BR112017026561A2 - moduladores alostéricos positivos do receptor muscarínico m2 - Google Patents
moduladores alostéricos positivos do receptor muscarínico m2Info
- Publication number
- BR112017026561A2 BR112017026561A2 BR112017026561-3A BR112017026561A BR112017026561A2 BR 112017026561 A2 BR112017026561 A2 BR 112017026561A2 BR 112017026561 A BR112017026561 A BR 112017026561A BR 112017026561 A2 BR112017026561 A2 BR 112017026561A2
- Authority
- BR
- Brazil
- Prior art keywords
- muscarinic receptor
- positive allosteric
- allosteric modulators
- modulators
- positive
- Prior art date
Links
- 102000017926 CHRM2 Human genes 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15171127.2 | 2015-06-09 | ||
| EP15171127 | 2015-06-09 | ||
| EP16156676.5 | 2016-02-22 | ||
| EP16156676 | 2016-02-22 | ||
| PCT/EP2016/062737 WO2016198342A1 (de) | 2015-06-09 | 2016-06-06 | Positiv allosterische modulatoren des muskarinergen m2 rezeptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017026561A2 true BR112017026561A2 (pt) | 2018-08-14 |
Family
ID=56101466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017026561-3A BR112017026561A2 (pt) | 2015-06-09 | 2016-06-06 | moduladores alostéricos positivos do receptor muscarínico m2 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US10435403B2 (pt) |
| EP (2) | EP3692991A1 (pt) |
| JP (1) | JP6908536B2 (pt) |
| KR (1) | KR20180016485A (pt) |
| CN (1) | CN107949562B (pt) |
| AU (1) | AU2016274433B2 (pt) |
| BR (1) | BR112017026561A2 (pt) |
| CA (1) | CA2988468A1 (pt) |
| CL (1) | CL2017003124A1 (pt) |
| CO (1) | CO2017012622A2 (pt) |
| CR (1) | CR20170566A (pt) |
| CU (1) | CU20170158A7 (pt) |
| DO (1) | DOP2017000288A (pt) |
| EA (1) | EA035465B1 (pt) |
| EC (1) | ECSP17081322A (pt) |
| HK (1) | HK1254348A1 (pt) |
| IL (2) | IL256119A (pt) |
| MX (1) | MX370113B (pt) |
| NI (1) | NI201700154A (pt) |
| PE (1) | PE20180252A1 (pt) |
| PH (1) | PH12017502224A1 (pt) |
| SG (1) | SG11201710164QA (pt) |
| TN (1) | TN2017000498A1 (pt) |
| TW (1) | TW201716405A (pt) |
| UY (1) | UY36714A (pt) |
| WO (1) | WO2016198342A1 (pt) |
| ZA (1) | ZA201800125B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018014869A (es) | 2016-06-02 | 2019-09-13 | Cloudbreak Therapeutics Llc | Composiciones y metodos de uso en nintedanib para tratar enfermedades oculares con neovascularizacion anormal. |
| EP3481823B1 (de) | 2016-07-11 | 2020-10-28 | Bayer Pharma Aktiengesellschaft | 7-substituierte 1-pyridyl-naphthyridin-3-carbonsäureamide und ihre verwendung |
| JOP20190045A1 (ar) * | 2016-09-14 | 2019-03-14 | Bayer Ag | مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها. |
| JOP20190086A1 (ar) | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
| CN110215899B (zh) * | 2019-04-01 | 2022-03-25 | 重庆科技学院 | 一种氨基酸功能化的金属有机骨架材料及其制备方法和应用 |
| CA3146811A1 (en) * | 2019-09-10 | 2021-03-18 | Cloudbreak Therapeutics, Llc | Methods for alleviating pterygium-associated worry about eye appearance |
| CN111057045A (zh) * | 2019-12-18 | 2020-04-24 | 安徽红杉生物医药科技有限公司 | Hcv ns3/4a蛋白酶抑制剂中间体及其合成方法、应用 |
| AU2021231765A1 (en) * | 2020-03-03 | 2022-10-06 | Redona Therapeutics, Inc. | Compounds targeting RNA-binding proteins or RNA-modifying proteins |
| CN114105881B (zh) | 2020-08-31 | 2024-01-26 | 沈阳海诺威医药科技有限公司 | 血小板聚集抑制剂及其制备方法和用途 |
| CN113072480B (zh) * | 2021-04-13 | 2022-09-30 | 常州佳德医药科技有限公司 | 一种手性(-)-5-氮杂螺[2.4]庚烷-7-醇、制备方法及应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3906365A1 (de) | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| IT1239283B (it) * | 1989-11-08 | 1993-10-19 | Erba Carlo Spa | Uso di un agente muscarinico da solo o insieme ad un noto farmaco antiaritmico per la prevenzione e/o il trattamento dell'aritmia ventricolare. |
| JP2758722B2 (ja) | 1993-08-13 | 1998-05-28 | ドング ホワ ファーマシューチカル インダストリアル カンパニー，リミテッド | 新規キノロンカルボン酸誘導体 |
| US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| WO2003050107A1 (en) | 2001-12-13 | 2003-06-19 | Wockhardt Limited | New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| CN1168446C (zh) * | 2002-08-26 | 2004-09-29 | 夏国瑾 | 氢溴酸槟榔碱作为制备抗心律失常药物的应用 |
| CA2526423A1 (en) * | 2003-05-21 | 2004-12-29 | Board Of Regents, The University Of Texas System | Inhibition of protein kinase c-mu (pkd) as a treatment for cardiac hypertrophy and heart failure |
| JP2005012561A (ja) | 2003-06-19 | 2005-01-13 | Sony Corp | 画像処理装置、画像処理方法および画像投射装置 |
| KR20060041254A (ko) * | 2003-07-24 | 2006-05-11 | 아스텔라스세이야쿠 가부시키가이샤 | 퀴놀론 유도체 또는 그의 염 |
| WO2005026145A2 (en) | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| WO2005026165A1 (en) | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| DE10343098A1 (de) | 2003-09-18 | 2005-04-14 | Bayer Healthcare Ag | Tetrahydrochinoxaline und ihre Verwendung |
| WO2005049602A1 (en) | 2003-11-18 | 2005-06-02 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| CA2548009A1 (en) | 2003-12-09 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Naphthyridine derivatives and their use as modulators of muscarinic receptors |
| NZ551128A (en) * | 2004-05-20 | 2010-03-26 | Diamedica Inc | Use of hepatic parasympathetic tone modulator and diabetes drug combinations for treating insulin resistance |
| AR057555A1 (es) * | 2005-10-27 | 2007-12-05 | Merck Frosst Canada Ltd | Un inhibidor de fosfodiesterasa-4 4-oxo-1-(3-sustituido fenil-1,4-dihidro-1,8-naftiridin-3-carboxamida y un procedimiento de preparacion del mismo |
| CN101411705B (zh) * | 2007-10-17 | 2011-06-01 | 北京赛德维康医药研究院 | 用于防治动脉粥样硬化的药物组合物 |
| WO2010093341A1 (en) | 2009-02-10 | 2010-08-19 | Janssen Pharmaceutica N.V. | C-7 isoxazolinyl quinolone/naphthyridine derivatives useful as antibacterial agents |
| DK2512243T3 (en) | 2009-12-17 | 2016-07-25 | Merck Sharp & Dohme | POSITIVE ALLOSTERIC QUINOLINAMIDE M1 RECEPTOR MODULATORS |
| US20130289019A1 (en) * | 2012-04-26 | 2013-10-31 | Amazing Grace, Inc. | Methods of treating behaviorial and/or mental disorders |
| CN103183676B (zh) * | 2013-03-12 | 2015-04-08 | 中国医学科学院医药生物技术研究所 | 一组1-取代-1,8萘啶甲酰胺衍生物及制备和应用 |
| GB201409044D0 (en) | 2014-05-21 | 2014-07-02 | Ucl Business Plc | New compounds |
| JP6623220B2 (ja) | 2014-11-03 | 2019-12-18 | バイエル ファーマ アクチエンゲゼルシャフト | ヒドロキシアルキル置換フェニルトリアゾール誘導体およびその使用 |
| ES2774517T3 (es) | 2015-06-09 | 2020-07-21 | Abbvie Inc | Moduladores del receptor nuclear (ROR) para el tratamiento de enfermedades inflamatorias y autoinmunes |
| JP2018521033A (ja) | 2015-06-09 | 2018-08-02 | ジェ イル ファーマシューティカル カンパニー リミテッド | 三環式誘導体化合物、その製造方法及びそれを含む薬学的組成物 |
| EP3481823B1 (de) | 2016-07-11 | 2020-10-28 | Bayer Pharma Aktiengesellschaft | 7-substituierte 1-pyridyl-naphthyridin-3-carbonsäureamide und ihre verwendung |
| JOP20190045A1 (ar) | 2016-09-14 | 2019-03-14 | Bayer Ag | مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها. |
-
2016
- 2016-06-06 SG SG11201710164QA patent/SG11201710164QA/en unknown
- 2016-06-06 EP EP19216135.4A patent/EP3692991A1/de not_active Withdrawn
- 2016-06-06 EA EA201890002A patent/EA035465B1/ru not_active IP Right Cessation
- 2016-06-06 TN TNP/2017/000498A patent/TN2017000498A1/en unknown
- 2016-06-06 CA CA2988468A patent/CA2988468A1/en active Pending
- 2016-06-06 AU AU2016274433A patent/AU2016274433B2/en not_active Expired - Fee Related
- 2016-06-06 KR KR1020187000247A patent/KR20180016485A/ko not_active Application Discontinuation
- 2016-06-06 BR BR112017026561-3A patent/BR112017026561A2/pt not_active Application Discontinuation
- 2016-06-06 CU CUP2017000158A patent/CU20170158A7/xx unknown
- 2016-06-06 MX MX2017016055A patent/MX370113B/es active IP Right Grant
- 2016-06-06 CN CN201680046695.4A patent/CN107949562B/zh active Active
- 2016-06-06 WO PCT/EP2016/062737 patent/WO2016198342A1/de active Application Filing
- 2016-06-06 EP EP16727193.1A patent/EP3307741B1/de active Active
- 2016-06-06 PE PE2017002542A patent/PE20180252A1/es unknown
- 2016-06-06 US US15/735,138 patent/US10435403B2/en active Active
- 2016-06-06 JP JP2017564437A patent/JP6908536B2/ja active Active
- 2016-06-06 CR CR20170566A patent/CR20170566A/es unknown
- 2016-06-06 UY UY0001036714A patent/UY36714A/es not_active Application Discontinuation
- 2016-06-07 TW TW105117915A patent/TW201716405A/zh unknown
-
2017
- 2017-12-05 IL IL256119A patent/IL256119A/en unknown
- 2017-12-06 CL CL2017003124A patent/CL2017003124A1/es unknown
- 2017-12-07 CO CONC2017/0012622A patent/CO2017012622A2/es unknown
- 2017-12-07 DO DO2017000288A patent/DOP2017000288A/es unknown
- 2017-12-07 NI NI201700154A patent/NI201700154A/es unknown
- 2017-12-07 PH PH12017502224A patent/PH12017502224A1/en unknown
- 2017-12-08 EC ECIEPI201781322A patent/ECSP17081322A/es unknown
-
2018
- 2018-01-08 ZA ZA2018/00125A patent/ZA201800125B/en unknown
- 2018-10-19 HK HK18113424.9A patent/HK1254348A1/zh unknown
-
2019
- 2019-08-13 US US16/539,652 patent/US20190367516A1/en not_active Abandoned
-
2020
- 2020-01-13 IL IL272017A patent/IL272017A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |