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BR9807627A - Análogo de fator x, dna recombinante codificante para um análogo de fator x, preparação contendo um análogo de fator x purificado ou uma sua proteìna precursora, preparação contendo análogo de fator xa apresentando alta estabilidade e integridade estrutural, usos de uma preparação e de um ácido nucleico, e, processos para a preparação de um preparado contendo análogo de fator x recombinante purificado, e para se preparar um preparado contendo fator xa ou análogo de fator xa ativos. - Google Patents

Análogo de fator x, dna recombinante codificante para um análogo de fator x, preparação contendo um análogo de fator x purificado ou uma sua proteìna precursora, preparação contendo análogo de fator xa apresentando alta estabilidade e integridade estrutural, usos de uma preparação e de um ácido nucleico, e, processos para a preparação de um preparado contendo análogo de fator x recombinante purificado, e para se preparar um preparado contendo fator xa ou análogo de fator xa ativos.

Info

Publication number
BR9807627A
BR9807627A BR9807627-2A BR9807627A BR9807627A BR 9807627 A BR9807627 A BR 9807627A BR 9807627 A BR9807627 A BR 9807627A BR 9807627 A BR9807627 A BR 9807627A
Authority
BR
Brazil
Prior art keywords
factor
analogue
preparation containing
preparation
preparing
Prior art date
Application number
BR9807627-2A
Other languages
English (en)
Inventor
Michele Himmelspach
Uwe Schlokat
Friedrich Dorner
Andreas Fischer
Johann Eibl
Original Assignee
Baxter Aktiengesellchaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Aktiengesellchaft filed Critical Baxter Aktiengesellchaft
Publication of BR9807627A publication Critical patent/BR9807627A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6432Coagulation factor Xa (3.4.21.6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21006Coagulation factor Xa (3.4.21.6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"ANáLOGO DE FATOR X, DNA RECOMBINANTE CODIFICANTE PARA UM ANáLOGO DE FATOR X, PREPARAçãO CONTENDO UM ANáLOGO DE FATOR X PURIFICADO OU UMA SUA PROTEìNA PRECURSORA, PREPARAçãO CONTENDO ANáLOGO DE FATOR XA APRESENTANDO ALTA ESTABILIDDE E INTEGRIDADE ESTRUTURAL, USOS DE UMA PREPARAçãO E DE UM áCIDO NUCLEICO, E, PROCESSOS PARA A PREPARAçãO DE UM PREPARADO CONTENDO ANáLOGO DE FATOR X RECOMBINANTE PURIFICADO, E PARA SE PREPARAR UM PREPARADO CONTENDO FATOR XA OU ANáLOGO DE FATOR XA ATIVOS". A invenção refere-se a análogos de Fator X que têm uma modificação na área do sítio de clivagem de ativação de Fator Xa naturalmente ocorrente, sendo que a referida modificação representa um sítio de processamento de uma protease que não cliva naturalmente nesta área da seq³ência do Fator X. A invenção também refere-se a preparações contendo os inéditos análogos de Fator X e a processos para sua produção.
BR9807627-2A 1997-02-27 1998-02-27 Análogo de fator x, dna recombinante codificante para um análogo de fator x, preparação contendo um análogo de fator x purificado ou uma sua proteìna precursora, preparação contendo análogo de fator xa apresentando alta estabilidade e integridade estrutural, usos de uma preparação e de um ácido nucleico, e, processos para a preparação de um preparado contendo análogo de fator x recombinante purificado, e para se preparar um preparado contendo fator xa ou análogo de fator xa ativos. BR9807627A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0033597A AT405516B (de) 1997-02-27 1997-02-27 Faktor x-analoge mit modifizierter proteasespaltstelle
PCT/AT1998/000045 WO1998038317A1 (de) 1997-02-27 1998-02-27 Faktor x-analoge mit modifizierter proteasespaltstelle

Publications (1)

Publication Number Publication Date
BR9807627A true BR9807627A (pt) 2000-02-22

Family

ID=3487868

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807627-2A BR9807627A (pt) 1997-02-27 1998-02-27 Análogo de fator x, dna recombinante codificante para um análogo de fator x, preparação contendo um análogo de fator x purificado ou uma sua proteìna precursora, preparação contendo análogo de fator xa apresentando alta estabilidade e integridade estrutural, usos de uma preparação e de um ácido nucleico, e, processos para a preparação de um preparado contendo análogo de fator x recombinante purificado, e para se preparar um preparado contendo fator xa ou análogo de fator xa ativos.

