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BR9910893B1 - Derivados de hyperforin, seus usos, e formulações contendo os mesmos - Google Patents

Derivados de hyperforin, seus usos, e formulações contendo os mesmos

Info

Publication number
BR9910893B1
BR9910893B1 BRPI9910893-3B1A BR9910893A BR9910893B1 BR 9910893 B1 BR9910893 B1 BR 9910893B1 BR 9910893 A BR9910893 A BR 9910893A BR 9910893 B1 BR9910893 B1 BR 9910893B1
Authority
BR
Brazil
Prior art keywords
same
formulations containing
hyperforin derivatives
hyperforin
derivatives
Prior art date
Application number
BRPI9910893-3B1A
Other languages
English (en)
Other versions
BR9910893A (pt
Inventor
Ezio Bombardelli
Paolo Marazzoni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR9910893A publication Critical patent/BR9910893A/pt
Publication of BR9910893B1 publication Critical patent/BR9910893B1/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/647Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring
    • C07C49/653Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring polycyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734Ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
BRPI9910893-3B1A 1998-06-10 1999-06-04 Derivados de hyperforin, seus usos, e formulações contendo os mesmos BR9910893B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI001312A IT1301679B1 (it) 1998-06-10 1998-06-10 Derivati dell'iperforina, loro uso e formulazioni che licontengono.
PCT/EP1999/003880 WO1999064388A1 (en) 1998-06-10 1999-06-04 Hyperforin derivatives, the use thereof and formulations containing them

Publications (2)

Publication Number Publication Date
BR9910893A BR9910893A (pt) 2001-03-06
BR9910893B1 true BR9910893B1 (pt) 2013-10-29

Family

ID=11380210

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9910893-3B1A BR9910893B1 (pt) 1998-06-10 1999-06-04 Derivados de hyperforin, seus usos, e formulações contendo os mesmos

Country Status (23)

Country Link
US (1) US6656510B2 (pt)
EP (2) EP1086071B1 (pt)
JP (1) JP4511726B2 (pt)
KR (1) KR100627933B1 (pt)
CN (1) CN1246278C (pt)
AT (1) ATE307103T1 (pt)
AU (1) AU763889B2 (pt)
BR (1) BR9910893B1 (pt)
CA (1) CA2334308C (pt)
CZ (1) CZ298859B6 (pt)
DE (1) DE69927813T2 (pt)
DK (1) DK1086071T3 (pt)
ES (1) ES2249893T3 (pt)
HK (1) HK1036791A1 (pt)
HU (1) HUP0102226A3 (pt)
IL (2) IL140151A0 (pt)
IT (1) IT1301679B1 (pt)
MX (1) MXPA00012177A (pt)
NO (1) NO328444B1 (pt)
PL (1) PL195797B1 (pt)
RU (1) RU2240304C2 (pt)
SK (1) SK286049B6 (pt)
WO (1) WO1999064388A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1126882B1 (de) * 1998-11-04 2009-12-30 Dr. Willmar Schwabe GmbH & Co. KG Stabile zubereitungen mit hyperforin
ITMI20020872A1 (it) 2002-04-23 2003-10-23 Indena Spa Derivati dell'iperforina loro uso e formulazioni che li contengono
ITMI20020871A1 (it) 2002-04-23 2003-10-23 Indena Spa Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono
US20060115556A1 (en) * 2004-12-01 2006-06-01 Foulger Sidney W Nutritional supplement drink containing xanthone extracts
US20060115555A1 (en) * 2004-12-01 2006-06-01 Foulger Sidney W Nutritional supplements containing xanthone extracts
BRPI0900614A2 (pt) 2009-02-13 2011-06-28 Univ Fed Do Rio Grande Do Sul Ufrgs extrato vegetal neuroativo, composição farmacêutica compreendendo o mesmo e processo para sua produção
JP2014527508A (ja) * 2011-06-03 2014-10-16 プレジデント アンド フェローズ オブ ハーバード カレッジ ハイパーフォリン類似物、合成方法、およびその使用
ITMI20131012A1 (it) 2013-06-19 2014-12-20 Indena Spa Derivati dell'iperforina e loro uso nella malattia di alzheimer
RU2676100C1 (ru) * 2018-10-05 2018-12-26 федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский политехнический университет Петра Великого" (ФГАОУ ВО "СПбПУ") Применение производных пиперазина для лечения болезни Альцгеймера и деменций альцгеймеровского типа с нарушенной внутриклеточной кальциевой сигнализацией

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2550266A (en) * 1948-12-11 1951-04-24 Swift & Co Preservation of food products
DE4239959A1 (de) * 1992-11-27 1994-06-01 Schwabe Willmar Gmbh & Co Johanniskraut-Trockenextrakt, Verfahren zu seiner Herstellung und seine Verwendung
DE19646977A1 (de) * 1995-09-29 1998-01-15 Schwabe Willmar Gmbh & Co Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen
DE19714450A1 (de) * 1997-04-08 1998-10-15 Schwabe Willmar Gmbh & Co Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitung
EP1047440A1 (en) * 1998-01-13 2000-11-02 Rexall Sundown, Inc. St. john's wort and methyl donor composition and uses thereof
US6224906B1 (en) * 1999-08-31 2001-05-01 Natreon Inc. St. John's wort composition

Also Published As

Publication number Publication date
DK1086071T3 (da) 2006-01-23
EP1607099A1 (en) 2005-12-21
PL195797B1 (pl) 2007-10-31
JP4511726B2 (ja) 2010-07-28
NO20006230L (no) 2001-02-01
CZ20004562A3 (en) 2001-06-13
ATE307103T1 (de) 2005-11-15
EP1086071A1 (en) 2001-03-28
IL140151A (en) 2006-12-10
AU4373999A (en) 1999-12-30
DE69927813T2 (de) 2006-04-20
SK18712000A3 (sk) 2001-06-11
HUP0102226A2 (hu) 2001-10-28
HUP0102226A3 (en) 2003-07-28
MXPA00012177A (es) 2004-09-06
PL344696A1 (en) 2001-11-19
ITMI981312A1 (it) 1999-12-10
RU2240304C2 (ru) 2004-11-20
CA2334308C (en) 2009-06-02
JP2002517478A (ja) 2002-06-18
CA2334308A1 (en) 1999-12-16
CZ298859B6 (cs) 2008-02-27
ES2249893T3 (es) 2006-04-01
DE69927813D1 (de) 2006-03-02
US20010020040A1 (en) 2001-09-06
KR20010052637A (ko) 2001-06-25
CN1246278C (zh) 2006-03-22
EP1086071B1 (en) 2005-10-19
US6656510B2 (en) 2003-12-02
IT1301679B1 (it) 2000-07-07
CN1304397A (zh) 2001-07-18
KR100627933B1 (ko) 2006-09-22
WO1999064388A1 (en) 1999-12-16
NO20006230D0 (no) 2000-12-07
AU763889B2 (en) 2003-07-31
BR9910893A (pt) 2001-03-06
IL140151A0 (en) 2002-02-10
HK1036791A1 (en) 2002-01-18
SK286049B6 (sk) 2008-01-07
NO328444B1 (no) 2010-02-22

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/10/2013, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2257 DE 08-04-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B15K Others concerning applications: alteration of classification

Ipc: A61K 31/122 (2006.01), C07C 69/013 (2006.0