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CL2011002787A1 - Compuestos derivados de 1-cianoetilheterociclilcarboxamida sustituidos, inhibidores de dipeptidilpeptidasa i (dppi) o catepsina c; composicion farmaceutica; combinacion faramceutica; y su uso en el tratamiento del asma, la enfermedad obstructiva cronica o la rinitis alergica. - Google Patents

Compuestos derivados de 1-cianoetilheterociclilcarboxamida sustituidos, inhibidores de dipeptidilpeptidasa i (dppi) o catepsina c; composicion farmaceutica; combinacion faramceutica; y su uso en el tratamiento del asma, la enfermedad obstructiva cronica o la rinitis alergica.

Info

Publication number
CL2011002787A1
CL2011002787A1 CL2011002787A CL2011002787A CL2011002787A1 CL 2011002787 A1 CL2011002787 A1 CL 2011002787A1 CL 2011002787 A CL2011002787 A CL 2011002787A CL 2011002787 A CL2011002787 A CL 2011002787A CL 2011002787 A1 CL2011002787 A1 CL 2011002787A1
Authority
CL
Chile
Prior art keywords
cyanoethylheterocyclylcarboxamide
dppi
dipeptidylpeptidase
cathepsin
asthma
Prior art date
Application number
CL2011002787A
Other languages
English (en)
Inventor
Rhonan Ford
Antonio Mete
Andrew Mather
Ian Millichip
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd filed Critical Astrazeneca Ab
Publication of CL2011002787A1 publication Critical patent/CL2011002787A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos derivados de 1-cianoetilheterociclilcarboxamida sustituidos, inhibidores de dipeptidilpeptidasa I (dppi) o catepsina C; composición farmacéutica; combinación farmacéutica; y su uso en el tratamiento del asma, la enfermedad obstructiva crónica o la rinitis alérgica.
CL2011002787A 2009-05-07 2011-11-07 Compuestos derivados de 1-cianoetilheterociclilcarboxamida sustituidos, inhibidores de dipeptidilpeptidasa i (dppi) o catepsina c; composicion farmaceutica; combinacion faramceutica; y su uso en el tratamiento del asma, la enfermedad obstructiva cronica o la rinitis alergica. CL2011002787A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17627909P 2009-05-07 2009-05-07
US18562909P 2009-06-10 2009-06-10

Publications (1)

Publication Number Publication Date
CL2011002787A1 true CL2011002787A1 (es) 2012-06-22

Family

ID=42271991

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011002787A CL2011002787A1 (es) 2009-05-07 2011-11-07 Compuestos derivados de 1-cianoetilheterociclilcarboxamida sustituidos, inhibidores de dipeptidilpeptidasa i (dppi) o catepsina c; composicion farmaceutica; combinacion faramceutica; y su uso en el tratamiento del asma, la enfermedad obstructiva cronica o la rinitis alergica.

Country Status (22)

Country Link
US (2) US8193239B2 (es)
EP (1) EP2427445A1 (es)
JP (1) JP2012526093A (es)
KR (1) KR20120034639A (es)
CN (1) CN102574830A (es)
AR (1) AR076551A1 (es)
AU (1) AU2010244218B2 (es)
BR (1) BRPI1015540A2 (es)
CA (1) CA2759581A1 (es)
CL (1) CL2011002787A1 (es)
CO (1) CO6450612A2 (es)
CR (1) CR20110579A (es)
CU (1) CU20110204A7 (es)
EA (1) EA201190235A1 (es)
EC (1) ECSP11011439A (es)
IL (1) IL215615A0 (es)
MX (1) MX2011011661A (es)
SG (1) SG175090A1 (es)
TW (1) TW201041889A (es)
UY (1) UY32611A (es)
WO (1) WO2010128324A1 (es)
ZA (1) ZA201108962B (es)

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EA023168B1 (ru) 2011-02-11 2016-04-29 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Ингибитор катепсина с
WO2012119941A1 (en) 2011-03-04 2012-09-13 Prozymex A/S Peptidyl nitrilcompounds as peptidase inhibitors
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WO2014140081A1 (en) * 2013-03-14 2014-09-18 Boehringer Ingelheim International Gmbh Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
WO2014140091A1 (en) 2013-03-14 2014-09-18 Boehringer Ingelheim International Gmbh Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
CA2914132A1 (en) 2013-06-21 2014-12-24 Lupin Limited Substituted heterocyclic compounds as crac modulators
AU2014300629A1 (en) 2013-06-24 2015-12-24 Lupin Limited Chromane and chromene derivatives and their use as CRAC modulators
CA2923484C (en) * 2013-09-09 2022-09-06 Prozymex A/S Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors
NO2699580T3 (es) 2014-01-24 2018-02-24
TWI720943B (zh) 2014-04-25 2021-03-11 日商中外製藥股份有限公司 以高用量含有４環性化合物的製劑
US9714229B2 (en) 2014-04-25 2017-07-25 Chugai Seiyaku Kabushiki Kaisha Crystal of tetracyclic compound
ES2664810T3 (es) 2014-06-12 2018-04-23 Pfizer Limited Derivados de imidazopiridazina como moduladores de la actividad del receptor GABAA
EP3174879B1 (en) 2014-08-01 2018-07-18 Boehringer Ingelheim International GmbH Substituted oxetanes and their use as inhibitors of cathepsin c
TWI718102B (zh) 2014-08-08 2021-02-11 日商中外製藥股份有限公司 ４環性化合物的非晶質體
EA031376B1 (ru) 2014-09-12 2018-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Спироциклические ингибиторы катепсина с
RU2740261C2 (ru) 2015-01-16 2021-01-12 Чугаи Сейяку Кабусики Кайся Комбинированное лекарственное средство
WO2016139355A1 (en) 2015-03-05 2016-09-09 Prozymex A/S N-substituted 3,3'-(biphenyl-4,4'-diyl)bis-2-aminopropanenitriles as dppi inhibitors
WO2016139351A1 (en) 2015-03-05 2016-09-09 Prozymex A/S Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors
CN106478629A (zh) * 2015-08-24 2017-03-08 上海医药工业研究院 一种利格列汀的制备工艺
DK3423451T3 (da) 2016-03-01 2022-11-28 Propellon Therapeutics Inc Inhibitorer af wdr5-protein-proteinbinding
JP2019507179A (ja) 2016-03-01 2019-03-14 プロペロン セラピューティックス インコーポレイテッド Ｗｄｒ５タンパク質−タンパク質結合の阻害剤
CN109789150A (zh) * 2016-07-29 2019-05-21 英斯梅德股份有限公司 某些用于治疗支气管扩张的(2s)-n-[(1s)-1-氰基-2-苯乙基]-1,4-氧杂氮杂环庚烷-2-甲酰胺
CN112055593B (zh) 2018-03-01 2024-04-09 阿斯利康(瑞典)有限公司 药物组合物
US11998553B2 (en) 2018-07-17 2024-06-04 Insmed Incorporated Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis
WO2020018551A1 (en) * 2018-07-17 2020-01-23 Insmed Incorporated Certain (2s)- n-[(1s)-1-cyano-2-phenylethyl]-1,4- oxazepane-2-carboxamides for treating inflammatory bowel disease
KR102635225B1 (ko) 2018-09-04 2024-02-07 추가이 세이야쿠 가부시키가이샤 4환성 화합물의 제조방법
CA3190610A1 (en) 2020-08-26 2022-03-03 Haisco Pharmaceuticals Pte. Ltd. Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof
CA3199568A1 (en) * 2020-12-04 2022-06-09 Reistone Biopharma Company Limited Small molecule inhibitor of cathepsin c and medicinal use thereof
JP2024505715A (ja) * 2021-02-05 2024-02-07 メッドシャイン ディスカバリー インコーポレイテッド １，４－オキサゼパンを含む縮合環誘導体
KR20240150486A (ko) * 2022-02-22 2024-10-15 하이스코 파마수티컬즈 피티이. 엘티디. 질소-함유 헤테로사이클릭 화합물의 제조 방법
WO2024008680A1 (en) 2022-07-06 2024-01-11 Chiesi Farmaceutici S.P.A. Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors

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Also Published As

Publication number Publication date
AU2010244218A1 (en) 2011-11-03
MX2011011661A (es) 2011-11-18
EA201190235A1 (ru) 2012-05-30
US20120329775A1 (en) 2012-12-27
US8193239B2 (en) 2012-06-05
CN102574830A (zh) 2012-07-11
UY32611A (es) 2010-12-31
CU20110204A7 (es) 2012-03-15
ECSP11011439A (es) 2011-12-30
ZA201108962B (en) 2012-08-29
US20100286118A1 (en) 2010-11-11
EP2427445A1 (en) 2012-03-14
SG175090A1 (en) 2011-11-28
AR076551A1 (es) 2011-06-22
JP2012526093A (ja) 2012-10-25
IL215615A0 (en) 2011-12-29
CA2759581A1 (en) 2010-11-11
TW201041889A (en) 2010-12-01
WO2010128324A1 (en) 2010-11-11
BRPI1015540A2 (pt) 2019-09-24
AU2010244218B2 (en) 2012-07-19
KR20120034639A (ko) 2012-04-12
CO6450612A2 (es) 2012-05-31
CR20110579A (es) 2012-01-09

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