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CA2130174A1 - 4-oxo-2 thioxoimidazolidine derivatives as inhibitors of blood platelet aggregation - Google Patents

4-oxo-2 thioxoimidazolidine derivatives as inhibitors of blood platelet aggregation

Info

Publication number
CA2130174A1
CA2130174A1 CA002130174A CA2130174A CA2130174A1 CA 2130174 A1 CA2130174 A1 CA 2130174A1 CA 002130174 A CA002130174 A CA 002130174A CA 2130174 A CA2130174 A CA 2130174A CA 2130174 A1 CA2130174 A1 CA 2130174A1
Authority
CA
Canada
Prior art keywords
oxo
inhibitors
platelet aggregation
blood platelet
thioxoimidazolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002130174A
Other languages
French (fr)
Other versions
CA2130174C (en
Inventor
Gerhard Zoller
Bernd Jablonka
Jochen Knolle
Melitta Just
Wolfgang Konig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2130174A1 publication Critical patent/CA2130174A1/en
Application granted granted Critical
Publication of CA2130174C publication Critical patent/CA2130174C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • External Artificial Organs (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to 4-oxo-2-thioxo-imidazolidine derivates of the general formula I

(see formula I) in which R1 to R4 and Y are defined as indicated in the description, processes for their preparation and their use as inhibitors of blood platelet aggregation, the metastasis of carcinoma cells and the binding of osteo-clasts to bone surfaces.
CA002130174A 1992-03-07 1993-02-24 4-oxo-2 thioxoimidazolidine derivatives as inhibitors of blood platelet aggregation Expired - Lifetime CA2130174C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4207254.9 1992-03-07
DE4207254A DE4207254A1 (en) 1992-03-07 1992-03-07 4-oxo-2-thioxoimidazolidin DERIVATIVES
PCT/EP1993/000424 WO1993018057A1 (en) 1992-03-07 1993-02-24 4-oxo-2 thioxoimidazolidine derivates as inhibitors of blood platelet aggregation

Publications (2)

Publication Number Publication Date
CA2130174A1 true CA2130174A1 (en) 1993-09-16
CA2130174C CA2130174C (en) 2003-09-09

Family

ID=6453475

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002130174A Expired - Lifetime CA2130174C (en) 1992-03-07 1993-02-24 4-oxo-2 thioxoimidazolidine derivatives as inhibitors of blood platelet aggregation

Country Status (16)

Country Link
EP (1) EP0629211B1 (en)
JP (1) JP3495369B2 (en)
KR (1) KR100278532B1 (en)
AT (1) ATE169634T1 (en)
AU (1) AU665617B2 (en)
CA (1) CA2130174C (en)
CZ (1) CZ286327B6 (en)
DE (2) DE4207254A1 (en)
DK (1) DK0629211T3 (en)
ES (1) ES2121993T3 (en)
HU (1) HU217430B (en)
IL (1) IL104960A (en)
SK (1) SK107294A3 (en)
TW (1) TW255888B (en)
WO (1) WO1993018057A1 (en)
ZA (1) ZA931537B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1069316C (en) * 1993-11-15 2001-08-08 赫彻斯特股份公司 Substituted 5-ring heterocycles, their preparation and their use

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228717A1 (en) * 1992-08-28 1994-03-03 Cassella Ag Imidazolidine derivatives
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
ZA963391B (en) * 1995-05-24 1997-10-29 Du Pont Merck Pharma Isoxazoline fibrinogen receptor antagonists.
US5554607A (en) * 1995-11-28 1996-09-10 American Home Products Corporation Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of atherosclerosis
US5599829A (en) * 1995-11-28 1997-02-04 American Home Products Corporation 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives for increasing HDL cholesterol levels
US5821372A (en) * 1995-11-28 1998-10-13 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
TW418195B (en) * 1995-11-28 2001-01-11 American Home Prod 2-thioxo-imidazolidin-4-one derivatives
DE59706273D1 (en) 1996-03-20 2002-03-21 Hoechst Ag Bone resorption inhibitors and vitronectin receptor antagonists
DE19629817A1 (en) * 1996-07-24 1998-01-29 Hoechst Ag New imino derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
DE19629816A1 (en) 1996-07-24 1998-01-29 Hoechst Ag New cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists
US5861517A (en) * 1996-11-21 1999-01-19 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
US5663363A (en) * 1996-11-21 1997-09-02 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
DE19741235A1 (en) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Novel imidazolidine derivatives, their preparation, their use and pharmaceutical compositions containing them
DE19741873A1 (en) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh New 5-ring heterocycles, their preparation, their use and pharmaceutical preparations containing them
DE19751251A1 (en) * 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituted imidazolidine derivatives, their manufacture, their use and pharmaceutical preparations containing them
DE19821483A1 (en) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh New imidazolidine derivatives useful as leukocyte adhesion and migration inhibitors and/or VLA-4 receptor antagonists for treating E.G. inflammatory and allergic disorders
DE19922462A1 (en) 1999-05-17 2000-11-23 Aventis Pharma Gmbh New phenylureidobenzyl-substituted spiro-imidazolidinedione derivatives, are inhibitors of leukocyte adhesion or migration or VLA-4 receptors, useful e.g. for treating inflammatory or allergic disease
DE10111877A1 (en) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Novel imidazolidine derivatives, their preparation, their use and pharmaceutical compositions containing them
DE10137595A1 (en) 2001-08-01 2003-02-13 Aventis Pharma Gmbh New 3-alkylaminoalkyl-imdazolidin-4-one derivatives, are VLA-4 receptor and leukocyte adhesion and/or migration inhibitors, useful e.g. for treating inflammatory, allergic, autoimmune or cardiovascular disease
TWI339093B (en) 2007-08-24 2011-03-11 Asustek Comp Inc Cellular phone with shiftless motion function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970225A (en) * 1990-02-13 1990-11-13 Bristol-Myers Squibb Company Imidazolidine carboxylic acids and esters as blood platelet aggregation inhibitors
DE4009506A1 (en) * 1990-03-24 1991-09-26 Hoechst Ag hydantoin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1069316C (en) * 1993-11-15 2001-08-08 赫彻斯特股份公司 Substituted 5-ring heterocycles, their preparation and their use

Also Published As

Publication number Publication date
DE59308872D1 (en) 1998-09-17
JPH07506567A (en) 1995-07-20
CZ286327B6 (en) 2000-03-15
JP3495369B2 (en) 2004-02-09
AU665617B2 (en) 1996-01-11
ATE169634T1 (en) 1998-08-15
KR100278532B1 (en) 2001-01-15
IL104960A (en) 1996-12-05
HUT69716A (en) 1995-09-28
KR950700321A (en) 1995-01-16
ZA931537B (en) 1993-09-27
CZ216694A3 (en) 1995-04-12
SK107294A3 (en) 1995-04-12
CA2130174C (en) 2003-09-09
WO1993018057A1 (en) 1993-09-16
EP0629211B1 (en) 1998-08-12
IL104960A0 (en) 1993-07-08
TW255888B (en) 1995-09-01
HU217430B (en) 2000-01-28
HU9402564D0 (en) 1994-11-28
ES2121993T3 (en) 1998-12-16
DE4207254A1 (en) 1993-09-09
EP0629211A1 (en) 1994-12-21
AU3498893A (en) 1993-10-05
DK0629211T3 (en) 1999-05-17

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130225

MKEC Expiry (correction)

Effective date: 20131009