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CL2008001621A1 - Metodo para detectar el componente caliqueamicina en un conjugado covalente caliqueamicina-portador en una muestra de fluido, donde la caliqueamicina se detecta luego de romper dicha union, preferentemente por espectrometria de masas; kit para determinar la concentracion de caliqueamicina en una muestra. - Google Patents

Metodo para detectar el componente caliqueamicina en un conjugado covalente caliqueamicina-portador en una muestra de fluido, donde la caliqueamicina se detecta luego de romper dicha union, preferentemente por espectrometria de masas; kit para determinar la concentracion de caliqueamicina en una muestra.

Info

Publication number
CL2008001621A1
CL2008001621A1 CL2008001621A CL2008001621A CL2008001621A1 CL 2008001621 A1 CL2008001621 A1 CL 2008001621A1 CL 2008001621 A CL2008001621 A CL 2008001621A CL 2008001621 A CL2008001621 A CL 2008001621A CL 2008001621 A1 CL2008001621 A1 CL 2008001621A1
Authority
CL
Chile
Prior art keywords
calicheamicin
sample
kit
concentration
detecting
Prior art date
Application number
CL2008001621A
Other languages
English (en)
Inventor
Xue Yuzhu
Ann Davis Jennifer
Jiang Zhiping
Amorusi Peter
Ji Ji Allena
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CL2008001621A1 publication Critical patent/CL2008001621A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Método para detectar la presencia del componente de caliqueamicina de un conjugado del portador-caliqueamicina en una muestra de fluido; y kit para determinar la concentración de caliqueamicina en una muestra.
CL2008001621A 2007-06-04 2008-06-04 Metodo para detectar el componente caliqueamicina en un conjugado covalente caliqueamicina-portador en una muestra de fluido, donde la caliqueamicina se detecta luego de romper dicha union, preferentemente por espectrometria de masas; kit para determinar la concentracion de caliqueamicina en una muestra. CL2008001621A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93318207P 2007-06-04 2007-06-04

Publications (1)

Publication Number Publication Date
CL2008001621A1 true CL2008001621A1 (es) 2009-03-20

Family

ID=40088741

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008001621A CL2008001621A1 (es) 2007-06-04 2008-06-04 Metodo para detectar el componente caliqueamicina en un conjugado covalente caliqueamicina-portador en una muestra de fluido, donde la caliqueamicina se detecta luego de romper dicha union, preferentemente por espectrometria de masas; kit para determinar la concentracion de caliqueamicina en una muestra.

Country Status (5)

Country Link
US (1) US20080299668A1 (es)
AR (1) AR066863A1 (es)
CL (1) CL2008001621A1 (es)
PA (1) PA8782501A1 (es)
PE (1) PE20090309A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2483289T3 (da) * 2009-10-02 2019-06-11 Biogen Ma Inc Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger
RU2013126477A (ru) 2010-11-08 2014-12-20 Дженентек, Инк. Вводимые подкожно антитела против рецептора il-6
JP5889912B2 (ja) 2010-11-17 2016-03-22 ジェネンテック， インコーポレイテッド アラニニルメイタンシノール抗体コンジュゲート
US9562252B2 (en) 2011-05-13 2017-02-07 Biogen Ma Inc. Methods of preventing and removing trisulfide bonds
MA45326A (fr) 2015-10-20 2018-08-29 Genentech Inc Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
CN106928363B (zh) * 2015-12-30 2020-09-25 广西医科大学 一种FAP纳米抗体Nb12
CN106928367B (zh) * 2015-12-30 2020-10-13 广西医科大学 一种FAP纳米抗体Nb62
CN113008820B (zh) * 2021-03-03 2022-10-28 南昌航空大学 一种测定巯基含量的方法
CN115290609B (zh) * 2021-12-22 2024-08-09 温州医科大学 快速检测肝素的试剂及检测方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4970198A (en) * 1985-10-17 1990-11-13 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5037651A (en) * 1987-01-30 1991-08-06 American Cyanamid Company Dihydro derivatives of LL-E33288 antibiotics
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5108912A (en) * 1987-01-30 1992-04-28 American Cyanamid Company Antitumor antibiotics (LL-E33288 complex)
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
US5043394A (en) * 1990-03-02 1991-08-27 Nova Petrochemicals Inc. Sulfenyl chloride adducts of hydrogenated nitrile rubber
US5364930A (en) * 1990-10-16 1994-11-15 Northwestern University Synthetic C1q peptide fragments
US5795725A (en) * 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US6324210B1 (en) * 1999-12-17 2001-11-27 Golden Bridge Technology Incorporated Sliding matched filter with flexible hardware complexity
US6980674B2 (en) * 2000-09-01 2005-12-27 Large Scale Proteomics Corp. Reference database
US6756397B2 (en) * 2002-04-05 2004-06-29 Immunogen, Inc. Prodrugs of CC-1065 analogs
EP1507556B1 (en) * 2002-05-02 2016-07-27 Wyeth Holdings LLC Calicheamicin derivative-carrier conjugates
CA2578131A1 (en) * 2004-09-10 2006-03-23 Wyeth Humanized anti-5t4 antibodies and anti-5t4 antibody/calicheamicin conjugates

Also Published As

Publication number Publication date
PE20090309A1 (es) 2009-04-18
PA8782501A1 (es) 2009-01-23
AR066863A1 (es) 2009-09-16
US20080299668A1 (en) 2008-12-04

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