Nothing Special   »   [go: up one dir, main page]

CA3066953A1 - Anticorps monoclonaux humains specifiques de cd33 et leurs procedes d'utilisation - Google Patents

Anticorps monoclonaux humains specifiques de cd33 et leurs procedes d'utilisation Download PDF

Info

Publication number
CA3066953A1
CA3066953A1 CA3066953A CA3066953A CA3066953A1 CA 3066953 A1 CA3066953 A1 CA 3066953A1 CA 3066953 A CA3066953 A CA 3066953A CA 3066953 A CA3066953 A CA 3066953A CA 3066953 A1 CA3066953 A1 CA 3066953A1
Authority
CA
Canada
Prior art keywords
seq
antibody
antigen
domain
binding fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3066953A
Other languages
English (en)
Inventor
Dimiter S. Dimitrov
Weizao Chen
Zhongyu Zhu
Rimas J. ORENTAS
Boro Dropulic
Dina SCHNEIDER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lentigen Technology Inc
US Department of Health and Human Services
Original Assignee
Lentigen Technology Inc
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lentigen Technology Inc, US Department of Health and Human Services filed Critical Lentigen Technology Inc
Publication of CA3066953A1 publication Critical patent/CA3066953A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des anticorps monoclonaux humains qui se lient spécifiquement à CD33. L'invention concerne également des conjugués d'anticorps qui comprennent les anticorps monoclonaux spécifiques de CD33 (ou des fragments de liaison à l'antigène). L'invention concerne en outre des procédés de détection, de diagnostic et de traitement du cancer positif à CD33.
CA3066953A 2017-06-30 2018-06-29 Anticorps monoclonaux humains specifiques de cd33 et leurs procedes d'utilisation Abandoned CA3066953A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762527165P 2017-06-30 2017-06-30
US62/527,165 2017-06-30
PCT/US2018/040257 WO2019006280A1 (fr) 2017-06-30 2018-06-29 Anticorps monoclonaux humains spécifiques de cd33 et leurs procédés d'utilisation

Publications (1)

Publication Number Publication Date
CA3066953A1 true CA3066953A1 (fr) 2019-01-03

Family

ID=62976328

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3066953A Abandoned CA3066953A1 (fr) 2017-06-30 2018-06-29 Anticorps monoclonaux humains specifiques de cd33 et leurs procedes d'utilisation

Country Status (2)

Country Link
CA (1) CA3066953A1 (fr)
WO (1) WO2019006280A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3138969A1 (fr) 2019-05-04 2020-11-12 Inhibrx, Inc. Polypeptides de liaison a cd33 et leurs utilisations
EP4225792A1 (fr) 2020-10-08 2023-08-16 Affimed GmbH Lieurs trispécifiques
IL308154A (en) 2021-07-30 2023-12-01 Affimed Gmbh Double structure antibodies
MX2024005106A (es) 2021-11-03 2024-07-02 Affimed Gmbh Ligandos biespecificos de cd16a.
WO2024196877A1 (fr) * 2023-03-22 2024-09-26 University Of Florida Research Foundation, Incorporated Anticorps monoclonaux de lapin ciblant des antigènes de leucémie myéloïde aiguë

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896111A (en) 1973-02-20 1975-07-22 Research Corp Ansa macrolides
US4151042A (en) 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
US4137230A (en) 1977-11-14 1979-01-30 Takeda Chemical Industries, Ltd. Method for the production of maytansinoids
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4265814A (en) 1978-03-24 1981-05-05 Takeda Chemical Industries Matansinol 3-n-hexadecanoate
US4307016A (en) 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
JPS5562090A (en) 1978-10-27 1980-05-10 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164687A (en) 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS5566585A (en) 1978-11-14 1980-05-20 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US4256746A (en) 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
JPS55102583A (en) 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS55164685A (en) 1979-06-08 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
JPS55164686A (en) 1979-06-11 1980-12-22 Takeda Chem Ind Ltd Novel maytansinoid compound and its preparation
US4309428A (en) 1979-07-30 1982-01-05 Takeda Chemical Industries, Ltd. Maytansinoids
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
JPS5645485A (en) 1979-09-21 1981-04-25 Takeda Chem Ind Ltd Production of c-15003pnd
EP0028683A1 (fr) 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotique C-15003 PHO et sa préparation
WO1982001188A1 (fr) 1980-10-08 1982-04-15 Takeda Chemical Industries Ltd Composes 4,5-deoxymaytansinoide et leur procede de preparation
US4450254A (en) 1980-11-03 1984-05-22 Standard Oil Company Impact improvement of high nitrile resins
US4313946A (en) 1981-01-27 1982-02-02 The United States Of America As Represented By The Secretary Of Agriculture Chemotherapeutically active maytansinoids from Trewia nudiflora
US4315929A (en) 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
JPS57192389A (en) 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US5079163A (en) 1985-03-29 1992-01-07 Cetus Corporation Recombinant ricin toxin fragments
US4689401A (en) 1986-03-06 1987-08-25 Cetus Corporation Method of recovering microbially produced recombinant ricin toxin a chain
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4892827A (en) 1986-09-24 1990-01-09 The United States Of America As Represented By The Department Of Health And Human Services Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5055303A (en) 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
EP0531434B1 (fr) 1990-05-11 1999-07-14 THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Exotoxines de pseudomonas ameliorees ayant une toxicite animale faible et une forte activite cytocide
US5608039A (en) 1990-10-12 1997-03-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Single chain B3 antibody fusion proteins and their uses
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
EP0630234B1 (fr) 1992-03-12 1997-06-11 Alkermes Controlled Therapeutics, Inc. Microspheres a liberation regulee contenant l'hormone adrenocorticotrope (acth)
AU675440B2 (en) 1992-06-18 1997-02-06 United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Recombinant (pseudomonas) exotoxin with increased activity
US5534496A (en) 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
JP3469580B2 (ja) 1993-10-01 2003-11-25 帝国臓器製薬株式会社 新規なペプチド誘導体
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5663149A (en) 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US6296843B1 (en) 1998-04-03 2001-10-02 The Penn State Research Foundation Mutagenized IL 13-based chimeric molecules
EP1109812B1 (fr) 1998-08-27 2005-05-04 Spirogen Limited Pyrrolo-benzodiazepines
CA2510550A1 (fr) 2003-01-10 2004-07-29 Pradman Qasba Domaines catalytiques de .beta./1,4)-galactosyltransferase i presentant des specificites modifiees de donneur et d'accepteur, domaines qui facilitent le pliage des proteines in vitro et methodes d'utilisation associees
ATE421967T1 (de) 2003-03-31 2009-02-15 Council Scient Ind Res Nichtvernetzende pyrroloä2,1-cüä1, 4übenzodiazepine als potentielle antitumor- agentien und ihre herstellung
AU2004284075A1 (en) 2003-10-22 2005-05-06 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
US20070258986A1 (en) 2003-11-19 2007-11-08 Govt of the US as represented by the secretary, Targeted Delivery System for Bioactive Agents
EP1689783B1 (fr) 2003-11-25 2010-05-19 The Government Of The United States, As Represented by The Secretary Of Health And Human Services Anticorps anti-cd22 et immunoconjugues mutes
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
WO2005085260A1 (fr) 2004-03-09 2005-09-15 Spirogen Limited Pyrrolobenzodiazepines
EP3006456B1 (fr) 2005-07-29 2018-09-19 The Government of the United States of America, as represented by the Secretary of Health and Human Services Exotoxines de pseudomonas mutées a antigenicité reduite
ES2374964T3 (es) 2006-01-25 2012-02-23 Sanofi Agentes citotóxicos que comprenden nuevos derivados de tomaimicina.
MX2009000709A (es) 2006-07-18 2009-02-04 Sanofi Aventis Anticuerpo antagonista contra epha2 para el tratamiento de cancer.
EP1914242A1 (fr) 2006-10-19 2008-04-23 Sanofi-Aventis Nouveau anticorps Anti-CD38 pour le traitement du cancer
US20090175784A1 (en) 2007-05-11 2009-07-09 Joshua Goldstein Anti-Alpha V Immunoliposome Composition, Methods, and Uses
ES2435779T3 (es) 2007-07-19 2013-12-23 Sanofi Agentes citotóxicos que comprenden nuevos derivados de tomaimicina y su uso terapéutico
DK2197903T3 (en) 2007-09-04 2015-01-05 Us Gov Health & Human Serv Deletions in Domain II from Pseudomonas exotoxin A that reduce non-specific TOXICITY
KR102021728B1 (ko) 2009-02-05 2019-09-16 이뮤노젠 아이엔씨 신규한 벤조디아제핀 유도체
EP2475398B1 (fr) 2009-09-11 2015-05-20 The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services Exotoxine a de pseudomonas améliorée avec une immunogénicité réduite
AU2011239507B2 (en) 2010-04-15 2015-04-09 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
AR088694A1 (es) 2011-11-17 2014-06-25 Pfizer Peptidos citotoxicos y conjugados de anticuerpo-farmaco de los mismos
US9416190B2 (en) 2012-09-27 2016-08-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mesothelin antibodies and methods for eliciting potent antitumor activity
CA2926215A1 (fr) 2013-10-06 2015-04-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Exotoxine a de pseudomonas modifiee
JP6502942B2 (ja) * 2013-12-13 2019-04-17 ジェネンテック， インコーポレイテッド 抗ｃｄ３３抗体とイムノコンジュゲート

Also Published As

Publication number Publication date
WO2019006280A1 (fr) 2019-01-03

Similar Documents

Publication Publication Date Title
US20210324090A1 (en) Monoclonal antibodies specific for fibroblast growth factor receptor 4 (fgfr4) and methods of their use
US11939377B2 (en) Affinity matured CD22-specific monoclonal antibody and uses thereof
US10548987B2 (en) Antibody-drug conjugates for targeting CD56-positive tumors
US12012455B2 (en) Human monoclonal antibodies specific for FLT3 and uses thereof
WO2017196847A1 (fr) Anticorps anti-nouveau récepteur variable d'antigène (vnar) et conjugués d'anticorps ciblant des antigènes tumoraux et viraux
US20220064324A1 (en) Cross species single domain antibodies targeting mesothelin for treating solid tumors
AU2018268970B2 (en) Human monoclonal antibody targeting tnfr2 for cancer immunotherapy
US12122843B2 (en) High affinity monoclonal antibodies targeting glypican-1 and methods of use
WO2017214182A1 (fr) Anticorps entièrement humain ciblant pdi pour l'immunothérapie anticancéreuse
CA3066953A1 (fr) Anticorps monoclonaux humains specifiques de cd33 et leurs procedes d'utilisation
WO2016022939A1 (fr) Anticorps monoclonaux humains spécifiques de 5t4 et leurs procédés d'utilisation
WO2019005208A1 (fr) Anticorps de la mésothéline humaine et utilisations dans une thérapie anticancéreuse

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20220301