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BRPI0606587A2 - uso de metilnaltrexona e compostos correlatos para tratar disfunção gastrintestinal pós-operatória - Google Patents

uso de metilnaltrexona e compostos correlatos para tratar disfunção gastrintestinal pós-operatória

Info

Publication number
BRPI0606587A2
BRPI0606587A2 BRPI0606587-2A BRPI0606587A BRPI0606587A2 BR PI0606587 A2 BRPI0606587 A2 BR PI0606587A2 BR PI0606587 A BRPI0606587 A BR PI0606587A BR PI0606587 A2 BRPI0606587 A2 BR PI0606587A2
Authority
BR
Brazil
Prior art keywords
methylnaltrexone
gastrointestinal dysfunction
related compounds
treat postoperative
postoperative gastrointestinal
Prior art date
Application number
BRPI0606587-2A
Other languages
English (en)
Inventor
Robert J Israel
Original Assignee
Progenics Pharmaceuticais Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenics Pharmaceuticais Inc filed Critical Progenics Pharmaceuticais Inc
Publication of BRPI0606587A2 publication Critical patent/BRPI0606587A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

USO DE METILNALTREXONA E COMPOSTOS CORRELATOS PARA TRATAR DISFUNçãO GASTRINTESTINAL PóS-OPERATóRIA. Métodos e composições para o tratamento pós-cirúrgico de disfunção gastrintestinal são providos. Os métodos incluem a administração de um derivado quaternário de noroximorfona (por ex., metilnaltrexona) a um paciente após uma colectomia segmental ser realizada no paciente.
BRPI0606587-2A 2005-01-20 2006-01-20 uso de metilnaltrexona e compostos correlatos para tratar disfunção gastrintestinal pós-operatória BRPI0606587A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64565205P 2005-01-20 2005-01-20
PCT/US2006/001939 WO2006078842A1 (en) 2005-01-20 2006-01-20 Use of methylnaltrexone and related compounds to treat post-operative gastrointestinal dysfunction

Publications (1)

Publication Number Publication Date
BRPI0606587A2 true BRPI0606587A2 (pt) 2009-07-07

Family

ID=36218809

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606587-2A BRPI0606587A2 (pt) 2005-01-20 2006-01-20 uso de metilnaltrexona e compostos correlatos para tratar disfunção gastrintestinal pós-operatória

Country Status (9)

Country Link
US (1) US20060205753A1 (pt)
EP (1) EP1845989A1 (pt)
JP (1) JP2008528497A (pt)
CN (1) CN101137378A (pt)
AU (1) AU2006206454A1 (pt)
BR (1) BRPI0606587A2 (pt)
CA (1) CA2595329A1 (pt)
MX (1) MX2007008756A (pt)
WO (1) WO2006078842A1 (pt)

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US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
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CA2945356C (en) 2007-03-29 2021-03-23 Progenics Pharmaceuticals, Inc. (r)-n-methylnaltrexone bromide and pharmaceutical compostitions therof useful as peripheral .mu. opioid receptor antagonist
JP5358587B2 (ja) 2008-02-06 2013-12-04 プロジェニックス・ファーマシューティカルス・インコーポレイテッド （ｒ），（ｒ）−２，２’−ビス−メチルナルトレキソンの製造及び用途
JP5647098B2 (ja) 2008-03-21 2014-12-24 ザ ユニヴァーシティー オヴ シカゴ オピオイド拮抗薬とｍＴＯＲ阻害薬を用いた治療
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Also Published As

Publication number Publication date
MX2007008756A (es) 2007-09-27
AU2006206454A1 (en) 2006-07-27
EP1845989A1 (en) 2007-10-24
CN101137378A (zh) 2008-03-05
WO2006078842A1 (en) 2006-07-27
JP2008528497A (ja) 2008-07-31
CA2595329A1 (en) 2006-07-27
US20060205753A1 (en) 2006-09-14

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