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BR112022005736A2 - Compostos de azaindol carboxamida para o tratamento de infecções micobacterianas - Google Patents

Compostos de azaindol carboxamida para o tratamento de infecções micobacterianas

Info

Publication number
BR112022005736A2
BR112022005736A2 BR112022005736A BR112022005736A BR112022005736A2 BR 112022005736 A2 BR112022005736 A2 BR 112022005736A2 BR 112022005736 A BR112022005736 A BR 112022005736A BR 112022005736 A BR112022005736 A BR 112022005736A BR 112022005736 A2 BR112022005736 A2 BR 112022005736A2
Authority
BR
Brazil
Prior art keywords
treatment
azaindol
mycobacterial infections
carboxamide compounds
compounds
Prior art date
Application number
BR112022005736A
Other languages
English (en)
Inventor
Kaneko Takushi
Fotouhi Nader
Original Assignee
The Global Alliance For Tb Drug Dev Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Global Alliance For Tb Drug Dev Inc filed Critical The Global Alliance For Tb Drug Dev Inc
Publication of BR112022005736A2 publication Critical patent/BR112022005736A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS DE AZAINDOL CARBOXAMIDA PARA O TRATAMENTO DE INFECÇÕES MICOBACTERIANAS. São fornecidos nesse relatório descritivo compostos de Fórmula (I) e Fórmula (II): bem como sais farmaceuticamente aceitáveis destes, em que os substituintes são como aqueles revelados no relatório descritivo. Esses compostos, e as composições farmacêuticas que os contêm, são úteis para o tratamento de tuberculose.
BR112022005736A 2019-09-26 2020-09-25 Compostos de azaindol carboxamida para o tratamento de infecções micobacterianas BR112022005736A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962906461P 2019-09-26 2019-09-26
PCT/US2020/052934 WO2021062316A1 (en) 2019-09-26 2020-09-25 Azaindole carboxamide compounds for the treatment of mycobacterial infections

Publications (1)

Publication Number Publication Date
BR112022005736A2 true BR112022005736A2 (pt) 2022-08-23

Family

ID=75166850

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022005736A BR112022005736A2 (pt) 2019-09-26 2020-09-25 Compostos de azaindol carboxamida para o tratamento de infecções micobacterianas

Country Status (10)

Country Link
US (1) US20230002372A1 (pt)
EP (1) EP4034108A4 (pt)
JP (1) JP2022549345A (pt)
KR (1) KR20220070491A (pt)
CN (1) CN114746090A (pt)
AU (1) AU2020353173A1 (pt)
BR (1) BR112022005736A2 (pt)
CA (1) CA3151408A1 (pt)
WO (1) WO2021062316A1 (pt)
ZA (1) ZA202203107B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4296674A1 (en) 2022-06-20 2023-12-27 Université Toulouse III - Paul Sabatier Innovative molecules decreasing virulence of mycobacterium for the treatment of tuberculosis
US20240254114A1 (en) * 2022-12-02 2024-08-01 Merck Sharp & Dohme Llc Preparation of fused azole derivatives as novel diacylglyceride 0-acyltransferase 2 inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005097129A2 (en) * 2004-04-05 2005-10-20 Takeda Pharmaceutical Company Limited 6-azaindole compound
US7838542B2 (en) * 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
JP2012107001A (ja) * 2010-10-22 2012-06-07 Shionogi & Co Ltd インドールアミド化合物を含有する医薬
PE20150634A1 (es) * 2012-08-17 2015-05-08 Bayer Cropscience Ag Azaindolcarboxamidas y azaindoltiocarboxamidas como insecticidas y acaricidas
CN104603106B (zh) * 2012-09-07 2017-05-10 诺华股份有限公司 吲哚甲酰胺衍生物及其用途
TWI675836B (zh) * 2014-03-25 2019-11-01 美商伊格尼塔公司 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑
AU2015239886B2 (en) * 2014-04-04 2018-02-01 Iomet Pharma Ltd Indole derivatives for use in medicine
US20170044100A1 (en) 2014-04-22 2017-02-16 The Johns Hopkins University Inhibitors of drug-resistant mycobacterium tuberculosis
CN105294688B (zh) * 2015-12-02 2017-03-22 北京工业大学 6‑氯‑N‑(取代苄基)‑1H‑吡咯并[2,3‑b]吡啶‑2‑酰胺化合物及其制备方法和应用
WO2018149986A1 (en) * 2017-02-16 2018-08-23 Oryzon Genomics, S.A. 2-(bicyclo-heteroaryl)-isonicotinic derivatives as histone demethylase inhibitors
GB201715342D0 (en) * 2017-09-22 2017-11-08 Univ Nottingham Compounds

Also Published As

Publication number Publication date
ZA202203107B (en) 2023-11-29
EP4034108A4 (en) 2023-09-13
EP4034108A1 (en) 2022-08-03
CN114746090A (zh) 2022-07-12
AU2020353173A1 (en) 2022-03-31
WO2021062316A1 (en) 2021-04-01
US20230002372A1 (en) 2023-01-05
KR20220070491A (ko) 2022-05-31
JP2022549345A (ja) 2022-11-24
CA3151408A1 (en) 2021-04-01

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