BRPI0822012A2 - Derivados de quinazolina de 6,7-dialcóxi úteis para o tratamento de distúrbios relacionados com câncer - Google Patents

Derivados de quinazolina de 6,7-dialcóxi úteis para o tratamento de distúrbios relacionados com câncer

Info

Publication number: BRPI0822012A2
Authority: BR; Brazil
Prior art keywords: treating cancer; related disorders; derivatives useful; quinazoline derivatives; dialkoxy
Prior art date: 2008-01-18

Application number

BRPI0822012-3A

Other languages

English (en)

Inventor

Ramanadham Jyothu Prasad

Bhujanga Rao Adibhatla Kali Satya

Bollepalli Nageshwara Rao

Nannapaneni Venkaiah Chowdary

Original Assignee

Natco Pharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-01-18

Filing date

2008-01-18

Publication date

2015-07-21

2008-01-18 Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd

2015-07-21 Publication of BRPI0822012A2 publication Critical patent/BRPI0822012A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0822012-3A 2008-01-18 2008-01-18 Derivados de quinazolina de 6,7-dialcóxi úteis para o tratamento de distúrbios relacionados com câncer BRPI0822012A2 (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IN2008/000036 WO2009090661A1 (en)	2008-01-18	2008-01-18	6.7-dialkoxy ouinazoline derivatives useful for treatment of cancer related disorders

Publications (1)

Publication Number	Publication Date
BRPI0822012A2 true BRPI0822012A2 (pt)	2015-07-21

Family

ID=39769348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0822012-3A BRPI0822012A2 (pt)	2008-01-18	2008-01-18	Derivados de quinazolina de 6,7-dialcóxi úteis para o tratamento de distúrbios relacionados com câncer

Country Status (27)

Country	Link
US (5)	US8143250B2 (pt)
EP (2)	EP3012251B1 (pt)
JP (1)	JP2011509995A (pt)
KR (2)	KR101762306B1 (pt)
CN (1)	CN101918374A (pt)
AP (1)	AP2886A (pt)
AU (1)	AU2008347940A1 (pt)
BR (1)	BRPI0822012A2 (pt)
CA (1)	CA2711737C (pt)
CY (1)	CY1118193T1 (pt)
DK (2)	DK3012251T3 (pt)
EA (1)	EA018514B1 (pt)
ES (2)	ES2593321T3 (pt)
HR (1)	HRP20161522T1 (pt)
HU (1)	HUE030640T2 (pt)
IL (1)	IL207046A (pt)
LT (1)	LT2229369T (pt)
MA (1)	MA32081B1 (pt)
MX (1)	MX2010007852A (pt)
NZ (1)	NZ586946A (pt)
PL (1)	PL2229369T3 (pt)
PT (1)	PT2229369T (pt)
SG (1)	SG187490A1 (pt)
SI (1)	SI2229369T1 (pt)
UA (1)	UA101010C2 (pt)
WO (1)	WO2009090661A1 (pt)
ZA (1)	ZA201005116B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUE030640T2 (en) *	2008-01-18	2017-06-28	Natco Pharma Ltd	6,7 dialkoxy-quinazoline derivatives useful in the treatment of cancer-related disorders
US9050341B2 (en) *	2009-07-14	2015-06-09	Natco Pharma Limited	Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives
CN101857618B (zh) *	2010-06-13	2015-11-25	中国海洋大学	作为蛋白酪氨酸激酶抑制剂的一系列喹唑啉糖衍生物，其制备方法和应用
EP2766356B1 (en) *	2011-10-12	2018-08-01	Teligene Ltd.	Quinazoline derivatives as kinases inhibitors and methods of use thereof
AR092289A1 (es) *	2011-11-14	2015-04-15	Sunshine Lake Pharma Co Ltd	Derivados de aminoquinazolina y sus sales y metodos de uso
US9546179B2 (en) *	2011-12-20	2017-01-17	Wei Qian	Heterocycle amido alkyloxy substituted quinazoline derivative and use thereof
US20150087687A1 (en)	2012-03-23	2015-03-26	Dennis Brown	Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
EP3071204B1 (en) *	2013-11-20	2019-02-20	SignalChem Lifesciences Corp.	Quinazoline derivatives as tam family kinase inhibitors
WO2017062500A2 (en)	2015-10-05	2017-04-13	The Trustees Of Columbia University In The City Of New York	Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
AU2017409559B2 (en) *	2017-04-15	2021-08-19	Natco Pharma Limited	An improved process for the preparation of N-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin -4-amine dihydrochloride
CN111499577A (zh) *	2019-01-30	2020-08-07	华东师范大学	邻二苯基取代五元含氮芳杂环类类化合物及其应用
US20240285642A1 (en)	2021-06-10	2024-08-29	Natco Pharma Limited	Egfr inhibitor for the treatment of head and neck cancer
GB202108302D0 (en) *	2021-06-10	2021-07-28	Natco Pharma Ltd	New treatment
CN115518071B (zh) *	2021-06-24	2024-03-19	中国人民解放军联勤保障部队第九〇一医院	一种化合物在制备抗食管癌的药物中的应用
WO2024121861A1 (en) *	2022-12-08	2024-06-13	Natco Pharma Limited	Egfr inhibitor for the treatment of head and neck cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US690221A (en)	1901-06-20	1901-12-31	Frederik Christian Viggo Arp	Stand for cycles.
US5332671A (en) *	1989-05-12	1994-07-26	Genetech, Inc.	Production of vascular endothelial cell growth factor and DNA encoding same
US5183884A (en) *	1989-12-01	1993-02-02	United States Of America	Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
NZ243082A (en)	1991-06-28	1995-02-24	Ici Plc	4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
GB9300059D0 (en)	1992-01-20	1993-03-03	Zeneca Ltd	Quinazoline derivatives
US5811098A (en) *	1992-11-24	1998-09-22	Bristol-Myers Squibb Company	Antibodies to HER4, human receptor tyrosine kinase
GB9323290D0 (en)	1992-12-10	1994-01-05	Zeneca Ltd	Quinazoline derivatives
GB9314893D0 (en)	1993-07-19	1993-09-01	Zeneca Ltd	Quinazoline derivatives
GB9314884D0 (en)	1993-07-19	1993-09-01	Zeneca Ltd	Tricyclic derivatives
DE122005000053I2 (de)	1995-03-30	2008-01-17	Pfizer Prod Inc	Chinazolinderivate
GB9508538D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivatives
US5747498A (en)	1996-05-28	1998-05-05	Pfizer Inc.	Alkynyl and azido-substituted 4-anilinoquinazolines
US6706721B1 (en) *	1998-04-29	2004-03-16	Osi Pharmaceuticals, Inc.	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
UA74803C2 (uk)	1999-11-11	2006-02-15	Осі Фармасьютікалз, Інк.	Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
WO2005070909A1 (en)	2004-01-22	2005-08-04	Natco Pharma Limited	An improved process for the preparation of gefitinib
WO2006090413A1 (en)	2005-02-23	2006-08-31	Natco Pharma Limited	Novel crystalline form of gefitinib and a process for its preparation
PE20070207A1 (es) *	2005-07-22	2007-03-09	Genentech Inc	Tratamiento combinado de los tumores que expresan el her
WO2007060691A2 (en)	2005-11-23	2007-05-31	Natco Pharma Limited	A novel process for the preparation of erlotinib
HUE030640T2 (en) *	2008-01-18	2017-06-28	Natco Pharma Ltd	6,7 dialkoxy-quinazoline derivatives useful in the treatment of cancer-related disorders

2008
- 2008-01-18 HU HUE08720099A patent/HUE030640T2/en unknown
- 2008-01-18 JP JP2010542740A patent/JP2011509995A/ja active Pending
- 2008-01-18 SI SI200831672A patent/SI2229369T1/sl unknown
- 2008-01-18 DK DK15199926.5T patent/DK3012251T3/en active
- 2008-01-18 EP EP15199926.5A patent/EP3012251B1/en active Active
- 2008-01-18 PL PL08720099T patent/PL2229369T3/pl unknown
- 2008-01-18 PT PT87200994T patent/PT2229369T/pt unknown
- 2008-01-18 LT LTEP08720099.4T patent/LT2229369T/lt unknown
- 2008-01-18 KR KR1020167018317A patent/KR101762306B1/ko active IP Right Grant
- 2008-01-18 SG SG2013004064A patent/SG187490A1/en unknown
- 2008-01-18 AU AU2008347940A patent/AU2008347940A1/en not_active Abandoned
- 2008-01-18 AP AP2010005357A patent/AP2886A/xx active
- 2008-01-18 WO PCT/IN2008/000036 patent/WO2009090661A1/en active Application Filing
- 2008-01-18 ES ES08720099.4T patent/ES2593321T3/es active Active
- 2008-01-18 DK DK08720099.4T patent/DK2229369T3/en active
- 2008-01-18 CN CN2008801248191A patent/CN101918374A/zh active Pending
- 2008-01-18 BR BRPI0822012-3A patent/BRPI0822012A2/pt not_active Application Discontinuation
- 2008-01-18 KR KR1020107015858A patent/KR101640161B1/ko active IP Right Grant
- 2008-01-18 MX MX2010007852A patent/MX2010007852A/es active IP Right Grant
- 2008-01-18 NZ NZ586946A patent/NZ586946A/en unknown
- 2008-01-18 ES ES15199926.5T patent/ES2642159T3/es active Active
- 2008-01-18 CA CA2711737A patent/CA2711737C/en active Active
- 2008-01-18 UA UAA201010197A patent/UA101010C2/ru unknown
- 2008-01-18 EP EP08720099.4A patent/EP2229369B1/en active Active
- 2008-01-18 EA EA201001173A patent/EA018514B1/ru unknown
- 2008-01-18 US US12/812,726 patent/US8143250B2/en active Active
2010
- 2010-07-09 US US12/833,789 patent/US8921362B2/en active Active
- 2010-07-15 IL IL207046A patent/IL207046A/en active IP Right Grant
- 2010-07-19 ZA ZA2010/05116A patent/ZA201005116B/en unknown
- 2010-08-13 MA MA33089A patent/MA32081B1/fr unknown
2014
- 2014-12-26 US US14/583,286 patent/US9481655B2/en active Active
2016
- 2016-09-16 CY CY20161100921T patent/CY1118193T1/el unknown
- 2016-10-05 US US15/286,464 patent/US20170079983A1/en not_active Abandoned
- 2016-11-17 HR HRP20161522TT patent/HRP20161522T1/hr unknown
2019
- 2019-03-11 US US16/298,944 patent/US20190201408A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HRP20161522T1 (hr)	2017-02-10
ZA201005116B (en)	2011-03-30
US20190201408A1 (en)	2019-07-04
IL207046A (en)	2015-09-24
CN101918374A (zh)	2010-12-15
KR20160086969A (ko)	2016-07-20
US20110039844A1 (en)	2011-02-17
AP2886A (en)	2014-05-31
ES2593321T3 (es)	2016-12-07
SG187490A1 (en)	2013-02-28
EA018514B1 (ru)	2013-08-30
KR20100121468A (ko)	2010-11-17
LT2229369T (lt)	2016-09-26
EP3012251B1 (en)	2017-08-30
WO2009090661A9 (en)	2010-06-17
IL207046A0 (en)	2010-12-30
SI2229369T1 (sl)	2016-11-30
PL2229369T3 (pl)	2017-01-31
MA32081B1 (fr)	2011-02-01
US20110034459A1 (en)	2011-02-10
AP2010005357A0 (en)	2010-08-31
PT2229369T (pt)	2016-11-24
DK2229369T3 (en)	2016-12-12
KR101762306B1 (ko)	2017-07-27
MX2010007852A (es)	2010-11-30
WO2009090661A1 (en)	2009-07-23
EP2229369B1 (en)	2016-08-17
KR101640161B1 (ko)	2016-07-15
DK3012251T3 (en)	2017-10-09
US20150141421A1 (en)	2015-05-21
HUE030640T2 (en)	2017-06-28
UA101010C2 (ru)	2013-02-25
EA201001173A1 (ru)	2011-04-29
EP2229369A1 (en)	2010-09-22
CY1118193T1 (el)	2017-06-28
CA2711737A1 (en)	2009-07-23
NZ586946A (en)	2012-06-29
EP3012251A1 (en)	2016-04-27
AU2008347940A1 (en)	2009-07-23
CA2711737C (en)	2015-03-31
JP2011509995A (ja)	2011-03-31
US9481655B2 (en)	2016-11-01
ES2642159T3 (es)	2017-11-15
US8143250B2 (en)	2012-03-27
US20170079983A1 (en)	2017-03-23
US8921362B2 (en)	2014-12-30

Publication	Publication Date	Title
BRPI0822012A2 (pt)	2015-07-21	Derivados de quinazolina de 6,7-dialcóxi úteis para o tratamento de distúrbios relacionados com câncer
BRPI0814542A2 (pt)	2014-09-30	Métodos e composições para o tratamento de câncer, tumores e desordens relacionadas a tumores
BRPI0716844A2 (pt)	2013-10-22	Inidores de quinase úteis para o tratamento de doenças proliferativas
BRPI0911757A2 (pt)	2013-09-17	composiÇÕes e mÉtodos para tratar distérbios digestivos.
BRPI0922122A2 (pt)	2017-08-01	composições e métodos para tratamento de doença celíaca.
BRPI0811718A2 (pt)	2014-11-18	Derivados de 3,3-espiroindolinona
SMP200900085B (it)	2010-11-12	3-imidazolil-indoli per il trattamento di malattieproliferative.
BRPI0812293A2 (pt)	2014-11-25	Derivados de 2-oxo-3-benzilbenzoxazol-2 -ona e compostos relacionados como inibidores de met quinase para o tratamento de tumores
CL2007003049A1 (es)	2008-05-16	Compuestos derivados de 2,4-diaminopirimidina; composicion farmaceutica, utiles para tratar trastornos proliferativos.
ATE555107T1 (de)	2012-05-15	2-aza-bicyclo-ä2,2,1-üheptan-derivate
BRPI0816784A2 (pt)	2015-03-24	Fatores neuro-endócrinos para o tratamento de doenças degenerativas
DE602008005634D1 (de)	2011-04-28	1,1,1-trifluor-2-hydroxy-3-phenylpropan-derivate
GB2467710B (en)	2013-02-20	Methods for treating social disorders
BRPI0813670A2 (pt)	2014-12-30	Compostos para tratamento
BRPI0920334A2 (pt)	2016-03-01	métodos para o tratamento de distúrbios pulmonares com formulações de amicacina lipossomal.
BRPI0911577A2 (pt)	2016-01-05	derivados espiro-indol para o tratamento de doenças parasíticas.
EP2323649A4 (en)	2011-09-07	TREATMENT OF VARIOUS DISORDERS WITH 7,8-DIHYDROXY FLAVONE AND ITS DERIVATIVES
BRPI0818170A2 (pt)	2017-05-16	5-cianotienopiridinas para o tratamento de tumores.
BRPI0820440A2 (pt)	2015-05-26	Inibidores aldh-2 no tratamento de desordens psiquiátricas
BRPI1007995A2 (pt)	2019-09-24	orto-aminoamidas para o tratamento de cãncer.
BRPI0922884A2 (pt)	2018-11-06	compostos para tratamento de câncer
BRPI0906606A2 (pt)	2015-07-14	Tratamento terapêutico para condições do pulmão.
BRPI0811527A2 (pt)	2014-11-18	Derivados de arilamida pirimidona
BRPI0718324A2 (pt)	2013-11-26	Métodos para o tratamento de depressão.
BRPI0920728A2 (pt)	2015-08-18	Composição estabilizada para tratamento de psoríase

Legal Events

Date	Code	Title	Description
2015-10-13	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 3A ANUIDADE
2016-01-26	B08H	Application fees: decision cancelled [chapter 8.8 patent gazette]	Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2336 DE 13/10/2015.
2018-01-23	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-24	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-12-17	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-03-03	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2020-11-03	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2021-02-23	B09B	Patent application refused [chapter 9.2 patent gazette]
2021-05-04	B12B	Appeal against refusal [chapter 12.2 patent gazette]