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BR112014016788A8 - composições de ácidos graxos poli-insaturados ômega-3 em forma de ácido livre, enriquecidas com dpa - Google Patents

composições de ácidos graxos poli-insaturados ômega-3 em forma de ácido livre, enriquecidas com dpa

Info

Publication number
BR112014016788A8
BR112014016788A8 BR112014016788A BR112014016788A BR112014016788A8 BR 112014016788 A8 BR112014016788 A8 BR 112014016788A8 BR 112014016788 A BR112014016788 A BR 112014016788A BR 112014016788 A BR112014016788 A BR 112014016788A BR 112014016788 A8 BR112014016788 A8 BR 112014016788A8
Authority
BR
Brazil
Prior art keywords
dpa
polyunsaturated fatty
free acid
compositions
fatty acid
Prior art date
Application number
BR112014016788A
Other languages
English (en)
Other versions
BR112014016788A2 (pt
Inventor
N M Machielse Bernardus
M Mehta Bharat
Wisler Gerald
Davidson Michael
Ralph Wood Peter
J Maines Timothy
Original Assignee
Chrysalis Pharma Ag
Omthera Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48744082&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014016788(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chrysalis Pharma Ag, Omthera Pharmaceuticals Inc filed Critical Chrysalis Pharma Ag
Publication of BR112014016788A2 publication Critical patent/BR112014016788A2/pt
Publication of BR112014016788A8 publication Critical patent/BR112014016788A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Materials For Photolithography (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

abstract of the disclosure dpa-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented. _________________________ tradução do resumo resumo patente de invenção: "composições de ácidos graxos poli-insaturados ômega-3 em forma de ácido livre, enri-quecidas com dpa". a presente invenção refere-se a composições farmacêuticas de ácidos graxos poli-insaturados em forma de ácido livre, enri-quecidas com dpa, a métodos terapêuticos para o uso das composições e a processos para o seu refino a partir de óleo de peixe. a presente invenção também provê métodos para tratar hipertrigliceridemia (200 mg/dl - 500 mg/dl) pela administração adjuvante de uma estatina e as composições farmacêuticas descritas no pedido de patente. métodos de tratamentos adicionais incluem, entre outros, tratamentos para aumentar as razões epa:aa, tratamentos para diminuir os níveis de apociii e tratamentos para reduzir ou prevenir a resistência a inibi-dores da agregação plaquetária.
BR112014016788A 2012-01-06 2013-01-04 composições de ácidos graxos poli-insaturados ômega-3 em forma de ácido livre, enriquecidas com dpa BR112014016788A8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261583796P 2012-01-06 2012-01-06
US201261664047P 2012-06-25 2012-06-25
US201261669940P 2012-07-10 2012-07-10
US201261680622P 2012-08-07 2012-08-07
US201261710517P 2012-10-05 2012-10-05
US201261713388P 2012-10-12 2012-10-12
PCT/US2013/020398 WO2013103902A1 (en) 2012-01-06 2013-01-04 Dpa-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form

Publications (2)

Publication Number Publication Date
BR112014016788A2 BR112014016788A2 (pt) 2017-06-13
BR112014016788A8 true BR112014016788A8 (pt) 2017-07-04

Family

ID=48744082

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016788A BR112014016788A8 (pt) 2012-01-06 2013-01-04 composições de ácidos graxos poli-insaturados ômega-3 em forma de ácido livre, enriquecidas com dpa

Country Status (34)

Country Link
US (5) US20150004224A1 (pt)
EP (2) EP3348262A1 (pt)
JP (3) JP6399655B2 (pt)
KR (2) KR102153143B1 (pt)
CN (3) CN108524483A (pt)
BR (1) BR112014016788A8 (pt)
CA (1) CA2860512C (pt)
CL (1) CL2014001803A1 (pt)
CO (1) CO7061070A2 (pt)
CY (1) CY1120663T1 (pt)
DK (1) DK2800563T3 (pt)
DO (1) DOP2014000159A (pt)
EC (1) ECSP14012527A (pt)
ES (1) ES2685703T3 (pt)
HK (2) HK1251457A1 (pt)
HR (1) HRP20181418T1 (pt)
HU (1) HUE039659T2 (pt)
IL (3) IL233517A (pt)
IN (1) IN2014DN06125A (pt)
LT (1) LT2800563T (pt)
MX (1) MX358319B (pt)
MY (1) MY165048A (pt)
NZ (1) NZ626699A (pt)
PE (1) PE20142459A1 (pt)
PH (2) PH12014501553B1 (pt)
PL (1) PL2800563T3 (pt)
PT (1) PT2800563T (pt)
RS (1) RS57777B1 (pt)
RU (2) RU2018116572A (pt)
SG (2) SG11201403805WA (pt)
SI (1) SI2800563T1 (pt)
UA (1) UA114615C2 (pt)
WO (1) WO2013103902A1 (pt)
ZA (1) ZA201405765B (pt)

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