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BR112015030918A2 - método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais - Google Patents

método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais

Info

Publication number
BR112015030918A2
BR112015030918A2 BR112015030918A BR112015030918A BR112015030918A2 BR 112015030918 A2 BR112015030918 A2 BR 112015030918A2 BR 112015030918 A BR112015030918 A BR 112015030918A BR 112015030918 A BR112015030918 A BR 112015030918A BR 112015030918 A2 BR112015030918 A2 BR 112015030918A2
Authority
BR
Brazil
Prior art keywords
progenitor cells
renal progenitor
cells
producing
drugs containing
Prior art date
Application number
BR112015030918A
Other languages
English (en)
Inventor
Osafune Kenji
Toyohara Takafumi
Yamagishi Yukiko
Original Assignee
Astellas Pharma Inc
Univ Kyoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc, Univ Kyoto filed Critical Astellas Pharma Inc
Publication of BR112015030918A2 publication Critical patent/BR112015030918A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0687—Renal stem cells; Renal progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

a presente invenção fornece: um método para produção de células progenitoras renais a partir de células mesodérmicas intermediárias, o método incluindo uma etapa para cultivo de células meso-dérmicas intermediárias em um meio de cultura que contém um ativador de sinalização de tgfss e um inibidor de bmp; as células progenitoras renais produzidas pelo método; uma composição farmacêutica contendo as células; e um agente terapêutico para doenças renais que compreendem as células.
BR112015030918A 2013-06-11 2014-06-11 método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais BR112015030918A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013123072 2013-06-11
JP2014092108 2014-04-25
PCT/JP2014/066081 WO2014200115A1 (ja) 2013-06-11 2014-06-11 腎前駆細胞の製造方法及び腎前駆細胞を含む医薬

Publications (1)

Publication Number Publication Date
BR112015030918A2 true BR112015030918A2 (pt) 2017-12-05

Family

ID=52022399

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015030918A BR112015030918A2 (pt) 2013-06-11 2014-06-11 método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais

Country Status (15)

Country Link
US (1) US11225642B2 (pt)
EP (1) EP3020803B1 (pt)
JP (1) JP6450311B2 (pt)
KR (1) KR102145967B1 (pt)
CN (1) CN105283542A (pt)
AU (1) AU2014279065B2 (pt)
BR (1) BR112015030918A2 (pt)
CA (1) CA2915085C (pt)
ES (1) ES2794074T3 (pt)
IL (1) IL243023B (pt)
MX (1) MX2015017036A (pt)
RU (1) RU2696315C2 (pt)
SG (1) SG11201510201PA (pt)
TW (1) TWI629360B (pt)
WO (1) WO2014200115A1 (pt)

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Also Published As

Publication number Publication date
US11225642B2 (en) 2022-01-18
EP3020803B1 (en) 2020-03-11
CN105283542A (zh) 2016-01-27
KR20160019509A (ko) 2016-02-19
CA2915085C (en) 2021-04-27
RU2015156492A (ru) 2017-07-14
RU2015156492A3 (pt) 2018-04-02
AU2014279065A1 (en) 2016-01-21
ES2794074T3 (es) 2020-11-17
SG11201510201PA (en) 2016-01-28
AU2014279065B2 (en) 2020-04-09
JPWO2014200115A1 (ja) 2017-02-23
MX2015017036A (es) 2016-07-21
US20160137985A1 (en) 2016-05-19
RU2696315C2 (ru) 2019-08-01
TWI629360B (zh) 2018-07-11
EP3020803A4 (en) 2017-02-22
EP3020803A1 (en) 2016-05-18
IL243023B (en) 2019-05-30
WO2014200115A1 (ja) 2014-12-18
CA2915085A1 (en) 2014-12-18
KR102145967B1 (ko) 2020-08-19
TW201536917A (zh) 2015-10-01
JP6450311B2 (ja) 2019-01-09

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