Nothing Special   »   [go: up one dir, main page]

BRPI0311877B8 - formulação farmacêutica ácida de insulina com estabilidade aperfeiçoada - Google Patents

formulação farmacêutica ácida de insulina com estabilidade aperfeiçoada

Info

Publication number
BRPI0311877B8
BRPI0311877B8 BRPI0311877A BR0311877A BRPI0311877B8 BR PI0311877 B8 BRPI0311877 B8 BR PI0311877B8 BR PI0311877 A BRPI0311877 A BR PI0311877A BR 0311877 A BR0311877 A BR 0311877A BR PI0311877 B8 BRPI0311877 B8 BR PI0311877B8
Authority
BR
Brazil
Prior art keywords
insulin
pharmaceutical formulation
combinations
improved stability
acidic
Prior art date
Application number
BRPI0311877A
Other languages
English (en)
Other versions
BR0311877A (pt
BRPI0311877B1 (pt
Inventor
Brunner-Schwarz Anette
Lill Norbert
Original Assignee
Aventis Pharma Deutschland Gmbh
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29723248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0311877(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Deutschland Gmbh, Sanofi Aventis Deutschland filed Critical Aventis Pharma Deutschland Gmbh
Publication of BR0311877A publication Critical patent/BR0311877A/pt
Publication of BRPI0311877B1 publication Critical patent/BRPI0311877B1/pt
Publication of BRPI0311877B8 publication Critical patent/BRPI0311877B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

"preparações ácidas de insulina com estabilidade aperfeiçoada". a invenção refere-se a uma formulação farmacêutica contendo um polipeptídio escolhido a partir de um grupo contendo insulina, um metabólito de insulina, um análogo de insulina, um derivado de insulina ou combinações destes; um tensoativo ou combinações de vários tensoativos; eventualmente um conservante ou combinações de vários conservantes; e eventualmente um agente isotônico, tampão ou outras substâncias auxiliares ou combinações das mesmas, sendo que a formulação farmacêutica apresenta um valor de ph na faixa ácida.
BRPI0311877A 2002-06-18 2003-06-05 formulação farmacêutica ácida de insulina com estabilidade aperfeiçoada BRPI0311877B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10227232A DE10227232A1 (de) 2002-06-18 2002-06-18 Saure Insulinzubereitungen mit verbesserter Stabilität
PCT/EP2003/005887 WO2003105888A1 (de) 2002-06-18 2003-06-05 Saure insulinzubereitungen mit verbesserter stabilität

Publications (3)

Publication Number Publication Date
BR0311877A BR0311877A (pt) 2005-04-05
BRPI0311877B1 BRPI0311877B1 (pt) 2017-04-11
BRPI0311877B8 true BRPI0311877B8 (pt) 2021-05-25

Family

ID=29723248

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0311877A BRPI0311877B8 (pt) 2002-06-18 2003-06-05 formulação farmacêutica ácida de insulina com estabilidade aperfeiçoada

Country Status (38)

