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CA2063030A1 - Substituted n-phenylpiperidines and drugs therefrom - Google Patents

Substituted n-phenylpiperidines and drugs therefrom

Info

Publication number
CA2063030A1
CA2063030A1 CA002063030A CA2063030A CA2063030A1 CA 2063030 A1 CA2063030 A1 CA 2063030A1 CA 002063030 A CA002063030 A CA 002063030A CA 2063030 A CA2063030 A CA 2063030A CA 2063030 A1 CA2063030 A1 CA 2063030A1
Authority
CA
Canada
Prior art keywords
see formula
substituted
radicals
alkyl
phenylpiperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002063030A
Other languages
French (fr)
Other versions
CA2063030C (en
Inventor
Wilfried Lubisch
Sabine Schult
Berthold Behl
Michael Kirchengast
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4117904A external-priority patent/DE4117904A1/en
Application filed by Individual filed Critical Individual
Publication of CA2063030A1 publication Critical patent/CA2063030A1/en
Application granted granted Critical
Publication of CA2063030C publication Critical patent/CA2063030C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Substituted N-phenylpiperid-ines I

(see formula I) (R1 = H, NO2, CN, halogen, C1-C4-alkyl, CF3, OCF3, OH, CH2OH, COOH, CHO, NH-CHO, NH2, CO-NH2, 5-tetrazinyl, R4-O-, R4-O-CH2-, R4-O-CO-, R4-CO-, R4-NH-CO, R4-CO-NH-, R4-SO2-NH-;
R2 = H, NO2, halogen, C1-C4-alkyl or R4-O-;
(see formula II) (see formula III) (see formula IV) (see formula V) (see formula VI) (see formula VII) (see formula VIII) R4 = C1-C4-alkyl or phenyl which can carry one of the R2 radicals;
R5, R6, H or one of the R4 radicals; R7 = one of the R1 radicals;
n = 0 or 1; m = 1 or 2;
with the proviso that R3 is (see formula IX) only when n is 1, and the optical isomers in the case of optical isomerism, and the physiologically tolerated acid addition salts, are suitable as drugs.
CA002063030A 1991-03-14 1992-03-13 Substituted n-phenylpiperidines and drugs therefrom Expired - Fee Related CA2063030C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4108184 1991-03-14
DEP4108184.6 1991-03-14
DE4117904A DE4117904A1 (en) 1991-05-31 1991-05-31 SUBSTITUTED N-PHENYLPIPERIDINES
DEP4117904.8 1991-05-31

Publications (2)

Publication Number Publication Date
CA2063030A1 true CA2063030A1 (en) 1992-09-15
CA2063030C CA2063030C (en) 2002-03-26

Family

ID=25901832

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002063030A Expired - Fee Related CA2063030C (en) 1991-03-14 1992-03-13 Substituted n-phenylpiperidines and drugs therefrom

Country Status (5)

Country Link
EP (1) EP0503411B1 (en)
JP (1) JP3058746B2 (en)
AT (1) ATE130851T1 (en)
CA (1) CA2063030C (en)
DE (1) DE59204456D1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184236B1 (en) 1998-08-18 2001-02-06 Hoffmann-La Roche Inc. Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative
EP0982026B1 (en) * 1998-08-18 2006-05-17 F. Hoffmann-La Roche Ag Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers
US7592450B2 (en) * 2002-03-13 2009-09-22 Janssen Pharmaceutica N.V. Piperazinyl-, piperidinyl- and morpholinyl-derivatives as inhibitors of histone deacetylase
JP4765627B2 (en) * 2003-09-22 2011-09-07 Ｍｓｄ株式会社 Novel piperidine derivatives
AR047759A1 (en) 2003-09-26 2006-02-22 Vertex Pharma FENIL DERIVATIVES - PIPERAZINE AS MODULATORS OF MUSCARNIC RECEPTORS
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP5187534B2 (en) * 2010-02-12 2013-04-24 有機合成薬品工業株式会社 Process for producing N-tert-butoxycarbonyl-4-formylpiperidine
WO2014140671A1 (en) * 2013-03-15 2014-09-18 Institut De Recherche Pour Le Developpement New arylaminoalcohol derivatives with antiplasmodial activity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE749887C (en) * 1941-10-02 1944-12-20 Process for the preparation of substituted 4-aminopiperidines
DK78744C (en) * 1949-07-20 1955-01-17 Knoll Ag Process for the preparation of 4- (N-phenyl-N-benzyl) -amino-1-alkylpiperidines or their derivatives substituted in the aromatic radicals.
GB1077173A (en) * 1965-03-19 1967-07-26 American Cyanamid Co Substituted alkylene piperidines and methods of preparation thereof
NL6703315A (en) * 1966-03-22 1967-09-25
EP0097000B1 (en) * 1982-06-10 1987-09-09 Beecham Wuelfing GmbH & Co KG Amine derivatives
US4902800A (en) * 1988-08-17 1990-02-20 American Home Products Corporation 1-Substituted-4-pyrrolidinopiperidines as inhibitors of interleukin 1
DE4032766A1 (en) * 1990-10-16 1992-04-30 Basf Ag PHENYLPIPERIDINOYLAMINE AND MEDICINAL PRODUCTS CONTAINING THEM

Also Published As

Publication number Publication date
JPH0578316A (en) 1993-03-30
ATE130851T1 (en) 1995-12-15
JP3058746B2 (en) 2000-07-04
EP0503411B1 (en) 1995-11-29
CA2063030C (en) 2002-03-26
EP0503411A1 (en) 1992-09-16
DE59204456D1 (en) 1996-01-11

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