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BR112014032964A2 - composto, composição farmacêutica, uso do composto, e, método para preparar o composto - Google Patents

composto, composição farmacêutica, uso do composto, e, método para preparar o composto

Info

Publication number
BR112014032964A2
BR112014032964A2 BR112014032964A BR112014032964A BR112014032964A2 BR 112014032964 A2 BR112014032964 A2 BR 112014032964A2 BR 112014032964 A BR112014032964 A BR 112014032964A BR 112014032964 A BR112014032964 A BR 112014032964A BR 112014032964 A2 BR112014032964 A2 BR 112014032964A2
Authority
BR
Brazil
Prior art keywords
compound
preparing
pharmaceutical composition
formula
âcompound
Prior art date
Application number
BR112014032964A
Other languages
English (en)
Inventor
Bai Hua
Zhong Jinqing
Liu Lifei
Zhu Qifeng
Zheng Xiaohe
Liu Xiaoyu
Zhao Xuyang
Gong Yongxiang
Original Assignee
Zhejiang Hisun Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49881293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014032964(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zhejiang Hisun Pharm Co Ltd filed Critical Zhejiang Hisun Pharm Co Ltd
Publication of BR112014032964A2 publication Critical patent/BR112014032964A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1 / 1 resumo “composto, composiã‡ãƒo farmacãšutica, uso do composto, e, mã‰todo para preparar um composto” sã£o fornecidos na presente invenã§ã£o novos derivados de benzodioxol e seus mã©todos de preparaã§ã£o. estes compostos representados pela fã³rmula (i) ou seus sais farmaceuticamente aceitã¡veis tãªm atividade inibidora de acetilcolinesterase, de modo que podem ser usados no tratamento 1 2 ou na prevenã§ã£o de mal de alzheimer. as definiã§ãµes de r , r e a de fã³rmula (i) podem ser vistas na descriã§ã£o.
BR112014032964A 2012-07-03 2013-07-03 composto, composição farmacêutica, uso do composto, e, método para preparar o composto BR112014032964A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210226125.7A CN103524515B (zh) 2012-07-03 2012-07-03 具有乙酰胆碱酯酶抑制活性的苯并间二氧杂环戊烯衍生物及其制备方法和用途
PCT/CN2013/000813 WO2014005421A1 (zh) 2012-07-03 2013-07-03 苯并间二氧杂环戊烯衍生物及其制备方法和用途

Publications (1)

Publication Number Publication Date
BR112014032964A2 true BR112014032964A2 (pt) 2017-06-27

Family

ID=49881293

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014032964A BR112014032964A2 (pt) 2012-07-03 2013-07-03 composto, composição farmacêutica, uso do composto, e, método para preparar o composto

Country Status (26)

