BR112014016108A2 - método de tratamento de perda óssea alvelar - Google Patents
método de tratamento de perda óssea alvelarInfo
- Publication number
- BR112014016108A2 BR112014016108A2 BR112014016108-9A BR112014016108A BR112014016108A2 BR 112014016108 A2 BR112014016108 A2 BR 112014016108A2 BR 112014016108 A BR112014016108 A BR 112014016108A BR 112014016108 A2 BR112014016108 A2 BR 112014016108A2
- Authority
- BR
- Brazil
- Prior art keywords
- alvelar
- treatment method
- bone loss
- loss treatment
- bone
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161580964P | 2011-12-28 | 2011-12-28 | |
US61/580,964 | 2011-12-28 | ||
PCT/US2012/068975 WO2013101451A1 (en) | 2011-12-28 | 2012-12-11 | Method of treating alvelor bone loss through the use of anti-sclerostin antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014016108A2 true BR112014016108A2 (pt) | 2018-09-11 |
Family
ID=47429046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014016108-9A BR112014016108A2 (pt) | 2011-12-28 | 2012-12-11 | método de tratamento de perda óssea alvelar |
Country Status (20)
Country | Link |
---|---|
US (3) | US9657090B2 (pt) |
EP (2) | EP2797953B1 (pt) |
JP (3) | JP6363954B2 (pt) |
KR (3) | KR102033669B1 (pt) |
CN (2) | CN104039828B (pt) |
AR (1) | AR089509A1 (pt) |
AU (3) | AU2012362898B2 (pt) |
BR (1) | BR112014016108A2 (pt) |
CA (1) | CA2858974A1 (pt) |
CL (1) | CL2014001719A1 (pt) |
EA (2) | EA202091676A1 (pt) |
ES (1) | ES2813524T3 (pt) |
HK (1) | HK1198367A1 (pt) |
IL (2) | IL232942B (pt) |
IN (1) | IN2014CN04634A (pt) |
MX (1) | MX354270B (pt) |
SG (2) | SG11201403718YA (pt) |
TW (3) | TW201811364A (pt) |
WO (1) | WO2013101451A1 (pt) |
ZA (1) | ZA201404610B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7592429B2 (en) * | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
EP3219725B1 (en) * | 2010-10-27 | 2020-12-16 | Amgen Inc. | Dkk1 antibodies and methods of use |
BR112013024493A2 (pt) | 2011-03-25 | 2018-06-26 | Amgen Inc. | cristais de anticorpo antiesclerostina e formulações dos mesmos |
BR112014016108A2 (pt) * | 2011-12-28 | 2018-09-11 | Amgen Inc | método de tratamento de perda óssea alvelar |
US10335098B2 (en) * | 2013-07-19 | 2019-07-02 | Axion Japan Co., Ltd. | Panoramic imaging apparatus and diagnostic imaging method in same apparatus |
MX2017011480A (es) * | 2015-03-13 | 2018-04-24 | Jiangsu Hengrui Medicine Co | Anticuerpo de anti-esclerostina, fragmento de union a antigeno y uso medico del mismo. |
JP2020502218A (ja) | 2016-12-21 | 2020-01-23 | メレオ バイオファーマ 3 リミテッド | 骨形成不全症の処置における抗スクレロスチン抗体の使用 |
EP3754021A4 (en) * | 2018-02-12 | 2021-11-10 | Aptacure Therapeutics Limited | APTAMER FOR SCLEROSTIN AND USE OF IT |
US20220122261A1 (en) * | 2018-10-30 | 2022-04-21 | Diagnocat Inc. | Probabilistic Segmentation of Volumetric Images |
US12062170B2 (en) * | 2018-10-30 | 2024-08-13 | Diagnocat Inc | System and method for classifying a tooth condition based on landmarked anthropomorphic measurements |
US20230130132A1 (en) * | 2020-03-26 | 2023-04-27 | Bone Sci. Bio Ltd. | Pharmaceutical compositions comprising amphiphilic peptides and methods of use thereof |
KR102472582B1 (ko) * | 2020-08-20 | 2022-11-30 | 한림대학교 산학협력단 | 인공관절 마모편에 의한 활막염과 골용해의 진단 및 치료 방법 |
KR20230079419A (ko) * | 2020-09-28 | 2023-06-07 | 안지티아 바이오메디슨즈 리미티드 | 항-스클레로스틴 구축물 및 이의 용도 |
Family Cites Families (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4411993A (en) | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
US4427115A (en) | 1981-10-19 | 1984-01-24 | Laipply Thomas C | One piece alcohol preparation device |
USRE32011E (en) | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
JPH0647532B2 (ja) * | 1983-08-31 | 1994-06-22 | ジ アツプジヨン カンパニ− | 歯槽骨吸収の治療 |
US6054561A (en) | 1984-02-08 | 2000-04-25 | Chiron Corporation | Antigen-binding sites of antibody molecules specific for cancer antigens |
DE3417525C1 (de) | 1984-05-11 | 1986-01-09 | Matter + Siegmann Ag, Wohlen | Vorrichtung zur quantitativen und qualitativen Erfassung von kohlenwasserstoffhaltigen Schwebeteilchen in Gasen |
US4902614A (en) | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
US5177197A (en) | 1990-02-27 | 1993-01-05 | Ludwig Institute For Cancer Research | Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein |
US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
JP3218637B2 (ja) | 1990-07-26 | 2001-10-15 | 大正製薬株式会社 | 安定なリポソーム水懸濁液 |
CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
JP2958076B2 (ja) | 1990-08-27 | 1999-10-06 | 株式会社ビタミン研究所 | 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法 |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
JPH04141095A (ja) | 1990-10-02 | 1992-05-14 | Chemo Sero Therapeut Res Inst | 組換え抗hiv改変抗体および改変抗体の調製方法 |
US5070108A (en) | 1990-10-12 | 1991-12-03 | Trustees Of The University Of Pennsylvania | Methods of treating osteoporosis, increasing bone mineral content and preventing the occurrence of compression fractures in a mammal |
AU662304B2 (en) | 1990-10-22 | 1995-08-31 | Fox Chase Cancer Center | DNA construct for providing RNA therapy |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
ATE181575T1 (de) | 1991-04-25 | 1999-07-15 | Chugai Pharmaceutical Co Ltd | Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor |
WO1994028929A1 (en) | 1993-06-07 | 1994-12-22 | Genentech, Inc. | Hiv envelope polypeptides |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5453492A (en) | 1993-07-28 | 1995-09-26 | La Jolla Cancer Research Foundation | 60 kDa transforming growth factor-β-binding protein and its use to detect or purify TGF-β |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
CA2187902A1 (en) | 1994-04-29 | 1995-11-09 | Peter Ten Dijke | Morphogenic protein-specific cell surface receptors and uses therefor |
DE4427221A1 (de) | 1994-08-01 | 1996-02-08 | Gsf Forschungszentrum Umwelt | Retrovirus-induzierte Osteoklasten-Modulation für die Osteoporose-Therapie |
US5846770A (en) | 1994-11-22 | 1998-12-08 | Genetics Institute, Inc. | DNA molecules encoding human chordin |
US6057421A (en) | 1994-11-30 | 2000-05-02 | Immpheron, Inc. | Variable heavy and light chain regions of murine monoclonal antibody 1F7 |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
CA2220912A1 (en) | 1995-06-05 | 1996-12-12 | Gregg A. Hastings | Human ccn-like growth factor |
US5738868A (en) | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
ES2312177T3 (es) | 1996-05-22 | 2009-02-16 | Viventia Biotech Inc. | Fragmentos de union a antigenos que detectan especificamente celulas cancerosas, nucleotidos que codifican los fragmentos y el uso de los mismos para la profilaxis y deteccion de canceres. |
US6133426A (en) | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
US5989909A (en) | 1997-09-26 | 1999-11-23 | Millennium Biotherapeutics, Inc. | Huchordin and uses thereof |
US6117911A (en) | 1997-04-11 | 2000-09-12 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
US6673901B2 (en) | 1997-06-12 | 2004-01-06 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
US6075007A (en) | 1997-07-17 | 2000-06-13 | Regeneron Pharmaceuticals, Inc. | Modified noggin polypeptide and compositions |
EP1000152A2 (en) | 1997-08-01 | 2000-05-17 | Genset | 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN MUSCLE AND OTHER MESODERMAL TISSUES |
US6815201B2 (en) | 1997-09-08 | 2004-11-09 | The Public Health Research Institute Of The City Of New York, Inc. | HIV-1 gp120 V1/V2 domain epitopes capable of generating neutralizing antibodies |
WO2002024888A2 (en) | 2000-09-01 | 2002-03-28 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
DE69934227T2 (de) | 1998-06-19 | 2007-10-04 | Mcgill University, Montreal | Auf Beta-Arabinose und dessen Analoga basierte Antisense-Oligonukleotide |
US6544485B1 (en) | 2001-01-29 | 2003-04-08 | Sharper Image Corporation | Electro-kinetic device with enhanced anti-microorganism capability |
NZ552959A (en) | 1998-11-27 | 2008-06-30 | Darwin Discovery Ltd | Compositions and methods for increasing bone mineralization |
US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
CN1345334A (zh) | 1999-01-29 | 2002-04-17 | 伊姆克罗尼系统公司 | 对kdr特异的抗体及其应用 |
CA2371434A1 (en) | 1999-06-09 | 2000-12-14 | Genentech, Inc. | Compositions and methods for the treatment of tumor |
CA2401175A1 (en) | 2000-03-02 | 2001-09-07 | Amgen, Inc. | Chordin-like-2 molecules and uses thereof |
US20020106650A1 (en) | 2000-06-01 | 2002-08-08 | Paszty Christopher J. | Cystine-knot polypeptides: cloaked-2 molecules and uses thereof |
AU2001272482A1 (en) | 2000-06-19 | 2002-01-02 | F.Hoffmann-La Roche Ag | Osteolevin gene polymorphisms |
DE60139944D1 (de) | 2000-10-12 | 2009-10-29 | Genentech Inc | Niederviskose konzentrierte proteinformulierungen |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
CA2374027A1 (en) | 2001-03-13 | 2002-09-13 | The Minister Of National Defence | Cloning, expression, sequencing, and functional enhancement of monoclonal scfv antibody against venezuelan equine encephalitis virus(vee) |
DE10145772A1 (de) | 2001-09-17 | 2003-04-10 | Bayer Cropscience Ag | DELTA·1·-Pyrroline |
CA2469025A1 (en) | 2001-12-06 | 2003-06-19 | Biocontrol Systems, Inc. | Sample collection and testing system |
US20030186915A1 (en) | 2002-02-11 | 2003-10-02 | Yang Pan | Regulatory polynucleotides and uses thereof |
JP4662714B2 (ja) | 2002-03-01 | 2011-03-30 | セルテック アール アンド ディー インコーポレイテッド | 骨密度を増減させる方法 |
WO2003087763A2 (en) | 2002-04-03 | 2003-10-23 | Celltech R & D, Inc. | Association of polymorphisms in the sost gene region with bone mineral density |
US20040023356A1 (en) | 2002-06-14 | 2004-02-05 | Robb Krumlauf | Wise/Sost nucleic acid sequences and amino acid sequences |
US7893218B2 (en) | 2003-06-16 | 2011-02-22 | Stowers Institute For Medical Research | Antibodies that specifically bind SOST peptides |
US7758876B2 (en) | 2002-11-01 | 2010-07-20 | The United States Of America As Represented By The Department Of Health And Human Services | Method of preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides |
US7642238B2 (en) | 2002-12-05 | 2010-01-05 | Shaughnessy John D | Molecular determinants of myeloma bone disease and uses thereof |
CA2509060A1 (en) * | 2002-12-27 | 2004-07-22 | Angiotech International Ag | Compositions and methods of using collagen and mmpi |
US20040141875A1 (en) | 2003-01-15 | 2004-07-22 | Rajiv Doshi | System and method for treating microorganisms within motor vehicle heating, ventilation, and air conditioning units |
US20050281756A1 (en) * | 2004-06-14 | 2005-12-22 | Eamonn Connolly | Use of lactic acid bacteria for decreasing gum bleeding and reducing oral inflammation |
GB0304030D0 (en) | 2003-02-21 | 2003-03-26 | King S College London | Teeth |
JP4660471B2 (ja) | 2003-03-14 | 2011-03-30 | セルテック アール アンド ディー, インコーポレイテッド | TGFβ結合タンパク質のリガンドおよびその使用 |
US20050158303A1 (en) | 2003-04-04 | 2005-07-21 | Genentech, Inc. | Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations |
CU23403A1 (es) | 2003-04-23 | 2009-08-04 | Centro Inmunologia Molecular | Anticuerpos recombinantes y fragmentos que reconocen el gangliósido n-glicolil gm3 y su uso para diagnóstico y tratamiento de tumores |
ES2586401T3 (es) | 2003-06-16 | 2016-10-14 | Ucb Pharma S.A. | Anticuerpos específicos para la esclerostina y métodos para aumentar la mineralización ósea |
US8461155B2 (en) | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
GB0324854D0 (en) | 2003-10-24 | 2003-11-26 | Expresson Biosystems Ltd | App/ena antisense |
US20050267233A1 (en) | 2004-05-25 | 2005-12-01 | Joshi Ashok V | Anti-microbial handle system |
CA2574881C (en) | 2004-08-04 | 2013-01-08 | Amgen Inc. | Antibodies to dkk-1 |
US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
US7592429B2 (en) * | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
US8541177B2 (en) | 2006-01-13 | 2013-09-24 | A Chan Holding B.V. | Treatment and diagnosis of abnormal bone density with an inhibitor of the glypican-sclerostin interaction |
US20100015665A1 (en) | 2006-11-10 | 2010-01-21 | Ucb Pharma S.A. | Antibodies and diagnostics |
EP2423226A3 (en) | 2006-11-10 | 2012-05-30 | Amgen Inc. | Antibody-based diagnostics and therapeutics |
EP4176884A1 (en) | 2006-12-29 | 2023-05-10 | Ossifi-Mab LLC | Methods of altering bone growth by administration of sost or wise antagonist or agonist |
AU2008209713B2 (en) | 2007-02-02 | 2012-01-19 | Novartis Ag | Modulators of sclerostin binding partners for treating bone-related disorders |
JP2010524846A (ja) | 2007-03-20 | 2010-07-22 | イーライ リリー アンド カンパニー | 抗スクレロスチン抗体 |
CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
TWI489993B (zh) | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素(sclerostin)抗體組合物及使用方法 |
WO2009056634A2 (en) | 2007-11-02 | 2009-05-07 | Novartis Ag | Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (lrp6) |
CA2707400A1 (en) | 2007-12-14 | 2009-06-25 | Amgen Inc. | Method for treating bone fracture with anti-sclerostin antibodies |
WO2009149189A2 (en) | 2008-06-03 | 2009-12-10 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
WO2010004179A2 (fr) | 2008-06-30 | 2010-01-14 | France Telecom | Communications cooperatives multicellulaires dans un reseau decentralise |
GB0903689D0 (en) | 2009-03-03 | 2009-04-15 | Sigmavision Ltd | Vehicle tyre measurement |
WO2010100200A2 (en) | 2009-03-05 | 2010-09-10 | Novartis Ag | Lyophilised antibody formulation |
WO2010100179A2 (en) | 2009-03-05 | 2010-09-10 | Novartis Ag | Self-forming gel system for sustained drug delivery |
WO2010115932A1 (en) | 2009-04-08 | 2010-10-14 | Novartis Ag | Combination for the treatment of bone loss |
WO2010130830A2 (en) | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against sclerostin and polypeptides comprising the same for the treatment of bone diseases and disorders |
WO2011128424A1 (en) * | 2010-04-16 | 2011-10-20 | Novartis Ag | Methods and compositions for improving implant osseointegration |
CN102946903B (zh) * | 2010-05-14 | 2014-11-26 | 安进公司 | 高浓度抗体制剂 |
WO2012028683A1 (en) | 2010-09-02 | 2012-03-08 | Novartis Ag | Antibody gel system for sustained drug delivery |
EP3219725B1 (en) | 2010-10-27 | 2020-12-16 | Amgen Inc. | Dkk1 antibodies and methods of use |
BR112014016108A2 (pt) * | 2011-12-28 | 2018-09-11 | Amgen Inc | método de tratamento de perda óssea alvelar |
-
2012
- 2012-12-11 BR BR112014016108-9A patent/BR112014016108A2/pt active Search and Examination
- 2012-12-11 SG SG11201403718YA patent/SG11201403718YA/en unknown
- 2012-12-11 CN CN201280064888.4A patent/CN104039828B/zh not_active Expired - Fee Related
- 2012-12-11 IN IN4634CHN2014 patent/IN2014CN04634A/en unknown
- 2012-12-11 EA EA202091676A patent/EA202091676A1/ru unknown
- 2012-12-11 CA CA2858974A patent/CA2858974A1/en not_active Abandoned
- 2012-12-11 WO PCT/US2012/068975 patent/WO2013101451A1/en active Application Filing
- 2012-12-11 EP EP12805890.6A patent/EP2797953B1/en active Active
- 2012-12-11 EP EP20170362.6A patent/EP3712168A3/en not_active Withdrawn
- 2012-12-11 SG SG10201509629QA patent/SG10201509629QA/en unknown
- 2012-12-11 KR KR1020147018792A patent/KR102033669B1/ko active IP Right Grant
- 2012-12-11 MX MX2014007965A patent/MX354270B/es active IP Right Grant
- 2012-12-11 JP JP2014550316A patent/JP6363954B2/ja not_active Expired - Fee Related
- 2012-12-11 EA EA201491286A patent/EA036740B1/ru unknown
- 2012-12-11 KR KR1020197029949A patent/KR20190120401A/ko not_active Application Discontinuation
- 2012-12-11 AU AU2012362898A patent/AU2012362898B2/en not_active Ceased
- 2012-12-11 KR KR1020207013720A patent/KR20200056473A/ko not_active Application Discontinuation
- 2012-12-11 CN CN201710477474.9A patent/CN107126560A/zh active Pending
- 2012-12-11 ES ES12805890T patent/ES2813524T3/es active Active
- 2012-12-11 US US14/362,322 patent/US9657090B2/en active Active
- 2012-12-27 TW TW106127894A patent/TW201811364A/zh unknown
- 2012-12-27 AR ARP120105033A patent/AR089509A1/es not_active Application Discontinuation
- 2012-12-27 TW TW101150690A patent/TWI706787B/zh not_active IP Right Cessation
- 2012-12-27 TW TW109121170A patent/TW202114733A/zh unknown
-
2014
- 2014-06-02 IL IL232942A patent/IL232942B/en active IP Right Grant
- 2014-06-23 ZA ZA2014/04610A patent/ZA201404610B/en unknown
- 2014-06-25 CL CL2014001719A patent/CL2014001719A1/es unknown
- 2014-11-24 HK HK14111876.0A patent/HK1198367A1/xx unknown
-
2017
- 2017-04-21 US US15/494,121 patent/US9913900B2/en active Active
- 2017-05-10 JP JP2017093679A patent/JP2017214359A/ja active Pending
-
2018
- 2018-01-29 AU AU2018200649A patent/AU2018200649A1/en not_active Abandoned
- 2018-01-31 US US15/885,043 patent/US20180169234A1/en not_active Abandoned
- 2018-06-11 IL IL259939A patent/IL259939B/en active IP Right Grant
- 2018-11-05 JP JP2018208003A patent/JP2019031567A/ja not_active Withdrawn
-
2019
- 2019-12-03 AU AU2019275548A patent/AU2019275548A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6930321A2 (es) | Curación de tejidos | |
BR112014016108A2 (pt) | método de tratamento de perda óssea alvelar | |
BR112014007603A2 (pt) | métodos de tratamento do câncer | |
BR112014004387A2 (pt) | aparelho de tratamento de vestuário | |
GB201110095D0 (en) | Method of treatment | |
EP2773754A4 (en) | Methods of Treatment | |
BR112013007678A2 (pt) | método para tratamento de doenças alérgicas | |
EP2740419A4 (en) | TREATMENT INSTRUMENT | |
BR112013016491A2 (pt) | método para tratamento de têxtil | |
BR112014031224A2 (pt) | método de descelularização de osso | |
BR112014004192A2 (pt) | composição de tratamento de sementes, e, método de tratamento de sementes | |
PL2825212T3 (pl) | Ulepszony sposób sterylizacji | |
ITBO20120529A1 (it) | Apparecchio di trattamento alimentare | |
BR112013022820A2 (pt) | método de tratamento | |
BR112014011089A2 (pt) | processo de esterilização | |
CO6900134A2 (es) | Tratamiento de mieloma múltiple | |
BR112014004618A2 (pt) | aparelho de sutura cirúrgico | |
IL220594A0 (en) | Treatment method | |
BR112013023142A2 (pt) | método de tratamento de cabelos | |
BR112014011008A2 (pt) | método de quantificação de tratamento de câncer | |
CO6811865A2 (es) | Método de tratamiento de la fiebre dengue | |
HK1201691A1 (en) | Sterilization method | |
SG11201400256PA (en) | Water treatment method | |
FI20116093L (fi) | Vettä käsittelevä laitos | |
CO6821930A2 (es) | Métodos de tratamiento de biomasa |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |