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BR112012029944A2 - processo para preparação de derivados de aminotetralinas substituídas com nitrogênio - Google Patents

processo para preparação de derivados de aminotetralinas substituídas com nitrogênio

Info

Publication number
BR112012029944A2
BR112012029944A2 BR112012029944A BR112012029944A BR112012029944A2 BR 112012029944 A2 BR112012029944 A2 BR 112012029944A2 BR 112012029944 A BR112012029944 A BR 112012029944A BR 112012029944 A BR112012029944 A BR 112012029944A BR 112012029944 A2 BR112012029944 A2 BR 112012029944A2
Authority
BR
Brazil
Prior art keywords
derivatives
aminotetralines
nitrogen substituted
preparing nitrogen
substituted aminotetralines
Prior art date
Application number
BR112012029944A
Other languages
English (en)
Inventor
Schule Arnaud
Ates Célia
Vasselin David
Phadtare Ganesh
Delatinne Jean-Pierre
Palacio Magali
Luisa Escudero Hernandez Maria
Carly Nicolas
Deutsch Paul
Yerande Swapnil
Pinilla Véronique
Original Assignee
Ucb Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma Gmbh filed Critical Ucb Pharma Gmbh
Publication of BR112012029944A2 publication Critical patent/BR112012029944A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/02—Carbamic acids; Salts of carbamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

processo paa preparação de derivados de aminotetralinas substituídas com nitrogênio. a presente invenção provê uma síntese alternativa de aminotetralinas n-substuídas compreendendo resolução de aminotetralinas n-substituídas de fórmula (ii), em que r^ 1^, r^ 2^ e r^ 3^ são como definidos para composto de fórmula (i).
BR112012029944A 2010-06-25 2011-06-24 processo para preparação de derivados de aminotetralinas substituídas com nitrogênio BR112012029944A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10006621 2010-06-25
PCT/EP2011/060655 WO2011161255A2 (en) 2010-06-25 2011-06-24 Novel process for the preparation of nitrogen substituted aminotetralins derivatives

Publications (1)

Publication Number Publication Date
BR112012029944A2 true BR112012029944A2 (pt) 2019-09-24

Family

ID=43086211

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012029944A BR112012029944A2 (pt) 2010-06-25 2011-06-24 processo para preparação de derivados de aminotetralinas substituídas com nitrogênio

Country Status (13)

Country Link
US (1) US8981121B2 (pt)
EP (1) EP2585428B1 (pt)
JP (1) JP5748848B2 (pt)
KR (1) KR20130122721A (pt)
CN (1) CN103119015B (pt)
AU (1) AU2011268871C1 (pt)
BR (1) BR112012029944A2 (pt)
CA (1) CA2798815C (pt)
EA (1) EA026337B1 (pt)
HK (1) HK1185339A1 (pt)
IL (1) IL222799A0 (pt)
MX (1) MX2012013818A (pt)
WO (1) WO2011161255A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014012935A1 (de) * 2012-07-20 2014-01-23 Bayer Pharma Aktiengesellschaft Substituierte aminoindan- und aminotetralin-carbonsäuren und ihre verwendung
CN111060625B (zh) * 2019-12-31 2022-04-05 北京鑫开元医药科技有限公司 2-(噻吩-2-基)乙基对甲苯磺酸酯及其异构体的检测方法
CN116283557A (zh) * 2023-04-06 2023-06-23 江苏汉邦科技股份有限公司 S型和r型氟比洛芬的拆分方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102553A (en) 1988-12-16 1992-04-07 The Amalgamated Sugar Company Time variable simulated moving bed process
US4968837A (en) * 1989-07-28 1990-11-06 Ethyl Corporation Resolution of racemic mixtures
US5382596A (en) * 1993-08-05 1995-01-17 Whitby Research, Inc. Substituted 2-aminotetralins
JPH0940667A (ja) 1995-07-26 1997-02-10 Mitsui Toatsu Chem Inc ピロリジノン誘導体およびその光学分割方法
FR2785196B1 (fr) 1998-10-29 2000-12-15 Inst Francais Du Petrole Procede et dispositif de separation avec des zones chromatographiques a longueur variable
WO2001017944A1 (fr) 1999-09-07 2001-03-15 Mitsubishi Rayon Co., Ltd. Procede relatif a l'elaboration d'aminoalcool optiquement actif
DK1232152T3 (da) * 1999-11-23 2004-04-05 Aderis Pharmaceuticals Inc Forbedret fremgangsmåde til fremstilling af nitrogensubstituerede aminotetraliner
CA2307390C (en) * 2000-05-01 2005-06-28 Torcan Chemical Ltd. Enzymatic resolution of aminotetralins
JP2001294582A (ja) 2000-04-12 2001-10-23 Fuji Chemical Industries Ltd 光学活性アミノブチロラクトンの製造法
ATE246919T1 (de) 2001-05-08 2003-08-15 Sanol Arznei Schwarz Gmbh Verbessertes transdermales therapeutisches system zur behandlung von morbus parkinson
DE10220230A1 (de) 2002-05-06 2003-11-27 Sanol Arznei Schwarz Gmbh Verwendung von Rotigotine zur Behandlung des Restless Leg Syndroms
JP4483165B2 (ja) 2002-10-01 2010-06-16 山川薬品工業株式会社 光学活性な３−（メチルアミノ）−１−（２−チエニル）プロパン−１−オールの製造方法および製造の中間体
DE10334188B4 (de) 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DE10361259A1 (de) 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von Rotigotine in einem Frühstadium von Morbus Parkinson zur Prävention des weiteren Neuronenverlustes
DE102004014841B4 (de) 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
US20070185346A1 (en) * 2006-02-03 2007-08-09 Vaidya Niteen A Kit for automated resolving agent selection and method thereof
EP1975161A1 (en) * 2007-03-28 2008-10-01 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituted- tetrahydro-napthalen-amine derivatives, their preparation and use as medicaments
CN102143937B (zh) * 2008-10-13 2014-07-02 因特奎姆私人控股公司 制备光学活性(s)-(-)-2-(n-丙基氨基)-5-甲氧基四氢化萘和(s)-(-)-2-(n-丙基氨基)-5-羟基四氢化萘化合物的方法

Also Published As

Publication number Publication date
AU2011268871A1 (en) 2013-01-10
CN103119015A (zh) 2013-05-22
AU2011268871B2 (en) 2015-01-22
JP5748848B2 (ja) 2015-07-15
WO2011161255A4 (en) 2012-06-21
MX2012013818A (es) 2013-01-24
EP2585428A2 (en) 2013-05-01
EP2585428B1 (en) 2017-05-10
IL222799A0 (en) 2012-12-31
CA2798815A1 (en) 2011-12-29
WO2011161255A3 (en) 2012-03-15
JP2013530977A (ja) 2013-08-01
HK1185339A1 (zh) 2014-02-14
US8981121B2 (en) 2015-03-17
KR20130122721A (ko) 2013-11-08
CA2798815C (en) 2017-01-03
CN103119015B (zh) 2016-01-27
EA026337B1 (ru) 2017-03-31
AU2011268871C1 (en) 2015-06-04
EA201201674A1 (ru) 2013-06-28
WO2011161255A2 (en) 2011-12-29
US20130102794A1 (en) 2013-04-25

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.