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BR112014012054A2 - métodos de tratamento com deferiprona - Google Patents

métodos de tratamento com deferiprona

Info

Publication number
BR112014012054A2
BR112014012054A2 BR112014012054A BR112014012054A BR112014012054A2 BR 112014012054 A2 BR112014012054 A2 BR 112014012054A2 BR 112014012054 A BR112014012054 A BR 112014012054A BR 112014012054 A BR112014012054 A BR 112014012054A BR 112014012054 A2 BR112014012054 A2 BR 112014012054A2
Authority
BR
Brazil
Prior art keywords
patient
deferiprone
reperfusion injury
methods
application
Prior art date
Application number
BR112014012054A
Other languages
English (en)
Inventor
Arnold Wright Graham
Chalmers Connelly John
Charles Wood John
Spino Michael
Ramesh Ghugre Nilesh
Original Assignee
Apotex Tech Inc
Children's Hospital Los Angeles
Sunnybrook Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Tech Inc, Children's Hospital Los Angeles, Sunnybrook Res Inst filed Critical Apotex Tech Inc
Publication of BR112014012054A2 publication Critical patent/BR112014012054A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)

Abstract

resumo “métodos de tratamento com deferiprona” o presente pedido é direcionado para métodos de tratar ou melhorar isque-mia miocárdica, um evento coronariano agudo, e uma lesão de reperfusão no mio-cárdio que compreende administrar uma quantidade terapeuticamente eficaz de deferiprona ou um sal farmaceuticamente aceitável do mesmo, a um paciente em necessidade do mesmo. o pedido é também direcionado para a redução do risco para lesões de reperfusão no miocárdio, bem como promover a remodelação benéfica do tecido cardíaco em um paciente, que compreende administrar uma quantidade terapeuticamente eficaz de deferiprona ou sal farmaceuticamente aceitável do mesmo a um paciente antes, durante ou após a terapia de reperfusão. o pedido também inclui métodos de selecionar um paciente para o tratamento da lesão de reperfusão, e subsequentemente tratar o paciente selecionado.
BR112014012054A 2011-11-18 2012-11-16 métodos de tratamento com deferiprona BR112014012054A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161561692P 2011-11-18 2011-11-18
US201261591854P 2012-01-27 2012-01-27
PCT/US2012/065663 WO2013075015A1 (en) 2011-11-18 2012-11-16 Methods of treatment with deferiprone

Publications (1)

Publication Number Publication Date
BR112014012054A2 true BR112014012054A2 (pt) 2017-05-30

Family

ID=48430216

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014012054A BR112014012054A2 (pt) 2011-11-18 2012-11-16 métodos de tratamento com deferiprona

Country Status (9)

Country Link
US (1) US20140314676A1 (pt)
EP (1) EP2780012A4 (pt)
JP (1) JP2014533697A (pt)
AU (1) AU2012327224A1 (pt)
BR (1) BR112014012054A2 (pt)
CA (1) CA2856229A1 (pt)
IL (1) IL232668A0 (pt)
WO (1) WO2013075015A1 (pt)
ZA (1) ZA201403739B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10694961B2 (en) 2011-06-13 2020-06-30 Cedaris-Sinai Medical Center Assessment of iron deposition post myocardial infarction as a marker of myocardial hemorrhage
US10694962B2 (en) 2011-06-13 2020-06-30 Cedars-Sinai Medical Center Assessment of iron deposition post myocardial infarction as a marker of myocardial hemorrhage
EP3585385A4 (en) * 2017-02-27 2020-12-30 The University of Adelaide METHODS AND PRODUCTS FOR REDUCING ADHESIONS
CN114533689A (zh) 2017-10-25 2022-05-27 奇斯药制品公司 延迟释放去铁酮片剂及其使用方法
WO2021072368A1 (en) * 2019-10-10 2021-04-15 Medstar Health, Inc. Noninvasive assessment of microvascular dysfunction
US20230165841A1 (en) * 2020-03-20 2023-06-01 Cedars-Sinai Medical Center Prevention and intervention of infarct expansion following hemorrhagic infarctions
JP2024502821A (ja) * 2020-12-31 2024-01-23 アリーナ ファーマシューティカルズ， インコーポレイテッド 処置方法
US12016850B2 (en) 2022-04-11 2024-06-25 Chiesi Farmaceutici S.P.A. Modified release pharmaceutical formulations comprising deferiprone
US12016851B2 (en) 2022-04-11 2024-06-25 Chiesi Farmaceutici S.P.A. Modified release pharmaceutical formulations comprising deferiprone

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2313270C (en) * 2000-06-30 2011-09-13 Apotex Inc. Use of deferiprone in treating and preventing iron-induced cardiac disease
US20030176360A1 (en) * 2000-07-05 2003-09-18 Yasutaka Igari Medicinal preparations for treating sex hormone-dependent diseases
JP2005537223A (ja) * 2002-04-05 2005-12-08 ニトロメッド，インク． 酸化窒素供与体、組成物および使用法
US7776312B2 (en) * 2004-08-13 2010-08-17 Healthpartners Research Foundation Method of treating Alzheimer's disease comprising administering deferoxamine (DFO) to the upper one-third of the nasal cavity
EP1827298A4 (en) * 2004-12-22 2011-09-28 Univ Emory THERAPEUTIC APPARATUS FOR IMPROVING THE PROTECTIVE EFFECTS OF POST-CONDITIONING ORGANS
BRPI0715123A2 (pt) * 2006-08-04 2013-06-04 Novartis Ag tratamento de disfunÇço endàcrina usando quelantes de ferro
WO2008138912A1 (en) * 2007-05-14 2008-11-20 Novartis Ag Use of iron chelator for the treatment of myocardial infarction
WO2010129845A1 (en) * 2009-05-07 2010-11-11 University Of Cincinnati Methods of preventing ischemic injury using peripheral nociceptive stimulation

Also Published As

Publication number Publication date
CA2856229A1 (en) 2013-05-23
EP2780012A4 (en) 2015-07-29
ZA201403739B (en) 2015-12-23
US20140314676A1 (en) 2014-10-23
WO2013075015A1 (en) 2013-05-23
IL232668A0 (en) 2014-07-31
JP2014533697A (ja) 2014-12-15
EP2780012A1 (en) 2014-09-24
AU2012327224A1 (en) 2013-06-06

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]