CA3095443A1 - Procedes a base d'anticorps de detection et de traitement de la maladie d'alzheimer - Google Patents
Procedes a base d'anticorps de detection et de traitement de la maladie d'alzheimer Download PDFInfo
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne des anticorps et des fragments de liaison à l'antigène qui se lient à la protéine tau phosphorylée et déphosphorylée et des procédés d'utilisation dans la détection et le traitement de la maladie d'Alzheimer et d'autres tauopathies. L'invention concerne également des procédés de détermination du stade de la maladie d'Alzheimer chez un sujet humain et de surveillance de l'efficacité d'une thérapie anti-tau.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862649208P | 2018-03-28 | 2018-03-28 | |
| US62/649,208 | 2018-03-28 | ||
| US201862664662P | 2018-04-30 | 2018-04-30 | |
| US62/664,662 | 2018-04-30 | ||
| US201862703299P | 2018-07-25 | 2018-07-25 | |
| US62/703,299 | 2018-07-25 | ||
| PCT/IB2019/000358 WO2019186276A2 (fr) | 2018-03-28 | 2019-03-27 | Procédés à base d'anticorps de détection et de traitement de la maladie d'alzheimer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3095443A1 true CA3095443A1 (fr) | 2019-10-03 |
Family
ID=66999856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3095443A Pending CA3095443A1 (fr) | 2018-03-28 | 2019-03-27 | Procedes a base d'anticorps de detection et de traitement de la maladie d'alzheimer |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP3774887A2 (fr) |
| JP (1) | JP2021520777A (fr) |
| KR (1) | KR20200144551A (fr) |
| CN (1) | CN112236452A (fr) |
| AU (1) | AU2019244481A1 (fr) |
| BR (1) | BR112020018868A2 (fr) |
| CA (1) | CA3095443A1 (fr) |
| IL (1) | IL277577A (fr) |
| MX (1) | MX2020009991A (fr) |
| RU (1) | RU2020135052A (fr) |
| SG (1) | SG11202008098TA (fr) |
| WO (1) | WO2019186276A2 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3689904A1 (fr) | 2013-03-13 | 2020-08-05 | Prothena Biosciences Limited | Tau immunotherapie |
| PL3452507T3 (pl) | 2016-05-02 | 2023-01-09 | Prothena Biosciences Limited | Immunoterapia tau |
| MY198194A (en) | 2016-05-02 | 2023-08-09 | Prothena Biosciences Ltd | Antibodies Recognizing Tau |
| WO2018204546A2 (fr) | 2017-05-02 | 2018-11-08 | Prothena Biosciences Limited | Anticorps reconnaissant la protéine tau |
| CA3070446A1 (fr) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | Traitement du cancer par blocage de l'interaction de tim-3 et de son ligand |
| CN113544149B (zh) | 2019-03-03 | 2024-11-15 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| US20220402979A1 (en) | 2019-09-09 | 2022-12-22 | Axon Neuroscience Se | Biomarkers and treatments of alzheimer's disease and mild cognitive impairment |
| CA3185040A1 (fr) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methodes de traitement de maladies inflammatoires par blocage de la galectine-3 |
| JP2023554382A (ja) * | 2020-12-16 | 2023-12-27 | ボイジャー セラピューティクス インコーポレイテッド | タウ結合化合物 |
| MX2023008317A (es) * | 2021-02-19 | 2023-07-24 | Eisai R&D Man Co Ltd | Anticuerpo anti tau fosforilada en la treonina 217 (pt217). |
| CN117003863A (zh) * | 2022-04-28 | 2023-11-07 | 厦门大学 | 针对p-tau 217的抗体及其用途 |
| CN114778856B (zh) * | 2022-05-30 | 2023-03-17 | 苏州宇测生物科技有限公司 | 磷酸化tau蛋白检测试剂盒 |
| CN115078736B (zh) * | 2022-06-24 | 2025-03-25 | 佛山市观迪医疗器械有限公司 | 一种用于阿尔茨海默症的均相免疫检测试剂盒 |
| CN119836437A (zh) * | 2022-08-19 | 2025-04-15 | 舒泰神(加州)生物科技有限公司 | 特异性识别程序性细胞死亡1配体1的抗体及其用途 |
| CN117624351B (zh) * | 2023-11-24 | 2024-07-05 | 无锡傲锐东源生物科技有限公司 | 一种抗人磷酸化tau181兔单克隆抗体及其应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4880935A (en) | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| FI102355B1 (fi) | 1988-02-11 | 1998-11-30 | Bristol Myers Squibb Co | Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
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| CU22615A1 (es) | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
| SI2275119T1 (sl) | 1995-07-27 | 2013-12-31 | Genentech, Inc. | Stabilna izotonična liofilizirana proteinska formulacija |
| PT871490E (pt) | 1995-12-22 | 2003-07-31 | Bristol Myers Squibb Co | Ligantes de hidrazona ramificada |
| AU5508798A (en) * | 1996-11-19 | 1998-06-10 | Trustees Of The University Of Pennsylvania, The | Diagnostic and therapeutic reagents for alzheimer's disease |
| EP0983303B1 (fr) | 1997-05-21 | 2006-03-08 | Biovation Limited | Procede de production de proteines non immunogenes |
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| DE10121982B4 (de) | 2001-05-05 | 2008-01-24 | Lts Lohmann Therapie-Systeme Ag | Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung |
| WO2004007722A2 (fr) | 2002-07-12 | 2004-01-22 | Axon Neuroscience Forschungs- Und Entwicklungs Gmbh | Animal transgenique exprimant la proteine tau de la maladie d'alzheimer |
| CN100386068C (zh) | 2002-12-03 | 2008-05-07 | 布朗歇特洛克菲勒神经科学研究所 | 传输物质穿过血脑屏障的人工低密度脂蛋白载体 |
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| HUE030079T2 (en) | 2004-09-23 | 2017-04-28 | Genentech Inc | Cysteine-manipulated antibodies and conjugates |
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| US8853505B2 (en) * | 2012-02-27 | 2014-10-07 | Syngenta Participations Ag | Variety corn line AA2205 |
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| WO2016079597A1 (fr) | 2014-11-19 | 2016-05-26 | Axon Neuroscience Se | Anticorps anti-tau humanisés dans la maladie d'alzheimer |
| AU2017214132A1 (en) * | 2016-02-05 | 2018-08-30 | Jiangsu Hengrui Medicine Co., Ltd. | Thrombin antibody, antigen-binding fragment and pharmaceutical use thereof |
-
2019
- 2019-03-27 SG SG11202008098TA patent/SG11202008098TA/en unknown
- 2019-03-27 BR BR112020018868-9A patent/BR112020018868A2/pt not_active IP Right Cessation
- 2019-03-27 KR KR1020207030584A patent/KR20200144551A/ko not_active Withdrawn
- 2019-03-27 AU AU2019244481A patent/AU2019244481A1/en not_active Abandoned
- 2019-03-27 EP EP19732436.1A patent/EP3774887A2/fr not_active Withdrawn
- 2019-03-27 JP JP2020551506A patent/JP2021520777A/ja active Pending
- 2019-03-27 CA CA3095443A patent/CA3095443A1/fr active Pending
- 2019-03-27 WO PCT/IB2019/000358 patent/WO2019186276A2/fr not_active Application Discontinuation
- 2019-03-27 CN CN201980029711.2A patent/CN112236452A/zh active Pending
- 2019-03-27 RU RU2020135052A patent/RU2020135052A/ru unknown
- 2019-03-27 MX MX2020009991A patent/MX2020009991A/es unknown
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2020
- 2020-09-24 IL IL277577A patent/IL277577A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL277577A (en) | 2020-11-30 |
| WO2019186276A8 (fr) | 2020-10-15 |
| JP2021520777A (ja) | 2021-08-26 |
| KR20200144551A (ko) | 2020-12-29 |
| WO2019186276A2 (fr) | 2019-10-03 |
| BR112020018868A2 (pt) | 2021-01-26 |
| SG11202008098TA (en) | 2020-10-29 |
| MX2020009991A (es) | 2020-10-14 |
| WO2019186276A3 (fr) | 2020-02-27 |
| AU2019244481A1 (en) | 2020-10-01 |
| EP3774887A2 (fr) | 2021-02-17 |
| RU2020135052A (ru) | 2022-04-29 |
| CN112236452A (zh) | 2021-01-15 |
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