Nothing Special   »   [go: up one dir, main page]

CA2227806A1 - Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use - Google Patents

Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use Download PDF

Info

Publication number
CA2227806A1
CA2227806A1 CA002227806A CA2227806A CA2227806A1 CA 2227806 A1 CA2227806 A1 CA 2227806A1 CA 002227806 A CA002227806 A CA 002227806A CA 2227806 A CA2227806 A CA 2227806A CA 2227806 A1 CA2227806 A1 CA 2227806A1
Authority
CA
Canada
Prior art keywords
ion
ions
transmission device
spectrometer
damp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002227806A
Other languages
French (fr)
Other versions
CA2227806C (en
Inventor
Andrew N. Krutchinsky
Alexandre Loboda
Victor L. Spicer
Erich W. Ens
Kenneth G. Standing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manitoba
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4162020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2227806(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Priority to CA002227806A priority Critical patent/CA2227806C/en
Priority to AT99900849T priority patent/ATE273561T2/en
Priority to JP2000528992A priority patent/JP4331398B2/en
Priority to DK99900849.3T priority patent/DK1050061T4/en
Priority to PCT/CA1999/000034 priority patent/WO1999038185A2/en
Priority to DE69919325.7T priority patent/DE69919325T3/en
Priority to EP99900849.3A priority patent/EP1050061B2/en
Priority to DE1050061T priority patent/DE1050061T1/en
Priority to AU20428/99A priority patent/AU745866B2/en
Publication of CA2227806A1 publication Critical patent/CA2227806A1/en
Priority to US09/989,882 priority patent/US6680475B2/en
Priority to US10/236,514 priority patent/USRE39099E1/en
Priority to US10/758,511 priority patent/US6833543B2/en
Priority to US10/919,859 priority patent/US7189963B2/en
Publication of CA2227806C publication Critical patent/CA2227806C/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Electron Sources, Ion Sources (AREA)

Abstract

A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and includes a damping gas, to damp spatial and energy spreads of ions generated by an ion source. The multipole rod set has the effect of guiding the ions along an ion path, so that they can be directed into the inlet of a mass spectrometer. The invention has particular application to MALDI (matrix-assisted laser desorption/ionization) ion sources, which produce a small supersonic jet or matrix molecules and ions, which is non-directional, and can have ions travelling in all available directions from the source and having a wide range of energy spreads. The ion transmission device can substantially spread out the generated ions along an ion axis. Consequently, a number of pulses of ions can be delivered to the time-of-flight or other spectrometer, for each cycle of the spectrometer.
CA002227806A 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use Expired - Lifetime CA2227806C (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA002227806A CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
DE1050061T DE1050061T1 (en) 1998-01-23 1999-01-25 SPECTROMETER WITH PULSED ION SOURCE, COUPLING DEVICE FOR DAMPING ION MOVEMENT, AND METHOD FOR USE THEREOF
AU20428/99A AU745866B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
JP2000528992A JP4331398B2 (en) 1998-01-23 1999-01-25 An analyzer with a pulsed ion source and a transport device for damping ion motion and method of use thereof
DK99900849.3T DK1050061T4 (en) 1998-01-23 1999-01-25 Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereof
PCT/CA1999/000034 WO1999038185A2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
DE69919325.7T DE69919325T3 (en) 1998-01-23 1999-01-25 Pulsed ion source spectrometer, coupling device for damping ion motion, and method of using same
EP99900849.3A EP1050061B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
AT99900849T ATE273561T2 (en) 1998-01-23 1999-01-25 PULSE ION SOURCE SPECTROMETER, COUPLING DEVICE FOR DAMPING ION MOVEMENT, AND METHOD OF USING THE SAME
US09/989,882 US6680475B2 (en) 1998-01-23 2001-11-21 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US10/236,514 USRE39099E1 (en) 1998-01-23 2002-09-06 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US10/758,511 US6833543B2 (en) 1998-01-23 2004-01-15 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US10/919,859 US7189963B2 (en) 1998-01-23 2004-08-17 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002227806A CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Publications (2)

Publication Number Publication Date
CA2227806A1 true CA2227806A1 (en) 1999-07-23
CA2227806C CA2227806C (en) 2006-07-18

Family

ID=4162020

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002227806A Expired - Lifetime CA2227806C (en) 1998-01-23 1998-01-23 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Country Status (8)

Country Link
EP (1) EP1050061B2 (en)
JP (1) JP4331398B2 (en)
AT (1) ATE273561T2 (en)
AU (1) AU745866B2 (en)
CA (1) CA2227806C (en)
DE (2) DE1050061T1 (en)
DK (1) DK1050061T4 (en)
WO (1) WO1999038185A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965884A (en) * 1998-06-04 1999-10-12 The Regents Of The University Of California Atmospheric pressure matrix assisted laser desorption
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
GB9820210D0 (en) * 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
DE60044899D1 (en) 1999-06-11 2010-10-14 Applied Biosystems Llc MALDI ION SOURCE WITH GAS PULSE, DEVICE AND METHOD FOR DETERMINING THE MOLECULAR WEIGHT LABILES MOLECULES
DE10010204A1 (en) 2000-03-02 2001-09-13 Bruker Daltonik Gmbh Conditioning ion beam for flight time mass spectrometer involves damping ion movements in conducting system with gas pules, feeding ions to system end and extracting ions via lens system
DE10010902A1 (en) 2000-03-07 2001-09-20 Bruker Daltonik Gmbh Tandem mass spectrometer consisting of two quadrupole filters
GB2364168B (en) * 2000-06-09 2002-06-26 Micromass Ltd Methods and apparatus for mass spectrometry
CA2340150C (en) * 2000-06-09 2005-11-22 Micromass Limited Methods and apparatus for mass spectrometry
GB2370685B (en) 2000-11-29 2003-01-22 Micromass Ltd Mass spectrometers and methods of mass spectrometry
EP1215712B1 (en) 2000-11-29 2010-09-08 Micromass UK Limited Mass spectrometer and methods of mass spectrometry
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6617577B2 (en) 2001-04-16 2003-09-09 The Rockefeller University Method and system for mass spectroscopy
US20040238754A1 (en) 2001-09-17 2004-12-02 Baranov Vladimir I. Method and apparatus for cooling and focusing ions
AU2002349241A1 (en) 2001-12-14 2003-06-30 Mds Inc., D.B.A. Mds Sciex Method of chemical of ionization at reduced pressures
WO2003081205A2 (en) 2002-03-21 2003-10-02 Thermo Finnigan Llc Ionization apparatus and method for mass spectrometer system
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
US7388194B2 (en) 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
WO2003083448A2 (en) * 2002-03-28 2003-10-09 Mds Sciex Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
CA2431603C (en) 2003-06-10 2012-03-27 Micromass Uk Limited Mass spectrometer
DE102004025841B4 (en) * 2004-05-24 2015-07-09 Bruker Daltonik Gmbh Method and apparatus for mass spectroscopic analysis of analytes
GB0420408D0 (en) * 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
DE102004051785B4 (en) 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Protein profiles with air MALDI
ES2389111T3 (en) 2005-12-02 2012-10-23 Sirtris Pharmaceuticals, Inc. Mass spectrometry assays for acetyltransferase / deacetylase activity
US8097425B2 (en) 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
DE102007043456B4 (en) 2007-07-31 2012-02-09 Bruker Daltonik Gmbh Matrix-assisted laser desorption with high ionization efficiency
EP3752824A4 (en) * 2018-02-13 2022-02-23 bioMérieux, Inc. Methods for confirming charged-particle generation in an instrument, and related instruments
US12205807B2 (en) 2020-04-01 2025-01-21 Mstm, Llc Multi-mode ionization apparatus and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4535235A (en) † 1983-05-06 1985-08-13 Finnigan Corporation Apparatus and method for injection of ions into an ion cyclotron resonance cell
EP0409362B1 (en) † 1985-05-24 1995-04-19 Finnigan Corporation Method of operating an ion trap
JPH03503815A (en) † 1987-12-24 1991-08-22 ユニサーチ　リミテッド mass spectrometer
CA1307859C (en) † 1988-12-12 1992-09-22 Donald James Douglas Mass spectrometer and method with improved ion transmission
DE4202123C2 (en) † 1992-01-27 1995-04-06 Bruker Franzen Analytik Gmbh Device for the mass spectrometric analysis of fast organic ions
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
DE19511333C1 (en) * 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Method and device for orthogonal injection of ions into a time-of-flight mass spectrometer
DE19629134C1 (en) † 1996-07-19 1997-12-11 Bruker Franzen Analytik Gmbh Device for transferring ions and measuring method carried out with the same
DE69806415T2 (en) * 1997-12-05 2003-02-20 The University Of British Columbia, Vancouver METHOD FOR THE EXAMINATION OF IONS IN AN APPARATUS WITH A FLIGHT-TIME SPECTROMETER AND A LINEAR QUADRUPOL ION TRAP

Also Published As

Publication number Publication date
DE1050061T1 (en) 2001-06-07
AU2042899A (en) 1999-08-09
WO1999038185A3 (en) 1999-10-21
DE69919325T2 (en) 2005-02-17
DE69919325T3 (en) 2017-03-02
WO1999038185A2 (en) 1999-07-29
JP4331398B2 (en) 2009-09-16
EP1050061B2 (en) 2016-10-19
DE69919325D1 (en) 2004-09-16
DK1050061T4 (en) 2017-01-23
EP1050061B1 (en) 2004-08-11
AU745866B2 (en) 2002-04-11
DK1050061T3 (en) 2004-11-22
CA2227806C (en) 2006-07-18
EP1050061A2 (en) 2000-11-08
JP2002502084A (en) 2002-01-22
ATE273561T2 (en) 2004-08-15

Similar Documents

Publication Publication Date Title
CA2227806A1 (en) Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
CA2444614A1 (en) Method and system for mass spectroscopy
KR100232430B1 (en) Apparatus and methods for trace component analysis
US5569917A (en) Apparatus for and method of forming a parallel ion beam
JP3791783B2 (en) Ion attachment mass spectrometer, ionizer, and ionization method
WO2005045419A3 (en) Ion source and methods for maldi mass spectrometry
EP1051730B1 (en) Quadrupele ion trap and time-of fligt spectrometer with such an ion trap
CA2192915A1 (en) Electrospray and atmospheric pressure chemical ionization mass spectrometer and ion source
CA2275140A1 (en) Multi-inlet mass spectrometer
CA2333721A1 (en) Pulsed ion source for ion trap mass spectrometer
CA2293483A1 (en) Hybrid ion mobility and mass spectrometer
WO2001026133A8 (en) High transmission, low energy beamline apparatus for ion implanter
CA2318586A1 (en) Mass spectrometry from surfaces
CA2539899A1 (en) Improved high performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
CA2520967A1 (en) Atmospheric pressure ion source
JPH11167895A (en) Mass spectroscope and dynamic range improving method for mass spectroscope
US8648295B2 (en) Combined distance-of-flight and time-of-flight mass spectrometer
EP1467398A3 (en) Mass spectrometer
WO2008071993A3 (en) Mass spectrometer
CA2567467A1 (en) Compact time-of-flight mass spectrometer
US20120241642A1 (en) Laser desorption ionization ion source with charge injection
US6545269B1 (en) Ion source for time-of-flight mass spectrometers for analyzing gas samples
JP3741567B2 (en) Vertical acceleration time-of-flight mass spectrometer
Wang et al. A method for background reduction in a supersonic jet/multiphoton ionization reflectron time-of-flight mass spectrometer
CN115172136B (en) Method for adjusting initial state of ion group

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20180123