Country Link
US (4) US20040048783A1 (pt)
EP (2) EP1517697B1 (pt)
JP (2) JP5237522B2 (pt)
KR (1) KR101040029B1 (pt)
CN (2) CN1662252A (pt)
AR (1) AR039688A1 (pt)
AU (1) AU2003238471B2 (pt)
BR (1) BRPI0311877B8 (pt)
CA (1) CA2490116C (pt)
CR (1) CR7614A (pt)
CY (1) CY1113537T1 (pt)
DE (1) DE10227232A1 (pt)
DK (1) DK1517697T3 (pt)
EC (1) ECSP045496A (pt)
ES (2) ES2817879T3 (pt)
HN (1) HN2003000184A (pt)
HR (1) HRP20041200B1 (pt)
IL (1) IL165788A (pt)
MA (1) MA27205A1 (pt)
ME (1) MEP28708A (pt)
MX (1) MXPA04012233A (pt)
MY (1) MY142354A (pt)
NO (1) NO328567B1 (pt)
NZ (1) NZ537211A (pt)
OA (1) OA12870A (pt)
PA (1) PA8575701A1 (pt)
PE (1) PE20040560A1 (pt)
PL (1) PL208773B1 (pt)
PT (2) PT2305288T (pt)
RS (1) RS52388B (pt)
RU (1) RU2313362C2 (pt)
SV (1) SV2004001556A (pt)
TN (1) TNSN04249A1 (pt)
TW (1) TWI315201B (pt)
UA (1) UA79477C2 (pt)
UY (1) UY27854A1 (pt)
WO (1) WO2003105888A1 (pt)
ZA (1) ZA200409273B (pt)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
PT1740154E (pt) * 2004-03-12 2009-09-11 Biodel Inc Composições de insulina com absorção melhorada
EP1758540A4 (en) * 2004-05-24 2007-06-20 Wockhardt Ltd PURIFICATION OF INSULIN-LIKE MATERIAL BY REVERSE-PHASE CHROMATOGRAPHY
UA75030C2 (en) * 2005-11-30 2006-03-15 Viktor Oleksandrovych Bykov Method for obtaining stable aqueous solutions of drugs
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
DE102006031962A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
US20100120660A1 (en) * 2007-04-30 2010-05-13 Per Balschmidt Highly concentrated insulin solutions and compositions
MX2010007342A (es) * 2008-01-04 2010-08-26 Biodel Inc Formulaciones de insulina para la liberacion de insulina como una funcion de los niveles de glucosa en el tejido.
AU2009203810B2 (en) 2008-01-09 2013-07-25 Sanofi-Aventis Deutschland Gmbh Novel insulin derivatives having an extremely delayed time-action profile
BRPI0907371A2 (pt) 2008-01-09 2015-11-24 Sanofi Aventis Deutschland derivados de insulina com um perfil de tempo-ação muito retardado
MX2011002255A (es) * 2008-08-29 2011-05-25 Genzyme Corp Formulaciones de peptidos liberados controlados.
WO2010028055A1 (en) * 2008-09-02 2010-03-11 Biodel, Inc. Insulin with a basal release profile
DK2349324T3 (en) 2008-10-17 2017-12-11 Sanofi Aventis Deutschland COMBINATION OF AN INSULIN AND A GLP-1 AGONIST
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
PT2451437T (pt) * 2009-07-06 2017-01-17 Sanofi Aventis Deutschland Preparações aquosas de insulina contendo metionina
MY180661A (en) 2009-11-13 2020-12-04 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
UY33025A (es) 2009-11-13 2011-06-30 Sanofi Aventis Deustschland Gmbh Composicion farmaceutica que comprende un agonista de glp-1 metionina
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
US8637458B2 (en) 2010-05-12 2014-01-28 Biodel Inc. Insulin with a stable basal release profile
AU2011202239C1 (en) * 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
WO2011156476A2 (en) * 2010-06-08 2011-12-15 Biodel Inc. Insulin with a basal release profile
PL2611458T3 (pl) 2010-08-30 2017-02-28 Sanofi-Aventis Deutschland Gmbh Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
CN102188367B (zh) * 2011-01-05 2012-11-07 山东新时代药业有限公司 一种甘精胰岛素注射液及其制备方法
JP2014504597A (ja) 2011-01-20 2014-02-24 ジーランド ファーマ アクティーゼルスカブ アシル化グルカゴン類似体とインスリン類似体の組合せ物
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AU2012293463B2 (en) * 2011-08-10 2016-08-04 Adocia Injectable solution of at least one type of basal insulin
AU2012300978B2 (en) 2011-08-29 2017-04-27 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
