CA2512479A1 - Polypeptides transmembrane et secretees et acides nucleiques encodant le tout - Google Patents

Polypeptides transmembrane et secretees et acides nucleiques encodant le tout Download PDF

Info

Publication number: CA2512479A1
Authority: CA; Canada
Prior art keywords: sequence identity; polypeptide; seq; amino acid; nucleic acid
Prior art date: 1999-03-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002512479A

Other languages

English (en)

Inventor

Luc Desnoyers

Dan L. Eaton

Audrey Goddard

Paul J. Godowski

Austin L. Gurney

James Pan

Timothy A. Stewart

Colin K.. Watanabe

William I. Wood

Zemin Zhang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Genentech Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-23

Filing date

2000-03-01

Publication date

2000-09-28

2000-03-01 Application filed by Individual filed Critical Individual

2000-03-01 Priority claimed from CA002361221A external-priority patent/CA2361221A1/fr

2000-09-28 Publication of CA2512479A1 publication Critical patent/CA2512479A1/fr

Status Abandoned legal-status Critical Current

Links

108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 785
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 784
229920001184 polypeptide Polymers 0.000 title claims abstract description 780
150000007523 nucleic acids Chemical class 0.000 title claims abstract description 514
102000039446 nucleic acids Human genes 0.000 title claims abstract description 317
108020004707 nucleic acids Proteins 0.000 title claims abstract description 317
238000000034 method Methods 0.000 claims abstract description 39
239000013598 vector Substances 0.000 claims abstract description 12
125000003275 alpha amino acid group Chemical group 0.000 claims description 397
239000002773 nucleotide Substances 0.000 claims description 367
125000003729 nucleotide group Chemical group 0.000 claims description 367
108091028043 Nucleic acid sequence Proteins 0.000 claims description 162
210000004027 cell Anatomy 0.000 claims description 98
108010076504 Protein Sorting Signals Proteins 0.000 claims description 83
108091026890 Coding region Proteins 0.000 claims description 63
150000001413 amino acids Chemical class 0.000 claims description 62
230000014509 gene expression Effects 0.000 claims description 47
238000004113 cell culture Methods 0.000 claims description 30
238000012258 culturing Methods 0.000 claims description 29
230000008569 process Effects 0.000 claims description 15
108060003951 Immunoglobulin Proteins 0.000 claims description 9
102000018358 immunoglobulin Human genes 0.000 claims description 9
241000588724 Escherichia coli Species 0.000 claims description 2
210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 2
102000001554 Hemoglobins Human genes 0.000 claims 1
108010054147 Hemoglobins Proteins 0.000 claims 1
210000005253 yeast cell Anatomy 0.000 claims 1
108020004414 DNA Proteins 0.000 description 577
102000053602 DNA Human genes 0.000 description 332
230000000295 complement effect Effects 0.000 description 209
125000000539 amino acid group Chemical group 0.000 description 166
238000012360 testing method Methods 0.000 description 128
239000012634 fragment Substances 0.000 description 118
235000001014 amino acid Nutrition 0.000 description 105
239000002299 complementary DNA Substances 0.000 description 104
108090000623 proteins and genes Proteins 0.000 description 99
235000018102 proteins Nutrition 0.000 description 94
102000004169 proteins and genes Human genes 0.000 description 94
238000009396 hybridization Methods 0.000 description 79
229940024606 amino acid Drugs 0.000 description 57
108090000144 Human Proteins Proteins 0.000 description 55
102000003839 Human Proteins Human genes 0.000 description 55
230000027455 binding Effects 0.000 description 51
239000000523 sample Substances 0.000 description 37
230000004071 biological effect Effects 0.000 description 31
238000004590 computer program Methods 0.000 description 31
102000005962 receptors Human genes 0.000 description 26
108020003175 receptors Proteins 0.000 description 26
238000002864 sequence alignment Methods 0.000 description 26
239000011800 void material Substances 0.000 description 24
230000000694 effects Effects 0.000 description 22
102000000589 Interleukin-1 Human genes 0.000 description 20
108010002352 Interleukin-1 Proteins 0.000 description 20
230000003068 static effect Effects 0.000 description 20
239000005557 antagonist Substances 0.000 description 19
238000012512 characterization method Methods 0.000 description 18
239000004743 Polypropylene Substances 0.000 description 17
239000000556 agonist Substances 0.000 description 17
238000006467 substitution reaction Methods 0.000 description 17
102000013691 Interleukin-17 Human genes 0.000 description 16
108050003558 Interleukin-17 Proteins 0.000 description 16
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 16
230000000977 initiatory effect Effects 0.000 description 16
229930182817 methionine Natural products 0.000 description 16
238000012216 screening Methods 0.000 description 16
241000124008 Mammalia Species 0.000 description 15
239000003814 drug Substances 0.000 description 15
239000012528 membrane Substances 0.000 description 15
210000001519 tissue Anatomy 0.000 description 15
102000000905 Cadherin Human genes 0.000 description 14
108050007957 Cadherin Proteins 0.000 description 14
238000011282 treatment Methods 0.000 description 14
102100039306 Nucleotide pyrophosphatase Human genes 0.000 description 13
108020004511 Recombinant DNA Proteins 0.000 description 13
108090001090 Lectins Proteins 0.000 description 12
239000000427 antigen Substances 0.000 description 12
108091007433 antigens Proteins 0.000 description 12
102000036639 antigens Human genes 0.000 description 12
230000004069 differentiation Effects 0.000 description 12
102000004190 Enzymes Human genes 0.000 description 11
108090000790 Enzymes Proteins 0.000 description 11
102000004856 Lectins Human genes 0.000 description 11
206010028980 Neoplasm Diseases 0.000 description 11
210000004899 c-terminal region Anatomy 0.000 description 11
229940088598 enzyme Drugs 0.000 description 11
102000008394 Immunoglobulin Fragments Human genes 0.000 description 10
108010021625 Immunoglobulin Fragments Proteins 0.000 description 10
210000001789 adipocyte Anatomy 0.000 description 10
230000006870 function Effects 0.000 description 10
239000011159 matrix material Substances 0.000 description 10
102000004127 Cytokines Human genes 0.000 description 9
108090000695 Cytokines Proteins 0.000 description 9
101001065559 Homo sapiens Lymphocyte antigen 6D Proteins 0.000 description 9
230000001419 dependent effect Effects 0.000 description 9
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
230000003993 interaction Effects 0.000 description 9
239000000203 mixture Substances 0.000 description 9
108010007718 Chromogranins Proteins 0.000 description 8
102000007345 Chromogranins Human genes 0.000 description 8
