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BRPI0516340A - composto, composição farmacêutica, método para tratar uma condição que é regulada ou normalizada via inibição de dpp-iv, método para tratar um distúrbio metabólico, método para tratar diabete tipo ii, método para diminuir glicose no sangue, método para tratamento e profilaxia de uma doença, método para tratar toleráncia não prejudicada a glicose insulino-resistente, método para a manufatura de uma composição farmacêutica e processo para a preparação de compostos - Google Patents

composto, composição farmacêutica, método para tratar uma condição que é regulada ou normalizada via inibição de dpp-iv, método para tratar um distúrbio metabólico, método para tratar diabete tipo ii, método para diminuir glicose no sangue, método para tratamento e profilaxia de uma doença, método para tratar toleráncia não prejudicada a glicose insulino-resistente, método para a manufatura de uma composição farmacêutica e processo para a preparação de compostos

Info

Publication number
BRPI0516340A
BRPI0516340A BRPI0516340-4A BRPI0516340A BRPI0516340A BR PI0516340 A BRPI0516340 A BR PI0516340A BR PI0516340 A BRPI0516340 A BR PI0516340A BR PI0516340 A BRPI0516340 A BR PI0516340A
Authority
BR
Brazil
Prior art keywords
treating
pharmaceutical composition
substituted
unsubstituted
inhibition
Prior art date
Application number
BRPI0516340-4A
Other languages
English (en)
Inventor
Abraham Thomas
Balasubramanian Gopalan
Prasada Rao V S Lingam
Daisy Manish Shah
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35311627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0516340(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of BRPI0516340A publication Critical patent/BRPI0516340A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO PARA TRATAR UMA CONDIçãO QUE é REGULADA OU NORMALIZADA VIA INIBIçãO DE DPP-IV, MéTODO PARA TRATAR UM DISTúRBIO METABóLICO, MéTODO PARA TRATAR DIABETE TIPO II, MéTODO PARA DIMINUIR GLICOSE NO SANGUE, MéTODO PARA TRATAMENTO E PROFILAXIA DE UMA DOENçA, MéTODO PARA TRATAR TOLERáNCIA NãO PREJUDICADA A GLICOSE INSULINO-RESISTENTE , MéTODO PARA A MANUFATURA DE UMA COMPOSIçãO FAMACêUTICA E PROCESSO PARA A PREPARAçãO DE COMPOSTOS. A presente invenção refere-se aos novos compostos úteis como inibidores de dipeptidil peptidase IV (DPP-IV) da fórmula (1) na qual Y é -S(O)~ m~-, -CH~ 2~, -CHF, OU -CF~ 2~; m é O, 1, ou 2; X é uma ligação, alquila de C~ 1~ -C~ 5~, ou -C (=o) -;a linha tracejada ¢----! no anel carbocíclico representa uma dupla ligação opcional; R¹ é um grupo cicloalquila substituído ou não substituído, arila substituído ou não substituído, arilalquila substituído ou não substituído, heteroarila substituído ou não substituido, anel heterocíclico substituído ou não substituído heterociclilalquila substituído ou não substituído, heteroarilalquila substituído ou não substituído, -CN, - COOR³, -CONR³R¬ 4¬, -OR³, -NR³R¬ 4¬, ou NR³COR¬ 4¬; R² é hidrogênio, nitrila (-CN), COOH, ou isóstere de um ácido carboxílico (tais como SO~ 3~H, CONOH, B (OH)~ 2~, P0~ 3~ R³R¬ 4¬, SO~ 2~NR³R¬ 4¬ , tetrazol, -COOR³ , -CONR³R¬ 4¬ , -NR³COR¬ 4¬ , ou - COOCOR³).
BRPI0516340-4A 2004-10-12 2005-07-26 composto, composição farmacêutica, método para tratar uma condição que é regulada ou normalizada via inibição de dpp-iv, método para tratar um distúrbio metabólico, método para tratar diabete tipo ii, método para diminuir glicose no sangue, método para tratamento e profilaxia de uma doença, método para tratar toleráncia não prejudicada a glicose insulino-resistente, método para a manufatura de uma composição farmacêutica e processo para a preparação de compostos BRPI0516340A (pt)

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PCT/IB2005/002204 WO2006040625A1 (en) 2004-10-12 2005-07-26 Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation

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CA2583457C (en) 2013-01-29
TW200614988A (en) 2006-05-16
WO2006040625A1 (en) 2006-04-20
JP4959569B2 (ja) 2012-06-27
US7524844B2 (en) 2009-04-28
AR053415A1 (es) 2007-05-09
IL182444A0 (en) 2007-07-24
US20060142585A1 (en) 2006-06-29
KR20070073887A (ko) 2007-07-10
US20070238728A1 (en) 2007-10-11
MY142423A (en) 2010-11-30
JP2008515962A (ja) 2008-05-15
AP2007003973A0 (en) 2007-07-30
MX2007004305A (es) 2007-06-18
EA200700720A1 (ru) 2007-08-31
EA013463B1 (ru) 2010-04-30
US7538128B2 (en) 2009-05-26
US7205323B2 (en) 2007-04-17
AU2005293266B2 (en) 2011-09-29
AU2005293266A1 (en) 2006-04-20
US20070232608A1 (en) 2007-10-04
CA2583457A1 (en) 2006-04-20
NZ554515A (en) 2009-12-24
EP1799639B1 (en) 2013-09-04

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