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CA2128244A1 - Solid Bodies Containing Active Substances and a Structure Consisting of Hydrophilic Macromolecules, Plus a Method of Producing Such Bodies - Google Patents

Solid Bodies Containing Active Substances and a Structure Consisting of Hydrophilic Macromolecules, Plus a Method of Producing Such Bodies

Info

Publication number
CA2128244A1
CA2128244A1 CA 2128244 CA2128244A CA2128244A1 CA 2128244 A1 CA2128244 A1 CA 2128244A1 CA 2128244 CA2128244 CA 2128244 CA 2128244 A CA2128244 A CA 2128244A CA 2128244 A1 CA2128244 A1 CA 2128244A1
Authority
CA
Canada
Prior art keywords
shaped articles
bodies
plus
producing
hydrophilic macromolecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2128244
Other languages
French (fr)
Other versions
CA2128244C (en
Inventor
Jens-Christian Wunderlich
Ursula Schick
Jurgen Werry
Jurgen Freidenreich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfatec Pharma GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27435369&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2128244(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4201179A external-priority patent/DE4201179A1/en
Priority claimed from DE4201173A external-priority patent/DE4201173C2/en
Application filed by Individual filed Critical Individual
Publication of CA2128244A1 publication Critical patent/CA2128244A1/en
Application granted granted Critical
Publication of CA2128244C publication Critical patent/CA2128244C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/022—Powders; Compacted Powders
    • A61K8/0225—Granulated powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Glanulating (AREA)

Abstract

The invention relates to accurately meterable shaped articles, for example granules or pellets, containing hydrophilic macromolecules, active compounds and optionally further pharmaceutically acceptable structure-forming substances and auxiliaries, the active compound being present in a matrix in dissolved, suspended or emulsified form, and a novel process for the production of these shaped articles, the process being particularly economically and ecologically acceptable, and use of the shaped articles as medicaments, in which the bioavailability, shelf life and tolerability is increased. Using the shaped articles or mixtures according to the invention, intermediates or final products for pharmacy, cosmetics, diagnosis, analysis or dietetics (healthcare) can additionally be advantageously prepared.
CA002128244A 1992-01-17 1993-01-18 Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies Expired - Fee Related CA2128244C (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DEP4201173.6 1992-01-17
DE4201179A DE4201179A1 (en) 1992-01-17 1992-01-17 Granulates or pellets comprising dispersion of active agent in hydrophilic macromolecules - are e.g. for treatment of depression, hypertension, rheumatism, etc.
DE4201173A DE4201173C2 (en) 1992-01-17 1992-01-17 Acute drugs in the form of pellets containing dihydropyridine derivatives and their preparation
DEP4201179.5 1992-01-17
US07/876,864 US5405616A (en) 1992-01-17 1992-04-30 Means for containing active substances, having a shell of hydrophilic macromolecules, active substances and process for preparation thereof
US07/876,877 1992-04-30
US07/876,864 1992-04-30
US07/876,877 US5384129A (en) 1992-01-17 1992-04-30 Pellets containing dihydropyridine derivatives process for the production thereof and use as rapid action dosage in heart and circulatory diseases

Publications (2)

Publication Number Publication Date
CA2128244A1 true CA2128244A1 (en) 1993-07-22
CA2128244C CA2128244C (en) 1998-09-22

Family

ID=27435369

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002128244A Expired - Fee Related CA2128244C (en) 1992-01-17 1993-01-18 Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies

Country Status (10)

