BR112023018874A2 - Camundongos geneticamente modificados compreendendo componentes do sistema imunológico celular humanizado com diversidade melhorada do repertório de tcrb - Google Patents
Camundongos geneticamente modificados compreendendo componentes do sistema imunológico celular humanizado com diversidade melhorada do repertório de tcrbInfo
- Publication number
- BR112023018874A2 BR112023018874A2 BR112023018874A BR112023018874A BR112023018874A2 BR 112023018874 A2 BR112023018874 A2 BR 112023018874A2 BR 112023018874 A BR112023018874 A BR 112023018874A BR 112023018874 A BR112023018874 A BR 112023018874A BR 112023018874 A2 BR112023018874 A2 BR 112023018874A2
- Authority
- BR
- Brazil
- Prior art keywords
- humanized
- mhc
- human
- cell
- alpha
- Prior art date
Links
- 241000699670 Mus sp. Species 0.000 title abstract 3
- 230000001413 cellular effect Effects 0.000 title abstract 2
- 210000000987 immune system Anatomy 0.000 title abstract 2
- BSDCIRGNJKZPFV-GWOFURMSSA-N (2r,3s,4r,5r)-2-(hydroxymethyl)-5-(2,5,6-trichlorobenzimidazol-1-yl)oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=CC(Cl)=C(Cl)C=C2N=C1Cl BSDCIRGNJKZPFV-GWOFURMSSA-N 0.000 title 1
- 101000763322 Homo sapiens M1-specific T cell receptor beta chain Proteins 0.000 title 1
- 101000763321 Homo sapiens T cell receptor beta chain MC.7.G5 Proteins 0.000 title 1
- 102100026964 M1-specific T cell receptor beta chain Human genes 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 2
- 108700018351 Major Histocompatibility Complex Proteins 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 241000283984 Rodentia Species 0.000 abstract 1
- 108091008874 T cell receptors Proteins 0.000 abstract 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 abstract 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0325—Animal model for autoimmune diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0337—Animal models for infectious diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0387—Animal model for diseases of the immune system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
camundongos geneticamente modificados compreendendo componentes do sistema imunológico celular humanizado com diversidade melhorada do repertório de tcrb. a presente invenção refere-se a animais não humanos (por exemplo, roedores, por exemplo, camundongos ou ratos) geneticamente manipulados para expressar um correceptor de células t humanizado (por exemplo, cd4 e/ou cd8 humanizado (por exemplo, cd8 alfa e/ou cd8 beta)), um receptor de células t (tcr) humano ou humanizado compreendendo um domínio variável codificado por pelo menos um segmento de gene de região variável de tcr humano e/ou um complexo principal de histo-compatibilidade humano ou humanizado que se liga ao correceptor de células t humanizado (por exemplo, mhc ii humano ou humanizado (por exemplo, cadeias de mhc ii alfa e/ou mhc ii alfa) e/ou mhc i (por exemplo, mhc i alfa) respectivamente, e, opcionalmente, beta 2 microglobulina humana ou humanizada). também são fornecidos embriões, tecidos e células que expressam o mesmo. métodos para a produção de um animal geneticamente manipulado que expressa pelo menos um correceptor de células t humanizado (por exemplo, cd4 e/ou cd8 humanizado), pelo menos um mhc humanizado que se associa ao correceptor de células t humanizado (por exemplo, mhc ii humanizado e/ou mhc i, respectivamente) e/ou ao tcr humanizado também são fornecidos. métodos para uso dos animais geneticamente manipulados que montam uma resposta imune de células t substancialmente humanizada para desenvolver terapêutica humana também são fornecidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163168774P | 2021-03-31 | 2021-03-31 | |
| PCT/US2022/022653 WO2022212582A1 (en) | 2021-03-31 | 2022-03-30 | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023018874A2 true BR112023018874A2 (pt) | 2023-10-03 |
Family
ID=81345957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023018874A BR112023018874A2 (pt) | 2021-03-31 | 2022-03-30 | Camundongos geneticamente modificados compreendendo componentes do sistema imunológico celular humanizado com diversidade melhorada do repertório de tcrb |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220322648A1 (pt) |
| EP (1) | EP4171216A1 (pt) |
| JP (1) | JP2024512702A (pt) |
| KR (1) | KR20230164150A (pt) |
| CN (2) | CN118511853A (pt) |
| AU (1) | AU2022249328A1 (pt) |
| BR (1) | BR112023018874A2 (pt) |
| CA (1) | CA3213460A1 (pt) |
| IL (1) | IL307238A (pt) |
| MX (1) | MX2023010796A (pt) |
| WO (1) | WO2022212582A1 (pt) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7569664B2 (en) | 2002-10-09 | 2009-08-04 | Immunocore Limited | Single chain recombinant T cell receptors |
| DK1802193T3 (da) | 2004-10-19 | 2014-06-10 | Regeneron Pharma | Fremgangsmåde til frembringelse af en homozygot mus til genetisk modifikation |
| US10464987B2 (en) | 2009-10-06 | 2019-11-05 | Abbvie Inc. | Human single-chain T cell receptors |
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| SG10201909638UA (en) | 2011-10-28 | 2019-11-28 | Regeneron Pharma | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| EP2770821B1 (en) | 2011-10-28 | 2017-09-13 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| ES2858978T3 (es) | 2011-10-28 | 2021-09-30 | Regeneron Pharma | Ratones con receptores de linfocitos T genéticamente modificados |
| AU2014218897C1 (en) | 2013-02-20 | 2019-03-07 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized T-cell co-receptors |
| WO2014130667A1 (en) | 2013-02-22 | 2014-08-28 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
| DK3280257T3 (da) * | 2015-04-06 | 2023-09-04 | Regeneron Pharma | Humaniseret T-celle-formidlet immunrespons i ikke-humane dyr |
| HRP20230497T1 (hr) * | 2016-06-03 | 2023-07-21 | Regeneron Pharmaceuticals, Inc. | Glodavci koji izražavaju egzogenu terminalnu dezoksinukleotidil transferazu |
| TWI827567B (zh) * | 2017-12-05 | 2024-01-01 | 美商再生元醫藥公司 | 具有經改造免疫球蛋白λ輕鏈的非人類動物及其用途 |
-
2022
- 2022-03-30 BR BR112023018874A patent/BR112023018874A2/pt unknown
- 2022-03-30 MX MX2023010796A patent/MX2023010796A/es unknown
- 2022-03-30 WO PCT/US2022/022653 patent/WO2022212582A1/en active Application Filing
- 2022-03-30 CN CN202410379293.2A patent/CN118511853A/zh active Pending
- 2022-03-30 JP JP2023560486A patent/JP2024512702A/ja active Pending
- 2022-03-30 CN CN202280021736.XA patent/CN116981357A/zh active Pending
- 2022-03-30 AU AU2022249328A patent/AU2022249328A1/en active Pending
- 2022-03-30 EP EP22718006.4A patent/EP4171216A1/en active Pending
- 2022-03-30 KR KR1020237037502A patent/KR20230164150A/ko unknown
- 2022-03-30 IL IL307238A patent/IL307238A/en unknown
- 2022-03-30 CA CA3213460A patent/CA3213460A1/en active Pending
- 2022-03-30 US US17/709,150 patent/US20220322648A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL307238A (en) | 2023-11-01 |
| MX2023010796A (es) | 2023-09-27 |
| AU2022249328A9 (en) | 2023-10-12 |
| AU2022249328A1 (en) | 2023-09-21 |
| EP4171216A1 (en) | 2023-05-03 |
| CA3213460A1 (en) | 2022-10-06 |
| CN118511853A (zh) | 2024-08-20 |
| CN116981357A (zh) | 2023-10-31 |
| JP2024512702A (ja) | 2024-03-19 |
| US20220322648A1 (en) | 2022-10-13 |
| WO2022212582A1 (en) | 2022-10-06 |
| KR20230164150A (ko) | 2023-12-01 |
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