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BR112013021837A2 - placa de gotícula suspensa - Google Patents

placa de gotícula suspensa

Info

Publication number
BR112013021837A2
BR112013021837A2 BR112013021837A BR112013021837A BR112013021837A2 BR 112013021837 A2 BR112013021837 A2 BR 112013021837A2 BR 112013021837 A BR112013021837 A BR 112013021837A BR 112013021837 A BR112013021837 A BR 112013021837A BR 112013021837 A2 BR112013021837 A2 BR 112013021837A2
Authority
BR
Brazil
Prior art keywords
microfluid
droplet
damping
circumferential
damping barrier
Prior art date
Application number
BR112013021837A
Other languages
English (en)
Other versions
BR112013021837B1 (pt
Inventor
Christof Fattinger
Claudia Mcginnis
Dieter Voegelin
Patrick Iaiza
Thomas Zumstein
Tom Kissling
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112013021837A2 publication Critical patent/BR112013021837A2/pt
Publication of BR112013021837B1 publication Critical patent/BR112013021837B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/16—Apparatus for enzymology or microbiology containing, or adapted to contain, solid media
    • C12M1/18—Multiple fields or compartments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/01—Drops
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/06—Crystallising dishes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

resumo patente de invenção: "placa de gotícula suspensa". a presente invenção refere-se a uma placa de gotícula suspensa (1) que compreende um número predeterminado de compartimentos de gotículas 9100, cada um sendo capaz de receber uma gotícula de um líquido. o compartimento de gotícula respectivo (10) compreende uma barreira de umedecimento de microfluidos circunferencial (102) que está disposta para circundar uma cavidade respectiva (100) e que impede uma gotícula de espalhar além da barreira de umedecimento de microfluidos (102). o compartimento respectivo (10) compreende um fundo fechado (101) e pelo menos uma barreira de umedecimento de microfluidos circunferencial adicional (104), cada barreira de umedecimento de microfluidos circunferencial adicional (104) que está disposta para circundar uma barreira de umedecimento de microfluidos circunferencial precedente (102). uma área umedecível (103) está disposta entre duas barreiras de umedecimento de microfluidos dispostas de modo adjacente.
BR112013021837-1A 2011-03-03 2012-03-02 Placa de gotícula suspensa BR112013021837B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11156741 2011-03-03
EP11156741.8 2011-03-03
PCT/EP2012/053588 WO2012117083A2 (en) 2011-03-03 2012-03-02 Hanging droplet plate

Publications (2)

Publication Number Publication Date
BR112013021837A2 true BR112013021837A2 (pt) 2016-08-09
BR112013021837B1 BR112013021837B1 (pt) 2019-09-17

Family

ID=44358285

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013021837-1A BR112013021837B1 (pt) 2011-03-03 2012-03-02 Placa de gotícula suspensa

Country Status (11)

Country Link
US (1) US9267933B2 (pt)
EP (1) EP2681305B1 (pt)
JP (1) JP5999518B2 (pt)
KR (1) KR101903809B1 (pt)
CN (1) CN103429729B (pt)
BR (1) BR112013021837B1 (pt)
CA (1) CA2825615C (pt)
ES (1) ES2546159T3 (pt)
HK (1) HK1191970A1 (pt)
MX (1) MX341295B (pt)
WO (1) WO2012117083A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2811012A1 (en) * 2013-06-07 2014-12-10 Eidgenossisch Technische Hochschule Zürich Hanging network plate
GB2539935A (en) 2015-07-01 2017-01-04 Insphero Ag Device for propagating microtissues
FR3040895B1 (fr) 2015-09-11 2020-01-10 Elvesys Substrat de support d'echantillon liquide, ensemble comportant un tel substrat et son utilisation
JP6873985B2 (ja) 2015-10-15 2021-05-19 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ インビトロで肝臓構築物を産生する方法およびその使用
JP2019070751A (ja) 2017-10-10 2019-05-09 オリンパス株式会社 観察装置および焦点調節方法
PL3693086T3 (pl) * 2019-02-08 2021-04-19 Lightcast Discovery Ltd Sposób manipulacji mikrokroplami
CN109988709B (zh) * 2019-04-01 2024-03-19 融智生物科技（青岛）有限公司 一种检测多种病原体的微流控芯片
WO2021075810A1 (ko) * 2019-10-14 2021-04-22 연세대학교 산학협력단 웰 플레이트유닛 및 이를 이용한 멀티 레이어 스페로이드 배양장치
DE102019216886A1 (de) * 2019-10-31 2021-05-06 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Transfer zumindest eines partikels in einer flüssigkeit von einer abgabeeinheit zu einer empfangseinheit
USD954990S1 (en) * 2020-03-06 2022-06-14 Lifenet Health Tray
TWI760120B (zh) 2021-02-25 2022-04-01 國立清華大學 懸滴裝置、形成懸滴之方法以及利用懸滴培養細胞之方法
KR102718818B1 (ko) 2022-02-22 2024-10-17 한국기계연구원 마이크로 스터러를 구비한 미세 웰 플레이트 및 이의 제조방법
DE102022201938A1 (de) 2022-02-24 2023-08-24 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Flüssigkeitstransfer zwischen rotierenden Modulen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4747197A (en) 1996-10-10 1998-05-05 Corning Incorporated Tool for the transport of liquid drops and method for the transfer of drops using such a tool
DE10210908A1 (de) 2002-03-05 2003-12-04 Alfred Nordheim Vorrichtung zum Aufbringen von flüssigen Medien und Verfahren dazu
JP2004254622A (ja) * 2003-02-26 2004-09-16 Yamanashi Tlo:Kk 胚性幹細胞（ｅｓ細胞）の胚様体（ｅｂ）形成のための培養容器及び培養方法
DE10362002B4 (de) 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
CN1737130A (zh) * 2005-07-12 2006-02-22 中国水产科学研究院黄海水产研究所 花鲈胚胎干细胞及培养方法
KR100836827B1 (ko) 2007-04-09 2008-06-10 전남대학교산학협력단 배아줄기세포의 배상체 형성용 배양용기
CN101117626A (zh) * 2007-07-12 2008-02-06 中国人民解放军军事医学科学院野战输血研究所 人胚胎干细胞体外诱导分化为肝细胞的方法
JP2009050194A (ja) 2007-08-27 2009-03-12 Sumitomo Bakelite Co Ltd 細胞凝集塊形成培養用容器
JP5490803B2 (ja) * 2008-09-22 2014-05-14 ウニヴェルジテート チューリッヒ プロレクトラート エムエヌヴェー 懸滴プレートおよび同懸滴プレートを使用する方法

Also Published As

Publication number Publication date
JP2014506799A (ja) 2014-03-20
WO2012117083A2 (en) 2012-09-07
US20140106395A1 (en) 2014-04-17
RU2013144195A (ru) 2015-04-10
BR112013021837B1 (pt) 2019-09-17
CA2825615A1 (en) 2012-09-07
CA2825615C (en) 2020-02-25
US9267933B2 (en) 2016-02-23
HK1191970A1 (en) 2014-08-08
EP2681305A2 (en) 2014-01-08
CN103429729A (zh) 2013-12-04
MX2013010005A (es) 2013-12-06
WO2012117083A3 (en) 2012-12-13
MX341295B (es) 2016-08-12
ES2546159T3 (es) 2015-09-21
KR101903809B1 (ko) 2018-10-02
KR20140003562A (ko) 2014-01-09
JP5999518B2 (ja) 2016-09-28
CN103429729B (zh) 2015-01-21
EP2681305B1 (en) 2015-08-05

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/03/2012, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/03/2012, OBSERVADAS AS CONDICOES LEGAIS