BR112018013955A2 - ligantes de dopamina d3 de 6,7,8,9-tetra-hidro-5h-pirido[2,3-d]azepina - Google Patents
ligantes de dopamina d3 de 6,7,8,9-tetra-hidro-5h-pirido[2,3-d]azepinaInfo
- Publication number
- BR112018013955A2 BR112018013955A2 BR112018013955-6A BR112018013955A BR112018013955A2 BR 112018013955 A2 BR112018013955 A2 BR 112018013955A2 BR 112018013955 A BR112018013955 A BR 112018013955A BR 112018013955 A2 BR112018013955 A2 BR 112018013955A2
- Authority
- BR
- Brazil
- Prior art keywords
- azepine
- pyrido
- dopamine
- tetrahydro
- binders
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- QIBPEANLJGMFBP-UHFFFAOYSA-N 6,7,8,9-tetrahydro-5h-pyrido[2,3-d]azepine Chemical compound C1CNCCC2=CC=CN=C21 QIBPEANLJGMFBP-UHFFFAOYSA-N 0.000 title 1
- 239000011230 binding agent Substances 0.000 title 1
- 229960003638 dopamine Drugs 0.000 title 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 2
- 208000010877 cognitive disease Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 201000000980 schizophrenia Diseases 0.000 abstract 2
- 201000009032 substance abuse Diseases 0.000 abstract 2
- 231100000736 substance abuse Toxicity 0.000 abstract 2
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000026331 Disruptive, Impulse Control, and Conduct disease Diseases 0.000 abstract 1
- 208000030990 Impulse-control disease Diseases 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 208000009668 Neurobehavioral Manifestations Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000012201 sexual and gender identity disease Diseases 0.000 abstract 1
- 208000015891 sexual disease Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
a presente invenção refere-se aos compostos de fórmula (i): e sais farmaceuticamente aceitáveis dos mesmos, em que as variáveis r1, r2, r3, r4, r5 e a são como definidas aqui; processos para a preparação de intermediários usados na preparação de; e composições contendo tais compostos e sais, e seus usos para o tratamento de distúrbios mediados por d3 (ou associados com d3) incluindo, por exemplo, vício de substância, abuso de substância, esquizofrenia (por exemplo, seus sintomas cognitivos), comprometimento cognitivo (por exemplo, comprometimento cognitivo associado com esquizofrenia ad, ou pd), doença de parkinson, mania, ansiedade, distúrbios de controle de impulso, distúrbios sexuais e depressão.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662279037P | 2016-01-15 | 2016-01-15 | |
| US62/279,037 | 2016-01-15 | ||
| PCT/IB2017/050094 WO2017122116A1 (en) | 2016-01-15 | 2017-01-09 | 6,7,8,9-TETRAHYDRO-5H-PYRIDO[2,3-d]AZEPINE DOPAMINE D3 LIGANDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018013955A2 true BR112018013955A2 (pt) | 2018-12-11 |
| BR112018013955B1 BR112018013955B1 (pt) | 2024-01-16 |
Family
ID=57838441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018013955-6A BR112018013955B1 (pt) | 2016-01-15 | 2017-01-09 | Compostos ligantes de dopamina d3 de 6,7,8,9-tetra-hidro-5h-pirido [2,3- d] azepina, composição farmacêutica que os compreende e uso dos mesmos |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10590128B2 (pt) |
| EP (1) | EP3402796B1 (pt) |
| JP (1) | JP6929857B2 (pt) |
| KR (1) | KR102206321B1 (pt) |
| CN (1) | CN108884093B (pt) |
| AU (1) | AU2017208119B2 (pt) |
| BR (1) | BR112018013955B1 (pt) |
| CA (1) | CA3011201C (pt) |
| ES (1) | ES2837018T3 (pt) |
| IL (1) | IL260298B (pt) |
| MX (1) | MX2018008653A (pt) |
| RU (1) | RU2712455C1 (pt) |
| SG (1) | SG11201805202VA (pt) |
| TW (1) | TWI633104B (pt) |
| WO (1) | WO2017122116A1 (pt) |
| ZA (1) | ZA201803776B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6929857B2 (ja) | 2016-01-15 | 2021-09-01 | ファイザー・インク | ６，７，８，９−テトラヒドロ−５Ｈ−ピリド［２，３−ｄ］アゼピンドーパミンＤ３リガンド |
| WO2018021447A1 (ja) | 2016-07-28 | 2018-02-01 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物 |
| CA3089498A1 (en) | 2018-01-26 | 2019-08-01 | Shionogi & Co., Ltd. | Condensed ring compounds having dopamine d3 receptor antagonistic effect |
| CN108997287B (zh) * | 2018-07-23 | 2021-12-28 | 陕西师范大学 | 以四氟硼酸的离子液体为氟源催化合成4-氟代四氢吡喃衍生物的方法 |
| CN109608451A (zh) * | 2018-12-17 | 2019-04-12 | 上海药明康德新药开发有限公司 | 一种2-氧亚基-吡啶并[2,3-d]氮杂卓-7(2H)-甲酸叔丁酯合成方法 |
| WO2023172497A2 (en) * | 2022-03-07 | 2023-09-14 | Drexel University | Compounds, compositions, and methods for treating, ameliorating, and/or preventing cocaine use disorder |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| AU2003218660A1 (en) | 2002-02-13 | 2003-09-04 | Glaxo Group Limited | Benzenesulfonamide derivatives and their use as dopamine d3 and d2 receptor liga ds |
| DE60304695T2 (de) | 2002-02-13 | 2006-09-21 | Glaxo Group Ltd., Greenford | 7-arylsulfonamido-2,3,4,5-tetrahydro-1h-benzo[d]azepin-derivate mit 5-hat-6-rezeptor affinität zur behandlung von erkrankungen des zentralnervensystems |
| US7732442B2 (en) | 2003-09-05 | 2010-06-08 | Ono Pharmaceutical Co., Ltd. | Chemokine receptor antagonist and medical use thereof |
| EP1694334B1 (en) | 2003-12-18 | 2011-10-19 | Abbott GmbH & Co. KG | Tetrahydrobenzazepines and their use in the modulation of the dopamine d3 receptor |
| US20050137186A1 (en) | 2003-12-18 | 2005-06-23 | Abbott Gmbh & Co. Kg. | Tetrahydrobenzazepines and their use |
| GB0412314D0 (en) | 2004-06-02 | 2004-07-07 | Glaxo Group Ltd | Compounds |
| US7541357B2 (en) * | 2004-07-15 | 2009-06-02 | Amr Technology, Inc. | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| KR20070112228A (ko) | 2005-04-01 | 2007-11-22 | 워너-램버트 캄파니 엘엘씨 | 정신분열증을 치료하기 위한테트라하이드로-피리도아제핀-8-온 및 관련 화합물 |
| ES2440483T3 (es) | 2005-09-01 | 2014-01-29 | Eli Lilly And Company | 2,3,4,5-Tetrahidro-1H-benzo[d]azepinas sustituidas con heterociclo enlazado en 6-N como agonistas del receptor 5-HT2C |
| US7897595B2 (en) | 2006-05-26 | 2011-03-01 | Forest Laboratories Holdings Limited | Pyridoazepine derivatives |
| CA2692440A1 (en) * | 2006-07-20 | 2008-01-24 | Cascade Therapeutics Inc. | Tetrahydro-5h-pyrido[2,3-d]azepines as 5-ht2c ligands |
| GB0619176D0 (en) | 2006-09-29 | 2006-11-08 | Lectus Therapeutics Ltd | Ion channel modulators & uses thereof |
| NZ576425A (en) | 2006-10-23 | 2012-04-27 | Cephalon Inc | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors |
| GB0710844D0 (en) | 2007-06-06 | 2007-07-18 | Lectus Therapeutics Ltd | Potassium ion channel modulators & uses thereof |
| EP2179385A2 (en) | 2007-07-09 | 2010-04-28 | Technion Research & Development Foundation Ltd. | Routing methods for multiple geographical entities |
| CN101712675B (zh) | 2008-10-07 | 2013-07-03 | 江苏恒谊药业有限公司 | 苯并含氮杂环衍生物及其在治疗神经精神疾病药物的应用 |
| CA3146333A1 (en) | 2009-03-18 | 2010-09-23 | Resverlogix Corp. | Phenyl-quinazolin-4(3h)-one and phenyl-pyrido[2,3-d]pyrimidin-4(3h)-one derivatives and compositions thereof useful as anti-inflammatory agents |
| WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| US8975235B2 (en) | 2011-03-20 | 2015-03-10 | Intermune, Inc. | Lysophosphatidic acid receptor antagonists |
| WO2014082379A1 (en) | 2012-11-29 | 2014-06-05 | Sunshine Lake Pharma Co.,Ltd. | Spiro ring compound as hepatitis c virus (hcv) inhibitor and uses thereof field of the invention |
| WO2014106800A2 (en) | 2013-01-04 | 2014-07-10 | Aurigene Discovery Technologies Limited | Substituted 2-amino pyrimidine derivatives as kinase inhibitors |
| GB201309085D0 (en) | 2013-05-20 | 2013-07-03 | Redx Pharma Ltd | Compounds |
| EP3013813B1 (en) * | 2013-06-27 | 2019-04-03 | Pfizer Inc | Heteroaromatic compounds and their use as dopamine d1 ligands |
| US20160159805A1 (en) | 2013-07-17 | 2016-06-09 | Bayer Cropscience Ag | Heterocyclic sulfonylamino(thio)carbonyl-derivatives with nematicidal properties |
| JP6929857B2 (ja) | 2016-01-15 | 2021-09-01 | ファイザー・インク | ６，７，８，９−テトラヒドロ−５Ｈ−ピリド［２，３−ｄ］アゼピンドーパミンＤ３リガンド |
-
2017
- 2017-01-09 JP JP2018536264A patent/JP6929857B2/ja active Active
- 2017-01-09 CN CN201780017459.4A patent/CN108884093B/zh active Active
- 2017-01-09 BR BR112018013955-6A patent/BR112018013955B1/pt active IP Right Grant
- 2017-01-09 ES ES17700748T patent/ES2837018T3/es active Active
- 2017-01-09 WO PCT/IB2017/050094 patent/WO2017122116A1/en active Application Filing
- 2017-01-09 AU AU2017208119A patent/AU2017208119B2/en active Active
- 2017-01-09 MX MX2018008653A patent/MX2018008653A/es unknown
- 2017-01-09 EP EP17700748.1A patent/EP3402796B1/en active Active
- 2017-01-09 KR KR1020187023277A patent/KR102206321B1/ko active IP Right Grant
- 2017-01-09 SG SG11201805202VA patent/SG11201805202VA/en unknown
- 2017-01-09 RU RU2018125942A patent/RU2712455C1/ru active
- 2017-01-09 US US16/069,585 patent/US10590128B2/en active Active
- 2017-01-09 CA CA3011201A patent/CA3011201C/en active Active
- 2017-01-13 TW TW106101286A patent/TWI633104B/zh active
-
2018
- 2018-06-07 ZA ZA2018/03776A patent/ZA201803776B/en unknown
- 2018-06-27 IL IL260298A patent/IL260298B/en unknown
-
2020
- 2020-01-23 US US16/750,505 patent/US11390623B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR102206321B1 (ko) | 2021-01-21 |
| TW201736367A (zh) | 2017-10-16 |
| MX2018008653A (es) | 2018-12-10 |
| BR112018013955B1 (pt) | 2024-01-16 |
| ZA201803776B (en) | 2020-09-30 |
| EP3402796B1 (en) | 2020-11-18 |
| CA3011201A1 (en) | 2017-07-20 |
| AU2017208119A1 (en) | 2018-06-28 |
| IL260298A (en) | 2018-08-30 |
| CN108884093B (zh) | 2021-07-09 |
| US11390623B2 (en) | 2022-07-19 |
| AU2017208119B2 (en) | 2019-11-07 |
| ES2837018T3 (es) | 2021-06-29 |
| EP3402796A1 (en) | 2018-11-21 |
| JP2019501930A (ja) | 2019-01-24 |
| CA3011201C (en) | 2020-09-22 |
| WO2017122116A1 (en) | 2017-07-20 |
| TWI633104B (zh) | 2018-08-21 |
| SG11201805202VA (en) | 2018-07-30 |
| CN108884093A (zh) | 2018-11-23 |
| US10590128B2 (en) | 2020-03-17 |
| JP6929857B2 (ja) | 2021-09-01 |
| KR20180100432A (ko) | 2018-09-10 |
| IL260298B (en) | 2021-07-29 |
| US20190047997A1 (en) | 2019-02-14 |
| US20200157098A1 (en) | 2020-05-21 |
| RU2712455C1 (ru) | 2020-01-29 |
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