Country Status (17)

Country Link
US (2) US6573071B1 (pt)
EP (1) EP0966536B1 (pt)
JP (1) JP4317976B2 (pt)
AR (1) AR012034A1 (pt)
AT (2) AT405516B (pt)
AU (1) AU744428B2 (pt)
BR (1) BR9807627A (pt)
CA (1) CA2282707A1 (pt)
CZ (1) CZ298298B6 (pt)
DE (1) DE59813518D1 (pt)
ES (1) ES2263199T3 (pt)
HU (1) HU225246B1 (pt)
IL (2) IL131346A0 (pt)
NO (1) NO327878B1 (pt)
PL (1) PL190734B1 (pt)
SK (1) SK286359B6 (pt)
WO (1) WO1998038317A1 (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405517B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
IL129427A0 (en) * 1999-04-13 2000-02-17 Yeda Res & Dev Preparation of biologically active molecules
AT410216B (de) * 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
AU2001249389A1 (en) * 2000-03-22 2001-10-03 The Children's Hospital Of Philadelphia Modified blood clotting factors and methods of use
US7223577B2 (en) * 2000-11-17 2007-05-29 Allergan, Inc. Post-translational modifications and Clostridial neurotoxins
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
US20040132156A1 (en) * 2002-10-04 2004-07-08 Schering Aktiengesellschaft Modified hepsin molecules having a substitute activation sequence and uses thereof
AU2005274406B2 (en) * 2004-08-17 2010-07-01 Csl Behring Gmbh Modified vitamin K dependent polypeptides
EP1728798A1 (en) * 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
MX336958B (es) * 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1820508A1 (en) * 2006-02-21 2007-08-22 CSL Behring GmbH Coagulation factor X polypeptides with modified activation properties
ATE548380T1 (de) 2006-04-20 2012-03-15 Kringle Pharma Inc Mutante des hgf-precursor-proteins und aktivierte form davon
GB0710321D0 (en) * 2007-05-30 2007-07-11 Nhs Blood & Transplant Method
US9956272B2 (en) 2007-05-30 2018-05-01 Bio Products Laboratory Limited Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
AU2008287340A1 (en) * 2007-08-15 2009-02-19 Amunix, Inc. Compositions and methods for modifying properties of biologically active polypeptides
CN101802188B (zh) 2007-09-28 2013-08-21 普托拉制药有限公司 用于因子Xa抑制剂的解毒剂和其使用方法
NZ592837A (en) 2008-11-14 2012-10-26 Portola Pharm Inc Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents
US8680050B2 (en) * 2009-02-03 2014-03-25 Amunix Operating Inc. Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
US8673860B2 (en) 2009-02-03 2014-03-18 Amunix Operating Inc. Extended recombinant polypeptides and compositions comprising same
US8703717B2 (en) 2009-02-03 2014-04-22 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
PT2414517T (pt) 2009-03-30 2016-12-27 Portola Pharm Inc Antídotos para inibidores do fator xa e métodos de utilização dos mesmos
NZ596778A (en) 2009-06-08 2013-11-29 Amunix Operating Inc Glucose-regulating polypeptides and methods of making and using same
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
EP2453910B1 (en) 2009-07-15 2016-08-31 Portola Pharmaceuticals, Inc. Unit dose formulation of antidote for factor xa inhibitors for use in preventing bleeding
BR112012004094A2 (pt) 2009-08-24 2016-03-08 Amunix Operating Inc composições de fator vii de coagulação e métodos para fazer e usar as mesmas
US8557961B2 (en) 2010-04-02 2013-10-15 Amunix Operating Inc. Alpha 1-antitrypsin compositions and methods of making and using same
CA2850603C (en) * 2011-09-30 2021-11-16 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
SG10201606783RA (en) 2012-02-15 2016-10-28 Amunix Operating Inc Factor viii compositions and methods of making and using same
BR112014019901A8 (pt) 2012-02-15 2018-01-02 Biogen Idec Inc Proteínas de fator viii recombinante
CN104302408B (zh) 2012-02-27 2016-12-14 阿穆尼克斯运营公司 Xten缀合组合物和制造其的方法
GB201211617D0 (en) * 2012-06-29 2012-08-15 Univ Aberdeen Production of cyclic peptides
AU2013293573B2 (en) 2012-07-25 2016-10-27 Catalyst Biosciences, Inc. Modified Factor X polypeptides and uses thereof
MX2015008813A (es) 2013-01-31 2016-03-31 Pfizer Composiciones y metodos para contrarrestar la inhibicion del factor xa.
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
CN105008530A (zh) * 2013-03-12 2015-10-28 诺和诺德股份有限公司 凝血酶敏感性凝固因子x分子
TWI667255B (zh) 2013-08-14 2019-08-01 美商生物化學醫療公司 因子viii-xten融合物及其用途
CN112195169A (zh) 2013-09-24 2021-01-08 辉瑞大药厂 包含重组人凝血因子Xa蛋白的异质性群体的组合物
RU2585532C2 (ru) * 2014-01-31 2016-05-27 Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук"(ФИЦ Биотехнологии РАН) Плазмида для экспрессии рекомбинантного фактора свёртываемости крови ix человека, клетка сно - продуцент рекомбинантного фактора свёртываемости крови ix человека и способ получения указанного фактора
WO2016028872A2 (en) 2014-08-19 2016-02-25 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor ix function
CN108472337B (zh) 2015-08-03 2022-11-25 比奥贝拉蒂治疗公司 因子ix融合蛋白以及其制备和使用方法
KR20180038560A (ko) 2015-08-28 2018-04-16 아뮤닉스 오퍼레이팅 인코포레이티드 키메라 폴리펩티드 조립체와 이의 제조 및 사용 방법
IL308416A (en) 2016-12-02 2024-01-01 Bioverativ Therapeutics Inc Methods for the treatment of hemophilic arthritis with the help of chimeric blood coagulation factors
SG11202010767SA (en) 2018-05-18 2020-11-27 Bioverativ Therapeutics Inc Methods of treating hemophilia a
KR102613936B1 (ko) * 2020-11-13 2023-12-15 한국생명공학연구원 자가분해능이 저하된 켁신 효소 및 이의 생산 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en) 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5597799A (en) 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
JP4236698B2 (ja) 1990-11-26 2009-03-11 ジェネティックス インスティチュート,リミテッド ライアビリティ カンパニー 宿主細胞でのpaceの発現およびその使用法
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
DE4325872C1 (de) 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
AT404838B (de) 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405517B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon

Also Published As

Publication number Publication date
NO994139D0 (no) 1999-08-26
IL131346A0 (en) 2001-01-28
CA2282707A1 (en) 1998-09-03
EP0966536B1 (de) 2006-04-26
WO1998038317A1 (de) 1998-09-03
NO994139L (no) 1999-10-27
ATE324454T1 (de) 2006-05-15
US6573071B1 (en) 2003-06-03
DE59813518D1 (de) 2006-06-01
PL335382A1 (en) 2000-04-25
HU225246B1 (en) 2006-08-28
AU744428B2 (en) 2002-02-21
US20030181381A1 (en) 2003-09-25
PL190734B1 (pl) 2005-12-30
NO327878B1 (no) 2009-10-12
AU6200298A (en) 1998-09-18
SK286359B6 (sk) 2008-08-05
CZ303299A3 (cs) 2000-02-16
HUP0100652A3 (en) 2003-01-28
IL131346A (en) 2007-05-15
CZ298298B6 (cs) 2007-08-22
ATA33597A (de) 1999-01-15
EP0966536A1 (de) 1999-12-29
JP4317976B2 (ja) 2009-08-19
HUP0100652A1 (hu) 2001-06-28
SK117199A3 (en) 2000-05-16
AT405516B (de) 1999-09-27
JP2001513631A (ja) 2001-09-04
AR012034A1 (es) 2000-09-27
ES2263199T3 (es) 2006-12-01
US7220569B2 (en) 2007-05-22

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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