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CL2011000880A1 - Compuestos derivados de pirazolo[1,5-a]pirimidin-3-il, inhibidores de tirosina de la familia trk cinasa; proceso para la preparacion de los compuestos; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos utiles para el tratamiento del dolor y del cancer. - Google Patents

Compuestos derivados de pirazolo[1,5-a]pirimidin-3-il, inhibidores de tirosina de la familia trk cinasa; proceso para la preparacion de los compuestos; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos utiles para el tratamiento del dolor y del cancer.

Info

Publication number
CL2011000880A1
CL2011000880A1 CL2011000880A CL2011000880A CL2011000880A1 CL 2011000880 A1 CL2011000880 A1 CL 2011000880A1 CL 2011000880 A CL2011000880 A CL 2011000880A CL 2011000880 A CL2011000880 A CL 2011000880A CL 2011000880 A1 CL2011000880 A1 CL 2011000880A1
Authority
CL
Chile
Prior art keywords
compounds
preparation
pain
cancer
treatment
Prior art date
Application number
CL2011000880A
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English (en)
Inventor
Yutong Jiang
Gan Zhang
Julia Haas
Steven W Andrews
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41328903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011000880(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of CL2011000880A1 publication Critical patent/CL2011000880A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DERIVADOS DE PIRAZOLO[1,5-A]PIRIMIDÍN-3-IL, DE LA FÓRMULA 1 EN DONDE R1, R2, R3, R4, X, Y Y N SON TALES COMO SE DEFINEN EN EL PLIEGO DE REIVINDICACIONES; ESTOS COMPUESTOS SON INHIBIDORES DE LA PROTEÍNA TIROSINA DE LA FAMILIA TRK CINASA Y SON ÚTILES EN EL TRATAMIENTO DEL DOLOR Y DEL CÁNCER. SE DESCRIBE TAMBIÉN UN<br /> PROCESO PARA LA PREPARACIÓN DE DICHOS COMPUESTOS; TAMBIÉN SE INCLUYEN COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN A UNO O MÁS DE LOS COMPUESTOS Y EL USO DE LOS COMPUESTOS EN LA PREPARACIÓN DE MEDICAMENTOS ÚTILES PARA EL TRATAMIENTO DEL DOLOR Y DEL CÁNCER.
CL2011000880A 2008-10-22 2011-04-19 Compuestos derivados de pirazolo[1,5-a]pirimidin-3-il, inhibidores de tirosina de la familia trk cinasa; proceso para la preparacion de los compuestos; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos utiles para el tratamiento del dolor y del cancer. CL2011000880A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10761608P 2008-10-22 2008-10-22

Publications (1)

Publication Number Publication Date
CL2011000880A1 true CL2011000880A1 (es) 2011-07-08

Family

ID=41328903

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011000880A CL2011000880A1 (es) 2008-10-22 2011-04-19 Compuestos derivados de pirazolo[1,5-a]pirimidin-3-il, inhibidores de tirosina de la familia trk cinasa; proceso para la preparacion de los compuestos; composicion farmaceutica que comprende a uno de los compuestos; y uso de los compuestos en la preparacion de medicamentos utiles para el tratamiento del dolor y del cancer.

Country Status (39)

Country Link
US (11) US8513263B2 (es)
EP (4) EP3106463B3 (es)
JP (5) JP5600111B2 (es)
KR (5) KR101853026B1 (es)
CN (2) CN102264736B (es)
AR (2) AR074052A1 (es)
AU (1) AU2009308465B2 (es)
BR (1) BRPI0919873B8 (es)
CA (1) CA2741313C (es)
CL (1) CL2011000880A1 (es)
CO (1) CO6440551A2 (es)
CR (1) CR20110261A (es)
CY (4) CY1118199T1 (es)
DK (4) DK3372605T3 (es)
ES (4) ES2588504T3 (es)
HK (2) HK1160640A1 (es)
HR (3) HRP20211722T1 (es)
HU (4) HUE037716T2 (es)
IL (3) IL212341A0 (es)
LT (4) LT2725028T (es)
LU (1) LUC00150I2 (es)
ME (1) ME03010B (es)
MX (1) MX2011004204A (es)
MY (1) MY169791A (es)
NL (1) NL301033I2 (es)
NO (2) NO3106463T3 (es)
NZ (1) NZ592809A (es)
PL (4) PL2350071T3 (es)
PT (4) PT3106463T (es)
RS (3) RS62869B1 (es)
RU (1) RU2018131134A (es)
SG (3) SG10201900514RA (es)
SI (4) SI2725028T1 (es)
SM (1) SMT201400153B (es)
TR (1) TR201807039T4 (es)
TW (4) TWI458729B (es)
UA (1) UA106054C2 (es)
UY (1) UY32192A (es)
WO (1) WO2010048314A1 (es)

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