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 8
102100032127 Lymphocyte antigen 6D Human genes 0.000 description 8
239000002253 acid Substances 0.000 description 8
239000003446 ligand Substances 0.000 description 8
102000040430 polynucleotide Human genes 0.000 description 8
108091033319 polynucleotide Proteins 0.000 description 8
239000002157 polynucleotide Substances 0.000 description 8
102000003810 Interleukin-18 Human genes 0.000 description 7
108090000171 Interleukin-18 Proteins 0.000 description 7
201000011510 cancer Diseases 0.000 description 7
229940079593 drug Drugs 0.000 description 7
230000003834 intracellular effect Effects 0.000 description 7
239000002523 lectin Substances 0.000 description 7
102000013392 Carboxylesterase Human genes 0.000 description 6
108010051152 Carboxylesterase Proteins 0.000 description 6
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 6
101000654676 Homo sapiens Semaphorin-6B Proteins 0.000 description 6
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 6
101710128782 Liver carboxylesterase Proteins 0.000 description 6
102100032796 Semaphorin-6B Human genes 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 6
230000015572 biosynthetic process Effects 0.000 description 6
150000001720 carbohydrates Chemical class 0.000 description 6
239000003795 chemical substances by application Substances 0.000 description 6
150000001875 compounds Chemical class 0.000 description 6
208000035475 disorder Diseases 0.000 description 6
239000003112 inhibitor Substances 0.000 description 6
230000002401 inhibitory effect Effects 0.000 description 6
238000004519 manufacturing process Methods 0.000 description 6
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 6
102000027257 transmembrane receptors Human genes 0.000 description 6
108091008578 transmembrane receptors Proteins 0.000 description 6
102000004308 Carboxylic Ester Hydrolases Human genes 0.000 description 5
108090000863 Carboxylic Ester Hydrolases Proteins 0.000 description 5
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 5
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
206010027476 Metastases Diseases 0.000 description 5
150000007513 acids Chemical class 0.000 description 5
210000004556 brain Anatomy 0.000 description 5
235000014633 carbohydrates Nutrition 0.000 description 5
230000001413 cellular effect Effects 0.000 description 5
238000006243 chemical reaction Methods 0.000 description 5
238000010367 cloning Methods 0.000 description 5
108010037896 heparin-binding hemagglutinin Proteins 0.000 description 5
210000000265 leukocyte Anatomy 0.000 description 5
230000009401 metastasis Effects 0.000 description 5
230000035755 proliferation Effects 0.000 description 5
239000001509 sodium citrate Substances 0.000 description 5
-1 survival factors Substances 0.000 description 5
230000001225 therapeutic effect Effects 0.000 description 5
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
206010061218 Inflammation Diseases 0.000 description 4
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 4
241001465754 Metazoa Species 0.000 description 4
241000699666 Mus <mouse, genus> Species 0.000 description 4
108091034117 Oligonucleotide Proteins 0.000 description 4
102000014105 Semaphorin Human genes 0.000 description 4
108050003978 Semaphorin Proteins 0.000 description 4
230000004913 activation Effects 0.000 description 4
239000003963 antioxidant agent Substances 0.000 description 4
230000003078 antioxidant effect Effects 0.000 description 4
238000003556 assay Methods 0.000 description 4
239000011575 calcium Substances 0.000 description 4
229910052791 calcium Inorganic materials 0.000 description 4
238000003776 cleavage reaction Methods 0.000 description 4
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 4
229940088597 hormone Drugs 0.000 description 4
239000005556 hormone Substances 0.000 description 4
230000001900 immune effect Effects 0.000 description 4
230000004054 inflammatory process Effects 0.000 description 4
238000003780 insertion Methods 0.000 description 4
230000037431 insertion Effects 0.000 description 4
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
150000002632 lipids Chemical class 0.000 description 4
230000007246 mechanism Effects 0.000 description 4
238000002703 mutagenesis Methods 0.000 description 4
231100000350 mutagenesis Toxicity 0.000 description 4
210000005036 nerve Anatomy 0.000 description 4
239000002243 precursor Substances 0.000 description 4
238000002360 preparation method Methods 0.000 description 4
238000000746 purification Methods 0.000 description 4
229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 description 4
238000012552 review Methods 0.000 description 4
230000007017 scission Effects 0.000 description 4
230000003248 secreting effect Effects 0.000 description 4
230000028327 secretion Effects 0.000 description 4
150000003384 small molecules Chemical class 0.000 description 4
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
239000007790 solid phase Substances 0.000 description 4
239000000243 solution Substances 0.000 description 4
229940124597 therapeutic agent Drugs 0.000 description 4
102000035160 transmembrane proteins Human genes 0.000 description 4
108091005703 transmembrane proteins Proteins 0.000 description 4
210000004881 tumor cell Anatomy 0.000 description 4
238000005406 washing Methods 0.000 description 4
108020004635 Complementary DNA Proteins 0.000 description 3
102000006587 Glutathione peroxidase Human genes 0.000 description 3
108700016172 Glutathione peroxidases Proteins 0.000 description 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
208000009329 Graft vs Host Disease Diseases 0.000 description 3
102000014150 Interferons Human genes 0.000 description 3
108010050904 Interferons Proteins 0.000 description 3
102000019223 Interleukin-1 receptor Human genes 0.000 description 3
108050006617 Interleukin-1 receptor Proteins 0.000 description 3
102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 description 3
108090001007 Interleukin-8 Proteins 0.000 description 3
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
108010052285 Membrane Proteins Proteins 0.000 description 3
108090000189 Neuropeptides Proteins 0.000 description 3
108700040559 Protocadherins Proteins 0.000 description 3
102000000705 Secretogranin II Human genes 0.000 description 3
108010002533 Secretogranin II Proteins 0.000 description 3
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
210000001744 T-lymphocyte Anatomy 0.000 description 3
239000013543 active substance Substances 0.000 description 3
238000004364 calculation method Methods 0.000 description 3
230000017455 cell-cell adhesion Effects 0.000 description 3
230000008859 change Effects 0.000 description 3
239000000356 contaminant Substances 0.000 description 3
239000013068 control sample Substances 0.000 description 3
235000018417 cysteine Nutrition 0.000 description 3
125000000151 cysteine group Chemical class N[C@@H](CS)C(=O)* 0.000 description 3
238000012217 deletion Methods 0.000 description 3
230000037430 deletion Effects 0.000 description 3
229940039227 diagnostic agent Drugs 0.000 description 3
239000000032 diagnostic agent Substances 0.000 description 3
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 3
229960002986 dinoprostone Drugs 0.000 description 3
201000010099 disease Diseases 0.000 description 3
239000003937 drug carrier Substances 0.000 description 3
239000003623 enhancer Substances 0.000 description 3
230000002255 enzymatic effect Effects 0.000 description 3
210000002950 fibroblast Anatomy 0.000 description 3
208000024908 graft versus host disease Diseases 0.000 description 3
229940072221 immunoglobulins Drugs 0.000 description 3
230000001404 mediated effect Effects 0.000 description 3
230000005012 migration Effects 0.000 description 3
238000013508 migration Methods 0.000 description 3
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 3
230000004044 response Effects 0.000 description 3
230000019491 signal transduction Effects 0.000 description 3
230000011664 signaling Effects 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
241000894007 species Species 0.000 description 3
239000000126 substance Substances 0.000 description 3
230000004083 survival effect Effects 0.000 description 3
ADHFFUOAOLWHGU-JPDUFPOXSA-N (2s)-2-[[(2s)-4-amino-2-[[(2s,3r)-2-[[(2s)-2-[[(2s)-2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-2-[[2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]hexanoyl]a Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](N)CO)C(C)C)C1=CC=CC=C1 ADHFFUOAOLWHGU-JPDUFPOXSA-N 0.000 description 2
QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
241000972773 Aulopiformes Species 0.000 description 2
101800001299 Cerebellin Proteins 0.000 description 2
102400001244 Cerebellin Human genes 0.000 description 2
108020004705 Codon Proteins 0.000 description 2
102000030746 Collagen Type X Human genes 0.000 description 2
108010022510 Collagen Type X Proteins 0.000 description 2
108010024212 E-Selectin Proteins 0.000 description 2
102100023471 E-selectin Human genes 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
108010043685 GPI-Linked Proteins Proteins 0.000 description 2
102000002702 GPI-Linked Proteins Human genes 0.000 description 2
102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 2
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 2
102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 2
GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 2
101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 2
101000852815 Homo sapiens Insulin receptor Proteins 0.000 description 2
101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 description 2
102000039996 IL-1 family Human genes 0.000 description 2
108091069196 IL-1 family Proteins 0.000 description 2
102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
208000022559 Inflammatory bowel disease Diseases 0.000 description 2
102000004877 Insulin Human genes 0.000 description 2
108090001061 Insulin Proteins 0.000 description 2
101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 description 2
102000004557 Interleukin-18 Receptors Human genes 0.000 description 2
108010017537 Interleukin-18 Receptors Proteins 0.000 description 2
108090001005 Interleukin-6 Proteins 0.000 description 2
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 description 2
101710157838 Lysozyme g Proteins 0.000 description 2
102000018697 Membrane Proteins Human genes 0.000 description 2
108010014251 Muramidase Proteins 0.000 description 2
102000016943 Muramidase Human genes 0.000 description 2
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 2
102000003992 Peroxidases Human genes 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
101800001357 Potential peptide Proteins 0.000 description 2
102400000745 Potential peptide Human genes 0.000 description 2
201000004681 Psoriasis Diseases 0.000 description 2
101100462969 Rattus norvegicus Pcdh3 gene Proteins 0.000 description 2
108090000184 Selectins Proteins 0.000 description 2
102000003800 Selectins Human genes 0.000 description 2
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
238000009825 accumulation Methods 0.000 description 2
230000009471 action Effects 0.000 description 2
210000000577 adipose tissue Anatomy 0.000 description 2
230000002776 aggregation Effects 0.000 description 2
238000004220 aggregation Methods 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
230000000890 antigenic effect Effects 0.000 description 2
239000000074 antisense oligonucleotide Substances 0.000 description 2
238000012230 antisense oligonucleotides Methods 0.000 description 2
238000013459 approach Methods 0.000 description 2
208000006673 asthma Diseases 0.000 description 2
230000033228 biological regulation Effects 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000008280 blood Substances 0.000 description 2
239000000872 buffer Substances 0.000 description 2
239000000969 carrier Substances 0.000 description 2
230000021164 cell adhesion Effects 0.000 description 2
229960003920 cocaine Drugs 0.000 description 2
230000009918 complex formation Effects 0.000 description 2
230000001086 cytosolic effect Effects 0.000 description 2
229940127089 cytotoxic agent Drugs 0.000 description 2
239000003145 cytotoxic factor Substances 0.000 description 2
238000011161 development Methods 0.000 description 2
230000018109 developmental process Effects 0.000 description 2
229960000633 dextran sulfate Drugs 0.000 description 2
238000003745 diagnosis Methods 0.000 description 2
229960002069 diamorphine Drugs 0.000 description 2
230000029087 digestion Effects 0.000 description 2
239000000539 dimer Substances 0.000 description 2
SLPJGDQJLTYWCI-UHFFFAOYSA-N dimethyl-(4,5,6,7-tetrabromo-1h-benzoimidazol-2-yl)-amine Chemical compound BrC1=C(Br)C(Br)=C2NC(N(C)C)=NC2=C1Br SLPJGDQJLTYWCI-UHFFFAOYSA-N 0.000 description 2
108010067341 ectonucleotide pyrophosphatase phosphodiesterase 1 Proteins 0.000 description 2
230000003511 endothelial effect Effects 0.000 description 2
230000003328 fibroblastic effect Effects 0.000 description 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
230000012010 growth Effects 0.000 description 2
230000036541 health Effects 0.000 description 2
230000011132 hemopoiesis Effects 0.000 description 2
102000047882 human INSR Human genes 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
210000000987 immune system Anatomy 0.000 description 2
238000011065 in-situ storage Methods 0.000 description 2
230000001965 increasing effect Effects 0.000 description 2
230000002757 inflammatory effect Effects 0.000 description 2
239000003999 initiator Substances 0.000 description 2
229940125396 insulin Drugs 0.000 description 2
108010042209 insulin receptor tyrosine kinase Proteins 0.000 description 2
102000014909 interleukin-1 receptor activity proteins Human genes 0.000 description 2
108040006732 interleukin-1 receptor activity proteins Proteins 0.000 description 2
239000002502 liposome Substances 0.000 description 2
239000004325 lysozyme Substances 0.000 description 2
229960000274 lysozyme Drugs 0.000 description 2
235000010335 lysozyme Nutrition 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
239000003550 marker Substances 0.000 description 2
239000000463 material Substances 0.000 description 2
230000035800 maturation Effects 0.000 description 2
239000003226 mitogen Substances 0.000 description 2
238000012544 monitoring process Methods 0.000 description 2
230000035772 mutation Effects 0.000 description 2
210000000440 neutrophil Anatomy 0.000 description 2
108010067588 nucleotide pyrophosphatase Proteins 0.000 description 2
238000004806 packaging method and process Methods 0.000 description 2
210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
239000008177 pharmaceutical agent Substances 0.000 description 2
229920002401 polyacrylamide Polymers 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
229940002612 prodrug Drugs 0.000 description 2
239000000651 prodrug Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
230000004853 protein function Effects 0.000 description 2
230000008929 regeneration Effects 0.000 description 2
238000011069 regeneration method Methods 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
206010039073 rheumatoid arthritis Diseases 0.000 description 2
235000019515 salmon Nutrition 0.000 description 2
229910052709 silver Inorganic materials 0.000 description 2
239000004332 silver Substances 0.000 description 2
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
239000001488 sodium phosphate Substances 0.000 description 2
229910000162 sodium phosphate Inorganic materials 0.000 description 2
239000007787 solid Substances 0.000 description 2
238000009987 spinning Methods 0.000 description 2
239000000758 substrate Substances 0.000 description 2
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
230000004614 tumor growth Effects 0.000 description 2
101150089124 ACR3 gene Proteins 0.000 description 1
229920000936 Agarose Polymers 0.000 description 1
WQVFQXXBNHHPLX-ZKWXMUAHSA-N Ala-Ala-His Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O WQVFQXXBNHHPLX-ZKWXMUAHSA-N 0.000 description 1
YYSWCHMLFJLLBJ-ZLUOBGJFSA-N Ala-Ala-Ser Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(O)=O YYSWCHMLFJLLBJ-ZLUOBGJFSA-N 0.000 description 1
108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
BHSYMWWMVRPCPA-CYDGBPFRSA-N Arg-Arg-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CCCN=C(N)N BHSYMWWMVRPCPA-CYDGBPFRSA-N 0.000 description 1
PMGDADKJMCOXHX-BQBZGAKWSA-N Arg-Gln Chemical compound NC(=N)NCCC[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(O)=O PMGDADKJMCOXHX-BQBZGAKWSA-N 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
PTNFNTOBUDWHNZ-GUBZILKMSA-N Asn-Arg-Met Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(O)=O PTNFNTOBUDWHNZ-GUBZILKMSA-N 0.000 description 1
LJUOLNXOWSWGKF-ACZMJKKPSA-N Asn-Asn-Glu Chemical compound C(CC(=O)O)[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)N)N LJUOLNXOWSWGKF-ACZMJKKPSA-N 0.000 description 1
KHCNTVRVAYCPQE-CIUDSAMLSA-N Asn-Lys-Asn Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O KHCNTVRVAYCPQE-CIUDSAMLSA-N 0.000 description 1
FANQWNCPNFEPGZ-WHFBIAKZSA-N Asp-Asp-Gly Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(O)=O FANQWNCPNFEPGZ-WHFBIAKZSA-N 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
102000001902 CC Chemokines Human genes 0.000 description 1
108010040471 CC Chemokines Proteins 0.000 description 1
108050006947 CXC Chemokine Proteins 0.000 description 1
102000019388 CXC chemokine Human genes 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
108090000994 Catalytic RNA Proteins 0.000 description 1
102000053642 Catalytic RNA Human genes 0.000 description 1
102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
102000000844 Cell Surface Receptors Human genes 0.000 description 1
108010001857 Cell Surface Receptors Proteins 0.000 description 1
102000010791 Chromogranin B Human genes 0.000 description 1
108010038439 Chromogranin B Proteins 0.000 description 1
208000032544 Cicatrix Diseases 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
102000029816 Collagenase Human genes 0.000 description 1
108060005980 Collagenase Proteins 0.000 description 1
108010071942 Colony-Stimulating Factors Proteins 0.000 description 1
102000007644 Colony-Stimulating Factors Human genes 0.000 description 1
108010005843 Cysteine Proteases Proteins 0.000 description 1
102000005927 Cysteine Proteases Human genes 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
102000011800 Desmosomal cadherin Human genes 0.000 description 1
108050002237 Desmosomal cadherin Proteins 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
238000009007 Diagnostic Kit Methods 0.000 description 1
206010014714 Endocrine neoplasms Diseases 0.000 description 1
241000283086 Equidae Species 0.000 description 1
108050001049 Extracellular proteins Proteins 0.000 description 1
108091008794 FGF receptors Proteins 0.000 description 1
208000002476 Falciparum Malaria Diseases 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 description 1
229920001917 Ficoll Polymers 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
NUSWUSKZRCGFEX-FXQIFTODSA-N Glu-Glu-Cys Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(O)=O NUSWUSKZRCGFEX-FXQIFTODSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
108010024636 Glutathione Proteins 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
108010009202 Growth Factor Receptors Proteins 0.000 description 1
102000009465 Growth Factor Receptors Human genes 0.000 description 1
241000282412 Homo Species 0.000 description 1
101001050607 Homo sapiens KH domain-containing, RNA-binding, signal transduction-associated protein 3 Proteins 0.000 description 1
101000950669 Homo sapiens Mitogen-activated protein kinase 9 Proteins 0.000 description 1
101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 1
101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
IPFKIGNDTUOFAF-CYDGBPFRSA-N Ile-Val-Arg Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N IPFKIGNDTUOFAF-CYDGBPFRSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
102000015696 Interleukins Human genes 0.000 description 1
108010063738 Interleukins Proteins 0.000 description 1
108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 description 1
102100023428 KH domain-containing, RNA-binding, signal transduction-associated protein 3 Human genes 0.000 description 1
PMGDADKJMCOXHX-UHFFFAOYSA-N L-Arginyl-L-glutamin-acetat Natural products NC(=N)NCCCC(N)C(=O)NC(CCC(N)=O)C(O)=O PMGDADKJMCOXHX-UHFFFAOYSA-N 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
102100024621 Layilin Human genes 0.000 description 1
101710147757 Layilin Proteins 0.000 description 1
LCPYQJIKPJDLLB-UWVGGRQHSA-N Leu-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CC(C)C LCPYQJIKPJDLLB-UWVGGRQHSA-N 0.000 description 1
AXVIGSRGTMNSJU-YESZJQIVSA-N Leu-Tyr-Pro Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2CCC[C@@H]2C(=O)O)N AXVIGSRGTMNSJU-YESZJQIVSA-N 0.000 description 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
