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BR9910898A - Indolinones substituted, preparation and use of them as pharmaceutical compositions - Google Patents

Indolinones substituted, preparation and use of them as pharmaceutical compositions

Info

Publication number
BR9910898A
BR9910898A BR9910898-4A BR9910898A BR9910898A BR 9910898 A BR9910898 A BR 9910898A BR 9910898 A BR9910898 A BR 9910898A BR 9910898 A BR9910898 A BR 9910898A
Authority
BR
Brazil
Prior art keywords
preparation
pharmaceutical compositions
indolinones
substituted
specifically
Prior art date
Application number
BR9910898-4A
Other languages
Portuguese (pt)
Inventor
Armin Heckel
Rainer Walter
Wolfgang Grell
Jacobus C A Van Meel
Norbert Redemann
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BR9910898A publication Critical patent/BR9910898A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Patente de Invenção: <B>"INDOLINONAS SUBSTITUìDAS, PREPARAçãO E UTILIZAçãO DAS MESMAS COMO COMPOSIçõES FARMACêUTICAS"<D>. A presente invenção refere-se as indolinonas substituídas da fórmula geral: onde R~ 1~ a R~ 5~ e X são definidos de acordo com a reivindicação 1, os isómeros e sais dos mesmos, especificamente os sais fisiologicamente aceitáveis dos mesmos que possuem propriedades farmacológicas valiosas, especificamente um efeito inibidor nas várias quinases e complexos de ciclina/CDK e na proliferação das várias células de tumor, composições farmacêuticas contendo estes compostos, seu uso e processos para preparação dos mesmos.Invention Patent: <B> "SUBSTITUTED INDOLINONES, PREPARATION AND USE OF THE SAME AS PHARMACEUTICAL COMPOSITIONS" <D>. The present invention relates to the substituted indolinones of the general formula: where R ~ 1 ~ to R ~ 5 ~ and X are defined according to claim 1, the isomers and salts thereof, specifically the physiologically acceptable salts thereof, which have valuable pharmacological properties, specifically an inhibitory effect on the various kinases and cyclin / CDK complexes and on the proliferation of the various tumor cells, pharmaceutical compositions containing these compounds, their use and processes for their preparation.

BR9910898-4A 1998-06-04 1999-05-28 Indolinones substituted, preparation and use of them as pharmaceutical compositions BR9910898A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (en) 1998-06-04 1998-06-04 Novel substituted indolinones, their preparation and their use as pharmaceuticals
PCT/EP1999/003692 WO1999062882A1 (en) 1998-06-04 1999-05-28 Substituted indolinones, the production thereof and their use as medicaments

Publications (1)

Publication Number Publication Date
BR9910898A true BR9910898A (en) 2001-02-13

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910898-4A BR9910898A (en) 1998-06-04 1999-05-28 Indolinones substituted, preparation and use of them as pharmaceutical compositions

Country Status (23)

Country Link
EP (1) EP1100779A1 (en)
JP (1) JP2002516906A (en)
KR (1) KR20010043973A (en)
CN (1) CN1303374A (en)
AU (1) AU764782B2 (en)
BG (1) BG104938A (en)
BR (1) BR9910898A (en)
CA (1) CA2328291A1 (en)
CO (1) CO5050294A1 (en)
DE (1) DE19824922A1 (en)
EA (1) EA003514B1 (en)
EE (1) EE200000723A (en)
HR (1) HRP20000831A2 (en)
HU (1) HUP0102210A3 (en)
ID (1) ID27035A (en)
IL (1) IL138702A0 (en)
NO (1) NO20006138L (en)
PL (1) PL344467A1 (en)
SK (1) SK18222000A3 (en)
TR (1) TR200003515T2 (en)
WO (1) WO1999062882A1 (en)
YU (1) YU73900A (en)
ZA (1) ZA200005435B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (en) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Novel substituted indolinones, their preparation and their use as pharmaceuticals
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
UA75054C2 (en) 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Substituted in position 6 indolinones, producing and use thereof as medicament
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
AU8664701A (en) * 2000-09-01 2002-03-22 Glaxo Group Ltd Oxindole derivatives
AU2001288374A1 (en) * 2000-09-01 2002-03-22 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
DE10117204A1 (en) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma Indolinones substituted in the 6-position, their preparation and their use as medicaments
EP1401413B1 (en) 2001-06-29 2006-11-22 AB Science Use of tyrosine kinase inhibitions for treating allergic diseases
WO2003002109A2 (en) * 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitors for treating autoimmune diseases
JP2005500041A (en) 2001-06-29 2005-01-06 アブ サイエンス Potent, selective and non-toxic C-KIT inhibitor
WO2003004007A2 (en) * 2001-06-29 2003-01-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (ibd)
ATE330608T1 (en) 2001-06-29 2006-07-15 Ab Science THE USE OF N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
JP2005508336A (en) 2001-09-27 2005-03-31 アラーガン、インコーポレイテッド 3- (Arylamino) methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (en) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド Kinase inhibitors for the treatment of diseases
DE102004012070A1 (en) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments
PE20060777A1 (en) 2004-12-24 2006-10-06 Boehringer Ingelheim Int INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
CN101547892B (en) * 2006-12-05 2014-08-20 艾尼纳制药公司 Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (en) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 Method for producing 4-N,N-dimethylamino methylaniline
CN103102352B (en) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 Tyrosine kinase inhibitor indolinone derivative
CN103130775B (en) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 As the dihydroindole ketone derivate of tyrosine kinase inhibitor
GB201208775D0 (en) * 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CN103848814B (en) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 The full ketone derivatives of substituted indole as tyrosine kinase inhibitor
MX2021013661A (en) 2019-05-10 2022-03-11 Deciphera Pharmaceuticals Llc Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof.
WO2024050297A1 (en) * 2022-09-02 2024-03-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE838623A (en) * 1976-02-16 1976-06-16 3-HYDROXYMETHYLENE-2-INDOLINONE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
JP2001503736A (en) * 1996-08-23 2001-03-21 スージェン・インコーポレーテッド Combinatorial library of indolinone and related products and methods for the treatment of disease
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
HRP20000831A2 (en) 2001-12-31
AU764782B2 (en) 2003-08-28
NO20006138D0 (en) 2000-12-01
CN1303374A (en) 2001-07-11
AU4370799A (en) 1999-12-20
JP2002516906A (en) 2002-06-11
EE200000723A (en) 2002-04-15
CA2328291A1 (en) 1999-12-09
EA200100001A1 (en) 2001-08-27
PL344467A1 (en) 2001-11-05
NO20006138L (en) 2001-02-01
KR20010043973A (en) 2001-05-25
ID27035A (en) 2001-02-22
HUP0102210A3 (en) 2002-12-28
IL138702A0 (en) 2001-10-31
SK18222000A3 (en) 2001-08-06
CO5050294A1 (en) 2001-06-27
EP1100779A1 (en) 2001-05-23
DE19824922A1 (en) 1999-12-09
HUP0102210A2 (en) 2001-11-28
YU73900A (en) 2003-04-30
TR200003515T2 (en) 2001-06-21
ZA200005435B (en) 2002-01-07
EA003514B1 (en) 2003-06-26
WO1999062882A1 (en) 1999-12-09
BG104938A (en) 2001-06-29

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.