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BR112015029462A2 - Inibidores de quinase - Google Patents

Inibidores de quinase

Info

Publication number
BR112015029462A2
BR112015029462A2 BR112015029462A BR112015029462A BR112015029462A2 BR 112015029462 A2 BR112015029462 A2 BR 112015029462A2 BR 112015029462 A BR112015029462 A BR 112015029462A BR 112015029462 A BR112015029462 A BR 112015029462A BR 112015029462 A2 BR112015029462 A2 BR 112015029462A2
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
compositions
compounds
compound
treatment
Prior art date
Application number
BR112015029462A
Other languages
English (en)
Other versions
BR112015029462A8 (pt
Inventor
Woo Chi-Kit
Alcaraz Lilian
Capaldi Carmelida
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of BR112015029462A2 publication Critical patent/BR112015029462A2/pt
Publication of BR112015029462A8 publication Critical patent/BR112015029462A8/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSTO, MÉTODO E USO DE INIBIDORES DE QUINASE. A presente invenção refere-se a compostos e composições que são inibidores de MAPK p38 úteis como agentes anti inflamatórios no tratamento, inter alia, de doenças do trato respiratório.
BR112015029462A 2013-06-06 2014-06-05 Inibidores de quinase BR112015029462A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13170921 2013-06-06
PCT/EP2014/061677 WO2014195400A1 (en) 2013-06-06 2014-06-05 Kinase inhibitors

Publications (2)

Publication Number Publication Date
BR112015029462A2 true BR112015029462A2 (pt) 2017-08-22
BR112015029462A8 BR112015029462A8 (pt) 2023-03-21

Family

ID=48569995

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015029462A BR112015029462A8 (pt) 2013-06-06 2014-06-05 Inibidores de quinase

Country Status (9)

Country Link
US (1) US9359354B2 (pt)
EP (1) EP3004098B1 (pt)
KR (1) KR20160015221A (pt)
CN (1) CN105308046A (pt)
BR (1) BR112015029462A8 (pt)
CA (1) CA2914449A1 (pt)
HK (1) HK1219104A1 (pt)
RU (1) RU2015151834A (pt)
WO (1) WO2014195400A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX359200B (es) 2011-12-09 2018-09-19 Chiesi Farm Spa Inhibidores de cinasa.
CA2914432A1 (en) 2013-06-06 2014-12-11 Chiesi Farmaceutici S.P.A. Kinase inhibitors
EP3394060A1 (en) 2015-12-23 2018-10-31 Chiesi Farmaceutici S.p.A. 1-(3-tert-butyl-2h-pyrazol-5-yl or 5-tert-butyl-isoxaol-3-yl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro-naphthalenyl) urea derivatives and their use as p38 mapk inhibitors
AR107165A1 (es) 2015-12-23 2018-03-28 Chiesi Farm Spa Inhibidores de quinasa
US10364245B2 (en) * 2017-06-07 2019-07-30 Chiesi Farmaceutici S.P.A. Kinase inhibitors
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
KR20200067170A (ko) 2017-10-05 2020-06-11 풀크럼 쎄러퓨틱스, 인코포레이티드 FSHD의 치료를 위하여 DUX4 및 하류 유전자 발현을 저감시키는 p38 키나제 저해제
CN108424372B (zh) * 2018-05-11 2021-08-10 浙江华贝药业有限责任公司 2,2,2-三氟-n-[(s)-4-羰基四氢萘-1-基]-乙酰胺的纯化工艺
TW202043407A (zh) * 2019-03-04 2020-12-01 日商拓自達電線股份有限公司 導電性接著劑組成物
AU2020311940A1 (en) 2019-07-11 2022-02-03 ESCAPE Bio, Inc. Indazoles and azaindazoles as LRRK2 inhibitors
CN114324669B (zh) * 2022-01-04 2023-11-14 宁波第二激素厂 一种鲑鱼促性腺激素释放激素类似物中l-精氨酸残留量的柱前手性衍生测定方法
CN115650824B (zh) * 2022-10-31 2024-01-23 合肥工业大学 手性二醇及其制备方法、制得的催化剂及制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007091152A1 (en) * 2006-02-09 2007-08-16 Pfizer Limited Triazolopyridine compounds
SG174134A1 (en) * 2009-02-17 2011-10-28 Chiesi Farma Spa Triazolopyridine derivatives as p38 map kinase inhibitors
GB201009731D0 (en) * 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
MX359200B (es) * 2011-12-09 2018-09-19 Chiesi Farm Spa Inhibidores de cinasa.
CA2914432A1 (en) * 2013-06-06 2014-12-11 Chiesi Farmaceutici S.P.A. Kinase inhibitors

Also Published As

Publication number Publication date
US20140364411A1 (en) 2014-12-11
CN105308046A (zh) 2016-02-03
EP3004098B1 (en) 2017-08-09
BR112015029462A8 (pt) 2023-03-21
RU2015151834A (ru) 2017-06-08
EP3004098A1 (en) 2016-04-13
KR20160015221A (ko) 2016-02-12
US9359354B2 (en) 2016-06-07
WO2014195400A1 (en) 2014-12-11
HK1219104A1 (zh) 2017-03-24
CA2914449A1 (en) 2014-12-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2517 DE 02-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA:

Ipc: A61K 31/475 (2006.01), A61P 11/06 (2006.01), C07D