102000009112 Mannose-Binding Lectin Human genes 0.000 description 1
108010087870 Mannose-Binding Lectin Proteins 0.000 description 1
102100037809 Mitogen-activated protein kinase 9 Human genes 0.000 description 1
102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
101100054965 Mus musculus Adipoq gene Proteins 0.000 description 1
OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical class CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 description 1
102000007339 Nerve Growth Factor Receptors Human genes 0.000 description 1
108010032605 Nerve Growth Factor Receptors Proteins 0.000 description 1
108020005187 Oligonucleotide Probes Proteins 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
108090000526 Papain Proteins 0.000 description 1
241001494479 Pecora Species 0.000 description 1
201000011152 Pemphigus Diseases 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
102000007079 Peptide Fragments Human genes 0.000 description 1
108010033276 Peptide Fragments Proteins 0.000 description 1
108700020962 Peroxidase Proteins 0.000 description 1
WEMYTDDMDBLPMI-DKIMLUQUSA-N Phe-Ile-Lys Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)N WEMYTDDMDBLPMI-DKIMLUQUSA-N 0.000 description 1
KIQUCMUULDXTAZ-HJOGWXRNSA-N Phe-Tyr-Tyr Chemical compound N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O KIQUCMUULDXTAZ-HJOGWXRNSA-N 0.000 description 1
108010001441 Phosphopeptides Proteins 0.000 description 1
108091000080 Phosphotransferase Proteins 0.000 description 1
108010089814 Plant Lectins Proteins 0.000 description 1
201000011336 Plasmodium falciparum malaria Diseases 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
239000004365 Protease Substances 0.000 description 1
102000001253 Protein Kinase Human genes 0.000 description 1
102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
108010067787 Proteoglycans Proteins 0.000 description 1
102000016611 Proteoglycans Human genes 0.000 description 1
101710141468 Protocadherin-3 Proteins 0.000 description 1
108091005682 Receptor kinases Proteins 0.000 description 1
101150108975 Rhd gene Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
101100109981 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ARR3 gene Proteins 0.000 description 1
241000242680 Schistosoma mansoni Species 0.000 description 1
108091058545 Secretory proteins Proteins 0.000 description 1
102000040739 Secretory proteins Human genes 0.000 description 1
206010040070 Septic Shock Diseases 0.000 description 1
QMCDMHWAKMUGJE-IHRRRGAJSA-N Ser-Phe-Val Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(O)=O QMCDMHWAKMUGJE-IHRRRGAJSA-N 0.000 description 1
XZKQVQKUZMAADP-IMJSIDKUSA-N Ser-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H](CO)C(O)=O XZKQVQKUZMAADP-IMJSIDKUSA-N 0.000 description 1
FZXOPYUEQGDGMS-ACZMJKKPSA-N Ser-Ser-Gln Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O FZXOPYUEQGDGMS-ACZMJKKPSA-N 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
108010071390 Serum Albumin Proteins 0.000 description 1
102000007562 Serum Albumin Human genes 0.000 description 1
241000700584 Simplexvirus Species 0.000 description 1
208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 description 1
208000006011 Stroke Diseases 0.000 description 1
241000282887 Suidae Species 0.000 description 1
COYHRQWNJDJCNA-NUJDXYNKSA-N Thr-Thr-Thr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O COYHRQWNJDJCNA-NUJDXYNKSA-N 0.000 description 1
108091023040 Transcription factor Proteins 0.000 description 1
102000040945 Transcription factor Human genes 0.000 description 1
102000044209 Tumor Suppressor Genes Human genes 0.000 description 1
108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 1
108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
241000251539 Vertebrata <Metazoa> Species 0.000 description 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
208000038016 acute inflammation Diseases 0.000 description 1
230000006022 acute inflammation Effects 0.000 description 1
238000007792 addition Methods 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
238000001042 affinity chromatography Methods 0.000 description 1
230000032683 aging Effects 0.000 description 1
238000012867 alanine scanning Methods 0.000 description 1
230000004075 alteration Effects 0.000 description 1
238000004873 anchoring Methods 0.000 description 1
238000010171 animal model Methods 0.000 description 1
238000000137 annealing Methods 0.000 description 1
230000000692 anti-sense effect Effects 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
239000002787 antisense oligonuctleotide Substances 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
235000009697 arginine Nutrition 0.000 description 1
108010008355 arginyl-glutamine Proteins 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000003376 axonal effect Effects 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
230000008827 biological function Effects 0.000 description 1
230000031018 biological processes and functions Effects 0.000 description 1
230000008512 biological response Effects 0.000 description 1
239000000090 biomarker Substances 0.000 description 1
229940098773 bovine serum albumin Drugs 0.000 description 1
239000008366 buffered solution Substances 0.000 description 1
244000309464 bull Species 0.000 description 1
230000002308 calcification Effects 0.000 description 1
238000004422 calculation algorithm Methods 0.000 description 1
238000012219 cassette mutagenesis Methods 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000030833 cell death Effects 0.000 description 1
230000024245 cell differentiation Effects 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
230000004663 cell proliferation Effects 0.000 description 1
230000035289 cell-matrix adhesion Effects 0.000 description 1
210000003570 cell-matrix junction Anatomy 0.000 description 1
230000004637 cellular stress Effects 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000012412 chemical coupling Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
230000035605 chemotaxis Effects 0.000 description 1
230000002759 chromosomal effect Effects 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
229960002424 collagenase Drugs 0.000 description 1
229940047120 colony stimulating factors Drugs 0.000 description 1
230000006957 competitive inhibition Effects 0.000 description 1
239000005289 controlled pore glass Substances 0.000 description 1
238000013270 controlled release Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
239000013078 crystal Substances 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
102000003675 cytokine receptors Human genes 0.000 description 1
108010057085 cytokine receptors Proteins 0.000 description 1
231100000433 cytotoxic Toxicity 0.000 description 1
239000002254 cytotoxic agent Substances 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000003413 degradative effect Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000001784 detoxification Methods 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
