CL2009001146A1 - Compuestos derivados de 5-(5-(2-(3,5-bis(trifluorometil)fenil)-n,2-dimetilpropanoamida)-4-(4-fluoro-2-metilfenil)piridin-2-il)pirrolidin-2-carboxamida, antagonistas de los receptores nk-1; composicion farmaceutica; y uso del compuesto para el tratamiento de la depresion; ansiedad, trastornos del sueño o emesis. - Google Patents
Compuestos derivados de 5-(5-(2-(3,5-bis(trifluorometil)fenil)-n,2-dimetilpropanoamida)-4-(4-fluoro-2-metilfenil)piridin-2-il)pirrolidin-2-carboxamida, antagonistas de los receptores nk-1; composicion farmaceutica; y uso del compuesto para el tratamiento de la depresion; ansiedad, trastornos del sueño o emesis.Info
- Publication number
- CL2009001146A1 CL2009001146A1 CL2009001146A CL2009001146A CL2009001146A1 CL 2009001146 A1 CL2009001146 A1 CL 2009001146A1 CL 2009001146 A CL2009001146 A CL 2009001146A CL 2009001146 A CL2009001146 A CL 2009001146A CL 2009001146 A1 CL2009001146 A1 CL 2009001146A1
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- Prior art keywords
- compound
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- emesis
- anxiety
- depression
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
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Abstract
COMPUESTO DE FÓRMULA (I) O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, DONDE PORQUE<br /> R ES ALQUILO DE 1-4 C.<br /> COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE DICHO COMPUESTO DE FÓRMULA (I), O UNA SAL<br /> FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, Y UN VEHÍCULO O EXCIPIENTE FARMACÉUTICAMENTE ACEPTABLE.<br /> USO DE DICHO COMPUESTO PARA EL TRATAMIENTO DE AFECCIONES PARA LAS QUE ES BENEFICIOSO EL<br /> ANTAGONISMO DEL RECEPTOR NK1.<br /> USO DE DICHO COMPUESTO PARA EL TRATAMIENTO DE DEPRESIÓN, ANSIEDAD, TRASTORNOS DEL SUEÑO O<br /> EMESIS.<br />
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0808747.0A GB0808747D0 (en) | 2008-05-14 | 2008-05-14 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2009001146A1 true CL2009001146A1 (es) | 2010-09-24 |
Family
ID=39571329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2009001146A CL2009001146A1 (es) | 2008-05-14 | 2009-05-12 | Compuestos derivados de 5-(5-(2-(3,5-bis(trifluorometil)fenil)-n,2-dimetilpropanoamida)-4-(4-fluoro-2-metilfenil)piridin-2-il)pirrolidin-2-carboxamida, antagonistas de los receptores nk-1; composicion farmaceutica; y uso del compuesto para el tratamiento de la depresion; ansiedad, trastornos del sueño o emesis. |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20090286836A1 (es) |
| EP (1) | EP2300452B1 (es) |
| JP (1) | JP5465716B2 (es) |
| KR (1) | KR101567116B1 (es) |
| CN (1) | CN102105458B (es) |
| AR (1) | AR071721A1 (es) |
| AU (1) | AU2009248102B8 (es) |
| BR (1) | BRPI0911990B1 (es) |
| CA (1) | CA2724219C (es) |
| CL (1) | CL2009001146A1 (es) |
| DK (1) | DK2300452T3 (es) |
| EA (1) | EA019037B1 (es) |
| ES (1) | ES2446866T3 (es) |
| GB (1) | GB0808747D0 (es) |
| IL (1) | IL209197A (es) |
| MX (1) | MX2010012421A (es) |
| PE (1) | PE20091847A1 (es) |
| PL (1) | PL2300452T3 (es) |
| TW (1) | TWI444376B (es) |
| UY (1) | UY31824A (es) |
| WO (1) | WO2009138393A1 (es) |
| ZA (1) | ZA201007904B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8426450B1 (en) * | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| RU2673084C2 (ru) | 2013-11-08 | 2018-11-22 | Киссеи Фармасьютикал Ко., Лтд. | Производное карбоксиметилпиперидина |
| TWI649307B (zh) * | 2014-05-07 | 2019-02-01 | 日商橘生藥品工業股份有限公司 | Cyclohexylpyridine derivative |
| WO2016021562A1 (ja) * | 2014-08-06 | 2016-02-11 | キッセイ薬品工業株式会社 | シアノチオフェン誘導体 |
| WO2018197638A1 (en) | 2017-04-27 | 2018-11-01 | Nerre Therapeutics Limited | Novel use of (5r)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-d-prolinamide |
| EP4096508A4 (en) * | 2020-01-30 | 2024-03-27 | Javed, Mohammad | COMBINATION THERAPIES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS |
| MX2022014901A (es) | 2020-06-02 | 2023-01-18 | Nerre Therapeutics Ltd | Antagonistas del receptor de neuroquinina (nk)-1 para su uso en el tratamiento de condiciones de fibrosis pulmonar promovidas por lesion mecanica a los pulmones. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL144717A0 (en) | 1999-02-24 | 2002-06-30 | Hoffmann La Roche | Phenyl-and pyridinyl derivatives |
| EP1394150B1 (en) | 1999-02-24 | 2011-01-19 | F. Hoffmann-La Roche AG | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists |
| US6303790B1 (en) | 1999-11-29 | 2001-10-16 | Hoffman-La Roche Inc. | Process for the preparation of pyridine derivatives |
| ATE400556T1 (de) | 2000-07-14 | 2008-07-15 | Hoffmann La Roche | N-oxide als nk1-rezeptorantagonistenprodrugs von 4-phenylpyridinderivaten |
| TWI287003B (en) | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
| TWI259180B (en) | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
| CA2444395C (en) | 2001-04-23 | 2010-12-21 | F. Hoffmann-La Roche Ag | Use of nk-1 receptor antagonists against benign prostatic hyperplasia |
| US20030083345A1 (en) * | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
| US6849624B2 (en) | 2001-07-31 | 2005-02-01 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted amides |
| CN1852712B (zh) | 2003-07-03 | 2010-06-09 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗精神分裂症的双重nk1/nk3拮抗剂 |
| CA2572645C (en) | 2004-07-06 | 2011-01-18 | F. Hoffmann-La Roche Ag | Process for preparing carboxamide derivatives used as intermediates in the synthesis of nk-1 receptor antagonists |
| US20060030600A1 (en) * | 2004-08-06 | 2006-02-09 | Patrick Schnider | Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia |
| CA2621564C (en) | 2005-09-09 | 2014-06-03 | Smithkline Beecham Corporation | Pyridine derivatives and their use in the treatment of psychotic disorders |
| DE602006015215D1 (de) | 2005-10-10 | 2010-08-12 | Glaxo Group Ltd | Prolinamidderivate als natriumkanalmodulatoren |
-
2008
- 2008-05-14 GB GBGB0808747.0A patent/GB0808747D0/en not_active Ceased
-
2009
- 2009-05-12 WO PCT/EP2009/055700 patent/WO2009138393A1/en active Application Filing
- 2009-05-12 US US12/464,171 patent/US20090286836A1/en not_active Abandoned
- 2009-05-12 MX MX2010012421A patent/MX2010012421A/es active IP Right Grant
- 2009-05-12 JP JP2011508893A patent/JP5465716B2/ja active Active
- 2009-05-12 PL PL09745725T patent/PL2300452T3/pl unknown
- 2009-05-12 UY UY0001031824A patent/UY31824A/es not_active Application Discontinuation
- 2009-05-12 PE PE2009000650A patent/PE20091847A1/es not_active Application Discontinuation
- 2009-05-12 CN CN2009801275140A patent/CN102105458B/zh active Active
- 2009-05-12 AR ARP090101713A patent/AR071721A1/es not_active Application Discontinuation
- 2009-05-12 KR KR1020107027927A patent/KR101567116B1/ko active IP Right Grant
- 2009-05-12 CL CL2009001146A patent/CL2009001146A1/es unknown
- 2009-05-12 DK DK09745725.3T patent/DK2300452T3/da active
- 2009-05-12 BR BRPI0911990-6A patent/BRPI0911990B1/pt active IP Right Grant
- 2009-05-12 TW TW098115612A patent/TWI444376B/zh not_active IP Right Cessation
- 2009-05-12 ES ES09745725.3T patent/ES2446866T3/es active Active
- 2009-05-12 EA EA201071299A patent/EA019037B1/ru not_active IP Right Cessation
- 2009-05-12 CA CA2724219A patent/CA2724219C/en active Active
- 2009-05-12 AU AU2009248102A patent/AU2009248102B8/en not_active Ceased
- 2009-05-12 US US12/991,515 patent/US8344005B2/en active Active
- 2009-05-12 EP EP09745725.3A patent/EP2300452B1/en active Active
-
2010
- 2010-11-04 ZA ZA2010/07904A patent/ZA201007904B/en unknown
- 2010-11-08 IL IL209197A patent/IL209197A/en active IP Right Grant
-
2012
- 2012-11-20 US US13/681,925 patent/US8822504B2/en active Active
-
2014
- 2014-05-16 US US14/280,280 patent/US9006271B2/en active Active
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