CA2342066A1 - Stabilized disinfectant preparation containing peroxides - Google Patents
Stabilized disinfectant preparation containing peroxides Download PDFInfo
- Publication number
- CA2342066A1 CA2342066A1 CA002342066A CA2342066A CA2342066A1 CA 2342066 A1 CA2342066 A1 CA 2342066A1 CA 002342066 A CA002342066 A CA 002342066A CA 2342066 A CA2342066 A CA 2342066A CA 2342066 A1 CA2342066 A1 CA 2342066A1
- Authority
- CA
- Canada
- Prior art keywords
- sodium
- constituted
- disinfectant
- acid
- taed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Cold disinfectant and sterilizing preparation, characterized in that it comprises a first part, constituted by a solution of tetracetyl-ethylendiami ne (TAED), sodium tripolyphosphate, sodium hydroxide or carbonate or other alka li in general, which are solubilized in water after heating, to which sodium alkylbenzenesulphonate, ethylendiamino-tetracetic acid sodium salt, isopropy l or ethyl or n-propyl or butyl alcohol and concentrated acetic acid are added to increase activity and stability, and a second part (activator) constitute d by peroxides of any kind.
Description
STABILIZED DISINFECTANT PREPARATION CONTAINING PEROXIDES
DESCRIPTION
The invention concerns the disinfection field and in particular it concerns the disinfection and sterilization of the material used in all the fields in which it is necessary to eliminate the pathogenic microbiologic forms of life, such as the sanitary field (from medico-surgical devices to hospital sheets).
The normal health rules impose that any medical or surgical device and the complementary accessories are perfectly disinfected and sterilized before being readmitted to use.
For all the multipurpose medico-surgical devices the disinfection and/or sterilization occurs after a suitable cleaning from residues and organic material, through sterilization in autoclave.
All the multipurpose and not multipurpose medico-surgical devices that don't tolerate high temperatures are disinfected and/or sterilized with the help of solutions called cold sterilizing solutions.
It is known that the peracetic acid is strongly oxidant and depending on its concentration it can be toxic, carcinogenic and even explosive with consequent danger in use.
The cold solutions currently on the market are characterized in that they have an acid pH to maintain the stability (few months), with the consequence that they result to be particularly corrosive towards the materials to be treated (medical and/or surgical devices) or have to be buffered with a neutral pH with the disadvantage that they must be used immediately or only for one cycle.
Therefore a new cold disinfectant-sterilizing solution has been studied and realized, which gives absolute guarantee also in the cold treatment.
The object of this patent is a new cold disinfectant-sterilizing solution comprising a first part constituted by a solution of tethracetyl-ethylendiammine (TAED), sodium tripolyposphate, sodium hydroxide or carbonate or other alkali in general which are solubilized in water after heating, to which sodium alkylbenzenesulphonate, ethylendiammino-tethracetic acid sodium salt, isopropyl or ethyl or n-propyl or butyl alcohol and concentrated acetic acid are added to increase the activity and the stability - the liquid phase so obtained remains stable for a long period (about five years) - and a second part (activator) constituted by peroxides of any kind.
The two parts are mixed only at the moment of use generating through a chemical reaction the peracetic acid which is the product desired and which is used as a cold disinfectant-sterilizing preparation.
The disinfectant-sterilizing solution so obtained has high stability and therefore it is usable, from the moment of its activation, for a period of at least five days, and however depending on the quantity of the equipment which has been disinfected-sterilized.The invention presents the following particular advantages:
- the solution obtained remains stable for a period of at least five days though working close to neutrality;
- the pH close to neutrality guarantees, differently from the known products, the absolute respect of the materials (medical devices) with which it is in contact;
- due to the low concentration of peracetic acid generated, it doesn't constitute an element of risk and danger for the personnel during the handling and it doesn't represent a polluting factor for the environment during preparation, storage, use and final disposal.
The solution can be successfully used for the cold disinfection-sterilization of thermosensitive and non- thermosensitive equipment, in the hospital and sanitary field in general.
The product can be used as disinfectant-sterilizing preparation in all the fields where it becomes necessary to eliminate pathogenic microbiological forms of life.
The aim of this procedure is to take into solution the tethracetylethylendianlmine's (TAED) acetic groups.
This can be achieved only through the presence of sodium hydroxide or carbonate, other allcali in general and through heating.
Sodium alkylbenzenesulphonate works as a surfactant and lowers the vapor pressure in the solution.
Ethylendiamminotethracetic acid sodium salt (EDTA) works as binder of the Fe+3, Ca+2, Mg~2 ions, which can degrade the active principle.
Sodium tripolyposphate, isopropyl alcohol and acetic acid are useful for stabilizing and for potentiating the germicide action of peracetic acid.
The various quantities of the different substances can undergo changes in order to obtain better characteristics of the final disinfectant and sterilizing compound, deducible either after laboratory studies and as a consequence of practical knowledge.
The powder part isn't subject to particular degradation or instability, and it is sufficient to keep it at normal temperature in suitable hermetic containers.
The liquid part shows excellent stability over time, which makes it usable up to three years after its production.
These are sufficient schematic indications to allow an expert person to put the project into effect; consequently, in tangible application, some variations may be made without affecting the substance of the innovative concept.
Therefore, with reference to the above description and to the enclosed table, the following claims are put forth.
DESCRIPTION
The invention concerns the disinfection field and in particular it concerns the disinfection and sterilization of the material used in all the fields in which it is necessary to eliminate the pathogenic microbiologic forms of life, such as the sanitary field (from medico-surgical devices to hospital sheets).
The normal health rules impose that any medical or surgical device and the complementary accessories are perfectly disinfected and sterilized before being readmitted to use.
For all the multipurpose medico-surgical devices the disinfection and/or sterilization occurs after a suitable cleaning from residues and organic material, through sterilization in autoclave.
All the multipurpose and not multipurpose medico-surgical devices that don't tolerate high temperatures are disinfected and/or sterilized with the help of solutions called cold sterilizing solutions.
It is known that the peracetic acid is strongly oxidant and depending on its concentration it can be toxic, carcinogenic and even explosive with consequent danger in use.
The cold solutions currently on the market are characterized in that they have an acid pH to maintain the stability (few months), with the consequence that they result to be particularly corrosive towards the materials to be treated (medical and/or surgical devices) or have to be buffered with a neutral pH with the disadvantage that they must be used immediately or only for one cycle.
Therefore a new cold disinfectant-sterilizing solution has been studied and realized, which gives absolute guarantee also in the cold treatment.
The object of this patent is a new cold disinfectant-sterilizing solution comprising a first part constituted by a solution of tethracetyl-ethylendiammine (TAED), sodium tripolyposphate, sodium hydroxide or carbonate or other alkali in general which are solubilized in water after heating, to which sodium alkylbenzenesulphonate, ethylendiammino-tethracetic acid sodium salt, isopropyl or ethyl or n-propyl or butyl alcohol and concentrated acetic acid are added to increase the activity and the stability - the liquid phase so obtained remains stable for a long period (about five years) - and a second part (activator) constituted by peroxides of any kind.
The two parts are mixed only at the moment of use generating through a chemical reaction the peracetic acid which is the product desired and which is used as a cold disinfectant-sterilizing preparation.
The disinfectant-sterilizing solution so obtained has high stability and therefore it is usable, from the moment of its activation, for a period of at least five days, and however depending on the quantity of the equipment which has been disinfected-sterilized.The invention presents the following particular advantages:
- the solution obtained remains stable for a period of at least five days though working close to neutrality;
- the pH close to neutrality guarantees, differently from the known products, the absolute respect of the materials (medical devices) with which it is in contact;
- due to the low concentration of peracetic acid generated, it doesn't constitute an element of risk and danger for the personnel during the handling and it doesn't represent a polluting factor for the environment during preparation, storage, use and final disposal.
The solution can be successfully used for the cold disinfection-sterilization of thermosensitive and non- thermosensitive equipment, in the hospital and sanitary field in general.
The product can be used as disinfectant-sterilizing preparation in all the fields where it becomes necessary to eliminate pathogenic microbiological forms of life.
The aim of this procedure is to take into solution the tethracetylethylendianlmine's (TAED) acetic groups.
This can be achieved only through the presence of sodium hydroxide or carbonate, other allcali in general and through heating.
Sodium alkylbenzenesulphonate works as a surfactant and lowers the vapor pressure in the solution.
Ethylendiamminotethracetic acid sodium salt (EDTA) works as binder of the Fe+3, Ca+2, Mg~2 ions, which can degrade the active principle.
Sodium tripolyposphate, isopropyl alcohol and acetic acid are useful for stabilizing and for potentiating the germicide action of peracetic acid.
The various quantities of the different substances can undergo changes in order to obtain better characteristics of the final disinfectant and sterilizing compound, deducible either after laboratory studies and as a consequence of practical knowledge.
The powder part isn't subject to particular degradation or instability, and it is sufficient to keep it at normal temperature in suitable hermetic containers.
The liquid part shows excellent stability over time, which makes it usable up to three years after its production.
These are sufficient schematic indications to allow an expert person to put the project into effect; consequently, in tangible application, some variations may be made without affecting the substance of the innovative concept.
Therefore, with reference to the above description and to the enclosed table, the following claims are put forth.
Claims (2)
1. Cold disinfectant and sterilizing preparation, characterized in that it comprises a first part, constituted by a solution of tethracetyl-ethylendiammine (TAED), sodium tripolyposphate, sodium hydroxide or carbonate or other alkali in general, which are solubilized in water after heating, to which sodium alkylbenzenesulphonate, ethylendiammino-tethracetic acid sodium salt, isopropyl or ethyl or n-propyl or butyl alcohol and concentrated acetic acid are added to increase activity and stability, and a second part (activator) constituted by peroxides of any kind.
2. Disinfectant sterilizing preparation according to claim 1, characterized in that the first part is constituted by the following substances in the respective indicative quantities:
~ tethracetylethylendiammine (TAED) from 0.1 to 50 g ~ sodium tripolyposphate from 0.1 to 100 g ~ sodium alkylbenzenesulphonate from 0.01 to 5 g ~ isopropyl alcohol (or ethyl or n-propyl or butyl) from 10 to 200 g ~ concentrated acetic acid from 0.1 to 10 g ~ sodium hydroxide or carbonate or other alkali in general from 0.1 to 10 g ~ ethylediamminotethracetic acid sodium salt (EDTA) from 0.01 to 5 g ~ distilled water up to 1000 g.
~ tethracetylethylendiammine (TAED) from 0.1 to 50 g ~ sodium tripolyposphate from 0.1 to 100 g ~ sodium alkylbenzenesulphonate from 0.01 to 5 g ~ isopropyl alcohol (or ethyl or n-propyl or butyl) from 10 to 200 g ~ concentrated acetic acid from 0.1 to 10 g ~ sodium hydroxide or carbonate or other alkali in general from 0.1 to 10 g ~ ethylediamminotethracetic acid sodium salt (EDTA) from 0.01 to 5 g ~ distilled water up to 1000 g.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98PD000116A ITPD980116A1 (en) | 1998-05-13 | 1998-05-13 | DISINFECTANT PREPARATION |
| ITPD98A116 | 1998-05-13 | ||
| ITPD98A281 | 1998-12-01 | ||
| IT000281 IT1302526B1 (en) | 1998-12-01 | 1998-12-01 | Stabilized cold disinfectant and sterilizing preparation |
| PCT/IT1999/000125 WO1999057980A1 (en) | 1998-05-13 | 1999-05-10 | Stabilized disinfectant preparation containing peroxides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2342066A1 true CA2342066A1 (en) | 1999-11-18 |
Family
ID=26331878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002342066A Abandoned CA2342066A1 (en) | 1998-05-13 | 1999-05-10 | Stabilized disinfectant preparation containing peroxides |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1091647A1 (en) |
| AU (1) | AU3847299A (en) |
| CA (1) | CA2342066A1 (en) |
| WO (1) | WO1999057980A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2355198A (en) * | 1999-05-06 | 2001-04-18 | Medichem Internat Ltd | An aldehyde-free sterilant and disinfectant based on a peroxide source in powder or kit form for mixing and/or diluting |
| US6506416B1 (en) | 1999-06-30 | 2003-01-14 | Kao Corporation | Virucide composition and sporicide composition |
| US20030228373A1 (en) * | 2002-01-22 | 2003-12-11 | Lonza Inc. | Composition including a triamine and a biocide and a method for inhibiting the growth of microorganisms with the same |
| US8969282B2 (en) * | 2009-02-05 | 2015-03-03 | American Sterilizer Company | Low odor, hard surface sporicide |
| US8969283B2 (en) * | 2009-02-05 | 2015-03-03 | American Sterilizer Company | Low odor, hard surface sporicides and chemical decontaminants |
| WO2020159892A1 (en) * | 2019-01-28 | 2020-08-06 | Hyprotek, Inc. | Antimicrobial composition with procoagulant, immunomodulatory, and tissue regenerative properties |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0056723B1 (en) * | 1981-01-21 | 1984-12-05 | Unilever Plc | Detergent compositions |
| DE3134050A1 (en) * | 1981-08-28 | 1983-03-10 | Dr. Franz Köhler Chemie GmbH, 6146 Alsbach | Solution for sterilising and removing pyrogens from stainless steel lines and filters in a closed system |
| GB8629534D0 (en) * | 1986-12-10 | 1987-01-21 | Unilever Plc | Enzymatic detergent & bleaching composition |
| WO1993002973A1 (en) * | 1991-08-05 | 1993-02-18 | Trawöger, Werner | Anti-fouling agent for wet surfaces |
| US5244593A (en) * | 1992-01-10 | 1993-09-14 | The Procter & Gamble Company | Colorless detergent compositions with enhanced stability |
| JP3811508B2 (en) * | 1994-08-31 | 2006-08-23 | ジョンソン株式会社 | Method for activating peroxide and composition thereof |
-
1999
- 1999-05-10 AU AU38472/99A patent/AU3847299A/en not_active Abandoned
- 1999-05-10 WO PCT/IT1999/000125 patent/WO1999057980A1/en not_active Application Discontinuation
- 1999-05-10 EP EP99921134A patent/EP1091647A1/en not_active Withdrawn
- 1999-05-10 CA CA002342066A patent/CA2342066A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU3847299A (en) | 1999-11-29 |
| WO1999057980A1 (en) | 1999-11-18 |
| EP1091647A1 (en) | 2001-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |