BRPI0922345A2 - Composto, método para estabilizar uma célula isolada in vitro, para melhorar uma condição em um animal, e para manter e sobrevivência da célula tronco, e, população das células isoladas - Google Patents
Composto, método para estabilizar uma célula isolada in vitro, para melhorar uma condição em um animal, e para manter e sobrevivência da célula tronco, e, população das células isoladasInfo
- Publication number
- BRPI0922345A2 BRPI0922345A2 BRPI0922345-2A BRPI0922345A BRPI0922345A2 BR PI0922345 A2 BRPI0922345 A2 BR PI0922345A2 BR PI0922345 A BRPI0922345 A BR PI0922345A BR PI0922345 A2 BRPI0922345 A2 BR PI0922345A2
- Authority
- BR
- Brazil
- Prior art keywords
- isolated cell
- vitro
- stabilizing
- animal
- maintaining
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR122021005861-0A BR122021005861B1 (pt) | 2008-12-03 | 2009-12-03 | Composto, métodos para estabilizar uma célula animal isolada in vitro e para manter a sobrevivência da célula, e, composição |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20080808P | 2008-12-03 | 2008-12-03 | |
US61/200,808 | 2008-12-03 | ||
PCT/US2009/066554 WO2010065721A1 (en) | 2008-12-03 | 2009-12-03 | Stem cell cultures |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0922345A2 true BRPI0922345A2 (pt) | 2015-08-11 |
BRPI0922345B1 BRPI0922345B1 (pt) | 2022-03-22 |
Family
ID=42233609
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0922345-2A BRPI0922345B1 (pt) | 2008-12-03 | 2009-12-03 | Composto, métodos in vitro para estabilizar uma célula animal isolada e para manter a sobrevivência da célula, e, composição |
BR122021005861-0A BR122021005861B1 (pt) | 2008-12-03 | 2009-12-03 | Composto, métodos para estabilizar uma célula animal isolada in vitro e para manter a sobrevivência da célula, e, composição |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122021005861-0A BR122021005861B1 (pt) | 2008-12-03 | 2009-12-03 | Composto, métodos para estabilizar uma célula animal isolada in vitro e para manter a sobrevivência da célula, e, composição |
Country Status (15)
Country | Link |
---|---|
US (7) | US8691573B2 (pt) |
EP (7) | EP2789618B1 (pt) |
JP (6) | JP5793795B2 (pt) |
KR (1) | KR101551998B1 (pt) |
CN (2) | CN105001196B (pt) |
AU (7) | AU2009322346B2 (pt) |
BR (2) | BRPI0922345B1 (pt) |
CA (3) | CA3128456A1 (pt) |
ES (5) | ES2971914T3 (pt) |
HK (3) | HK1161590A1 (pt) |
IL (2) | IL213205A (pt) |
PT (1) | PT3623374T (pt) |
SG (2) | SG171903A1 (pt) |
WO (1) | WO2010065721A1 (pt) |
ZA (2) | ZA201104019B (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101551998B1 (ko) * | 2008-12-03 | 2015-09-09 | 더 스크립스 리서치 인스티튜트 | 줄기 세포 배양 |
CN105861446B (zh) | 2009-10-16 | 2021-10-01 | 斯克里普斯研究所 | 多能细胞的诱导 |
WO2011103196A1 (en) | 2010-02-17 | 2011-08-25 | Amgen Inc. | Aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain |
EP2655601A4 (en) | 2010-12-22 | 2014-09-10 | Fate Therapeutics Inc | CELL CULTURAL PLATFORM FOR INDIVIDUAL CELL SIZING AND IMPROVED RESOLUTION OF IPSCS |
CA2849244C (en) * | 2011-09-22 | 2023-10-10 | Karl Tryggvason | Cell culture substrate comprising a laminin and a cadherin |
ES2779152T3 (es) * | 2013-10-07 | 2020-08-13 | Kadmon Corporation Llc | Derivados de (2-(5-isoindolin-2-il)pirimidin-4-il)-amina como inhibidores de Rho-quinasa para tratar enfermedades autoinmunes |
WO2015134652A1 (en) | 2014-03-04 | 2015-09-11 | Bahram Valamehr | Improved reprogramming methods and cell culture platforms |
US10023879B2 (en) | 2014-06-04 | 2018-07-17 | Fate Therapeutics, Inc. | Minimal volume reprogramming of mononuclear cells |
CN105085489B (zh) | 2014-11-05 | 2019-03-01 | 益方生物科技(上海)有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
CN114058582A (zh) | 2015-01-26 | 2022-02-18 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
CN117737124A (zh) | 2015-10-16 | 2024-03-22 | 菲特治疗公司 | 用于诱导和维护基态多能性的平台 |
JP6928604B2 (ja) | 2015-11-04 | 2021-09-01 | フェイト セラピューティクス,インコーポレイテッド | 万能性細胞のゲノム改変 |
EP3371301A4 (en) | 2015-11-04 | 2019-06-26 | Fate Therapeutics, Inc. | METHOD AND COMPOSITIONS FOR INDUCING THE DIFFERENTIATION OF HEMATOPOIETIC CELLS |
EP3405568A4 (en) | 2016-01-20 | 2019-12-04 | Fate Therapeutics, Inc. | COMPOUNDS AND METHODS FOR IMMUNOCELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES |
WO2017156527A1 (en) * | 2016-03-11 | 2017-09-14 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Aurora kinase and janus kinase inhibitors for prevention of graft versus host disease |
CN106632057B (zh) * | 2016-08-23 | 2019-06-25 | 中国农业科学院兰州畜牧与兽药研究所 | 一种离子液体及利用其合成Thiazovivin的方法 |
JP7098615B2 (ja) | 2016-12-05 | 2022-07-11 | フェイト セラピューティクス,インコーポレイテッド | 養子免疫療法における免疫細胞調節のための組成物および方法 |
US20230065740A1 (en) | 2018-12-28 | 2023-03-02 | Spv Therapeutics Inc. | Cyclin-dependent kinase inhibitors |
JP7477983B2 (ja) * | 2020-02-12 | 2024-05-02 | 株式会社カネカ | 細胞凝集抑制剤 |
EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
US20240262815A1 (en) * | 2021-05-07 | 2024-08-08 | Voronoi Inc. | Heteroaryl derivative, method for preparing same, and pharmaceutical composition comprising same as active ingredient |
WO2023233339A1 (en) | 2022-06-01 | 2023-12-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
WO2023240248A2 (en) | 2022-06-09 | 2023-12-14 | Umoja Biopharma, Inc. | Compositions and methods for nk cell differentiation |
AU2023314782A1 (en) | 2022-07-27 | 2025-01-30 | Umoja Biopharma, Inc. | Differentiation of stem cells in suspension culture |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
EP0257275A3 (en) * | 1986-07-28 | 1990-05-23 | American Cyanamid Company | Cephalosporin and penicillin derivatives |
US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
IE66205B1 (en) | 1990-06-14 | 1995-12-13 | Paul A Bartlett | Polypeptide analogs |
US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
US5663046A (en) | 1994-06-22 | 1997-09-02 | Pharmacopeia, Inc. | Synthesis of combinatorial libraries |
US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5958792A (en) | 1995-06-07 | 1999-09-28 | Chiron Corporation | Combinatorial libraries of substrate-bound cyclic organic compounds |
US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
US6185506B1 (en) | 1996-01-26 | 2001-02-06 | Tripos, Inc. | Method for selecting an optimally diverse library of small molecules based on validated molecular structural descriptors |
WO1998017299A1 (en) | 1996-10-18 | 1998-04-30 | The Board Of Trustees Of The Leland Stanford Junior University | Isozyme-specific activators of protein kinase c, methods and compositions |
SE511957C2 (sv) | 1996-12-06 | 1999-12-20 | Ericsson Telefon Ab L M | Broadcasting över ATM |
US6399334B1 (en) | 1997-09-24 | 2002-06-04 | Invitrogen Corporation | Normalized nucleic acid libraries and methods of production thereof |
EP0928790B1 (en) * | 1998-01-02 | 2003-03-05 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
EP2241541A1 (en) | 1998-01-05 | 2010-10-20 | Neogenesis, Inc. | Method for identifying a member of a mass-coded combinatorial library |
US6841347B1 (en) | 1998-02-05 | 2005-01-11 | The General Hospital Corporation | In vivo construction of DNA libraries |
US6541211B1 (en) | 1998-05-20 | 2003-04-01 | Selectide Corporation | Apparatus and method for synthesizing combinational libraries |
AU7922900A (en) * | 1999-10-27 | 2001-05-08 | Novartis Ag | Thiazole and imidazo (4,5-b) pyridine compounds and their pharmaceutical use |
MXPA02009185A (es) | 2000-03-22 | 2003-05-23 | Cellemetry Llc | Metodo y aparato para registrar la ubicacion electronica de un aparato movil de comunicaciones celulares. |
WO2001090415A2 (en) | 2000-05-20 | 2001-11-29 | The Regents Of The University Of Michigan | Method of producing a dna library using positional amplification |
EP1299381B1 (en) * | 2000-06-28 | 2008-05-07 | AstraZeneca AB | Substituted quinazoline derivatives and their use as inhibitors |
JP3777158B2 (ja) | 2000-11-10 | 2006-05-24 | アミコージェン・インコーポレイテッド | 一方向性の一本鎖dna切片を用いた組換えdnaライブラリーの製造方法 |
US20020132823A1 (en) * | 2001-01-17 | 2002-09-19 | Jiahuai Han | Assay method |
JP3857270B2 (ja) | 2001-07-02 | 2006-12-13 | アストラゼネカ・アクチエボラーグ | ケモカイン受容体活性のモジュレーターとして有用なピペリジン誘導体 |
HN2002000156A (es) * | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización. |
EP1603905A1 (en) * | 2003-02-10 | 2005-12-14 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
EP2543376A1 (en) * | 2004-04-08 | 2013-01-09 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
ATE499370T1 (de) * | 2005-01-19 | 2011-03-15 | Bristol Myers Squibb Co | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3- aminderivate und verwandte verbindungen als p2y1- rezeptor-hemmer zur behandlung thromboembolischer erkrankungen |
EP1863794A2 (en) * | 2005-03-16 | 2007-12-12 | Targegen, Inc. | Pyrimidine compounds and methods of use |
US20090069360A1 (en) * | 2006-03-16 | 2009-03-12 | David Bryant Batt | Organic Compounds |
KR20090004976A (ko) * | 2006-04-19 | 2009-01-12 | 아스테라스 세이야쿠 가부시키가이샤 | 아졸카르복사미드 유도체 |
TW200808325A (en) * | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
CN101563449A (zh) * | 2006-09-22 | 2009-10-21 | 理化学研究所 | 干细胞培养基及干细胞培养方法 |
CA2668209A1 (en) * | 2006-10-31 | 2008-05-08 | Schering Corporation | Anilinopiperazine derivatives and methods of use thereof |
US20080182328A1 (en) * | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
PL2368555T3 (pl) | 2007-01-31 | 2017-02-28 | Biosuccess Biotech Company | Kompozycje i sposoby stosowania estrów forbolu |
US7838889B2 (en) | 2007-08-10 | 2010-11-23 | Eastman Kodak Company | Solid-state area illumination system |
MX2010004499A (es) * | 2007-10-24 | 2010-05-20 | Astellas Pharma Inc | Compuesto de azolcarboxamida o sal de el. |
NZ602832A (en) * | 2008-07-14 | 2014-04-30 | Gilead Sciences Inc | Fused heterocyclic hdac inhibitor compounds |
WO2010012793A1 (en) * | 2008-08-01 | 2010-02-04 | Bayer Cropscience Sa | Fungicide aminothiazole derivatives |
KR101551998B1 (ko) | 2008-12-03 | 2015-09-09 | 더 스크립스 리서치 인스티튜트 | 줄기 세포 배양 |
US8004201B2 (en) * | 2009-03-06 | 2011-08-23 | Himax Analogic, Inc. | LED circuit |
JO3421B1 (ar) | 2011-06-20 | 2019-10-20 | H Lundbeck As | طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية |
-
2009
- 2009-12-03 KR KR1020117015337A patent/KR101551998B1/ko active IP Right Grant
- 2009-12-03 EP EP14175853.2A patent/EP2789618B1/en active Active
- 2009-12-03 ES ES21189950T patent/ES2971914T3/es active Active
- 2009-12-03 CA CA3128456A patent/CA3128456A1/en active Pending
- 2009-12-03 BR BRPI0922345-2A patent/BRPI0922345B1/pt active IP Right Grant
- 2009-12-03 SG SG2011040003A patent/SG171903A1/en unknown
- 2009-12-03 ES ES09831108.7T patent/ES2489040T3/es active Active
- 2009-12-03 EP EP19205703.2A patent/EP3623374B1/en active Active
- 2009-12-03 JP JP2011539689A patent/JP5793795B2/ja active Active
- 2009-12-03 PT PT192057032T patent/PT3623374T/pt unknown
- 2009-12-03 ES ES16174428T patent/ES2712074T3/es active Active
- 2009-12-03 BR BR122021005861-0A patent/BR122021005861B1/pt active IP Right Grant
- 2009-12-03 US US13/132,379 patent/US8691573B2/en active Active
- 2009-12-03 CN CN201510256027.1A patent/CN105001196B/zh active Active
- 2009-12-03 AU AU2009322346A patent/AU2009322346B2/en active Active
- 2009-12-03 ES ES19205703T patent/ES2898303T3/es active Active
- 2009-12-03 EP EP21189950.5A patent/EP3936508B1/en active Active
- 2009-12-03 EP EP16174428.9A patent/EP3103804B1/en active Active
- 2009-12-03 ES ES18196634T patent/ES2779001T3/es active Active
- 2009-12-03 EP EP23207671.1A patent/EP4296270A3/en active Pending
- 2009-12-03 WO PCT/US2009/066554 patent/WO2010065721A1/en active Application Filing
- 2009-12-03 SG SG2014000269A patent/SG196784A1/en unknown
- 2009-12-03 EP EP09831108.7A patent/EP2370445B1/en active Active
- 2009-12-03 EP EP18196634.2A patent/EP3441394B1/en active Active
- 2009-12-03 CA CA2995883A patent/CA2995883C/en active Active
- 2009-12-03 CA CA2745266A patent/CA2745266C/en active Active
- 2009-12-03 CN CN200980156028.1A patent/CN102307882B/zh active Active
-
2011
- 2011-05-29 IL IL213205A patent/IL213205A/en active IP Right Grant
- 2011-05-31 ZA ZA2011/04019A patent/ZA201104019B/en unknown
- 2011-06-01 US US13/150,933 patent/US8044201B2/en active Active
-
2012
- 2012-02-21 HK HK12101691.6A patent/HK1161590A1/xx unknown
- 2012-03-22 HK HK12102882.3A patent/HK1162488A1/xx unknown
- 2012-08-14 ZA ZA2012/06083A patent/ZA201206083B/en unknown
-
2013
- 2013-10-10 IL IL228818A patent/IL228818A/en active IP Right Grant
-
2014
- 2014-02-24 US US14/188,616 patent/US9340525B2/en active Active
-
2015
- 2015-07-22 JP JP2015144532A patent/JP6127092B2/ja active Active
- 2015-09-23 AU AU2015230747A patent/AU2015230747B2/en active Active
-
2016
- 2016-04-14 US US15/098,546 patent/US9896655B2/en active Active
- 2016-04-22 HK HK16104657.8A patent/HK1216883A1/zh unknown
-
2017
- 2017-02-01 AU AU2017200667A patent/AU2017200667B2/en active Active
- 2017-04-10 JP JP2017077236A patent/JP6476398B2/ja active Active
-
2018
- 2018-01-05 US US15/863,501 patent/US10351822B2/en active Active
- 2018-05-03 AU AU2018203091A patent/AU2018203091B2/en active Active
- 2018-12-26 JP JP2018242072A patent/JP6860544B2/ja active Active
-
2019
- 2019-06-04 US US16/431,643 patent/US10975352B2/en active Active
- 2019-07-30 AU AU2019210531A patent/AU2019210531B2/en active Active
-
2021
- 2021-03-08 US US17/195,385 patent/US20210403862A1/en active Pending
- 2021-03-25 JP JP2021050945A patent/JP7256218B2/ja active Active
- 2021-07-01 AU AU2021204635A patent/AU2021204635B2/en active Active
-
2023
- 2023-03-30 JP JP2023054562A patent/JP7621405B2/ja active Active
- 2023-10-17 AU AU2023251440A patent/AU2023251440A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0922345A2 (pt) | Composto, método para estabilizar uma célula isolada in vitro, para melhorar uma condição em um animal, e para manter e sobrevivência da célula tronco, e, população das células isoladas | |
BRPI1009981A2 (pt) | sistemas , métodos e composições para otimizar os enxertos enriquecidos de tecido e célula | |
BRPI0912386A2 (pt) | composto, e, métodos para melhorar memória em um indivíduo e para tratar condições relacionadas a uma quinase | |
BRPI0908092A2 (pt) | Edulcorante, método para preparar uma composição edulcorante, e, composição edulcorante | |
BRPI0814299A2 (pt) | Preparação sólida, e, métodos para estabilizar um composto em uma preparação sólida, e para produzir uma preparação sólida | |
BRPI0916015A2 (pt) | "palmilha, método para fabricação de uma palmilha e calçado" | |
BRPI0912384A2 (pt) | composição, e, método para preparar uma composição | |
BRPI0914208A2 (pt) | célula de eletrólise, e, método | |
BRPI0904322A2 (pt) | Célula solar sensibilizada por corante, e, método para produção de uma célula solar sensibilizada por corante. | |
BRPI0807756A2 (pt) | Método para produzir um l-aminoácido. | |
BRPI0916689A2 (pt) | composição farmacêutica estabilizada, preparação sólida, e, métodos para estabilizar uma composição farmacêutica, e para estabilizar uma preparação sólida. | |
BRPI0924664A2 (pt) | eletrodo ,e ,método para construir um eletrodo. | |
IT1395716B1 (it) | Cuscinetto, meccanismo di fissaggio e metodo per fissare almeno un pattino. | |
PT1917029E (pt) | Um método de tratamento de células cancerígenas para criar uma célula cancerígena modificada que provoca uma resposta imunogénica | |
BRPI1013430A2 (pt) | Células acetogênicas, acetona e método para a fabricação da mesma | |
BRPI0716048A2 (pt) | bateria e mÉtodo para fabricaÇço de um catodo para uma bateria. | |
BRPI1011264A2 (pt) | método para fabricar uma bateria de eletrólito sólido, e, bateria de eletrólito sólido. | |
BRPI0916787A2 (pt) | artigo, e, método para fabricar um artigo | |
BRPI0717451A2 (pt) | Anodo para eletrólise | |
BRPI0918661A2 (pt) | hélice, vaso, e, método para montagem de uma hélice | |
BRPI0909552A2 (pt) | método, conjunto e kit para fixação de um artigo em uma superficie de suporte e artigo. | |
BRPI1013889A2 (pt) | Célula de levedura, e, método para gerar uma célula de levedura. | |
BR112012002771A2 (pt) | armação para uma célula galvânica, célula, galvânica, método para produzir uma célula galvânica e método para montar um bloco | |
BRPI0915289A2 (pt) | inserto para solas, sola, e, calçado. | |
BRPI0913136A2 (pt) | método para produzir uma peça e peça. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 513/02 Ipc: C07D 513/02 (2006.01), C07D 417/12 (2006.01), C07D |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/12/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |