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BR112018074853A2 - métodos para detectar a presença de pelo menos um genogrupo de norovírus em uma amostra de fezes e para selecionar um paciente que sofre de gastroenterite aguda, e, kit - Google Patents

métodos para detectar a presença de pelo menos um genogrupo de norovírus em uma amostra de fezes e para selecionar um paciente que sofre de gastroenterite aguda, e, kit

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Publication number
BR112018074853A2
BR112018074853A2 BR112018074853-6A BR112018074853A BR112018074853A2 BR 112018074853 A2 BR112018074853 A2 BR 112018074853A2 BR 112018074853 A BR112018074853 A BR 112018074853A BR 112018074853 A2 BR112018074853 A2 BR 112018074853A2
Authority
BR
Brazil
Prior art keywords
norovirus genogroup
methods
stool sample
acute gastroenteritis
selecting
Prior art date
Application number
BR112018074853-6A
Other languages
English (en)
Inventor
Tabb Michelle
Ramos Kristen
Lee Peter
Huang Raymond
Chen Jules
Original Assignee
Quest Diagnostics Investments Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Investments Llc filed Critical Quest Diagnostics Investments Llc
Publication of BR112018074853A2 publication Critical patent/BR112018074853A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
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  • Microbiology (AREA)
  • Biotechnology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

a presente descrição provê métodos e composições para determinar se um paciente que exibe gastroenterite aguda vai beneficiar do tratamento com agentes terapêuticos que inibem o genogrupo i (gi) de norovírus ou o genogrupo ii (gii) de norovírus. os métodos aqui descritos baseiam-se na detecção do genogrupo i (gi) de norovírus e do genogrupo ii (gii) de norovírus em uma amostra de fezes sem extrair ácidos nucleicos virais de um espécimen clínico antes da realização de pcr de transcrição reversa em tempo real. kits para uso na prática dos métodos também são providos.
BR112018074853-6A 2016-06-03 2017-06-02 métodos para detectar a presença de pelo menos um genogrupo de norovírus em uma amostra de fezes e para selecionar um paciente que sofre de gastroenterite aguda, e, kit BR112018074853A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662345331P 2016-06-03 2016-06-03
US62/345,331 2016-06-03
PCT/US2017/035686 WO2017210558A1 (en) 2016-06-03 2017-06-02 Methods for detecting norovirus

Publications (1)

Publication Number Publication Date
BR112018074853A2 true BR112018074853A2 (pt) 2019-04-02

Family

ID=60477891

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018074853-6A BR112018074853A2 (pt) 2016-06-03 2017-06-02 métodos para detectar a presença de pelo menos um genogrupo de norovírus em uma amostra de fezes e para selecionar um paciente que sofre de gastroenterite aguda, e, kit

Country Status (7)

Country Link
US (3) US10793924B2 (pt)
EP (1) EP3464647A4 (pt)
CN (1) CN110073005A (pt)
BR (1) BR112018074853A2 (pt)
CA (1) CA3025675A1 (pt)
MX (2) MX2018014922A (pt)
WO (1) WO2017210558A1 (pt)

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CN109265542B (zh) * 2018-09-27 2021-06-15 国药中生生物技术研究院有限公司 特异性结合诺如病毒gii.4基因型vp1蛋白或vlp的抗体及其制备方法和应用
CN110343783B (zh) * 2019-07-08 2020-04-28 广东省公共卫生研究院 基于高通量测序的诺如病毒测序引物、试剂盒及检测方法
CN110592284A (zh) * 2019-10-12 2019-12-20 福建谷科生物科技有限公司 一种快速检测诺如病毒的试剂盒
CN110791589A (zh) * 2019-10-18 2020-02-14 张家口健垣科技有限公司 一种用于rna恒温扩增检测诺如病毒的引物和探针、试剂盒及检测方法
CN111019908B (zh) * 2019-12-13 2022-10-14 广东省微生物研究所（广东省微生物分析检测中心） 一种从牡蛎中高效提取诺如病毒的样本高通量前处理方法及试剂盒
CN111187861B (zh) * 2020-02-26 2023-05-23 中国热带农业科学院热带生物技术研究所 一种对海产品诺如病毒gii.4的检测方法
US20240307419A1 (en) * 2021-01-29 2024-09-19 Kansas State University Research Foundation Conformationally-constrained inhibitors of 3c or 3c-like proteases
CN112725543B (zh) * 2021-03-04 2022-05-10 广东省科学院微生物研究所(广东省微生物分析检测中心) 人源诺如病毒gii.4型的特征性核酸鉴别引物组、试剂盒和检测方法
CN113025758A (zh) * 2021-04-07 2021-06-25 拱北海关技术中心 用于检测水产品gi型诺如病毒的引物、探针及试剂盒
CN114317814B (zh) * 2021-08-12 2024-06-14 中国科学院微生物研究所 用于检测临床样本中gi.7型诺如病毒的试剂盒及专用引物
CN116042928B (zh) * 2023-02-22 2024-01-02 中国人民解放军军事科学院军事医学研究院 用于扩增和检测消化道病毒核酸序列的引物组

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Also Published As

Publication number Publication date
EP3464647A4 (en) 2020-01-01
MX2018014922A (es) 2019-08-29
CA3025675A1 (en) 2017-12-07
US10793924B2 (en) 2020-10-06
US20210095352A1 (en) 2021-04-01
US12077830B2 (en) 2024-09-03
EP3464647A1 (en) 2019-04-10
US20190211408A1 (en) 2019-07-11
CN110073005A (zh) 2019-07-30
US20230279513A1 (en) 2023-09-07
MX2022014633A (es) 2023-01-11
WO2017210558A1 (en) 2017-12-07
US11555223B2 (en) 2023-01-17

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