CL2015001392A1 - Compuestos y sus métodos de empleo - Google Patents
Compuestos y sus métodos de empleoInfo
- Publication number
- CL2015001392A1 CL2015001392A1 CL2015001392A CL2015001392A CL2015001392A1 CL 2015001392 A1 CL2015001392 A1 CL 2015001392A1 CL 2015001392 A CL2015001392 A CL 2015001392A CL 2015001392 A CL2015001392 A CL 2015001392A CL 2015001392 A1 CL2015001392 A1 CL 2015001392A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- methods
- heterocicles
- glutaminase
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
COMPUESTOS DERIVADOS DE HETEROCICLOS NITROGENADOS, MODULADORES DE GLUTAMINASA ; COMPOSICION FARMACEUTICA; Y UN METODO PARA TRATAR EL CANCER,
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2012/085023 WO2014079011A1 (en) | 2012-11-22 | 2012-11-22 | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
PCT/CN2013/000294 WO2014079136A1 (en) | 2012-11-22 | 2013-03-15 | Compounds, pharmaceutical compositions and uses as glutaminase inhibitors for treating cancers thereof |
PCT/CN2013/001428 WO2014079150A1 (en) | 2012-11-22 | 2013-11-21 | Compounds and their methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015001392A1 true CL2015001392A1 (es) | 2016-04-22 |
Family
ID=50775393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015001392A CL2015001392A1 (es) | 2012-11-22 | 2015-05-22 | Compuestos y sus métodos de empleo |
Country Status (36)
Country | Link |
---|---|
US (2) | US10087172B2 (es) |
EP (2) | EP3456719A1 (es) |
JP (2) | JP6333277B2 (es) |
KR (1) | KR20150085079A (es) |
CN (2) | CN108727307A (es) |
AR (1) | AR093598A1 (es) |
AU (2) | AU2013347771B2 (es) |
BR (1) | BR112015011830A2 (es) |
CA (1) | CA2893510C (es) |
CL (1) | CL2015001392A1 (es) |
CR (1) | CR20150316A (es) |
CY (1) | CY1120581T1 (es) |
DK (1) | DK2922850T3 (es) |
EA (2) | EA201890754A1 (es) |
EC (1) | ECSP15026557A (es) |
ES (1) | ES2690390T3 (es) |
HK (1) | HK1214593A1 (es) |
HR (1) | HRP20181628T1 (es) |
HU (1) | HUE040111T2 (es) |
IL (1) | IL238958B (es) |
LT (1) | LT2922850T (es) |
MX (1) | MX367389B (es) |
MY (1) | MY177344A (es) |
NZ (1) | NZ708382A (es) |
PE (1) | PE20151072A1 (es) |
PH (2) | PH12015501150A1 (es) |
PL (1) | PL2922850T3 (es) |
PT (1) | PT2922850T (es) |
RS (1) | RS57859B1 (es) |
SA (1) | SA515360469B1 (es) |
SG (2) | SG11201504049VA (es) |
SI (1) | SI2922850T1 (es) |
TR (1) | TR201812360T4 (es) |
TW (2) | TW201906825A (es) |
UA (1) | UA117360C2 (es) |
WO (3) | WO2014079011A1 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8604016B2 (en) | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
RS62447B1 (sr) | 2012-11-16 | 2021-11-30 | Calithera Biosciences Inc | Heterociklični inhibitori glutaminaze |
CA2892089A1 (en) | 2012-11-21 | 2014-05-30 | Rene M. Lemieux | Glutaminase inhibitors and methods of use |
WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
BR112015012536A2 (pt) * | 2012-12-03 | 2017-07-11 | Calithera Biosciences Inc | tratamento de câncer com inibidores heterocíclicos da glutaminase |
JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
SG10201912524QA (en) | 2013-01-15 | 2020-04-29 | Incyte Holdings Corp | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors |
JP2016528298A (ja) | 2013-08-23 | 2016-09-15 | インサイト・コーポレイションIncyte Corporation | Pimキナーゼ阻害剤として有用なフロピリジン及びチエノピリジンカルボキシアミド化合物 |
JP6783663B2 (ja) * | 2014-01-06 | 2020-11-11 | ライゼン・ファーマシューティカルズ・エスアー | 新規グルタミナーゼ阻害剤 |
KR20160127149A (ko) | 2014-03-21 | 2016-11-02 | 아지오스 파마슈티컬스 아이엔씨. | 화합물 및 이의 사용 방법 |
AP2016009530A0 (en) | 2014-04-30 | 2016-10-31 | Pfizer | Cycloalkyl-linked diheterocycle derivatives |
GB201409624D0 (en) | 2014-05-30 | 2014-07-16 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
ES2788449T3 (es) | 2014-07-03 | 2020-10-21 | Univ Texas | Inhibidores de GLS1 para tratar enfermedades |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
WO2016014890A1 (en) * | 2014-07-24 | 2016-01-28 | Calithera Biosciences, Inc. | Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase |
WO2016022969A1 (en) | 2014-08-07 | 2016-02-11 | Calithera Biosciences, Inc. | Crystal forms of glutaminase inhibitors |
US10245254B2 (en) | 2014-10-03 | 2019-04-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Glutaminase inhibitors |
EP3280415A4 (en) | 2015-04-06 | 2018-12-26 | Calithera Biosciences Inc. | Treatment of lung cancer with inhibitors of glutaminase |
WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
JP6895396B2 (ja) * | 2015-06-30 | 2021-06-30 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 疾患を処置するためのgls1阻害薬 |
TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Pim激酶抑制劑之鹽 |
WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
KR20180059544A (ko) | 2015-10-05 | 2018-06-04 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 글루타미나제 억제제와 면역-종양학적 약제에 의한 병용 요법 |
US10040789B2 (en) * | 2015-11-30 | 2018-08-07 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
CN109503570B (zh) * | 2015-12-18 | 2020-08-25 | 诺言医药科技(上海)有限公司 | 一种含有索拉非尼的药物组合物及其应用 |
WO2017112831A1 (en) | 2015-12-22 | 2017-06-29 | Board Of Regents, The University Of Texas System | Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl) acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide |
EP3503886A4 (en) * | 2016-08-25 | 2020-07-22 | Calithera Biosciences, Inc. | POLYTHERAPY INCLUDING GLUTAMINASE INHIBITORS |
US10195197B2 (en) | 2016-08-25 | 2019-02-05 | Calithera Biosciences, Inc. | Combination therapy with glutaminase inhibitors |
EP3697764A4 (en) | 2017-10-18 | 2021-07-21 | Board Of Regents, The University Of Texas System | GLUTAMINASE INHIBITOR THERAPY |
TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
EP3876928B1 (en) | 2018-11-08 | 2024-10-23 | Merck Sharp & Dohme LLC | Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection |
WO2020191356A1 (en) * | 2019-03-21 | 2020-09-24 | Goncalves Marcus | Anti-fructose therapy for colorectal and small intestine cancers |
CN110746416A (zh) * | 2019-09-05 | 2020-02-04 | 中国药科大学 | 含有三氮唑结构的谷氨酰胺酶gls1抑制剂或其可药用的盐、其制备方法及用途 |
CN112898200A (zh) * | 2021-01-20 | 2021-06-04 | 都创(上海)医药科技股份有限公司 | 5-溴-6-甲氧基吡啶-2-羧酸酯的合成方法 |
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CA2892089A1 (en) | 2012-11-21 | 2014-05-30 | Rene M. Lemieux | Glutaminase inhibitors and methods of use |
US9029531B2 (en) | 2012-11-22 | 2015-05-12 | Agios Pharmaceuticals, Inc. | Compounds and their methods of use |
WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
WO2014138391A1 (en) | 2013-03-06 | 2014-09-12 | The Johns Hopkins University | Targeting glutamine metabolism in brain tumors |
JP6783663B2 (ja) | 2014-01-06 | 2020-11-11 | ライゼン・ファーマシューティカルズ・エスアー | 新規グルタミナーゼ阻害剤 |
KR20160127149A (ko) | 2014-03-21 | 2016-11-02 | 아지오스 파마슈티컬스 아이엔씨. | 화합물 및 이의 사용 방법 |
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2012
- 2012-11-22 WO PCT/CN2012/085023 patent/WO2014079011A1/en active Application Filing
-
2013
- 2013-03-15 WO PCT/CN2013/000294 patent/WO2014079136A1/en active Application Filing
- 2013-11-21 KR KR1020157016414A patent/KR20150085079A/ko not_active Application Discontinuation
- 2013-11-21 CA CA2893510A patent/CA2893510C/en active Active
- 2013-11-21 CN CN201810824418.2A patent/CN108727307A/zh active Pending
- 2013-11-21 RS RS20181133A patent/RS57859B1/sr unknown
- 2013-11-21 CN CN201380070365.5A patent/CN104936954B/zh not_active Expired - Fee Related
- 2013-11-21 EA EA201890754A patent/EA201890754A1/ru unknown
- 2013-11-21 EP EP18183580.2A patent/EP3456719A1/en not_active Withdrawn
- 2013-11-21 PT PT13857585T patent/PT2922850T/pt unknown
- 2013-11-21 UA UAA201506066A patent/UA117360C2/uk unknown
- 2013-11-21 BR BR112015011830A patent/BR112015011830A2/pt not_active Application Discontinuation
- 2013-11-21 AU AU2013347771A patent/AU2013347771B2/en not_active Ceased
- 2013-11-21 DK DK13857585.7T patent/DK2922850T3/en active
- 2013-11-21 SG SG11201504049VA patent/SG11201504049VA/en unknown
- 2013-11-21 EA EA201590987A patent/EA030646B1/ru not_active IP Right Cessation
- 2013-11-21 LT LTEP13857585.7T patent/LT2922850T/lt unknown
- 2013-11-21 HU HUE13857585A patent/HUE040111T2/hu unknown
- 2013-11-21 SI SI201331140T patent/SI2922850T1/sl unknown
- 2013-11-21 ES ES13857585.7T patent/ES2690390T3/es active Active
- 2013-11-21 US US14/646,634 patent/US10087172B2/en active Active
- 2013-11-21 EP EP13857585.7A patent/EP2922850B1/en active Active
- 2013-11-21 PL PL13857585T patent/PL2922850T3/pl unknown
- 2013-11-21 JP JP2015543242A patent/JP6333277B2/ja not_active Expired - Fee Related
- 2013-11-21 MY MYPI2015001355A patent/MY177344A/en unknown
- 2013-11-21 PE PE2015000674A patent/PE20151072A1/es unknown
- 2013-11-21 WO PCT/CN2013/001428 patent/WO2014079150A1/en active Application Filing
- 2013-11-21 TR TR2018/12360T patent/TR201812360T4/tr unknown
- 2013-11-21 MX MX2015006493A patent/MX367389B/es active IP Right Grant
- 2013-11-21 SG SG10201609940RA patent/SG10201609940RA/en unknown
- 2013-11-21 NZ NZ708382A patent/NZ708382A/en unknown
- 2013-11-22 TW TW107111990A patent/TW201906825A/zh unknown
- 2013-11-22 TW TW102142566A patent/TWI629268B/zh not_active IP Right Cessation
- 2013-11-22 AR ARP130104322A patent/AR093598A1/es unknown
-
2015
- 2015-05-21 IL IL238958A patent/IL238958B/en not_active IP Right Cessation
- 2015-05-22 SA SA515360469A patent/SA515360469B1/ar unknown
- 2015-05-22 PH PH12015501150A patent/PH12015501150A1/en unknown
- 2015-05-22 CL CL2015001392A patent/CL2015001392A1/es unknown
- 2015-06-15 CR CR20150316A patent/CR20150316A/es unknown
- 2015-06-22 EC ECIEPI201526557A patent/ECSP15026557A/es unknown
-
2016
- 2016-03-04 HK HK16102486.9A patent/HK1214593A1/zh not_active IP Right Cessation
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2017
- 2017-11-24 PH PH12017502141A patent/PH12017502141A1/en unknown
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2018
- 2018-04-24 JP JP2018082754A patent/JP2018150316A/ja active Pending
- 2018-04-30 AU AU2018202954A patent/AU2018202954A1/en not_active Abandoned
- 2018-08-17 CY CY20181100864T patent/CY1120581T1/el unknown
- 2018-08-21 US US16/107,220 patent/US10689375B2/en not_active Expired - Fee Related
- 2018-10-10 HR HRP20181628TT patent/HRP20181628T1/hr unknown
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