BR9809652A - Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3 - Google Patents
Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3Info
- Publication number
- BR9809652A BR9809652A BR9809652-4A BR9809652A BR9809652A BR 9809652 A BR9809652 A BR 9809652A BR 9809652 A BR9809652 A BR 9809652A BR 9809652 A BR9809652 A BR 9809652A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- optionally substituted
- group
- aryl
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"DERIVADOS DE QUINOLINA-4-CARBOXAMIDA COMO ANTAGONISTAS DE RECEPTOR NK-2 E NK-3". Composto, ou um solvato ou um sal do mesmo, de fórmula (I): em que, Ar é um grupo arila ou um cicloalquidienila C~ 5-7~ opcionalmente substituído, ou um grupo cicloalquila C~ 5-7~ ou um grupo heterocíclico aromático com anel único ou fundido opcionalmente substituído; R é alquila C~ 1-6~, cicloalquila C~ 3-7~, cicloalquilalquila C~ 3-7~, fenila ou fenil-alquila C~ 1-6~ opcionalmente substituída, um anel heteroaromático com cinco membros opcionalmente substituído compreendendo até quatro heteroátomos selecionados dentre O e N, hidroxi alquila C~ 1-6~, amino alquila C~ 1-6~, alquilaminoalquila C~ 1-6~, di-alquilaminoalquila C~ 1-6~, acilaminoalquila C~ 1-6~, alcoxialquila C~ 1-6~, alquilcarbonila C~ 1-6~, carboxi, alcoxicarbonila C~ 1-6~, alcoxicarbonila C~ 1-6~ alquila C~ 1-6~, aminocarbonila, alquilaminocarbonila C~ 1-6~, dialquilaminocarbonila C~ 1-6~, halogênio alquila C~ 1-6~; ou R é um grupo -(CH~ 2~)~ p~- em que p é 2 ou 3, cujo grupo forma um anel com um átomo de carbono de Ar; R~ 1~ representa hidrogênio ou até quatro substituintes opcionais selecionados dentre a lista consistindo de: alquila C~ 1-6~, alquenila C~ 1-6~, arila, alcoxi C~ 1-6~, hidroxi, halogênio, nitro, ciano, carboxi, carboxamido, sulfonamido, alcoxicarbonila C~ 1-6~, trifluorometila, aciloxi, ftalimido, amino ou mono- e di-alquilamino C~ 1-6~; R~ 2~ representa uma porção - (CH~ 2~)~ n~-NY~ 1~Y~ 2~ em que n é um número inteiro na faixa de 1 a 9, Y~ 1~ e Y~ 2~ são independentemente selecionados dentre hidrogênio; alquila C~ 1-6~; alquila C~ 1-6~ substituída com hidroxi, alquilamino C~ 1-6~ ou bis (alquil C~ 1-6~) amino; alquenila C~ 1-6~; arila ou aril-alquila C~ 1-6~ ou Y~ 1~ e Y~ 2~ juntos com o átomo de nitrogênio, em que eles são fixados, representam um grupo heterocíclico com anel único ou fundido N-ligado opcionalmente substituído; R~ 3~ é alquila C~ 1-6~, cicloalquila C~ 3-7~, cicloalquilquila C~ 4-7~ ramificado ou linear, arila opcionalmente substituída, ou um grupo heterocíclico aromático com anel único ou fundido opcionalmente substituído; e R~ 4~ representa hidrogênio ou alquila C~ 1-6~; uma composição farmacêutica compreendendo este composto, processo para preparar este composto e o uso deste composto em remédios.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9710750.2A GB9710750D0 (en) | 1997-05-23 | 1997-05-23 | Novel compounds |
| IT002354 IT1295358B1 (it) | 1997-10-17 | 1997-10-17 | Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3 |
| ITMI972775 IT1296976B1 (it) | 1997-12-16 | 1997-12-16 | Derivati chinolinici procedimento per la loro preparazione e uso come antagonisti del recettore nk3 |