WO2013063292A1 (en) 2011-10-25 2013-05-02 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US10350139B2 (en) 2011-10-25 2019-07-16 Corning Incorporated Pharmaceutical glass packaging assuring pharmaceutical sterility
WO2013104861A1 (fr) 2012-01-09 2013-07-18 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide substitue
US20150314003A2 (en) 2012-08-09 2015-11-05 Adocia Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
MX360107B (es) 2012-11-13 2018-10-23 Adocia Formulación de acción rápida de insulina que comprende un compuesto aniónico sustituido.
RU2015129087A (ru) 2012-12-19 2017-02-02 Вокхардт Лимитед Стабильная водная композиция, содержащая инсулин человека или его аналог или производное
SG11201503576XA (en) 2012-12-21 2015-06-29 Sanofi Sa Exendin-4 Derivatives
CN104870469A (zh) 2012-12-26 2015-08-26 沃克哈特有限公司 药物组合物
TWI641381B (zh) * 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
KR102180215B1 (ko) 2013-04-03 2020-11-18 사노피 장시간-작용 제형의 인슐린에 의한 당뇨병의 치료
US9707153B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9700486B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9707154B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9603775B2 (en) 2013-04-24 2017-03-28 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9713572B2 (en) 2013-04-24 2017-07-25 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9717649B2 (en) 2013-04-24 2017-08-01 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9707155B2 (en) 2013-04-24 2017-07-18 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9839579B2 (en) 2013-04-24 2017-12-12 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9700485B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9717648B2 (en) 2013-04-24 2017-08-01 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US9849066B2 (en) 2013-04-24 2017-12-26 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
EP3080149A1 (en) 2013-12-13 2016-10-19 Sanofi Dual glp-1/glucagon receptor agonists
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／ｇｉｐ受體促效劑
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
JP7173953B2 (ja) * 2014-01-09 2022-11-16 サノフイ インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
US9895424B2 (en) 2014-01-09 2018-02-20 Sanofi Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
JP6641280B2 (ja) 2014-01-09 2020-02-05 サノフイＳａｎｏｆｉ インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
SG11201604706TA (en) 2014-01-09 2016-07-28 Sanofi Sa Stabilized pharmaceutical formulations of insulin aspart
AU2015206890B2 (en) 2014-01-20 2019-05-23 Hanmi Pharm. Co., Ltd. Long-acting insulin and use thereof
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
AR100695A1 (es) 2014-05-30 2016-10-26 Hanmi Pharm Ind Co Ltd Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
KR102569907B1 (ko) * 2014-10-23 2023-08-24 엔지엠 바이오파마슈티컬스, 아이엔씨. 펩티드 변이체를 포함하는 약제학적 조성물 및 그의 사용 방법
JP6970615B2 (ja) 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリングラルギン／リキシセナチド固定比処方
AR102869A1 (es) 2014-12-16 2017-03-29 Lilly Co Eli Composiciones de insulina de rápida acción
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
WO2017179615A1 (ja) * 2016-04-15 2017-10-19 富士フイルム株式会社 マイクロニードルアレイ及びマイクロニードルアレイの製造方法
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
US11396534B2 (en) 2016-09-23 2022-07-26 Hanmi Pharm. Co., Ltd. Insulin analogs with reduced affinity to insulin receptor and use thereof
CA3054899A1 (en) 2017-03-23 2018-09-27 Hanmi Pharm. Co., Ltd. Insulin analog complex with reduced affinity for insulin receptor and use thereof
NZ758298A (en) 2017-06-01 2022-11-25 Lilly Co Eli Rapid-acting insulin compositions
WO2020239837A1 (en) * 2019-05-29 2020-12-03 Sanofi Drug delivery device

