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BR112014012607A2 - métodos de tratamento usando um inibidor de interferon gama - Google Patents

métodos de tratamento usando um inibidor de interferon gama

Info

Publication number
BR112014012607A2
BR112014012607A2 BR112014012607A BR112014012607A BR112014012607A2 BR 112014012607 A2 BR112014012607 A2 BR 112014012607A2 BR 112014012607 A BR112014012607 A BR 112014012607A BR 112014012607 A BR112014012607 A BR 112014012607A BR 112014012607 A2 BR112014012607 A2 BR 112014012607A2
Authority
BR
Brazil
Prior art keywords
interferon gamma
treatment methods
ifn
methods
gamma inhibitor
Prior art date
Application number
BR112014012607A
Other languages
English (en)
Inventor
A Welcher Andrew
B Chung James
J Boedigheimer Michael
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47295210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014012607(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR112014012607A2 publication Critical patent/BR112014012607A2/pt

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • G—PHYSICS
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
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Abstract

resumo “métodos de tratamento usando um inibidor de interferon gama” a presente invenção abrange métodos de tratamento de doenças mediadas por interferon gama (ifn-?) usando inibidores de ifn-?, como anticorpos anti-huifn-?, em que os níveis de expressão de um ou mais biomarcadores são determinados antes da administração do inibidor de ifn-? e/ou após a administração. também são contemplados métodos de tratamento usando doses particulares farmacodinamicamente eficazes de um anticorpo anti-huifn-?.
BR112014012607A 2011-11-23 2012-11-21 métodos de tratamento usando um inibidor de interferon gama BR112014012607A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161563357P 2011-11-23 2011-11-23
US201261616846P 2012-03-28 2012-03-28
US201261651900P 2012-05-25 2012-05-25
PCT/US2012/066348 WO2013078378A1 (en) 2011-11-23 2012-11-21 Methods of treatment using an antibody against interferon gamma

Publications (1)

Publication Number Publication Date
BR112014012607A2 true BR112014012607A2 (pt) 2017-06-20

Family

ID=47295210

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014012607A BR112014012607A2 (pt) 2011-11-23 2012-11-21 métodos de tratamento usando um inibidor de interferon gama

Country Status (17)

Country Link
US (4) US20130142809A1 (pt)
EP (2) EP3196210A1 (pt)
JP (2) JP2015505300A (pt)
KR (1) KR20140097336A (pt)
CN (1) CN104159919A (pt)
AU (1) AU2012340624B2 (pt)
BR (1) BR112014012607A2 (pt)
CA (1) CA2854921A1 (pt)
CL (1) CL2014001345A1 (pt)
EA (1) EA201491011A1 (pt)
HK (1) HK1203519A1 (pt)
IL (1) IL232510A0 (pt)
MX (1) MX2014006241A (pt)
PH (1) PH12014501122A1 (pt)
SG (1) SG11201402490XA (pt)
WO (1) WO2013078378A1 (pt)
ZA (1) ZA201403451B (pt)

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BR112014012607A2 (pt) 2011-11-23 2017-06-20 Amgen Inc métodos de tratamento usando um inibidor de interferon gama
AU2014241162A1 (en) 2013-03-27 2015-10-22 Cedars-Sinai Medical Center Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways
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BR112017012222A2 (pt) * 2014-12-09 2018-01-30 Merck Sharp & Dohme métodos para derivar um biomarcador de assinatura gênica e para tratar um paciente que tem um tumor, método e sistema para testar uma amostra de tumor removida de um paciente, e, kit.
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CN113092770A (zh) * 2019-12-23 2021-07-09 首都医科大学附属北京世纪坛医院 尿液白蛋白及其多肽片段在过敏性疾病中的应用
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CN117295952A (zh) * 2021-03-12 2023-12-26 詹森生物科技公司 用于预测溃疡性结肠炎中治疗响应的方法
CN112794903B (zh) * 2021-04-14 2021-06-25 广州市雷德生物科技有限公司 一种特异性结合IFN-γ的抗体及其应用
CN116284381B (zh) * 2023-05-16 2023-09-05 北京百普赛斯生物科技股份有限公司 抗IFN-γ的抗体及其应用

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