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CA2391129A1 - Transduction de cellules souches hematopoietiques par vecteur de lentivirus - Google Patents

Transduction de cellules souches hematopoietiques par vecteur de lentivirus Download PDF

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Publication number
CA2391129A1
CA2391129A1 CA002391129A CA2391129A CA2391129A1 CA 2391129 A1 CA2391129 A1 CA 2391129A1 CA 002391129 A CA002391129 A CA 002391129A CA 2391129 A CA2391129 A CA 2391129A CA 2391129 A1 CA2391129 A1 CA 2391129A1
Authority
CA
Canada
Prior art keywords
vector
hematopoietic stem
cells
stem cells
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002391129A
Other languages
English (en)
Inventor
Wen Yong Chen
Xiaoyun Wu
John C. Kappes
Tim M. Townes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UAB Research Foundation
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2391129A1 publication Critical patent/CA2391129A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16045—Special targeting system for viral vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des compositions et des procédés de préparation et d'utilisation de ces compositions en rapport avec la transduction de cellules souches hématopoïétiques. Elle concerne des vecteurs de lentivirus capables d'effectuer la transduction de populations purifiées de cellules souches hématopoïétiques. On peut mettre en application ces compositions et ces procédés afin de traiter des maladies présentant des troubles sanguins, telles que la drépanocytose ou la thalassémie.
CA002391129A 1999-11-10 2000-11-10 Transduction de cellules souches hematopoietiques par vecteur de lentivirus Abandoned CA2391129A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16462599P 1999-11-10 1999-11-10
US60/164,625 1999-11-10
PCT/US2000/030882 WO2001034843A1 (fr) 1999-11-10 2000-11-10 Transduction de cellules souches hematopoietiques par vecteur de lentivirus

Publications (1)

Publication Number Publication Date
CA2391129A1 true CA2391129A1 (fr) 2001-05-17

Family

ID=22595350

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002391129A Abandoned CA2391129A1 (fr) 1999-11-10 2000-11-10 Transduction de cellules souches hematopoietiques par vecteur de lentivirus

Country Status (5)

Country Link
EP (1) EP1230394A4 (fr)
JP (1) JP2003517301A (fr)
AU (1) AU784988B2 (fr)
CA (1) CA2391129A1 (fr)
WO (1) WO2001034843A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7575924B2 (en) 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
AU2002327412A1 (en) 2001-08-02 2003-02-17 Institut Clayton De La Recherche Methods and compositions relating to improved lentiviral vector production systems
WO2003029412A2 (fr) 2001-10-02 2003-04-10 Institut Clayton De La Recherche Procedes et compositions se rapportant a des vecteurs lentiviraux a expression reduite et leurs applications
IL163875A0 (en) 2002-03-07 2005-12-18 Univ Delaware Methods, compositions, and kits for enhancing oli gonucleotide mediated nucleic acid sequence alteration using compositions comprising a histone de
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2012094193A2 (fr) * 2011-01-03 2012-07-12 Bluebird Bio, Inc. Procédés pour améliorer l'administration de cellules transduites avec un gène
TWI654206B (zh) 2013-03-16 2019-03-21 諾華公司 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症
EP4406610A3 (fr) 2014-04-07 2024-10-30 Novartis AG Traitement du cancer à l'aide d'un récepteur antigénique chimérique anti-cd19
WO2015183885A1 (fr) * 2014-05-27 2015-12-03 Dana-Farber Cancer Institute, Inc. Procédés et compositions pour perturber l'expression génique dans des lignées de cellules souches hématopoïétiques in vivo
AU2016245958B2 (en) 2015-04-08 2021-09-09 Novartis Ag CD20 therapies, CD22 therapies, and combination therapies with a CD19 Chimeric Antigen Receptor (CAR) - expressing cell
TWI650419B (zh) * 2016-09-13 2019-02-11 中央研究院 藉移植增加壽命及/或治療細胞增殖疾病之方法
BR112019006781A2 (pt) 2016-10-07 2019-07-30 Novartis Ag receptores de antígeno quiméricos para o tratamento de câncer
WO2019009979A1 (fr) 2017-07-06 2019-01-10 The Medical College Of Wisconsin, Inc. Nouvelle stratégie d'enrichissement in vitro et in vivo ciblant les lymphocytes dérivés de csh transduites par un vecteur pour la thérapie de troubles
JP2021522278A (ja) 2018-04-27 2021-08-30 ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． ライソゾーム病を改善するための、レンチウイルスベクターが形質導入されたｔ−ｒａｐａ細胞の使用
CA3157966A1 (fr) * 2019-10-16 2021-04-22 Orchard Therapeutics (Europe) Limited Compositions et procedes destines a modifier des cellules eucaryotes

Also Published As

Publication number Publication date
AU784988B2 (en) 2006-08-17
WO2001034843A1 (fr) 2001-05-17
EP1230394A4 (fr) 2002-12-18
JP2003517301A (ja) 2003-05-27
AU1594401A (en) 2001-06-06
EP1230394A1 (fr) 2002-08-14

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