Country Link
EP (2) EP0701815B1 (en)
JP (1) JPH07502736A (en)
AT (2) ATE142484T1 (en)
AU (1) AU679906B2 (en)
CA (1) CA2128244C (en)
DE (2) DE59303759C5 (en)
DK (2) DK0621777T3 (en)
ES (2) ES2092808T3 (en)
GR (2) GR3021223T3 (en)
WO (1) WO1993013757A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714575B1 (en) * 1994-01-03 1996-02-02 Rhone Poulenc Nutrition Animal New granules containing living organisms for animal feed.
SE9704401D0 (en) * 1997-11-28 1997-11-28 Astra Ab Matrix pellets for greasy, oily or sticky drug substances
EP1243318B1 (en) * 2001-03-22 2005-03-02 Cognis Iberia, S.L. Microcapsules (VII)
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
FR2843302B1 (en) * 2002-08-09 2004-10-22 Centre Nat Rech Scient GALENIC FORM FOR COLLECTIVE DELIVERY OF ACTIVE PRINCIPLES
FR2843301B1 (en) * 2002-08-09 2004-10-22 Centre Nat Rech Scient GALENIC FORM FOR THE COLIC DELIVERY OF ACTIVE INGREDIENTS
ES2529568T3 (en) * 2002-10-16 2015-02-23 Medskin Solutions Dr. Suwelack Ag Use of molded bodies for external application
US9107804B2 (en) 2002-12-10 2015-08-18 Nortec Development Associates, Inc. Method of preparing biologically active formulations
US7872095B2 (en) 2004-07-19 2011-01-18 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
FR2887455B1 (en) * 2005-06-28 2007-08-10 Sanofi Aventis Sa FORMULATION WITH PROLONGED RELEASE OF ACTIVE MEDICINAL PRINCIPLES
CA2664315C (en) 2006-09-15 2016-01-19 Echo Pharmaceuticals B.V. Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances
JP2010503663A (en) * 2006-09-15 2010-02-04 エコ・ファーマシューティカルズ・ビー．ブイ． Granules containing pharmaceutically active substance and method for producing the same
US8273376B2 (en) 2006-11-17 2012-09-25 Da Volterra Colonic delivery of metallo-dependent enzymes
EP2243470A1 (en) 2009-04-22 2010-10-27 Dr. Suwelack Skin & Health Care AG Freeze-dried coated moulded body
AU2013296803B2 (en) * 2012-08-01 2018-03-08 Eric Ostertag Free flowing, frozen compositions comprising a therapeutic agent
ITMI20122145A1 (en) * 2012-12-14 2014-06-15 Velleja Res Srl COMPOSITIONS FOR ORAL USE HYDRO-LAYERED CONTAINERS OF COLLAGEN, ELASTIN AND VITAMIN C FAVOR THE EXTRA-CELLULAR MATRIX DEPOSITION
LU102656B1 (en) 2021-03-11 2022-09-12 Prosecur Gmbh Liquid food supplement for immune stimulation, process for its production and use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1248863B (en) * 1959-01-30
GB887901A (en) * 1960-04-13 1900-01-01
IE53696B1 (en) * 1981-12-02 1989-01-18 Wyeth John & Brother Ltd Solid shaped articles
EP0138216B1 (en) * 1983-10-14 1993-01-07 Sumitomo Pharmaceuticals Company, Limited Sustained-release ifn preparation for parenteral administration
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
US4642903A (en) * 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
FR2634121B1 (en) * 1988-07-13 1992-05-07 Imedex PROCESS FOR THE PREPARATION OF COLLAGEN MICROPARTICLES AND PRODUCTS OBTAINED
JPH02135052A (en) * 1988-11-17 1990-05-23 Taiyo Kagaku Co Ltd Preparation of granular food
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
FR2650502B1 (en) * 1989-08-07 1994-05-27 Delagrange Laboratoires NEW ORAL GALENIC FORM IMPROVING BIOAVAILABILITY
US5079018A (en) * 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5215756A (en) * 1989-12-22 1993-06-01 Gole Dilip J Preparation of pharmaceutical and other matrix systems by solid-state dissolution
JPH07502912A (en) 1992-01-17 1995-03-30 アルファテック−ファルマ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング Method for producing soft gelatin capsules based on the dropping method
ATE156350T1 (en) 1992-01-17 1997-08-15 Alfatec Pharma Gmbh PELLETS CONTAINING PEPTIDE MEDICINAL SUBSTANCES AND THEIR PRODUCTION AND USE
DE59306197D1 (en) 1992-01-17 1997-05-22 Alfatec Pharma Gmbh PLANT ACTIVE SUBSTANCE EXTRACTING CRYOPELLETED MOLDED BODIES AND THEIR PHARMACEUTICAL OR COSMETIC USE
DE4221880A1 (en) * 1992-07-03 1994-01-05 Alfatec Pharma Gmbh Solid and liquid solutions of poorly water-soluble drugs

Also Published As

Publication number Publication date
EP0621777A1 (en) 1994-11-02
GR3030675T3 (en) 1999-11-30
GR3021223T3 (en) 1997-01-31
CA2128244C (en) 1998-09-22
EP0621777B1 (en) 1996-09-11
ATE142484T1 (en) 1996-09-15
DK0621777T3 (en) 1996-10-21
DE59303759C5 (en) 2009-04-09
ES2133633T3 (en) 1999-09-16
EP0701815B1 (en) 1999-06-30
ATE181666T1 (en) 1999-07-15
JPH07502736A (en) 1995-03-23
ES2092808T3 (en) 1996-12-01
DE59309678D1 (en) 1999-08-05
DK0701815T3 (en) 2000-02-07
DE59303759D1 (en) 1996-10-17
AU679906B2 (en) 1997-07-17
AU3343293A (en) 1993-08-03
EP0701815A1 (en) 1996-03-20
WO1993013757A1 (en) 1993-07-22

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Legal Events

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