208000037765 diseases and disorders Diseases 0.000 description 1
239000012636 effector Substances 0.000 description 1
150000002066 eicosanoids Chemical class 0.000 description 1
210000003890 endocrine cell Anatomy 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
210000003038 endothelium Anatomy 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
230000006862 enzymatic digestion Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
HVCNNTAUBZIYCG-UHFFFAOYSA-N ethyl 2-[4-[(6-chloro-1,3-benzothiazol-2-yl)oxy]phenoxy]propanoate Chemical compound C1=CC(OC(C)C(=O)OCC)=CC=C1OC1=NC2=CC=C(Cl)C=C2S1 HVCNNTAUBZIYCG-UHFFFAOYSA-N 0.000 description 1
210000003527 eukaryotic cell Anatomy 0.000 description 1
239000003527 fibrinolytic agent Substances 0.000 description 1
238000000684 flow cytometry Methods 0.000 description 1
235000013305 food Nutrition 0.000 description 1
230000004927 fusion Effects 0.000 description 1
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 1
229960002963 ganciclovir Drugs 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
235000004554 glutamine Nutrition 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
230000013595 glycosylation Effects 0.000 description 1
238000006206 glycosylation reaction Methods 0.000 description 1
229930004094 glycosylphosphatidylinositol Natural products 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
201000000459 head and neck squamous cell carcinoma Diseases 0.000 description 1
210000003494 hepatocyte Anatomy 0.000 description 1
102000056088 human LY6D Human genes 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
230000002055 immunohistochemical effect Effects 0.000 description 1
238000009169 immunotherapy Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000028709 inflammatory response Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
102000006495 integrins Human genes 0.000 description 1
108010044426 integrins Proteins 0.000 description 1
230000008611 intercellular interaction Effects 0.000 description 1
229940047124 interferons Drugs 0.000 description 1
230000018276 interleukin-1 production Effects 0.000 description 1
230000021995 interleukin-8 production Effects 0.000 description 1
229940047122 interleukins Drugs 0.000 description 1
230000009545 invasion Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000011813 knockout mouse model Methods 0.000 description 1
108010091798 leucylleucine Proteins 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
235000018977 lysine Nutrition 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
230000003211 malignant effect Effects 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
201000001441 melanoma Diseases 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
239000008267 milk Substances 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
150000002772 monosaccharides Chemical class 0.000 description 1
208000031225 myocardial ischemia Diseases 0.000 description 1
210000000822 natural killer cell Anatomy 0.000 description 1
230000009826 neoplastic cell growth Effects 0.000 description 1
230000001537 neural effect Effects 0.000 description 1
210000004412 neuroendocrine cell Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
230000005937 nuclear translocation Effects 0.000 description 1
239000002751 oligonucleotide probe Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
230000002018 overexpression Effects 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
244000045947 parasite Species 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000007310 pathophysiology Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
201000001976 pemphigus vulgaris Diseases 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
210000000578 peripheral nerve Anatomy 0.000 description 1
108040007629 peroxidase activity proteins Proteins 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000012071 phase Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
230000026731 phosphorylation Effects 0.000 description 1
238000006366 phosphorylation reaction Methods 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
239000003726 plant lectin Substances 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
230000008488 polyadenylation Effects 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
230000004481 post-translational protein modification Effects 0.000 description 1
230000000770 proinflammatory effect Effects 0.000 description 1
AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
208000027490 protocadherin 3 Diseases 0.000 description 1
230000005855 radiation Effects 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
238000010188 recombinant method Methods 0.000 description 1
108091008146 restriction endonucleases Proteins 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
201000009410 rhabdomyosarcoma Diseases 0.000 description 1
108091092562 ribozyme Proteins 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
230000037387 scars Effects 0.000 description 1
210000004739 secretory vesicle Anatomy 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
230000001235 sensitizing effect Effects 0.000 description 1
210000002265 sensory receptor cell Anatomy 0.000 description 1
230000036303 septic shock Effects 0.000 description 1
238000012163 sequencing technique Methods 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
239000012064 sodium phosphate buffer Substances 0.000 description 1
229940048086 sodium pyrophosphate Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
210000003046 sporozoite Anatomy 0.000 description 1
230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
206010041823 squamous cell carcinoma Diseases 0.000 description 1
208000017572 squamous cell neoplasm Diseases 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000010473 stable expression Effects 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000035882 stress Effects 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
210000001138 tear Anatomy 0.000 description 1
235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
229960000103 thrombolytic agent Drugs 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
230000002463 transducing effect Effects 0.000 description 1
238000010361 transduction Methods 0.000 description 1
230000026683 transduction Effects 0.000 description 1
230000009261 transgenic effect Effects 0.000 description 1
230000014616 translation Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
230000032258 transport Effects 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
229940038773 trisodium citrate Drugs 0.000 description 1
230000006433 tumor necrosis factor production Effects 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
230000002792 vascular Effects 0.000 description 1
210000005166 vasculature Anatomy 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000002676 xenobiotic agent Substances 0.000 description 1

Landscapes

Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CA002512479A 1999-03-23 2000-03-01 Polypeptides transmembrane et secretees et acides nucleiques encodant le tout Abandoned CA2512479A1 (fr)

Applications Claiming Priority (35)

Application Number	Priority Date	Filing Date	Title
US12577899P	1999-03-23	1999-03-23
US12577499P	1999-03-23	1999-03-23
US60/125,778		1999-03-23
US60/125,774		1999-03-23
US12582699P	1999-03-24	1999-03-24
US60/125,826		1999-03-24
US12703599P	1999-03-31	1999-03-31
US60/127,035		1999-03-31
US12770699P	1999-04-05	1999-04-05
US60/127,706		1999-04-05
US13035999P	1999-04-21	1999-04-21
US60/130,359		1999-04-21
US13127099P	1999-04-27	1999-04-27
US13127299P	1999-04-27	1999-04-27
US13129199P	1999-04-27	1999-04-27
US60/131,291		1999-04-27
US60/131,270		1999-04-27
US60/131,272		1999-04-27
US13238399P	1999-05-04	1999-05-04
US13237199P	1999-05-04	1999-05-04
US13237999P	1999-05-04	1999-05-04
US60/132,371		1999-05-04
US60/132,379		1999-05-04
US60/132,383		1999-05-04
US13575099P	1999-05-25	1999-05-25
US60/135,750		1999-05-25
US13816699P	1999-06-08	1999-06-08
US60/138,166		1999-06-08
US14479199P	1999-07-20	1999-07-20
US60/144,791		1999-07-20
US14697099P	1999-08-03	1999-08-03
US60/146,970		1999-08-03
US17026299P	1999-12-09	1999-12-09
US60/170,262		1999-12-09
CA002361221A CA2361221A1 (fr)	1999-03-23	2000-03-01	Proteine inedite declenchant la differenciation de chondrocytes

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002361221A Division CA2361221A1 (fr)	1999-03-23	2000-03-01	Proteine inedite declenchant la differenciation de chondrocytes

Publications (1)

Publication Number	Publication Date
CA2512479A1 true CA2512479A1 (fr)	2000-09-28

Family

ID=35415097

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
CA002510931A Abandoned CA2510931A1 (fr)	1999-03-23	2000-03-01	Polypeptides pro4334 et acides nucleiques les encodant
CA002510797A Expired - Fee Related CA2510797C (fr)	1999-03-23	2000-03-01	Polypeptides secretes et transmembranaires et acides nucleiques les codant
CA002510982A Abandoned CA2510982A1 (fr)	1999-03-23	2000-03-01	Proteine pro 1890 semblable a la lectine, acides nucleiques codants, anticorps de pro 1890 et leurs utilisations
CA002510806A Abandoned CA2510806A1 (fr)	1999-03-23	2000-03-01	Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides
CA002512479A Abandoned CA2512479A1 (fr)	1999-03-23	2000-03-01	Polypeptides transmembrane et secretees et acides nucleiques encodant le tout
CA002512291A Abandoned CA2512291A1 (fr)	1999-03-23	2000-03-01	Polypeptides pro4356 et acides nucleiques codant lesdits polypeptides

Family Applications Before (4)

Application Number	Title	Priority Date	Filing Date
CA002510931A Abandoned CA2510931A1 (fr)	1999-03-23	2000-03-01	Polypeptides pro4334 et acides nucleiques les encodant
CA002510797A Expired - Fee Related CA2510797C (fr)	1999-03-23	2000-03-01	Polypeptides secretes et transmembranaires et acides nucleiques les codant
CA002510982A Abandoned CA2510982A1 (fr)	1999-03-23	2000-03-01	Proteine pro 1890 semblable a la lectine, acides nucleiques codants, anticorps de pro 1890 et leurs utilisations
CA002510806A Abandoned CA2510806A1 (fr)	1999-03-23	2000-03-01	Polypeptides secretes et transmembranaires et acides nucleiques codant lesdits polypeptides

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CA002512291A Abandoned CA2512291A1 (fr)	1999-03-23	2000-03-01	Polypeptides pro4356 et acides nucleiques codant lesdits polypeptides

Country Status (1)

Country	Link
CA (6)	CA2510931A1 (fr)

2000
- 2000-03-01 CA CA002510931A patent/CA2510931A1/fr not_active Abandoned
- 2000-03-01 CA CA002510797A patent/CA2510797C/fr not_active Expired - Fee Related
- 2000-03-01 CA CA002510982A patent/CA2510982A1/fr not_active Abandoned
- 2000-03-01 CA CA002510806A patent/CA2510806A1/fr not_active Abandoned
- 2000-03-01 CA CA002512479A patent/CA2512479A1/fr not_active Abandoned
- 2000-03-01 CA CA002512291A patent/CA2512291A1/fr not_active Abandoned

Also Published As

Publication number	Publication date
CA2510806A1 (fr)	2000-09-28
CA2510797C (fr)	2009-12-08
CA2510797A1 (fr)	2000-09-28
CA2510931A1 (fr)	2000-09-28
CA2512291A1 (fr)	2000-09-28
CA2510982A1 (fr)	2000-09-28

Publication	Publication Date	Title
EP1210418B1 (fr)	2010-08-18	Polypeptides secretes et transmembranaires ainsi que les acides nucleiques codant pour ceux-ci
AU764092B2 (en)	2003-08-07	Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2421056A1 (fr)	2002-03-28	Polypeptide servant de marqueur diagnostique de presence de tumeurs du colon
US7105639B2 (en)	2006-09-12	Anti-PRO 4405 antibodies
US7728108B2 (en)	2010-06-01	PRO1550 polypeptides
AU2003213166B2 (en)	2008-07-03	Novel polypeptides having sequence similarity to GDNFR and nucleic acids encoding the same
US7435793B2 (en)	2008-10-14	Peptides that induce chondrocyte redifferentiation
US6984519B2 (en)	2006-01-10	Nucleic acids encoding peptides that induce chondrocyte redifferentiation
AU2003261484B2 (en)	2006-06-15	Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU2005205758B2 (en)	2007-09-13	Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1612220A2 (fr)	2006-01-04	Transmembranprotéine sécrétée et acides nucléiques l'encodant
EP1300417B1 (fr)	2006-07-05	Polypeptide sécrété et transmembranaire ainsi que les acide nucléique codant pour celle-ci
US20090148878A1 (en)	2009-06-11	Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1591452B1 (fr)	2008-05-21	Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
EP1956030B1 (fr)	2009-11-11	Polypeptides sécrétés et transmembranaires, et acides nucléiques les codant
EP1621619B1 (fr)	2007-05-30	Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
CA2512479A1 (fr)	2000-09-28	Polypeptides transmembrane et secretees et acides nucleiques encodant le tout
EP1624061A1 (fr)	2006-02-08	Polypeptides sécrétés et transmembranaires ainsi que les acides nucléiques codant pour ceux-ci
US20060073547A1 (en)	2006-04-06	Secreted and transmembrane polypeptides and nucleic acids encoding the same

Legal Events

Date	Code	Title	Description
2005-07-27	EEER	Examination request
2011-03-01	FZDE	Dead