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BR112016002079A2 - Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido - Google Patents

Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido

Info

Publication number
BR112016002079A2
BR112016002079A2 BR112016002079A BR112016002079A BR112016002079A2 BR 112016002079 A2 BR112016002079 A2 BR 112016002079A2 BR 112016002079 A BR112016002079 A BR 112016002079A BR 112016002079 A BR112016002079 A BR 112016002079A BR 112016002079 A2 BR112016002079 A2 BR 112016002079A2
Authority
BR
Brazil
Prior art keywords
acid additive
oxymorpone
oxymorphone
acid
solid
Prior art date
Application number
BR112016002079A
Other languages
English (en)
Inventor
Grant Ewart
Matharu Saroop
archer Nicolas
Heinrich Brian
Original Assignee
Johnson Matthey Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey Plc filed Critical Johnson Matthey Plc
Publication of BR112016002079A2 publication Critical patent/BR112016002079A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESSO PARA PREPARAÇÃO DE UM ADITIVO ÁCIDO DE OXIMORFONA, SOLUÇÃO AQUOSA DE ADITIVO ÁCIDO DE OXIMORFONA, ADITIVO ÁCIDO DE OXIMORFONA SÓLIDO, E, ALCALOIDE DE OXIMORFONA SÓLIDO. A presente invenção fornece um processo para a preparação de um aditivo ácido de oximorfona, o dito processo compreendendo hidrogenar uma solução aquosa de 14-hidroximorfinona e um ácido para formar uma solução do aditivo ácido de oximorfona, em que a hidrogenação é realizada em uma ou mais temperaturas maiores do que 40°C na presença de um catalisador de hidrogenação e gás hidrogênio, em que o nível de 6(Alfa)-oximorfol produzido é de 3,00% de área como determinado por HPLC.
BR112016002079A 2013-08-02 2014-02-05 Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido BR112016002079A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361861777P 2013-08-02 2013-08-02
PCT/GB2014/050317 WO2015015146A1 (en) 2013-08-02 2014-02-05 Process for the preparation of oxymorphone

Publications (1)

Publication Number Publication Date
BR112016002079A2 true BR112016002079A2 (pt) 2017-09-05

Family

ID=50114388

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002079A BR112016002079A2 (pt) 2013-08-02 2014-02-05 Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido

Country Status (9)

Country Link
US (3) US9120800B2 (pt)
EP (1) EP3027622B8 (pt)
CN (2) CN110172063A (pt)
AU (1) AU2014298257B2 (pt)
BR (1) BR112016002079A2 (pt)
CA (1) CA2919602C (pt)
GB (1) GB2517000B (pt)
RU (1) RU2637934C2 (pt)
WO (1) WO2015015146A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110172063A (zh) * 2013-08-02 2019-08-27 庄信万丰股份有限公司 用于制备氢羟吗啡酮的方法
GB201313915D0 (en) * 2013-08-02 2013-09-18 Johnson Matthey Plc Process
US9918979B2 (en) * 2015-01-29 2018-03-20 Johnson Matthey Public Limited Company Process of preparing low ABUK oxymorphone hydrochloride
US20160340362A1 (en) * 2015-05-20 2016-11-24 Noramco, Inc. Process For The Preparation Of Oxymorphone Freebase

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US6291675B1 (en) 1996-05-21 2001-09-18 The United States As Represented By The Department Of Health And Human Services Methods of o-demethylation and n-deprotection
US6067749A (en) 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
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IL160193A0 (en) * 2001-08-23 2004-07-25 Akzo Nobel Nv Process for the preparation of a 14-hydroxynormorphinone derivative
US20030139396A1 (en) * 2002-01-22 2003-07-24 Karen Gibson Method of treatment
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HUE034668T2 (hu) 2003-09-22 2018-02-28 Glaxosmithkline Australia Pty Ltd Eljárás morfinán-származékok szintézisére és azok intermedierjei
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TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
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WO2006005112A1 (en) 2004-07-09 2006-01-19 Tasmanian Alkaloids Pty Ltd Process for the synthesis of hydromorphone
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JP5695296B2 (ja) 2006-03-02 2015-04-01 マリンクロッド エルエルシー 低レベルのアルファ，ベータ−不飽和ケトン化合物を伴うモルフィナン−６−オン生成物の製造方法
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CA2870056C (en) * 2012-06-11 2021-01-19 Siegfried Ag Improved method of preparing oxymorphone
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CN110172063A (zh) * 2013-08-02 2019-08-27 庄信万丰股份有限公司 用于制备氢羟吗啡酮的方法

Also Published As

Publication number Publication date
US20190225622A1 (en) 2019-07-25
CN110172063A (zh) 2019-08-27
RU2016107369A (ru) 2017-09-05
GB2517000A (en) 2015-02-11
RU2637934C2 (ru) 2017-12-08
EP3027622B1 (en) 2019-04-03
CA2919602A1 (en) 2015-02-05
CA2919602C (en) 2018-03-13
US20150038715A1 (en) 2015-02-05
AU2014298257B2 (en) 2016-11-10
EP3027622B8 (en) 2019-06-12
US20150329553A1 (en) 2015-11-19
AU2014298257A1 (en) 2016-02-25
US9120800B2 (en) 2015-09-01
CN105452253A (zh) 2016-03-30
EP3027622A1 (en) 2016-06-08
WO2015015146A1 (en) 2015-02-05
GB2517000B (en) 2018-05-09
GB201401922D0 (en) 2014-03-19

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 489/08

Ipc: C07D 489/08 (2006.01), A61P 25/04 (2006.01)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]