| PCT/EP1998/003014 WO1998052942A1 (en) | 1997-05-23 | 1998-05-18 | Quinoline-4-carboxamide derivatives as nk-2 and nk-3 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9809652A true BR9809652A (pt) | 2001-09-11 |
Family
ID=27268859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9809652-4A BR9809652A (pt) | 1997-05-23 | 1998-05-18 | Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3 |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0983262B1 (pt) |
| JP (1) | JP2002500645A (pt) |
| CN (1) | CN1264378A (pt) |
| AP (1) | AP9901695A0 (pt) |
| AR (1) | AR012732A1 (pt) |
| AT (1) | ATE244711T1 (pt) |
| AU (1) | AU8209898A (pt) |
| BG (1) | BG104009A (pt) |
| BR (1) | BR9809652A (pt) |
| CA (1) | CA2291111A1 (pt) |
| CO (1) | CO4950515A1 (pt) |
| DE (1) | DE69816290T2 (pt) |
| DZ (1) | DZ2498A1 (pt) |
| EA (1) | EA199901062A1 (pt) |
| ES (1) | ES2201509T3 (pt) |
| HU (1) | HUP0002300A3 (pt) |
| ID (1) | ID22876A (pt) |
| IL (1) | IL133036A0 (pt) |
| MA (1) | MA26501A1 (pt) |
| NO (1) | NO995711L (pt) |
| OA (1) | OA11515A (pt) |
| PE (1) | PE75199A1 (pt) |
| PL (1) | PL336942A1 (pt) |
| SK (1) | SK159299A3 (pt) |
| TR (1) | TR199902883T2 (pt) |
| WO (1) | WO1998052942A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9825554D0 (en) | 1998-11-20 | 1999-01-13 | Smithkline Beecham Spa | Novel Compounds |
| US6780875B2 (en) * | 1998-11-20 | 2004-08-24 | Smithkline Beecham S.P.A. | Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists |
| AR021355A1 (es) * | 1998-11-20 | 2002-07-17 | Smithkline Beecham Spa | Derivados de quinolina. procedimiento para su preparacion, composicion farmaceutica que los comprende, y el uso de los mismos para la fabricacion de unmedicamento |
| AU4038600A (en) | 1999-03-29 | 2000-10-16 | Neurogen Corporation | 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands |
| AU4802500A (en) * | 1999-04-26 | 2000-11-10 | Neurogen Corporation | 2-aminoquinolinecarboxamides: neurokinin receptor ligands |
| WO2002013825A1 (en) * | 2000-08-11 | 2002-02-21 | Smithkline Beecham P.L.C. | Novel pharmaceutical use of quinnoline derivatives |
| WO2002038547A1 (en) * | 2000-11-13 | 2002-05-16 | Glaxosmithkline Spa | Quinoline derivatives as nk-3 and nk-2 antagonists |
| GB0028964D0 (en) * | 2000-11-28 | 2001-01-10 | Smithkline Beecham Spa | Novel compounds |
| AU2002226356A1 (en) * | 2000-11-28 | 2002-06-11 | Glaxosmithkline S.P.A. | Quinoline derivatives as nk-3 antagonists |
| US6540733B2 (en) | 2000-12-29 | 2003-04-01 | Corazon Technologies, Inc. | Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion |
| GB0109122D0 (en) * | 2001-04-11 | 2001-05-30 | Smithkline Beecham Spa | Novel compounds |
| ATE318266T1 (de) * | 2001-04-11 | 2006-03-15 | Glaxosmithkline Spa | 3-substituierte chinolin-4- carbonsäureamidderivate als nk-3- und nk-2- rezeptorantagonisten |
| MY134211A (en) * | 2001-05-18 | 2007-11-30 | Smithkline Beecham Corp | Novel use |
| GB0425075D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| GB0425076D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| GB0425077D0 (en) * | 2004-11-12 | 2004-12-15 | Smithkline Beecham Corp | Novel compounds |
