CL2009000733A1 - Compuestos derivados de (hetero) aril-ciclohexano sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, demencia senil, sintomas de abstinencia, abuso de alcohol. - Google Patents
Compuestos derivados de (hetero) aril-ciclohexano sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, demencia senil, sintomas de abstinencia, abuso de alcohol.Info
- Publication number
- CL2009000733A1 CL2009000733A1 CL2009000733A CL2009000733A CL2009000733A1 CL 2009000733 A1 CL2009000733 A1 CL 2009000733A1 CL 2009000733 A CL2009000733 A CL 2009000733A CL 2009000733 A CL2009000733 A CL 2009000733A CL 2009000733 A1 CL2009000733 A1 CL 2009000733A1
- Authority
- CL
- Chile
- Prior art keywords
- receptor
- orl
- epilepsy
- anxiety
- alzheimer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
COMPUESTOS DE FÓRMULA GENERAL 1, DONDE R1, R2, R3, Y1, Y1', Y2, Y2', Y3, Y3', Y4, Y4', Y Q SON COMO SE HAN DEFINIDO EN EL PLIEGO DE REIVINDICACIONES QUE POSEEN AFINIDAD CON EL RECEPTOR DE OPLOIDES IJ Y CON EL RECEPTOR ORL-1; COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN DICHOS COMPUESTOS EN FORMA DE ESTEREOISÓMERO INDIVIDUAL O DE MEZCLA DE VARIOS DE LOS COMPUESTOS LIBRES Y/O DE SUS SALES FISIOLÓGICAMENTE COMPATIBLES Y/O SOLVATOS; Y SU USO PARA TRATAR EL DOLOR, ANSIEDAD, DEPRESIÓN, EPILEPSIA, ALZHEIMER, DEMENCIA SENIL, SÍNTOMAS DE ABSTINENCIA, ABUSO DE ALCOHOL..
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08005797 | 2008-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000733A1 true CL2009000733A1 (es) | 2009-05-15 |
Family
ID=39671382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000733A CL2009000733A1 (es) | 2008-03-27 | 2009-03-25 | Compuestos derivados de (hetero) aril-ciclohexano sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, demencia senil, sintomas de abstinencia, abuso de alcohol. |
Country Status (17)
Country | Link |
---|---|
US (1) | US7977370B2 (es) |
EP (1) | EP2280941B1 (es) |
JP (1) | JP5650637B2 (es) |
CN (1) | CN102046597B (es) |
AR (1) | AR071066A1 (es) |
AU (1) | AU2009228637B2 (es) |
CA (1) | CA2718209A1 (es) |
CL (1) | CL2009000733A1 (es) |
ES (1) | ES2544488T3 (es) |
HK (1) | HK1153744A1 (es) |
HU (1) | HUE026184T2 (es) |
IL (1) | IL208137A (es) |
MX (1) | MX2010010446A (es) |
PE (1) | PE20091657A1 (es) |
PL (1) | PL2280941T3 (es) |
RU (1) | RU2502733C2 (es) |
WO (1) | WO2009118163A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20120075499A (ko) | 2008-03-27 | 2012-07-06 | 그뤼넨탈 게엠베하 | 치환된 4-아미노사이클로헥산 유도체 |
SI2271613T1 (sl) | 2008-03-27 | 2014-08-29 | Grunenthal Gmbh | Hidroksimetilcikloheksilamini |
WO2009118169A1 (de) | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | Spiro(5.5)undecan derivate |
RU2526251C2 (ru) | 2008-03-27 | 2014-08-20 | Грюненталь Гмбх | Замещенные циклогексилдиамины |
CL2009000733A1 (es) | 2008-03-27 | 2009-05-15 | Gruenenthal Chemie | Compuestos derivados de (hetero) aril-ciclohexano sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, demencia senil, sintomas de abstinencia, abuso de alcohol. |
KR101615505B1 (ko) | 2008-03-27 | 2016-04-26 | 그뤼넨탈 게엠베하 | 치환된 스피로사이클릭 사이클로헥산 유도체 |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4065573A (en) | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
US4115589A (en) | 1977-05-17 | 1978-09-19 | The Upjohn Company | Compounds, compositions and method of use |
US4366172A (en) | 1977-09-29 | 1982-12-28 | The Upjohn Company | 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use |
US4239780A (en) * | 1979-10-11 | 1980-12-16 | The Upjohn Company | Phospholipase A2 inhibition |
DE19830105C1 (de) * | 1998-07-06 | 2000-02-17 | Gruenenthal Gmbh | Acridinderivate |
US6632836B1 (en) * | 1998-10-30 | 2003-10-14 | Merck & Co., Inc. | Carbocyclic potassium channel inhibitors |
US6600015B2 (en) * | 2000-04-04 | 2003-07-29 | Hoffmann-La Roche Inc. | Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity |
GB0012240D0 (en) | 2000-05-19 | 2000-07-12 | Merck Sharp & Dohme | Therapeutic agents |
MXPA03001721A (es) * | 2000-08-30 | 2003-05-27 | Hoffmann La Roche | Peptidos ciclicos selectivos. |
DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
DE10135636A1 (de) | 2001-07-17 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 4-Aminocyclohexanole |
PE20030320A1 (es) * | 2001-07-17 | 2003-04-03 | Gruenenthal Chemie | Derivados sustituidos de 4-aminociclohexanol |
IL159317A0 (en) | 2001-07-18 | 2004-06-01 | Dipiemme Dies And Plastic Mach | A corrugated/undulated sheet having protuberances in the grooves defined by the corrugations, process and apparatus |
DE10213051B4 (de) | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
DE10252666A1 (de) | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10252665A1 (de) | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
DE10252650A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
WO2004043900A2 (de) | 2002-11-12 | 2004-05-27 | Grünenthal GmbH | 4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate |
DE50312412D1 (en) | 2002-11-12 | 2010-03-25 | Gruenenthal Gmbh | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative |
DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10360793A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023508A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
DE102004023507A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
DE102004023501A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023506A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004023632A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
DE102004023522A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE102005016460A1 (de) | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
DE102005061430A1 (de) | 2005-12-22 | 2007-07-05 | Grünenthal GmbH | Substituierte Imidazolin-Derivate |
DE102005061429A1 (de) | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxazol-Derivate |
DE102005061428A1 (de) | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
DE102005061427A1 (de) | 2005-12-22 | 2007-06-28 | Grünenthal GmbH | Substituierte Oxadiazol-Derivate |
DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
FR2902695B1 (fr) * | 2006-06-26 | 2009-11-20 | Packaging Partner | Etiquette d'information inviolable |
DE102006033114A1 (de) * | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
BRPI0718874A2 (pt) * | 2006-12-22 | 2015-06-23 | Novartis Ag | Compostos orgânicos |
EP2179104A4 (en) | 2007-07-13 | 2012-01-18 | Tinnerman Palnut Engineered Products | SEAM CLAMP WITH HEAT LOCK |
WO2009118169A1 (de) | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | Spiro(5.5)undecan derivate |
KR101615505B1 (ko) | 2008-03-27 | 2016-04-26 | 그뤼넨탈 게엠베하 | 치환된 스피로사이클릭 사이클로헥산 유도체 |
CL2009000733A1 (es) | 2008-03-27 | 2009-05-15 | Gruenenthal Chemie | Compuestos derivados de (hetero) aril-ciclohexano sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, demencia senil, sintomas de abstinencia, abuso de alcohol. |
RU2526251C2 (ru) | 2008-03-27 | 2014-08-20 | Грюненталь Гмбх | Замещенные циклогексилдиамины |
KR20120075499A (ko) * | 2008-03-27 | 2012-07-06 | 그뤼넨탈 게엠베하 | 치환된 4-아미노사이클로헥산 유도체 |
SI2271613T1 (sl) | 2008-03-27 | 2014-08-29 | Grunenthal Gmbh | Hidroksimetilcikloheksilamini |
-
2009
- 2009-03-25 CL CL2009000733A patent/CL2009000733A1/es unknown
- 2009-03-25 CA CA2718209A patent/CA2718209A1/en not_active Abandoned
- 2009-03-25 RU RU2010143451/04A patent/RU2502733C2/ru not_active IP Right Cessation
- 2009-03-25 HU HUE09725704A patent/HUE026184T2/en unknown
- 2009-03-25 JP JP2011501139A patent/JP5650637B2/ja not_active Expired - Fee Related
- 2009-03-25 AU AU2009228637A patent/AU2009228637B2/en not_active Ceased
- 2009-03-25 PE PE2009000444A patent/PE20091657A1/es not_active Application Discontinuation
- 2009-03-25 ES ES09725704.2T patent/ES2544488T3/es active Active
- 2009-03-25 WO PCT/EP2009/002172 patent/WO2009118163A1/de active Application Filing
- 2009-03-25 EP EP20090725704 patent/EP2280941B1/de not_active Not-in-force
- 2009-03-25 AR ARP090101056A patent/AR071066A1/es unknown
- 2009-03-25 PL PL09725704T patent/PL2280941T3/pl unknown
- 2009-03-25 MX MX2010010446A patent/MX2010010446A/es active IP Right Grant
- 2009-03-25 CN CN2009801201880A patent/CN102046597B/zh not_active Expired - Fee Related
- 2009-03-25 US US12/410,692 patent/US7977370B2/en not_active Expired - Fee Related
-
2010
- 2010-09-14 IL IL208137A patent/IL208137A/en not_active IP Right Cessation
-
2011
- 2011-08-01 HK HK11107909.2A patent/HK1153744A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL208137A0 (en) | 2010-12-30 |
ES2544488T3 (es) | 2015-08-31 |
CA2718209A1 (en) | 2009-10-01 |
CN102046597B (zh) | 2013-09-11 |
RU2010143451A (ru) | 2012-05-10 |
EP2280941A1 (de) | 2011-02-09 |
AU2009228637A1 (en) | 2009-10-01 |
JP5650637B2 (ja) | 2015-01-07 |
US7977370B2 (en) | 2011-07-12 |
CN102046597A (zh) | 2011-05-04 |
WO2009118163A1 (de) | 2009-10-01 |
EP2280941B1 (de) | 2015-05-06 |
MX2010010446A (es) | 2010-11-05 |
AU2009228637B2 (en) | 2013-12-19 |
HK1153744A1 (en) | 2012-04-05 |
HUE026184T2 (en) | 2016-05-30 |
US20090247573A1 (en) | 2009-10-01 |
JP2011515429A (ja) | 2011-05-19 |
PE20091657A1 (es) | 2009-11-07 |
RU2502733C2 (ru) | 2013-12-27 |
PL2280941T3 (pl) | 2015-10-30 |
IL208137A (en) | 2015-10-29 |
AR071066A1 (es) | 2010-05-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2009000731A1 (es) | Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea. | |
CL2009000732A1 (es) | Compuestos derivados de hidroximetil ciclohexilaminas sustituidos; composicion farmaceutica que contiene a dicho compuesto y sus uso como moduladores del receptor de opiodes u y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso del alcohol, hipertension, anorexia, obesidad y diarrea. | |
CL2009000734A1 (es) | Compuestos derivados de 4-aminociclohexano sustituido; composicion farmaceutica que comprende a dichos compuestos; y su uso como moduladores del receptor de opioides u y el receptor orl-1 en el tratamiento de la ansiedad, estres, depresion, epilepsia y alzheimer. | |
CL2009000733A1 (es) | Compuestos derivados de (hetero) aril-ciclohexano sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, demencia senil, sintomas de abstinencia, abuso de alcohol. | |
CL2009000735A1 (es) | Compuestos derivados de 1,4 di-amino-ciclohexil sustituido, moduladores del receptor de opioides y el receptor orl-1; composicion farmaceutica que comprende dichos compuestos; y uso para el tratamiento del dolor, estados de ansiedad, depresion, epilepsia, disfuncion sexual, enfermedades cardiovasculares. | |
AR076753A1 (es) | Derivados de carboxamida y urea aromaticas sustituidas como ligandos del receptor de vanilloides. | |
CU20110204A7 (es) | Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750 | |
CR11801A (es) | Derivados de indazol sustituidos con fenilo y benzodioxinilo | |
CL2008000212A1 (es) | Compuestos derivados de fenotiazina; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar diabetes, reducir los niveles de glucemia, adiccion a nicotina, adiccion al alcohol, trastornos del sistema nervioso central, entre | |
CO6280399A2 (es) | Peptidil nitrilos y uso de los mismos como inhibidores de peptidil peptidasa i | |
DOP2007000092A (es) | Derivados de cicloalquilaminoácidos | |
PA8623101A1 (es) | Compuestos farmaceuticamente activos | |
MA32175B1 (fr) | Oxadiazoanthracènes pour le traitement du diabète | |
CR20110621A (es) | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)1h-pirazol-1-il]octano-o heptano-nitrilo como inhbidores de jak | |
CL2009000404A1 (es) | Compuestos derivados de piperidin-indol-sustituidos, moduladores de receptores nociceptina/orl1; proceso de preparacion de dichos compuestos; composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades del snc, cardiovasculares, metabolicas, entre otras. | |
NI201100084A (es) | Antagonistas del receptor de orexina de isonicotinamida. | |
CR10682A (es) | Compuestos de tiazol pirazolopirimidina | |
CR20130671A (es) | Antagonistas de trpv4 | |
UY32853A (es) | Nuevos compuestos de oxadiazol | |
CL2011002617A1 (es) | Compuestos derivados de arilsulfonamidas 2,5-disustituidas, moduladores del receptor ccr3; composicion farmaceutica que los comprende; y uso del compuesto o de la composicion para prevenir y/o tratar un trastorno inflamatorio o inmunoregulador tal como asma, rinitis, vih, enfermedad de alzheimer, entre otros. | |
UY33014A (es) | Nuevos compuestos de diazinil-pirazolilo | |
CO6382089A2 (es) | Compuestos,composiciones y metodos para el tratamiento de enfermadades causadas por un b-amiloide y sinucleinopatias | |
PA8781701A1 (es) | Derivados de 7-alquinil-1,8- naftiridonas, su preparaciones y su aplicacion en terapeutica | |
CO6351723A2 (es) | Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1 | |
NI201100015A (es) | Compuestos novedosos activos como antagonistas de receptor muscarínico. |