LA EXPRESIÓN DEL COMPONENTE C5 DEL COMPLEMENTO; CÉLULA; VECTOR; COMPOSICIÓN FARMACÉUTICA Y MÉTODOS PARA SU USO (DIVISIONAL DE SOL. N°2710-15).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361782531P | 2013-03-14 | 2013-03-14 | |
US201361837399P | 2013-06-20 | 2013-06-20 | |
US201361904579P | 2013-11-15 | 2013-11-15 | |
US201361912777P | 2013-12-06 | 2013-12-06 | |
US201461942367P | 2014-02-20 | 2014-02-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2016000882A1 true CL2016000882A1 (es) | 2016-12-09 |
Family
ID=50678278
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015002710A CL2015002710A1 (es) | 2013-03-14 | 2015-09-14 | Composiciones de arni contra el componente c5 del complemento y métodos para su uso. |
CL2016000882A CL2016000882A1 (es) | 2013-03-14 | 2016-04-14 | Composiciones de arni contra el componente c5 del complemento y métodos para su uso (divisional de sol. n°2710-15). |
CL2017002014A CL2017002014A1 (es) | 2013-03-14 | 2017-08-07 | Composiciones de arni contra el componente c5 del complemento y métodos para su uso. (divisional solicitud 2710-2015) |
CL2019000107A CL2019000107A1 (es) | 2013-03-14 | 2019-01-14 | Composiciones de arni contra el componente c5 del complemento y métodos para su uso.(divisional solicitud 201702014) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015002710A CL2015002710A1 (es) | 2013-03-14 | 2015-09-14 | Composiciones de arni contra el componente c5 del complemento y métodos para su uso. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017002014A CL2017002014A1 (es) | 2013-03-14 | 2017-08-07 | Composiciones de arni contra el componente c5 del complemento y métodos para su uso. (divisional solicitud 2710-2015) |
CL2019000107A CL2019000107A1 (es) | 2013-03-14 | 2019-01-14 | Composiciones de arni contra el componente c5 del complemento y métodos para su uso.(divisional solicitud 201702014) |
Country Status (33)
Country | Link |
---|---|
US (7) | US9249415B2 (es) |
EP (2) | EP2970974B1 (es) |
JP (4) | JP6524060B2 (es) |
KR (4) | KR102605775B1 (es) |
CN (2) | CN105324485B (es) |
AU (3) | AU2014244116B9 (es) |
BR (1) | BR112015022876B1 (es) |
CA (2) | CA3216595A1 (es) |
CL (4) | CL2015002710A1 (es) |
CR (1) | CR20150493A (es) |
CY (1) | CY1120289T1 (es) |
DK (1) | DK2970974T3 (es) |
DO (1) | DOP2015000234A (es) |
EA (1) | EA201591707A1 (es) |
ES (1) | ES2649490T3 (es) |
GT (1) | GT201500293A (es) |
HK (2) | HK1221484A1 (es) |
HR (1) | HRP20171813T1 (es) |
HU (1) | HUE034987T2 (es) |
IL (2) | IL265594B (es) |
LT (1) | LT2970974T (es) |
ME (1) | ME03043B (es) |
MX (2) | MX366660B (es) |
NZ (1) | NZ712336A (es) |
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EP3191591A1 (en) | 2014-09-12 | 2017-07-19 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting complement component c5 and methods of use thereof |
EP3194596A1 (en) | 2014-09-16 | 2017-07-26 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
EP3307316A1 (en) | 2015-06-12 | 2018-04-18 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
EP3469083A1 (en) | 2016-06-10 | 2019-04-17 | Alnylam Pharmaceuticals, Inc. | COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) |
WO2020060987A1 (en) | 2018-09-18 | 2020-03-26 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use |
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