Country Link
US (1) US9346818B2 (pt)
EP (1) EP2871184B1 (pt)
JP (1) JP6113275B2 (pt)
KR (1) KR101650776B1 (pt)
CN (2) CN103524515B (pt)
AU (1) AU2013286523B2 (pt)
BR (1) BR112014032964A2 (pt)
CA (1) CA2878000C (pt)
CL (1) CL2014003607A1 (pt)
DK (1) DK2871184T3 (pt)
EA (1) EA026210B1 (pt)
ES (1) ES2645643T3 (pt)
HK (1) HK1202857A1 (pt)
IL (1) IL236395A (pt)
IN (1) IN2014DN11112A (pt)
MX (1) MX357774B (pt)
MY (1) MY167075A (pt)
NO (1) NO2871184T3 (pt)
NZ (1) NZ703549A (pt)
PE (1) PE20150349A1 (pt)
PH (1) PH12015500012A1 (pt)
PT (1) PT2871184T (pt)
SG (1) SG11201500007WA (pt)
UA (1) UA113444C2 (pt)
WO (1) WO2014005421A1 (pt)
ZA (1) ZA201500692B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103524515B (zh) * 2012-07-03 2016-07-06 浙江海正药业股份有限公司 具有乙酰胆碱酯酶抑制活性的苯并间二氧杂环戊烯衍生物及其制备方法和用途
CN105859732B (zh) * 2016-04-11 2018-04-06 浙江海正药业股份有限公司 制备ad‑35的工艺
JP2019515052A (ja) * 2016-05-13 2019-06-06 デルノバ・インコーポレイテッドＤｅｌＮｏｖａ，Ｉｎｃ． 化学的除神経から生じる副作用の処置
CN110812358B (zh) * 2018-08-10 2022-04-05 浙江海正药业股份有限公司 化合物ad-35在治疗与胃肠蠕动障碍相关疾病中的应用
CN113185447B (zh) * 2021-05-06 2023-07-21 四川大学 邻苯二甲酰半胱酰胺类化合物、其制备方法和用途
WO2023116915A1 (zh) * 2021-12-24 2023-06-29 珠海市藤栢医药有限公司 AChE/SERT双靶点抑制剂及其制备方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087541A (en) * 1975-03-06 1978-05-02 Boehringer Ingelheim Gmbh 2-(Aralkylaminoalkyl)phthalimidines
US5175157A (en) * 1985-11-27 1992-12-29 Boehringer Ingelheim Gmbh Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JPH0610496B2 (ja) * 1987-09-17 1994-02-09 ダイハツ工業株式会社 車両用自動変速機のクラッチ構造
JP2777159B2 (ja) * 1988-12-22 1998-07-16 エーザイ株式会社 環状アミン誘導体を含有する医薬
IL125809A (en) 1998-08-17 2005-08-31 Finetech Lab Ltd Process and intermediates for production of donepezil and related compounds
DE60129210T2 (de) * 2000-02-29 2008-03-20 Mitsubishi Pharma Corp. Zyklische amid-derivate
EP1468684A4 (en) * 2002-01-22 2008-02-27 Eisai R&D Man Co Ltd SIGMA RECEPTOR BINDING MOLECULE WITH INDANO DERIVATIVE
US7446203B2 (en) 2003-07-01 2008-11-04 Hetero Drugs Limited Preparation of intermediates for acetycholinesterase inhibitors
WO2005076749A2 (en) 2004-02-11 2005-08-25 Jubilant Organosys Limited A novel process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine
CA2635550A1 (en) 2006-01-04 2007-07-12 Cipla Limited Process and intermediate for preparation of donepezil
AU2007207149A1 (en) 2006-01-18 2007-07-26 Siena Biotech S.P.A. Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof
WO2008073452A1 (en) * 2006-12-11 2008-06-19 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
CN103524515B (zh) * 2012-07-03 2016-07-06 浙江海正药业股份有限公司 具有乙酰胆碱酯酶抑制活性的苯并间二氧杂环戊烯衍生物及其制备方法和用途

Also Published As

Publication number Publication date
MX357774B (es) 2018-07-24
MX2015000334A (es) 2015-04-14
KR20150034224A (ko) 2015-04-02
CL2014003607A1 (es) 2015-03-13
PH12015500012B1 (en) 2015-03-02
CN103524515B (zh) 2016-07-06
CN104395303A (zh) 2015-03-04
EP2871184A4 (en) 2015-12-23
IL236395A0 (en) 2015-02-26
DK2871184T3 (da) 2017-11-13
US9346818B2 (en) 2016-05-24
AU2013286523A1 (en) 2015-02-05
PH12015500012A1 (en) 2015-03-02
EP2871184B1 (en) 2017-09-06
US20150191480A1 (en) 2015-07-09
MY167075A (en) 2018-08-10
JP2015525740A (ja) 2015-09-07
EA026210B1 (ru) 2017-03-31
AU2013286523B2 (en) 2017-06-22
ES2645643T3 (es) 2017-12-07
UA113444C2 (xx) 2017-01-25
EP2871184A1 (en) 2015-05-13
EA201590074A1 (ru) 2015-07-30
NZ703549A (en) 2015-11-27
CN103524515A (zh) 2014-01-22
HK1202857A1 (en) 2015-10-09
ZA201500692B (en) 2016-01-27
SG11201500007WA (en) 2015-02-27
NO2871184T3 (pt) 2018-02-03
CA2878000C (en) 2020-05-05
KR101650776B1 (ko) 2016-08-25
PE20150349A1 (es) 2015-02-28
IL236395A (en) 2017-01-31
WO2014005421A1 (zh) 2014-01-09
CN104395303B (zh) 2017-12-12
JP6113275B2 (ja) 2017-04-12
CA2878000A1 (en) 2014-01-09
IN2014DN11112A (pt) 2015-09-25
PT2871184T (pt) 2017-11-14

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements