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BR112017014328A2 - anticorpos compreendendo um domínio de ligação de antígeno dependente de concentração de íon, variantes de região fc, anticorpos de ligação à il-8, métodos de produção dos mesmos e para prolongamento ou redução da meia-vida de um anticorpo em plasma, composição farmacêutica, ácido nucleico, vetor, célula hospedeira - Google Patents

anticorpos compreendendo um domínio de ligação de antígeno dependente de concentração de íon, variantes de região fc, anticorpos de ligação à il-8, métodos de produção dos mesmos e para prolongamento ou redução da meia-vida de um anticorpo em plasma, composição farmacêutica, ácido nucleico, vetor, célula hospedeira

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Publication number
BR112017014328A2
BR112017014328A2 BR112017014328-3A BR112017014328A BR112017014328A2 BR 112017014328 A2 BR112017014328 A2 BR 112017014328A2 BR 112017014328 A BR112017014328 A BR 112017014328A BR 112017014328 A2 BR112017014328 A2 BR 112017014328A2
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BR
Brazil
Prior art keywords
antibodies
ion concentration
prolonging
antibody
vector
Prior art date
Application number
BR112017014328-3A
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English (en)
Other versions
BR112017014328B1 (pt
Inventor
Igawa Tomoyuki
Maeda Atsuhiko
Haraya Kenta
Tachibana Tatsuhiko
Iwayanagi Yuki
Hori Yuji
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of BR112017014328A2 publication Critical patent/BR112017014328A2/pt
Publication of BR112017014328B1 publication Critical patent/BR112017014328B1/pt

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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Abstract

a presente invenção refere-se em um aspecto não exclusivo a moléculas para aperfeiçoamento adicional de anticorpos que podem se ligar a antígenos de uma maneira dependente da concentração de íon. um aspecto não exclusivo alternativo provê variantes de região fc seguras e mais vantajosas que têm ligação diminuída a ada preexistente. em um aspecto não exclusivo alternativo provê anticorpos contra il-8 que são superiores como agentes farmacêuticos.
BR112017014328-3A 2015-02-05 2016-02-04 Anticorpos compreendendo um domínio de ligação ao antígeno dependente de concentração de íon e anticorpos de ligação à il-8 BR112017014328B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2015021371 2015-02-05
JP2015-021371 2015-02-05
JP2015185254 2015-09-18
JP2015-185254 2015-09-18
PCT/JP2016/000577 WO2016125495A1 (en) 2015-02-05 2016-02-04 Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof

Publications (2)

Publication Number Publication Date
BR112017014328A2 true BR112017014328A2 (pt) 2018-01-02
BR112017014328B1 BR112017014328B1 (pt) 2025-01-14

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EP3816179A3 (en) 2021-08-04
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JP2024096311A (ja) 2024-07-12
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US20200172610A1 (en) 2020-06-04
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