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868358A (en) 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product
US3758683A (en) 1971-04-30 1973-09-11 R Jackson Insulin product
US4153689A (en) * 1975-06-13 1979-05-08 Takeda Chemical Industries, Ltd. Stable insulin preparation for nasal administration
GB1554157A (en) * 1975-06-13 1979-10-17 Takeda Chemical Industries Ltd Stable insulin preparation for intra nasal administration
GB1527605A (en) * 1975-08-20 1978-10-04 Takeda Chemical Industries Ltd Insulin preparation for intranasal administration
JPS52156913A (en) * 1976-06-21 1977-12-27 Toko Yakuhin Kogyo Kk Production of injectionable medicine
EP0018609B1 (de) 1979-04-30 1983-09-21 Hoechst Aktiengesellschaft Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
US4783441A (en) 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
JPS55153712A (en) 1979-05-18 1980-11-29 Kao Corp Insulin pharmaceutical preparation and its production
DE3033127A1 (de) 1980-09-03 1982-04-08 Hoechst Ag, 6000 Frankfurt Neue analoga des insulins
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
EP0083619A1 (en) 1981-07-17 1983-07-20 Nordisk Insulinlaboratorium A stable aqueous, therapeutic insulin preparation and a process for preparing it
NL193099C (nl) 1981-10-30 1998-11-03 Novo Industri As Gestabiliseerde insuline-oplossing.
DE3316363A1 (de) 1983-05-05 1984-11-08 Deutsche Babcock Anlagen Ag, 4200 Oberhausen Walzenrost fuer muellverbrennungsanlagen
DE3326473A1 (de) 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3326472A1 (de) 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
US5177068A (en) * 1984-04-19 1993-01-05 National Research Development Corporation Pharmaceutical compositions
CA1244347A (en) 1984-05-29 1988-11-08 Eddie H. Massey Stabilized insulin formulations
US4839341A (en) * 1984-05-29 1989-06-13 Eli Lilly And Company Stabilized insulin formulations
DE3576120D1 (de) * 1984-06-09 1990-04-05 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DK347086D0 (da) 1986-07-21 1986-07-21 Novo Industri As Novel peptides
DK113585D0 (da) 1985-03-12 1985-03-12 Novo Industri As Nye peptider
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
EP0200383A3 (en) 1985-04-15 1987-09-02 Eli Lilly And Company An improved method for administering insulin
DE3526995A1 (de) 1985-07-27 1987-02-05 Hoechst Ag Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US5496924A (en) 1985-11-27 1996-03-05 Hoechst Aktiengesellschaft Fusion protein comprising an interleukin-2 fragment ballast portion
DE3541856A1 (de) 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
CA1275922C (en) 1985-11-28 1990-11-06 Harunobu Amagase Treatment of cancer
DE3544295A1 (de) 1985-12-14 1987-06-19 Bayer Ag Thermoplastische formmassen mit hoher kriechstromfestigkeit
DE10075034I1 (de) 1987-02-25 2001-05-23 Novo Nordisk As Insulinderivate
US5034415A (en) 1987-08-07 1991-07-23 Century Laboratories, Inc. Treatment of diabetes mellitus
DE3726655A1 (de) 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
DK257988D0 (da) 1988-05-11 1988-05-11 Novo Industri As Nye peptider
DE3827533A1 (de) 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5210038A (en) * 1988-12-22 1993-05-11 Becton, Dickinson And Company Multiplate subculture solid media devices
JPH04502465A (ja) 1988-12-23 1992-05-07 ノボ　ノルディスク　アクティーゼルスカブ ヒトインシュリン類似物質
US4994439A (en) * 1989-01-19 1991-02-19 California Biotechnology Inc. Transmembrane formulations for drug administration
PT93057B (pt) 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
US4886164A (en) * 1989-06-16 1989-12-12 Enviro Med, Inc. Containers for medical waste
US5358857A (en) 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
DE69129110T2 (de) 1990-05-10 1998-12-10 Bechgaard International Research And Development A/S, Hellerup Pharmazeutische zubereitung enthaltend n-glykofurole und n-äthylenglykole
US5397771A (en) 1990-05-10 1995-03-14 Bechgaard International Research And Development A/S Pharmaceutical preparation
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
DK10191D0 (da) 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
US6468959B1 (en) 1991-12-05 2002-10-22 Alfatec-Pharm Gmbh Peroral dosage form for peptide containing medicaments, in particular insulin
US5614219A (en) 1991-12-05 1997-03-25 Alfatec-Pharma Gmbh Oral administration form for peptide pharmaceutical substances, in particular insulin
DE4140186C2 (de) * 1991-12-05 1996-07-04 Alfatec Pharma Gmbh Perorale Applikationsform für Peptidarzneistoffe, insbesondere Insulin
SG46612A1 (en) 1992-12-02 1998-02-20 Hoechst Ag Process for obtaining proinsulin in processing correctly linked cystine bridges
PL310007A1 (en) 1992-12-18 1995-11-13 Lilly Co Eli Insulin analogues
JP2743761B2 (ja) * 1993-03-19 1998-04-22 松下電器産業株式会社 走査型プローブ顕微鏡および原子種同定方法
US5514656A (en) * 1993-05-28 1996-05-07 Abbott Laboratories Method of providing enteral nutritional support for patients undergoing radiation therapy and/or chemotherapy
US5882944A (en) 1993-06-23 1999-03-16 The Regents Of The University Of California Methods for G protein coupled receptor activity screening
US5506203C1 (en) 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
EP0637073A1 (en) * 1993-07-29 1995-02-01 STMicroelectronics S.r.l. Process for realizing low threshold P-channel MOS transistors for complementary devices (CMOS)
US5534488A (en) 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
DE4405179A1 (de) 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
DE4406467A1 (de) * 1994-02-23 1995-08-24 Dragoco Gerberding Co Ag Isolongifolanol-Derivate, ihre Herstellung und ihre Verwendung
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5559094A (en) 1994-08-02 1996-09-24 Eli Lilly And Company AspB1 insulin analogs
AU695323B2 (en) 1994-09-09 1998-08-13 Takeda Chemical Industries Ltd. Sustained release preparation containing metal salt of a peptide
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US5707641A (en) 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
US5496164A (en) * 1994-10-20 1996-03-05 The Conair Group, Inc. In-line tubing die
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
EP0831922A2 (en) 1995-06-08 1998-04-01 Therexsys Limited Improved pharmaceutical compositions for gene therapy
CA2224381A1 (en) 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. Method of producing sustained-release preparation
JPH11292787A (ja) * 1995-08-15 1999-10-26 Asahi Chem Ind Co Ltd 生理活性ペプチドを含有する経粘膜投与製剤
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5948751A (en) 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
US5656772A (en) * 1996-07-19 1997-08-12 Markel; Philip A. Gas pressure gauge clamp
US5783556A (en) * 1996-08-13 1998-07-21 Genentech, Inc. Formulated insulin-containing composition
US6310038B1 (en) 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
US6043214A (en) * 1997-03-20 2000-03-28 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
IL131796A0 (en) 1997-03-20 2001-03-19 Novo Nordisk As Zinc free insulin crystals for use in pulmonary compositions
ZA984697B (en) 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
ZA989744B (en) 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
EP1044016B1 (en) 1998-01-09 2005-03-16 Novo Nordisk A/S Stabilised insulin compositions
AU758146B2 (en) 1998-10-16 2003-03-13 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
US6211144B1 (en) * 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
US6489292B1 (en) 1998-11-18 2002-12-03 Novo Nordisk A/S Stable aqueous insulin preparations without phenol and cresol
DE19908041A1 (de) 1999-02-24 2000-08-31 Hoecker Hartwig Kovalent verbrückte Insulindimere
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6720001B2 (en) 1999-10-18 2004-04-13 Lipocine, Inc. Emulsion compositions for polyfunctional active ingredients
CA2394213A1 (en) 1999-12-16 2001-06-21 Eli Lilly And Company Polypeptide compositions with improved stability
WO2001052937A1 (en) 2000-01-24 2001-07-26 Medtronic Minimed, Inc. Mixed buffer system for stabilizing polypeptide formulations
JP4711520B2 (ja) * 2000-03-21 2011-06-29 日本ケミカルリサーチ株式会社 生理活性ペプチド含有粉末
US6267481B1 (en) * 2000-04-05 2001-07-31 Jeng Tai Umbrella Mfg., Corp. Illumination assembly for an umbrella
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
CN1160122C (zh) * 2001-04-20 2004-08-04 清华大学 一种制备口服胰岛素油相制剂的方法
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US6960551B2 (en) * 2002-08-23 2005-11-01 Exxonmobil Research And Engineering Company Functionalized periodic mesoporous materials, their synthesis and use
US6906897B1 (en) * 2003-02-28 2005-06-14 Western Digital Technologies, Inc. Disk drive including an actuator main coil and an actuator secondary coil with a lateral segment and method of operating same

Also Published As

Publication number Publication date
JP2011006492A (ja) 2011-01-13
RU2005100959A (ru) 2005-06-27
CA2490116C (en) 2012-07-24
HRP20041200B1 (hr) 2013-05-31
EP2305288A2 (de) 2011-04-06
US20050171009A1 (en) 2005-08-04
AU2003238471B2 (en) 2009-02-19
RU2313362C2 (ru) 2007-12-27
EP2305288A3 (de) 2013-12-11
US7476652B2 (en) 2009-01-13
DK1517697T3 (da) 2013-01-28
PA8575701A1 (es) 2004-02-07
ES2817879T3 (es) 2021-04-08
PT1517697E (pt) 2012-12-17
ME00180B (me) 2010-10-10
JP5237522B2 (ja) 2013-07-17
MA27205A1 (fr) 2005-01-03
EP1517697B1 (de) 2012-10-10
RS52388B (sr) 2013-02-28
KR101040029B1 (ko) 2011-06-10
MEP28708A (en) 2010-10-10
US20090082255A1 (en) 2009-03-26
SV2004001556A (es) 2004-03-08
CR7614A (es) 2005-06-16
PE20040560A1 (es) 2004-09-24
AU2003238471A1 (en) 2003-12-31
ECSP045496A (es) 2005-03-10
ZA200409273B (en) 2005-08-31
PT2305288T (pt) 2020-09-16
BR0311877A (pt) 2005-04-05
US7713930B2 (en) 2010-05-11
CN1662252A (zh) 2005-08-31
US20100216692A1 (en) 2010-08-26
JP2005532365A (ja) 2005-10-27
AR039688A1 (es) 2005-03-09
EP2305288B1 (de) 2020-07-15
UY27854A1 (es) 2003-12-31
PL372072A1 (en) 2005-07-11
BRPI0311877B1 (pt) 2017-04-11
HRP20041200A2 (en) 2005-06-30
HN2003000184A (es) 2008-01-15
OA12870A (en) 2006-09-15
TW200409642A (en) 2004-06-16
NO328567B1 (no) 2010-03-22
RS105704A (sr) 2007-02-05
WO2003105888A1 (de) 2003-12-24
UA79477C2 (en) 2007-06-25
CN102133393A (zh) 2011-07-27
NO20050036L (no) 2005-01-04
TNSN04249A1 (en) 2007-03-12
IL165788A0 (en) 2006-01-15
US20040048783A1 (en) 2004-03-11
MY142354A (en) 2010-11-15
PL208773B1 (pl) 2011-06-30
CY1113537T1 (el) 2016-06-22
CA2490116A1 (en) 2003-12-24
IL165788A (en) 2011-05-31
CN102133393B (zh) 2014-05-28
DE10227232A1 (de) 2004-01-15
NZ537211A (en) 2006-08-31
MXPA04012233A (es) 2005-02-25
EP1517697A1 (de) 2005-03-30
TWI315201B (en) 2009-10-01
KR20050010939A (ko) 2005-01-28
ES2397158T3 (es) 2013-03-05

Similar Documents

Publication Publication Date Title
BRPI0311877B8 (pt) formulação farmacêutica ácida de insulina com estabilidade aperfeiçoada
BRPI0208210B8 (pt) preparação de insulina pobre em zinco e isenta de zinco com estabilidade aperfeiçoada
BR0315767A (pt) Composição imunogência, método para fabricar uma vacina, kit, vacina, recipiente com uma superfìcie interna repelente à água, e, método para preservar uma composição que compreende ipv e um agente estabilizador
PE20110236A1 (es) Proteccion y mejoramiento de celulas, tejidos y organos que responden a la eritropoyetina
BR0112461A (pt) Composições que contém componentes terapeuticamente ativos tendo uma solubilidade aumentada
UY26704A1 (es) Nueva composición farmacéutica
AR030245A1 (es) Composiciones de gel que contienen metronidazol
UY25055A1 (es) Formulaciones farmacéuticas que contienen voriconazol
BRPI0409516A (pt) composição, uso de uma composição e processo de melhora da penetração de um ativo farmacêutico
FI964285A (fi) Taksaanien luokkaan kuuluviin johdannaisiin perustuvat farmaseuttiset valmisteet
ES2181501T3 (es) Composicion cosmetica.
PE20001296A1 (es) El uso de una combinacion de tipranavir y ritonavir para mejorar la farmacocinetica del tipranavir
BR0013012A (pt) Composição contendo substância ativa, sua produção e seu uso
ATE367165T1 (de) Xanthangummi enthaltende reepithelialisierende pharmazeutische zubereitungen
DE60101486D1 (de) Verwendung von Polyaminosäurederivate als Konservierungsmittel
SV1998000040A (es) Composiciones farmaceuticas ref. pu3210/sv
BR0206960A (pt) Composição farmacêutica oral, e, uso de um polìmero de ftalato de hidroxipropilmetilcelulose
ES2136464T3 (es) Procedimiento de teñido por oxidacion en dos tiempos de las fibras queratinicas con una sal o un complejo de manganeso y un 1-naftol 4-sustituido y kit de teñido.
BR0009778A (pt) Composições antifúngicas de pseudomicina e métodos para utilização das mesmas
BR9903337A (pt) Composição cosmética lìquida aquosa transparente com uma só fase, utilização cosmética da composição e processo para solubilizar um parahidroxibenzoato de alquila
RS50074B (sr) Farmaceutski preparat koji sadrži paracetamol i drotaverin
PE20241354A1 (es) Formulaciones conservadas
KR960033462A (ko) 필란두스(Phyllanthus) 속 식물의 추출물을 포함하는 B형 간염 치료제
CO5680394A2 (es) Composiciones farmaceuticas acuosas de 2,6 diisopropilfenol
KR940018095A (ko) 항알러지성 의약조성물

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 11/04/2017, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/06/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF