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BR112015007637A2 - oligo rna de dupla hélice específico para amfiregulina, estrutura de oligo rna de dupla hélice e composição para prevenir ou tratar doenças respiratórias contendo o mesmo - Google Patents

oligo rna de dupla hélice específico para amfiregulina, estrutura de oligo rna de dupla hélice e composição para prevenir ou tratar doenças respiratórias contendo o mesmo

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Publication number
BR112015007637A2
BR112015007637A2 BR112015007637A BR112015007637A BR112015007637A2 BR 112015007637 A2 BR112015007637 A2 BR 112015007637A2 BR 112015007637 A BR112015007637 A BR 112015007637A BR 112015007637 A BR112015007637 A BR 112015007637A BR 112015007637 A2 BR112015007637 A2 BR 112015007637A2
Authority
BR
Brazil
Prior art keywords
stranded
double
amphyregulin
oligo
oligo rna
Prior art date
Application number
BR112015007637A
Other languages
English (en)
Inventor
Park Han-Oh
CHAE Jeiwook
Oh Yoon Pyoung
Original Assignee
Bioneer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioneer Corp filed Critical Bioneer Corp
Publication of BR112015007637A2 publication Critical patent/BR112015007637A2/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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Abstract

resumo oligo rna de dupla hƒlice especêfico para amfiregulina, estrutura de oligo rna de dupla hƒlice e composi‚ìo para prevenir ou tratar doen‚as respiratîrias contendo o mesmo, refere-se a um oligo sirna de fita dupla espec’fico de anfiregulina, que pode inibir a express‹o de anfiregulina com alta efici�ncia e ser efetivamente usado para a preven�‹o ou tratamento de doen�as respirat—rias. alžm disso, a inven�‹o compreende compostos hidrof’licos e hidrof—bicos, ligados ao oligo sirna de fita dupla espec’fico de anfiregulina por liga�‹o covalente œnica ou liga�‹o covalente mediada por ligante, de modo a aumentar a estabilidade in vivo e a efici�ncia de libera�‹o intracelular do oligo sirna de fita dupla, e para nanopart’culas compostas de estruturas de oligo sirna. a estrutura de oligo sirna de fita dupla espec’fico de anfiregulina, de acordo com a presente inven�‹o, pode aumentar a estabilidade do oligo sirna de fita dupla espec’fico sem comprometer a fun�‹o do oligo sirna de fita dupla espec’fico para anfiregulina e, ao mesmo tempo, pode efetivamente aumentar a permeabilidade de membrana do oligo sirna de fita dupla. 1/1
BR112015007637A 2012-10-05 2013-10-07 oligo rna de dupla hélice específico para amfiregulina, estrutura de oligo rna de dupla hélice e composição para prevenir ou tratar doenças respiratórias contendo o mesmo BR112015007637A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120110559 2012-10-05
PCT/KR2013/008949 WO2014054927A1 (ko) 2012-10-05 2013-10-07 엠피레귤린 특이적 이중 나선 올리고 rna, 그러한 이중나선 올리고 rna를 포함하는 이중나선 올리고 rna 구조체 및 이를 포함하는 호흡기 질환의 예방 또는 치료용 조성물

Publications (1)

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BR112015007637A2 true BR112015007637A2 (pt) 2017-08-08

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US (1) US20150259690A1 (pt)
EP (1) EP2905337A4 (pt)
JP (1) JP2015532100A (pt)
KR (1) KR20150064065A (pt)
CN (1) CN104781403A (pt)
AU (1) AU2013325384A1 (pt)
BR (1) BR112015007637A2 (pt)
CA (1) CA2887069A1 (pt)
WO (1) WO2014054927A1 (pt)

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EP3018209B1 (en) * 2013-07-05 2019-10-16 Bioneer Corporation Respiratory disease-related gene specific sirna, double-helical oligo rna structure containing sirna, compositon containing same for preventing or treating respiratory disease
JP6426268B2 (ja) * 2014-04-04 2018-11-21 バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ 新規の二重らせんオリゴｒｎａおよびこれを含む線維症または呼吸器疾患の予防または治療用薬学組成物
CN108220320A (zh) * 2018-02-12 2018-06-29 武汉伊艾博科技有限公司 人双调蛋白克隆至人工改造的表达载体pGEX-4T-1及其原核可溶性表达的研究
MX2020012652A (es) * 2018-05-25 2021-05-27 Bioneer Corp Oligonucleotido bicatenario especifico del gen de anfirregulina y composicion para prevenir y tratar enfermedades relacionadas con la fibrosis y enfermedades respiratorias, que comprende el mismo.
EP4151236A4 (en) * 2020-05-14 2024-06-26 Bioneer Corporation COMPOSITION FOR PREVENTING OR TREATING A DISEASE ASSOCIATED WITH OBESITY CONTAINING A DOUBLE-STRANDED OLIGONUCLEOTIDE STRUCTURE SPECIFIC TO AMPHIREGULIN

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US20150259690A1 (en) 2015-09-17
KR20150064065A (ko) 2015-06-10
EP2905337A4 (en) 2016-10-12
EP2905337A1 (en) 2015-08-12
WO2014054927A1 (ko) 2014-04-10
AU2013325384A1 (en) 2015-04-30
CA2887069A1 (en) 2014-04-10
CN104781403A (zh) 2015-07-15
JP2015532100A (ja) 2015-11-09

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