| CN101189211A (zh) * | 2005-06-03 | 2008-05-28 | 阿斯利康(瑞典)有限公司 | 作为nk3拮抗剂的喹啉衍生物 |
| GB0515580D0 (en) | 2005-07-29 | 2005-09-07 | Merck Sharp & Dohme | Therapeutic compounds |
| AR057130A1 (es) | 2005-09-21 | 2007-11-14 | Astrazeneca Ab | Quinolinas de alquilsulfoxido y una composicion farmaceutica |
| DE202007017299U1 (de) * | 2007-12-12 | 2009-04-23 | Drebo Werkzeugfabrik Gmbh | Bohrer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0940391B1 (en) * | 1994-05-27 | 2004-08-18 | GlaxoSmithKline S.p.A. | Quinoline derivatives as tachykinin NK3 receptor antagonists |
| AR004735A1 (es) * | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
-
1998
- 1998-05-18 BR BR9809652-4A patent/BR9809652A/pt not_active IP Right Cessation
- 1998-05-18 CN CN98807356A patent/CN1264378A/zh active Pending
- 1998-05-18 ES ES98932069T patent/ES2201509T3/es not_active Expired - Lifetime
- 1998-05-18 HU HU0002300A patent/HUP0002300A3/hu unknown
- 1998-05-18 TR TR1999/02883T patent/TR199902883T2/xx unknown
- 1998-05-18 EA EA199901062A patent/EA199901062A1/ru unknown
- 1998-05-18 IL IL13303698A patent/IL133036A0/xx unknown
- 1998-05-18 PL PL98336942A patent/PL336942A1/xx unknown
- 1998-05-18 SK SK1592-99A patent/SK159299A3/sk unknown
- 1998-05-18 EP EP98932069A patent/EP0983262B1/en not_active Expired - Lifetime
- 1998-05-18 AP APAP/P/1999/001695A patent/AP9901695A0/en unknown
- 1998-05-18 AU AU82098/98A patent/AU8209898A/en not_active Abandoned
- 1998-05-18 ID IDW991432A patent/ID22876A/id unknown
- 1998-05-18 CA CA002291111A patent/CA2291111A1/en not_active Abandoned
- 1998-05-18 DE DE69816290T patent/DE69816290T2/de not_active Expired - Fee Related
- 1998-05-18 JP JP54996798A patent/JP2002500645A/ja not_active Ceased
- 1998-05-18 AT AT98932069T patent/ATE244711T1/de not_active IP Right Cessation
- 1998-05-18 WO PCT/EP1998/003014 patent/WO1998052942A1/en not_active Application Discontinuation
- 1998-05-19 DZ DZ980108A patent/DZ2498A1/xx active
- 1998-05-20 PE PE1998000398A patent/PE75199A1/es not_active Application Discontinuation
- 1998-05-21 AR ARP980102363A patent/AR012732A1/es not_active Application Discontinuation
- 1998-05-21 MA MA25086A patent/MA26501A1/fr unknown
- 1998-05-22 CO CO98029024A patent/CO4950515A1/es unknown
-
1999
- 1999-11-22 NO NO995711A patent/NO995711L/no not_active Application Discontinuation
- 1999-11-23 OA OA9900253A patent/OA11515A/en unknown
- 1999-12-14 BG BG104009A patent/BG104009A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0983262A1 (en) | 2000-03-08 |
| CN1264378A (zh) | 2000-08-23 |
| JP2002500645A (ja) | 2002-01-08 |
| BG104009A (en) | 2000-07-31 |
| AR012732A1 (es) | 2000-11-08 |
| ES2201509T3 (es) | 2004-03-16 |
| CA2291111A1 (en) | 1998-11-26 |
| AU8209898A (en) | 1998-12-11 |
| ID22876A (id) | 1999-12-16 |
| HUP0002300A3 (en) | 2002-01-28 |
| DE69816290T2 (de) | 2004-05-27 |
| HUP0002300A2 (hu) | 2001-06-28 |
| MA26501A1 (fr) | 2004-12-20 |
| WO1998052942A1 (en) | 1998-11-26 |
| OA11515A (en) | 2004-02-04 |
| SK159299A3 (en) | 2000-06-12 |
| DZ2498A1 (fr) | 2003-01-25 |
| AP9901695A0 (en) | 1999-12-31 |
| PL336942A1 (en) | 2000-07-17 |
| EP0983262B1 (en) | 2003-07-09 |
| PE75199A1 (es) | 1999-10-22 |
| IL133036A0 (en) | 2001-03-19 |
| NO995711L (no) | 2000-01-19 |
| DE69816290D1 (de) | 2003-08-14 |
| NO995711D0 (no) | 1999-11-22 |
| EA199901062A1 (ru) | 2000-08-28 |
| ATE244711T1 (de) | 2003-07-15 |
| CO4950515A1 (es) | 2000-09-01 |
| TR199902883T2 (xx) | 2000-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9809652A (pt) | Derivados de quinolina-4-carboxamida como antagonistas de receptor nk-2 e nk-3 | |
| BR9915475A (pt) | Derivados da quinolina-4-carboxamida comoantagonistas dos receptores de nk-3 e nk-2 | |
| AR004972A1 (es) | Compuesto quinolino 4-carboxamidas n-sustituidas, un procedimiento para su preparacion, el uso de los mismos para la fabricacion de un medicamento, una composicion farmaceutica y un antagonista nk-2/nk-3 combinado. | |
| AR088921A2 (es) | PROCESO PARA LA PREPARACION DE DERIVADOS DE ACETILENO QUE TIENEN ACTIVIDAD ANTAGONISTA mGluR5, COMPOSICIONES Y USO DE LOS COMPUESTOS | |
| EP1724262A4 (en) | 1- (2H) -ISOCHINOLONDERIVAT | |
| AR004735A1 (es) | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. | |
| BR0306208A (pt) | Compostos de dibenzilamina e seu uso farmacêutico | |
| TW200745029A (en) | Sulfonamide derivatives exhibiting PGD2 receptor antagonism | |
| WO2003024967A3 (en) | Indolizines as kinase protein inhibitors | |
| BRPI0707491B8 (pt) | compostos úteis como agentes moduladores de receptores de mineralocorticóides, os referidos agentes compreendendo os mesmos e composições farmacêuticas | |
| MY135686A (en) | Indole derivatives useful as histamine h3 antagonists | |
| PT1289955E (pt) | Piperidinas para utilizacao como antagonistas dos receptores da orexina | |
| NO2012021I1 (no) | Perampanel eller salter eller hydrater derav | |
| BR0109855A (pt) | Derivados de 8-isoquinolinxantina e 8-quinolixantina como inibidores de pde 5 | |
| BRPI0615111B8 (pt) | composto, composição farmacêutica, e, uso do composto | |
| AR039127A1 (es) | Compuesto de quinolina, procedimiento para su preparacion, composicion farmaceutica que lo comprende y uso del mismo para la fabricacion de un medicamento | |
| AR035548A1 (es) | Compuestos organicos | |
| MX9202142A (es) | Nuevos derivados de urea, proceso para su preparacion, y composicion farmaceutica que los comprende. | |
| ATE377602T1 (de) | Morphinanderivate und ihre medizinische anwendung | |
| AR068115A1 (es) | Derivado del acido pirazolcarboxilico metodo de produccion del mismo y fungicida | |
| NO20001046D0 (no) | 6,7-asymmetriske disubstituerte kinoksalinkarboksylsyrederivater, addisjonssalter derav og fremgangsmõter ved fremstilling av begge | |
| ATE154021T1 (de) | N-cyclohexyl benzamide derivate, ihre herstellungen und therapeutischen anwendungen | |
| DE69934514D1 (de) | Chinolinderivate als nk-2 und nk-3 rezeptor-liganden | |
| EE200000059A (et) | Tetrahüdro-gamma-karboliinid | |
| BRPI0412163A (pt) | derivados de quinazolinona 5-substituìda |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A,7A,8A E 9A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |