BR112019001327A2 - anticorpos anti-idiotípicos e métodos relacionados - Google Patents
anticorpos anti-idiotípicos e métodos relacionadosInfo
- Publication number
- BR112019001327A2 BR112019001327A2 BR112019001327-0A BR112019001327A BR112019001327A2 BR 112019001327 A2 BR112019001327 A2 BR 112019001327A2 BR 112019001327 A BR112019001327 A BR 112019001327A BR 112019001327 A2 BR112019001327 A2 BR 112019001327A2
- Authority
- BR
- Brazil
- Prior art keywords
- related methods
- idiotype antibodies
- idiotypic antibodies
- cells
- specifically
- Prior art date
Links
- 230000003302 anti-idiotype Effects 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662369008P | 2016-07-29 | 2016-07-29 | |
| US62/369,008 | 2016-07-29 | ||
| PCT/US2017/044560 WO2018023100A2 (en) | 2016-07-29 | 2017-07-29 | Anti-idiotypic antibodies and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019001327A2 true BR112019001327A2 (pt) | 2019-04-30 |
Family
ID=59656185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019001327-0A BR112019001327A2 (pt) | 2016-07-29 | 2017-07-29 | anticorpos anti-idiotípicos e métodos relacionados |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240018268A1 (de) |
| EP (1) | EP3491024A2 (de) |
| JP (2) | JP7062640B2 (de) |
| KR (2) | KR102553195B1 (de) |
| CN (2) | CN117903316A (de) |
| AU (1) | AU2017301887A1 (de) |
| BR (1) | BR112019001327A2 (de) |
| CA (1) | CA3031734A1 (de) |
| MA (1) | MA45784A (de) |
| MX (1) | MX2019001184A (de) |
| WO (1) | WO2018023100A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4269562A3 (de) | 2016-07-12 | 2023-12-27 | Kite Pharma, Inc. | Antigenbindende moleküle und verfahren zur verwendung davon |
| CN117903316A (zh) * | 2016-07-29 | 2024-04-19 | 朱诺治疗学股份有限公司 | 抗独特型抗体及相关方法 |
| US10626187B2 (en) | 2016-09-28 | 2020-04-21 | Kite Pharma, Inc. | Antigen binding molecules specific for an anti-CD19 scFv |
| EP3592851A1 (de) * | 2017-03-07 | 2020-01-15 | H. Hoffnabb-La Roche Ag | Verfahren zur entdeckung alternativer antigenspezifischer antikörpervarianten |
| KR20200064060A (ko) * | 2017-07-29 | 2020-06-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | 재조합 수용체를 발현하는 세포 증폭용 시약 |
| US20210179709A1 (en) * | 2017-10-31 | 2021-06-17 | Novartis Ag | Anti-car compositions and methods |
| CN108508200B (zh) * | 2018-04-18 | 2023-12-22 | 上海星湾生物技术有限公司 | 检测表达cd19 car的细胞的方法及其应用 |
| EP3876958A1 (de) | 2018-11-08 | 2021-09-15 | Juno Therapeutics, Inc. | Verfahren und kombinationen zur behandlung und t-zell-modulation |
| GB201820444D0 (en) * | 2018-12-14 | 2019-01-30 | Adaptimmune Ltd | Marker for T cell expansion |
| CN111349161B (zh) * | 2018-12-20 | 2022-02-08 | 上海星湾生物技术有限公司 | 抗cd19抗体的单克隆抗体及其应用 |
| JP2022529977A (ja) * | 2019-04-19 | 2022-06-27 | アロジーン セラピューティクス，インコーポレイテッド | ４ｇ７由来キメラ抗原受容体に対する抗体 |
| AU2020334237A1 (en) * | 2019-08-19 | 2022-02-10 | Universität Basel | Cell therapy methods |
| CA3159380A1 (en) | 2019-10-30 | 2021-05-06 | Juno Therapeutics Gmbh | Cell selection and/or stimulation devices and methods of use |
| JP2022554353A (ja) | 2019-11-07 | 2022-12-28 | ジュノー セラピューティクス インコーポレイテッド | Ｔ細胞療法と（ｓ）－３－［４－（４－モルホリン－４－イルメチル－ベンジルオキシ）－１－オキソ－１，３－ジヒドロ－イソインドール－２－イル］－ピペリジン－２，６－ジオンとの併用 |
| WO2021100585A1 (ja) * | 2019-11-20 | 2021-05-27 | 国立大学法人東海国立大学機構 | キメラ抗原受容体遺伝子改変リンパ球の調製方法 |
| CN110894238B (zh) * | 2019-11-25 | 2021-01-19 | 华道(上海)生物医药有限公司 | Car-t细胞的检测用单克隆抗体、试剂盒及应用 |
| AU2021221277A1 (en) * | 2020-02-11 | 2022-08-25 | Crispr Therapeutics Ag | Anti-idiotype antibodies targeting anti-CD19 chimeric antigen receptor |
| WO2022003158A1 (en) * | 2020-07-03 | 2022-01-06 | Cellectis S.A. | Method for determining potency of chimeric antigen receptor expressing immune cells |
| US20220064334A1 (en) * | 2020-07-17 | 2022-03-03 | Janssen Biotech, Inc. | Anti-idiotypic antibodies against anti-klk2 antibodies |
| CN112143707A (zh) * | 2020-09-29 | 2020-12-29 | 广东先康达生物科技有限公司 | 一种治疗自身免疫细胞的免疫细胞及其应用 |
| US20230398148A1 (en) | 2020-11-04 | 2023-12-14 | Juno Therapeutics, Inc. | Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods |
| US11883432B2 (en) | 2020-12-18 | 2024-01-30 | Century Therapeutics, Inc. | Chimeric antigen receptor system with adaptable receptor specificity |
| US20240108654A1 (en) | 2021-03-03 | 2024-04-04 | Juno Therapeutics, Inc. | Combination of a t cell therapy and a dgk inhibitor |
| JP2024511418A (ja) | 2021-03-22 | 2024-03-13 | ジュノー セラピューティクス インコーポレイテッド | 治療用細胞組成物の効力を決定する方法 |
| WO2022204071A1 (en) | 2021-03-22 | 2022-09-29 | Juno Therapeutics, Inc. | Method to assess potency of viral vector particles |
| EP4313126A1 (de) | 2021-03-29 | 2024-02-07 | Juno Therapeutics, Inc. | Kombination aus einer car-t-zelltherapie und einer immunmodulatorischen verbindung zur behandlung von lymphomen |
| JP2024517863A (ja) | 2021-05-06 | 2024-04-23 | ジュノ・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞を刺激し、形質導入する方法 |
| TW202321311A (zh) * | 2021-08-02 | 2023-06-01 | 日商諾伊爾免疫生物科技股份有限公司 | 與scFv等之連接子結合的抗體 |
| WO2024220588A1 (en) | 2023-04-18 | 2024-10-24 | Juno Therapeutics, Inc. | Cytotoxicity assay for assessing potency of therapeutic cell compositions |
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2017
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- 2017-07-29 WO PCT/US2017/044560 patent/WO2018023100A2/en unknown
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| CN117903316A (zh) | 2024-04-19 |
| AU2017301887A1 (en) | 2019-02-07 |
| WO2018023100A2 (en) | 2018-02-01 |
| KR20190044626A (ko) | 2019-04-30 |
| MA45784A (fr) | 2019-06-05 |
| JP2022084583A (ja) | 2022-06-07 |
| CN110088133A (zh) | 2019-08-02 |
| CN110088133B (zh) | 2023-12-08 |
| WO2018023100A3 (en) | 2018-03-08 |
| RU2019105532A (ru) | 2020-08-28 |
| JP2019527553A (ja) | 2019-10-03 |
| KR20230107408A (ko) | 2023-07-14 |
| RU2019105532A3 (de) | 2020-10-22 |
| CA3031734A1 (en) | 2018-02-01 |
| JP7062640B2 (ja) | 2022-05-06 |
| EP3491024A2 (de) | 2019-06-05 |
| KR102553195B1 (ko) | 2023-07-07 |
| MX2019001184A (es) | 2019-09-26 |
| US20240018268A1 (en) | 2024-01-18 |
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