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BR112013013663A2 - ácidos 1-benzilcicloalquilcarboxílicos substituídos e sua utilização - Google Patents

ácidos 1-benzilcicloalquilcarboxílicos substituídos e sua utilização

Info

Publication number
BR112013013663A2
BR112013013663A2 BR112013013663A BR112013013663A BR112013013663A2 BR 112013013663 A2 BR112013013663 A2 BR 112013013663A2 BR 112013013663 A BR112013013663 A BR 112013013663A BR 112013013663 A BR112013013663 A BR 112013013663A BR 112013013663 A2 BR112013013663 A2 BR 112013013663A2
Authority
BR
Brazil
Prior art keywords
benzylcycloalkylcarboxylic
acids
substituted
benzylcycloalkylcarboxylic acids
Prior art date
Application number
BR112013013663A
Other languages
English (en)
Inventor
Andreas Knorr
Elisabeth Woltering
Eva-Maria Becker
Frank Wunder
Friederike Stoll
Johannes-Peter Stasch
Karl-Heinz Schlemmer
Michael G Hahn
Peter Kolkhof
Sherif El Sheikh
Thomas Lampe
Volkhart Min-Jian Li
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102010062544A external-priority patent/DE102010062544A1/de
Priority claimed from DE102011006974A external-priority patent/DE102011006974A1/de
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of BR112013013663A2 publication Critical patent/BR112013013663A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/02Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112013013663A 2010-12-07 2011-12-05 ácidos 1-benzilcicloalquilcarboxílicos substituídos e sua utilização BR112013013663A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102010062544A DE102010062544A1 (de) 2010-12-07 2010-12-07 Substituierte 1-Benzylcycloalkylcarbonsäuren und ihre Verwendung
DE102011006974A DE102011006974A1 (de) 2011-04-07 2011-04-07 Substituierte 1-Benzylcycloalkylcarbonsäuren und ihre Verwendung
PCT/EP2011/071747 WO2012076466A2 (de) 2010-12-07 2011-12-05 Substituierte 1-benzylcycloalkylcarbonsäuren und ihre verwendung

Publications (1)

Publication Number Publication Date
BR112013013663A2 true BR112013013663A2 (pt) 2016-09-06

Family

ID=45463539

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013013663A BR112013013663A2 (pt) 2010-12-07 2011-12-05 ácidos 1-benzilcicloalquilcarboxílicos substituídos e sua utilização

Country Status (26)

Country Link
US (1) US9018258B2 (pt)
EP (1) EP2649045B1 (pt)
JP (1) JP5989660B2 (pt)
KR (1) KR20130136504A (pt)
CN (1) CN103492361B (pt)
AP (1) AP2013006953A0 (pt)
AR (1) AR084220A1 (pt)
AU (1) AU2011340721A1 (pt)
BR (1) BR112013013663A2 (pt)
CA (1) CA2819880C (pt)
CL (1) CL2013001600A1 (pt)
CO (1) CO6771409A2 (pt)
CR (1) CR20130259A (pt)
DO (1) DOP2013000125A (pt)
EA (1) EA201300669A1 (pt)
EC (1) ECSP13012668A (pt)
ES (1) ES2544532T3 (pt)
HK (1) HK1192879A1 (pt)
IL (1) IL226422A0 (pt)
MA (1) MA34721B1 (pt)
MX (1) MX2013006053A (pt)
SG (1) SG190296A1 (pt)
TW (1) TW201249782A (pt)
UY (1) UY33776A (pt)
WO (1) WO2012076466A2 (pt)
ZA (1) ZA201305076B (pt)

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JP2021512959A (ja) 2018-02-06 2021-05-20 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司Jiangsu Hengrui Medicine Co., Ltd. ピラゾロ[1,5−a][1,3,5]トリアジン−2−アミン誘導体、その製造法、およびその医薬用途
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TW202342420A (zh) * 2022-02-18 2023-11-01 大陸商江蘇恆瑞醫藥股份有限公司 羧酸類化合物、其製備方法及其在醫藥上的應用
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Also Published As

Publication number Publication date
CN103492361B (zh) 2015-07-15
ECSP13012668A (es) 2013-08-30
CR20130259A (es) 2013-06-28
TW201249782A (en) 2012-12-16
ES2544532T3 (es) 2015-09-01
SG190296A1 (en) 2013-06-28
ZA201305076B (en) 2014-12-23
WO2012076466A2 (de) 2012-06-14
EP2649045A2 (de) 2013-10-16
US20120172448A1 (en) 2012-07-05
KR20130136504A (ko) 2013-12-12
MA34721B1 (fr) 2013-12-03
MX2013006053A (es) 2013-06-18
CO6771409A2 (es) 2013-10-15
JP5989660B2 (ja) 2016-09-07
CA2819880C (en) 2019-01-22
US9018258B2 (en) 2015-04-28
CL2013001600A1 (es) 2013-10-25
IL226422A0 (en) 2013-07-31
DOP2013000125A (es) 2013-11-15
AR084220A1 (es) 2013-05-02
CN103492361A (zh) 2014-01-01
JP2014510017A (ja) 2014-04-24
UY33776A (es) 2012-06-29
EA201300669A1 (ru) 2013-11-29
AU2011340721A1 (en) 2013-06-20
HK1192879A1 (zh) 2014-09-05
WO2012076466A3 (de) 2012-08-30
AP2013006953A0 (en) 2013-06-30
CA2819880A1 (en) 2012-06-14
EP2649045B1 (de) 2015-05-27

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